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PD-1 gene polymorphism in children with subacute sclerosing panencephalitis

Piskin I. | Calk M. | Abuhandan M. | Kolsal E. | Celik S. | Iscan A.

Article | 2013 | Neuropediatrics44 ( 4 ) , pp.187 - 190

Subacute sclerosing panencephalitis (SSPE) is a progressive inflammatory and degenerative disorder of the central nervous system. Several factors influence the risk of chronic brain infection with the mutant measles virus. However, to date, no pathogenic mechanism that may predispose to SSPE has been determined. Studies have indicated that specific polymorphisms in certain host genes are probably involved in impairing the ability of host immune cells to eradicate the measles virus in SSPE patients. Programmed cell death protein 1 (PD-1), a member of the CD28 family, is a negative regulator of the immune system. The purpose of our st . . .udy was to investigate whether PD-1 gene polymorphisms affect susceptibility to the development of SSPE in Turkish children. In total, 109 subjects (54 SSPE patients and 55 healthy controls) were genotyped for the PD-1.9 C/T (rs2227982) single-nucleotide polymorphism (SNP). The distributions of T alleles in the PD-1.9 polymorphism in SSPE patients and healthy controls were 2.8 and 10.9%, respectively. There was a statistically significant difference between the groups; the 95% confidence interval (CI) was 0.06 to 0.85 and the odds ratio (OR) was 0.23 (?2 test). Thus, we identified an association between SSPE and the PD-1 rs2227982 gene polymorphism; the frequency of T alleles was higher in controls than in SSPE patients. © Georg Thieme Verlag KG Stuttgart. New York Daha fazlası Daha az

Liver function tests in children and adolescents receiving risperidone treatment for a year: A longitudinal, observational study from Turkey

Karaman, Mehmet Goksin | ErdoGan, Ayten | Tufan, Evren | Yurteri, Nihal | Ozdemir, Esra | Ankarali, Handan


Objective. To determine the changes in liver function tests after long-term risperidone treatment in a child and adolescent population. Methods. Weight, alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transpeptidase, alkaline phosphatase and serum bilirubin of the patients were assessed in pre-treatment period, and at the sixth and 12th months of treatment. One hundred children and adolescents (aged between 3 and 18 years) were enrolled to the study. Results. Liver enzyme and bilirubin levels are higher than normal in 21.0% of the patients without clinical symptoms. No cases of hepatic failure or jaundice were s . . .een. Only in an 8-year-old boy were there ALT level increases up to three-fold and AST level increases up to two-fold. After discontinuation of the risperidone treatment, enzyme levels were normalized in this patient. Alkaline phosphatase, alanine and aspartate aminotransferases were the most frequently increased enzymes. Conclusion. In this study, after long-term risperidone treatment of children and adolescents there was no evidence of clinically significant increases of liver enzymes and bilirubin levels. These results indicate that risperidone treatment may rarely cause serious liver enzyme increases, and may commonly cause clinically insignificant changes in liver function tests Daha fazlası Daha az

The evaluation of cystatin C, IL-1 beta, and TNF-alpha levels in total saliva and gingival crevicular fluid from 11- to 16-year-old children

Ulker, A. Evren | Tulunoglu, Oezlem | Ozmeric, Nurdan | Can, Murat | Demirtas, Selda

Article | 2008 | JOURNAL OF PERIODONTOLOGY79 ( 5 ) , pp.854 - 860

Background: The aim of this study was to evaluate the levels of cystatin C, interleukin-1 beta (IL-1 beta), and tumor necrosis factor-alpha (TNF-alpha) in the total saliva and gingival crevicular fluid (GCF) of periodontally healthy children (PHC) and children with gingivitis (CG) who were between I I and 16 years old. Methods: The study was carried out with 10 PHC and 25 CG. Unstimulated total saliva and GCF samples were obtained. Clinical parameters, including probing depth (PD), clinical attachment loss (CAL), plaque index (PI), gingival index (GI), and gingival bleeding index (GBI), were assessed. GCF samples were collected from . . . four maxillary upper incisors. After sampling, biochemical analyses were performed using latex particle-enhanced turbidimetric immunoassay for cystatin C and enzyme-linked immunosorbent assay for IL-1 beta and TNF-alpha. The multivariate analysis of variance test was used for statistical evaluation. Results: In total saliva, cystatin C and TNF-a levels were higher in PHC, and IL-1 beta levels were higher in CG, but the differences were not statistically significant. In GCF, cystatin C levels were higher in PHC (P >0.05), whereas TNF-alpha and IL-1 beta levels were higher in CG (P >0.05). In the CG group, there were positive correlations between the GCF cystatin C level and the PI of the sampled site (r = 0.488; P Daha fazlası Daha az

Epiploic Appendagitis as a Rare Cause of Acute Abdomen in the Pediatric Population: Report of Three Cases

Ozturk, Mesut | Aslan, Serdar | Saglam, Dilek | Bekci, Tumay | Bilgici, Meltem Ceyhan

Article | 2018 | EURASIAN JOURNAL OF MEDICINE50 ( 1 ) , pp.56 - 58

Epiploic appendagitis, caused by inflammation of small adipose tissue on the colon wall, is a rare cause of acute abdominal pain in the pediatric population. It is nearly impossible to establish a specific diagnosis merely on the basis of clinical findings; thus, radiological evaluation is always necessary. In this report, we present the cases of three children with abdominal pain who were diagnosed with epiploic appendagitis. All cases were successfully treated with conservative management.

