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EFFECT OF LINOPIRDINE ON FORCED SWIMMING TEST IN RATS

Uzunok, Baris | Kahveci, Nevzat | Suyen, Guldal Gulec | Buyukuysal, M. Cagatay

Article | 2019 | NOBEL MEDICUS15 ( 1 ) , pp.41 - 46

Objective: In this study, we aimed to investigate the effect of Kv7 type voltage-gated potassium channel blocker linopirdin in Forced Swimming Test (FST) in rats. Material and Method: For this purpose, on the second day of the swimming test, rats received %0.9 NaCl (4 mu l) or a Kv7 type voltage-gated potassium channel blocker linopirdine (0.1, 1, 10 mu g/4 mu l) intracerebroventricularly (i.c.v.), 15 min before the test. Results: Linopirdine at a dose of 0.1 mu g/4 mu l significantly decreased immobilisation (p=0.003) and significantly increased swimming (p

Sleep problems, anxıety, depressıon and fatıgue on famıly members of adult intensıve care unıt patıents

Çelik S. | Genç G. | Kinetli Y. | Aşılıoğlı M. | Sarı M. | Madenoğlu Kıvanç M.

Article | 2016 | International journal of nursing practice22 ( 5 ) , pp.512 - 522

The purpose of this study was to determine the levels of sleep problems, anxiety, depression and fatigue in family members of intensive care patients in Turkey and factors affecting these complaints. This cross-sectional study was carried out with 350 first-degree relatives of intensive care patients at a university and state hospital. Data were collected between 5 January and 30 May 2014 using a personal information form, the Visual Analogue Scale for Fatigue, the Hospital Anxiety and Depression Scale and the modified Post Sleep Inventory. Of the 350 family members, 76% reported moderate or more serious problems. Anxiety was report . . .ed by 81.4% of the family members, and depression by 94.2%. Family members in the study had fatigue, with average scores of 79.42. There were significant correlations between the Visual Analogue Scale for Fatigue and anxiety, depression and scores on the Modified Post-Sleep Inventory (P Daha fazlası Daha az

Sleep problems, anxiety, depression and fatigue on family members of adult intensive care unit patients

Celik, Sevim | Genc, Gizem | Kinetli, Yasemin | Asiliogli, Meral | Sari, Merve | Kivanc, Meral Madenoglu

Article | 2016 | INTERNATIONAL JOURNAL OF NURSING PRACTICE22 ( 5 ) , pp.512 - 522

The purpose of this study was to determine the levels of sleep problems, anxiety, depression and fatigue in family members of intensive care patients in Turkey and factors affecting these complaints. This cross-sectional study was carried out with 350 first-degree relatives of intensive care patients at a university and state hospital. Data were collected between 5 January and 30 May 2014 using a personal information form, the Visual Analogue Scale for Fatigue, the Hospital Anxiety and Depression Scale and the modified Post Sleep Inventory. Of the 350 family members, 76% reported moderate or more serious problems. Anxiety was report . . .ed by 81.4% of the family members, and depression by 94.2%. Family members in the study had fatigue, with average scores of 79.42. There were significant correlations between the Visual Analogue Scale for Fatigue and anxiety, depression and scores on the Modified Post-Sleep Inventory ( Daha fazlası Daha az

Evaluation of Newborn Mothers' Status of Bonding to the Baby, Experiencing Depression, and Associated Factors

Topan, Aysel | Demirel, Serap | Alkan, Isin | Ayyildiz, Tulay Kuzlu | Dogru, Sevda

Article | 2019 | MEDICAL JOURNAL OF BAKIRKOY15 ( 2 ) , pp.160 - 169

Objective: The aim of this study is to evaluate newly delivered mothers' status of bonding to their babies, their status of experiencing depression following delivery. and associated factors. Methods: The study was descriptive and sectional-type; and performed in a public hospital between February 1 and April 1 2015. Sample of the study was composed of 150 women who approved to participate in the study during this time interval. Participant information form. Mother to Infant Bonding Scale and Edinburgh Postnatal Depression Scale were used as data collection tools. Data were collected by face-to-face interview technique. Kruskal Wall . . .is. Mann-Whitney U, student-t test and correlation analysis were used for statistical analysis of the data. Results: It was found that mean score of women from mother-to-infant bonding scale was 1.13 +/- 1.81. mean score from depression scale was 8.12 +/- 4.85 and 16.7% of the women were within the risk group for depression. A statistically significant difference was detected between mother to infant bonding status of women in the study and their status of willingness at last pregnancy (p0.05). There was a significant difference between women's status of getting support from their spouses during the pregnancy and experiencing depression ( Daha fazlası Daha az

