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Evaluation of serum uric acid levels in psoriasis vulgaris

Yilmaz E. | Tamer E. | Artüz F. | Külcü Çakmak S. | Köktürk F.

Article | 2017 | Turkish Journal of Medical Sciences47 ( 2 ) , pp.531 - 534

Background/aim: Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with the components of metabolic syndrome. In this study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by taking the presence of metabolic syndrome criteria into account, since it is one of the most important factors that affect serum uric acid levels. Materials and methods: In this cross-sectional study, we evaluated 70 psoriasis patients and 70 he . . .althy individuals who were matched with the patients according to the presence of metabolic syndrome. We evaluated the demographic features, levels of serum uric acid, Psoriasis Area Severity Index (PASI) scores, presence of psoriatic arthritis, nail involvement, and metabolic syndrome criteria of the patients. Results: Serum uric acid levels of psoriasis patients were significantly higher than those of controls. There was a positive correlation between PASI scores and serum uric acid levels of the patients. Conclusion: As hyperuricemia had a close relationship with psoriasis and PASI scores, we suggest monitoring patients with psoriasis for serum uric acid levels during treatment and follow-up. © TÜBİTAK Daha fazlası Daha az

Ischemia modified albumin and plasma oxidative stress markers in Alzheimer's disease

Can M. | Varlibas F. | Guven B. | Akhan O. | Yuksel G.A.

Article | 2013 | European Neurology69 ( 6 ) , pp.377 - 380

Objectives: The objective of this study was to determine ischemia modified albumin (IMA) and oxidant status in Alzheimer's disease (AD). Therefore, we evaluated the IMA and oxidant status by measuring serum uric acid, albumin and gamma-glutamyltransferase (GGT) in AD. Methods: The plasma albumin, uric acid, GGT and IMA levels were measured by spectrophotometric methods in 32 AD patients and 32 healthy controls. The Mini Mental Status Examination and Clinical Dementia Rating Scale were used to evaluate the cognitive functions of AD patients. Results: AD patients had significantly higher IMA levels as compared to those of the controls . . . respectively. Uric acid concentrations were significantly decreased and GGT values were significantly increased in AD when compared with control group. Albumin levels of the patients were also compared and no significant difference was detected. Conclusion: Oxidative stress and IMA levels rise in AD. However, large prospective studies are required to understand the mechanisms leading to increased IMA levels during AD, whether preceded or not by AD. © 2013 S. Karger AG, Basel Daha fazlası Daha az

Relationship between Uric Acid and Subtle Cognitive Dysfunction in Chronic Kidney Disease

Afsar, Baris | Elsurer, Rengin | Covic, Adrian | Johnson, Richard J. | Kanbay, Mehmet

Article | 2011 | AMERICAN JOURNAL OF NEPHROLOGY34 ( 1 ) , pp.49 - 54

Background: Elevated serum uric acid has been associated with cognitive dysfunction and vascular cognitive impairment in the elderly. Serum uric acid is also commonly elevated in chronic kidney disease (CKD), but its relationship with cognitive function in these patients has not been addressed. Methods: Subjects with CKD (defined as eGFR

Purine catabolic enzymes and nitric oxide in patients with recurrent aphthous ulceration

Gurel A. | Altinyazar H.C. | Unalacak M. | Armutcu F. | Koca R.

Article | 2007 | Oral Diseases13 ( 6 ) , pp.570 - 574

Objectives: Recurrent aphthous ulceration (RAU) is one of the most common oral mucosal disorders found in humans. Although the exact etiology of RAU is unkown, local and systemic conditions, and genetic, immunologic, and infectious factors all have been identified as potential etiopathogenic agents. The aim of our study was to compare serum xanthine oxidase (XO) and adenosine deaminase (AD) activities, and malondialdehyde (MDA), nitric oxide (NO) and uric acid (UA) levels in a group of patients affected by RAU and in a group of healthy controls. Subjects and methods: A total of 26 patients with minor RAU were included in the study. . . .Twenty-six healthy volunteers were selected to form the control group. AD and XO activities, and UA, NO, and MDA levels were studied in the serum samples of all patients and controls. Results: Serum XO and AD activities, and MDA, NO, and UA levels were significantly higher in RAU patients than in controls. Conclusion: Increased XO and AD activities, NO and UA levels and lipid peroxidation were thought to take part in the pathogenesis of RAU. Hence the effects of XO inhibitors in the treatment of RAU should be evaluated in future studies. © 2007 The Authors Daha fazlası Daha az

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