Leptin levels in children with obstructive sleep apnea syndrome

Sogut, Ayhan | Acikgoz, Serefden | Uzun, Lokman | Ugur, Mehmet Birol | Altin, Remzi | Dagli, Elif | Kaditis, Athanasios

Article | 2016 | TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX64 ( 4 ) , pp.283 - 288

Introduction: The aim of this study is to assess the effect of obstructive sleep apnea syndrome (OSAS) severity on leptin levels in children. Patients and Methods: Children with habitual snoring underwent overnight polysomnography. Fasting venous blood samples were obtained between 8 AM and 9 AM, following the night of the sleep study. Children with an apnea-hypopnea index of >= 5/h were included in the moderate-to-severe OSAS group while those with an apnea-hypopnea index of < 5/h formed the mild OSAS/primary snoring group. Results: 47 children (51% male and 49% female; mean age 7.8 +/- 2.6 years) were recruited. Twenty seven parti . . .cipants were diagnosed with moderate-to-severe OSAS, and twenty children who had AHI < 5 were included in the mild OSAS/primary snoring. The two groups did not differ regarding age, gender and body mass index z score (p> 0.05). Furthermore there were no differences in log serum leptin levels (p= 0.749). Log serum leptin levels correlated with the BMI z score in the whole study group (p= 0.001; r= 0.499) but they were not associated with apnea-hypopnea index, mean and lowest oxygen saturation during sleep. Conclusion: Serum leptin levels are affected by adiposity but not by OSAS severity among children with habitual snoring Daha fazlası Daha az

Radiologic aspects of abdominal hydatidosis in children - A study of 31 cases in Turkey

Erdem, LO | Erdem, CZ | Karlioguz, K | Uner, C

Article | 2004 | CLINICAL IMAGING28 ( 3 ) , pp.196 - 200

Objective: To determine the location and radiological characteristics in children with abdominal hydatid disease (HD). Materials and methods: Thirty-one children (average age: 7.2 years) with abdominal HD were studied. The number, location, diameter and internal architecture of the cysts were assessed with abdominal ultrasonography (US) and computed tomography (CT). Density measurements and enhancement patterns were determined on CT. Results: Twenty-one children had hepatic HD. The remaining 10 children had both hepatic and extrahepatic cysts. There were splenic cysts in five children, peritoneal cysts in two children and combined s . . .plenic and peritoneal cysts in three children. The most common site of the cysts was the liver (64%), followed by the spleen (20%) and the peritoneal cavity (16%). The seven intraabdominal cysts, which were not detected by US, were 20 min or less in diameter. Conclusion: CT may demonstrate additional small intrahepatic or unsuspected extrahepatic cysts. Although rare, splenic or peritoneal hydatidosis should be included in the differential diagnosis of a cystic splenic or peritoneal lesion. Familiarity with atypical locations of HD may be helpful in making a prompt, accurate diagnosis. We think that in particular patients, especially those who had diagnostic problem and who are under surgical planning, CT should be performed additionally. (C) 2004 Elsevier Inc. All rights reserved Daha fazlası Daha az

The Frequency of Lysosomal Acid Lipase Deficiency in Children With Unexplained Liver Disease

Kuloglu, Zarife | Kansu, Aydan | Selbuz, Suna | Kalayci, Ayhan G. | Sahin, Gulseren | Kirsaclioglu, Ceyda Tuna | Demiroren, Kaan


Objectives: Evidence suggests that lysosomal acid lipase deficiency (LAL-D) is often underdiagnosed because symptoms may be nonspecific. We aimed to investigate the prevalence of LAL-D in children with unexplained liver disease and to identify demographic and clinical features with a prospective, multicenter, cross-sectional study. Methods: Patients (aged 3 months-18 years) who had unexplained transaminase elevation, unexplained hepatomegaly or hepatosplenomegaly, obesity-unrelated liver steatosis, biopsy-proven cryptogenic fibrosis and cirrhosis, or liver transplantation for cryptogenic cirrhosis were enrolled. A Web-based electron . . .ic data collection system was used. LAL activity (nmol/punch/h) was measured using the dried blood spot method and classified as LAL-D(0.37). Asecond dried blood spot sample was obtained from patients with intermediate LAL activity for confirmation of the result. Results: A total of 810 children (median age 5.6 years) from 795 families were enrolled. The reasons for enrollment were unexplained transaminase elevation (62%), unexplained organomegaly (45%), obesity-unrelated liver steatosis (26%), cryptogenic fibrosis and cirrhosis (6%), and liver transplantation for cryptogenic cirrhosis Daha fazlası Daha az

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