Open-label study of adjunct modafinil for the treatment of patients with fatigue, sleepiness, and major depression treated with selective serotonin reuptake inhibitors

Konuk, Numan | Atasoy, Nuray | Atik, Levent | Akay, Omer

Article | 2006 | ADVANCES IN THERAPY23 ( 4 ) , pp.646 - 654

Despite the efficacy of selective serotonin reuptake inhibitors (SSRIs) in the treatment of major depression, a significant number of patients show partial or no remission of symptoms. Some evidence suggests that psychostimulant augmentation may be helpful in treating patients with residual symptoms of depression. The efficacy of modafinil in augmenting SSRIs in depressed patients with residual fatigue or excessive daytime sleepiness has yet to be systematically investigated. In a series of 25 patients with major depressive disorder, according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, . . . who showed significant residual symptoms after an adequate SSRI trial (12 wk) and who were evaluated according to the Fatigue Severity Scale (FSS), subjects with scores >= 4 were given open-label modafinil augmentation for a minimum of an additional 6 wk. Treatment response was assessed prospectively with the FSS, the Epworth Sleepiness Scale (ESS), and the Hamilton Rating Scale for Depression (HAM-D) during the first visit and at the second and sixth weeks. Twenty-one of 25 patients in this series who were treated with modafinil and SSRIs completed the 6-wk augmentation trial. At end-point assessment, all patients showed significant improvement in fatigue and sleepiness in FSS and ESS scores, as well as in HAM-D scores (P Daha fazlası Daha az

Correlations between alexithymia and pain severity, depression, and anxiety among patients with chronic and episodic migraine

Yalug, Irem | Selekler, Macit | Erdogan, Ayten | Kutlu, Ayse | Dundar, Gulmine | Ankarali, Handan | Aker, Tamer

Article | 2010 | PSYCHIATRY AND CLINICAL NEUROSCIENCES64 ( 3 ) , pp.231 - 238

Aims: Some studies have found elevated alexithymia among patients with chronic pain, but the correlations between alexithymia and the severity of pain, depression, and anxiety among migraine patients are unclear. The aims of the present study were to investigate whether individuals suffering from episodic migraine (EM) differ from those with chronic migraine (CM) in regards to depression, anxiety, and alexithymia measures and to investigate the association of alexithymia with the results of depression and anxiety test inventories and illness characteristics. Methods: A total of 165 subjects with EM and 135 subjects with CM were stud . . .ied. The Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and Toronto Alexithymia Scale (TAS) were administered to all subjects. The correlation between alexithymia and sociodemographic variables, family history of migraine and illness characteristics (pain severity, frequency of episode, duration of illness) were evaluated. Results: Compared with EM patients, the CM patients had significantly higher scores on measures of depression but not alexithymia and anxiety. There was a positive correlation between TAS scores and age and education in both migraine groups, but there was no correlation between TAS scores and other demographic variables. Depression and anxiety were significantly correlated with alexithymia in both migraine groups. Conclusion: Our results indicate that CM patients are considerably more depressive than EM patients. In this study, depression and anxiety were significantly correlated with alexithymia in both migraine groups. Our results demonstrate a positive association between depression, anxiety, and alexithymia in migraine patients Daha fazlası Daha az

Relationship of Cognitive Functions with Daily Living Activities, Depression, Anxiety and Clinical Variables in Hospitalized Elderly Patients

Akca, Ayse Semra Demir | Saracli, Ozge | Emre, Ufuk | Atasoy, Nuray | Gudul, Serdar | Barut, Banu Ozen | Senormanci, Omer

Article | 2014 | NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY51 ( 3 ) , pp.267 - 274

Introduction: Cognitive impairment in elderly patients, which may be a sign of dementia, depression, anxiety or medical diseases, has been determined as a risk factor for functional loss. In this study, we aimed to investigate the frequency of cognitive impairment and to investigate the relationship of cognitive status with sociodemographic variables, daily living activities, anxiety and depression in elderly inpatients. Method: The sample of this cross-sectional and descriptive study consists of 243 patients aged 65 years and older who were hospitalized in Bulent Ecevit University Hospital. A sociodemographic questionnaire,, the Mi . . .ni-Mental State Examination (MMSE), Activities of Daily Living Scale, Lawton-Brody Instrumental Daily Activities Scale, Geriatric Depression Scale (GDS) and the Beck Anxiety Inventory were used for data collection. Results: One hundred and six (43.6%) patients were female and 137 (56.4%) were male. The patients were divided into two groups according to the Mini-Mental State Examination (MMSE) 23/24 cut-off score. The cognitive decline was statistically significantly more frequent in patients who were older, female, less educated, low socioeconomic status, and living in rural areas. There were more problems in the basic and instrumental activities of daily living and nutrition in patients with cognitive decline. Anxiety and depression scores were higher in this group. In our study, although the frequency of cognitive decline and depression according to GDS were 56% and 48%, respectively; we found that only 10.5% of patients applied to the psychiatrist, and 9.3% of patients received psychiatric treatment. Conclusion: Cognitive decline may cause deterioration in the daily living activities, nutrition and capacity for independent functioning. Older age, female, low education, low socioeconomic status and living in rural area are important risk factors for cognitive impairment. Cognitive decline in older age may be associated with depression and anxiety. We assume that when cognitive decline, depression and other psychiatric problems are unidentified, it may contribute to deterioration of mental health in medically ill elderly Daha fazlası Daha az

HbA1c Is Related with Uremic Pruritus in Diabetic and Nondiabetic Hemodialysis Patients

Afsar, Baris | Afsar, Rengin Elsurer

Article | 2012 | RENAL FAILURE34 ( 10 ) , pp.1264 - 1269

Objective: Uremic pruritus (UP) remains a frequent problem in hemodialysis (HD) patients and is related to mortality. Poor glycemic control, as evaluated by hemoglobin A1c (HbA1c), is also associated with morbidity and mortality in HD patients. In this study, we investigated the relationship between UP and HbA1c in HD patients. Methods: Sociodemographic, clinical, and laboratory variables, depressive symptoms, and health-related quality of life were assessed. Severity of UP was evaluated by visual analogue scale (VAS). The scale consisted of a 10 cm horizontal line marked from 0 (denoting no itch) to 10 (denoting worst possible imag . . .inable itch). Results: Totally, 75 patients (male/female, 41/34; diabetic/nondiabetic, 29/46; age, 51.9 +/- 13.5 years) were included. The VAS pruritus score was higher in diabetic patients compared with nondiabetic patients (4.7 +/- 2.8 vs. 3.0 +/- 1.0, p : 0.015). In diabetics, VAS pruritus score was independently related with calcium-phosphorus product (beta : +0.637, p < 0.0001), intact parathyroid hormone (beta : +0.343, p : 0.017), HbA1c (beta : +0.310, p : 0.027), and Beck depression score (beta : +0.474, p : 0.002). In nondiabetics, VAS pruritus score was independently related with calcium-phosphorus product (beta: +0.486, p : 0.004), intact parathyroid hormone (beta : +0.302, p : 0.041), and HbA1c (beta : +0.341, p : 0.033). In the whole patient group, VAS pruritus score was independently related with calcium-phosphorus product (beta : +0.372, p : 0.001), intact parathyroid hormone (beta : +0.241, p : 0.008), HbA1c (beta : +0.227, p : 0.031), and Beck depression score (beta : +0.298, p : 0.003). Conclusions: In both diabetic and nondiabetic patients, HbA1c is closely related with pruritus in HD patients Daha fazlası Daha az

Irritable bowel syndrome in haemodialysis: Prevalence, link with quality of life and depression

Afsar, Baris | Elsurer, Rengin | Yilmaz, M. Ilker | Eyileten, Tayfun | Yenicesu, Muejdat

Article | 2010 | NEPHROLOGY15 ( 2 ) , pp.197 - 202

Aim: Health-related quality of life (HRQOL) is decreased in haemodialysis (HD) patients. Irritable bowel syndrome (IBS) is highly prevalent in general population. This study evaluated the prevalence of IBS and its association with HRQOL and depression in HD. Methods: Sociodemographic and laboratory variables were recorded. Severity of depressive symptoms and HRQOL were assessed by the Beck Depression Inventory (BDI) and Short Form 36 (SF-36), respectively. Diagnosis of IBS was based on Rome II criteria. Results: Among 236 patients 69 (29.2%) had IBS. Patients with IBS had lower SF-36 scores and had higher depressive symptoms than pa . . .tients without IBS. Presence of IBS was associated with sleep disturbance (odds ratio (OR) = 2.012; P = 0.045), physical component summary score (OR = 0.963, P = 0.029), mental component summary score (OR = 0.962, P = 0.023), BDI score (OR = 1.040, P = 0.021) and albumin (OR = 0.437, P = 0.01). Conclusion: IBS is highly prevalent in HD patients. Presence of IBS is closely related with HRQOL and depression Daha fazlası Daha az

The effect of montelukast on depression behavior in rat forced swimming test

Gonca, Ersoz

Article | 2017 | JOURNAL OF MOOD DISORDERS7 ( 2 ) , pp.104 - 109

Objective: Montelukast (brand name: Singulair), which is used for treatment of chronic asthma, is a leukotriene receptor antagonist. The psychiatric side effects of montelukast use in asthma patients are controversial. The aim of this study is to examine the effect of montelukast treatment on depression behavior in both healthy and asthmatic rats. Method: 50 wistar albino female rats, of between 150 and 250 g in weight, were used in this study. The study was conducted with two groups: Group I: healthy group; including control, asthma, and montelukast-treated asthma subgroups (n=20) and Group II: asthmatic group including control, as . . .thma, and montelukast-treated asthma subgroups (n=30). The bronchial asthma model was employed for all the rats in the asthmatic group. In this model, the animals were sensitized by giving ovalbumin intraperitoneally and they were also provoked by breathing ovalbumin. Montelukast was given to the rats intraperitoneally at a dose of 10 mg/kg for 10 days in montelukast-treated subgroups of both groups. A forced swimming test was used to determine the effect of montelukast treatment on depression behavior. Results: In the healthy rats (Group I), immobility time increased in montelukast-treated asthmatic rats compared to the control subgroup (p0.05). However, in this group (Group II), immobility time was higher in montelukast-treated asthmatic rats compared to saline treated asthmatic rats ( Daha fazlası Daha az

Bone Pain Assessment and Relationship with Parathyroid Hormone and Health-Related Quality of Life in Hemodialysis

Elsurer, Rengin | Afsar, Baris | Mercanoglu, Esra

Article | 2013 | RENAL FAILURE35 ( 5 ) , pp.667 - 672

Renal osteodystrophy is a common problem in renal failure patients. Bone pain is a common manifestation of renal osteodystrophy. The aim of the study was to assess the intensity of chronic bone pain via visual analog scale (VAS) and its relationship with parathyroid hormone, health-related quality of life (HRQoL), and depression in hemodialysis patients. Ninety-five patients recruited were asked to rate chronic bone pain via VAS. Depressive symptoms and HRQoL were assessed by Beck Depression Inventory (BDI) and Short-Form 36, respectively. VAS was positively correlated with intact parathyroid hormone (r (_) +0.322, p (-) 0.001), pho . . .sphorus (r- +0.300, p -0.003), alkaline phosphatase (r- +0.275, p = 0.009), and negatively correlated with physical component (r= - 0.320, p 0.002) and mental component summary scores (r = -0.247, p = 0.016). In multivariate linear regression analysis, logVAS was independently associated with serum phosphorus (beta = 0.072, 95% confidence interval: 0.020-0.123, p = 0.007), log intact parathyroid hormone (beta = 0.176, 95% confidence interval: 0.041-0.310, p = 0.011), and physical component summary score (beta = -0.018, 95% confidence interval: -0.031-(-0.005), p - 0.008). VAS is correlated with bone metabolism markers, namely, intact parathyroid hormone, and may be used to assess the intensity of chronic bone pain. The intensity of chronic bone pain is related with HRQoL in hemodialysis patients Daha fazlası Daha az

Assessment of Relation Between Subjective Memory Complaints and Objective Cognitive Performance of Elderly Over 55 Years Old Age

Acikgoz, Mustafa | Ozen Barut, Banu | Emre, Ufuk | Tascilar, Nida | Atalay, Adnan | Kokturk, Furuzan

Article | 2014 | NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY51 ( 1 ) , pp.57 - 62

Introduction: This study investigated the frequency of forgetfulness in elderly individuals over 55 years of age and examined the association of subjective memory complaints (SMCs) with objective cognitive functions,, depression and other risk factors. Methods: We recruited 405 patients over 55 years of age who were referred to Neurology, Cardiology, or Physical Therapy and Rehabilitation outpatient clinics. All subjects were questioned regarding forgetfulness and then were administered the Subjective Memory Complaint (SMC) Scale, Mini Mental Test (MMT), Verbal Fluency Test (VFT), Clock Drawing Test (CDT) and the Geriatric Depressio . . .n Scale (GDS). Subjects with SMC were compared with those without SMC in terms of cognition, depression and some laboratory parameters. Results: Of the patients, 42.5% complained of forgetfulness. None of these patients had been admitted to hospital for this complaint. Women and patients with low education had more forgetfulness as well as poorer results on the SMC Scale, MMT, VFT, and GDS. Patients with SMC had lower hemoglobin, ferritin and free T4 levels. Female gender and depression was found to be a risk factor for SMCs. Conclusion: SMCs are common in people over 55 years of age. Being a woman as well as depression was found to be a risk factor for SMC. Since depression is a treatable condition, these people should be assessed carefully in terms of depressive symptoms. Laboratory parameters, such as hemoglobin, ferritin and free T4 levels should be investigated in patients with SMC. Unlike the other cognitive tests, CDT performance is independent of subjective memory complaints. Elderly patients rarely visit hospital with complaint of SMC, therefore, clinicians should be watchful for this problem Daha fazlası Daha az

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