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Effect of thyroidectomy on the histology of rat sublingual gland

Oncu M. | Kanter M. | Gokcimen A. | Kavakli D. | Oncu M. | Ural M. | Karaoz E.

Article | 2004 | APMIS112 ( 2 ) , pp.119 - 122

This study was carried out to investigate the effect of thyroidectomy on the histology of rat sublingual gland. Twenty-eight male Wistar albino rats, aged 4 weeks and weighing between 45-55 g, were used. The rats were divided into two experimental groups (control and thyroidectomy), each containing 14 animals. Total thyroidectomy of rats was performed under ether anesthesia in thyroidectomy group. The rats in the control group were sham operated without having the thyroidectomy. Seven rats randomly selected from both groups were fixed using the perfusion fixation technique 2 and 6 weeks after thyroidectomy, and their sublingual glan . . .ds were harvested for histological investigation. No histological difference was observed between the two groups 2 weeks after thyroidectomy. However, 6 weeks after thyroidectomy considerable cytoplasmic vacuolization of the epithelial cells of the mucous tubules was seen in the thyroidectomy group compared to the controls. Enlargement of mucous tubules was also observed, and the lumina in most of the tubules was quite dilated. In the stroma surrounding the parenchymal tissues, increased lipid tissue mass was observed. In addition, increased connective tissue mass and mononuclear cell infiltrations were evident. Furthermore, the number of mast cells was significantly higher in the thyroidectomy group than in the controls 6 weeks after thyroidectomy. It was concluded that the thyroid gland and hormones might have an influence on the histology of the sublingual gland Daha fazlası Daha az

Inadvertent parathyroidectomy and temporary hypocalcemia: An adverse natural outcome or a true complication during thyroidectomy?

Irkorucu O. | Tascilar O. | Cakmak G.K. | Emre A.U. | Ucan H.B. | Karakaya K. | Comert M.

Article | 2007 | Endocrine Regulations41 ( 1 ) , pp.143 - 148

Objective. The aim of this study was to assess the factors that might predict patients at increased risk for inadvertent parathyroidectomy and postoperative symptomatic hypocalcemia during thyroidectomy. Methods. Demographic data as well as the data on preoperative diagnosis, preoperative ultrasonography reports, operation reports, histological findings, and postoperative symptomatic hypocalcemia were collected. A total of 273 (83 male and 190 female patients) thyroid operations were included in this study. Results. Histopathological examination identified inadvertent parathyroidectomy in 10 (3.7%) cases. Statistical analysis identi . . .fied the presence of cervical lymphadenopathy as detected by preoperative ultrasonography as a risk factor for inadvertent parathyroidectomy. In 57 patients (20.9%) clinically symptomatic postoperative hypocalcemia was observed. However, the difference in the frequency of such hypocalcemia between the patients with and without inadvertent parathyroidectomy was not significant. Statistical evaluation identified total thyroidectomy as a risk factor for postoperative hypocalcemia ( Daha fazlası Daha az

Efficacy of intraoperative single dose methylprednisolone on recurrent laryngeal nerve function after thyroidectomy

Emre A.U. | Cakmak G.K. | Arpaci D.K. | Ilikhan S.U. | Damar M.

Article | 2016 | International Surgery101 ( 03.Apr ) , pp.116 - 120

Recurrent laryngeal nerve (RLN) palsy is an important complication of thyroid surgery. Injuries can either be permanent or temporary. Prevention or shortening the recovery period of temporary palsies is an area of interest. Some surgeons prefer to use corticosteroids for this purpose as is used for facial nerve palsies although there are conflicting data in the literature. We aimed to investigate the efficacy of perioperative single dose methylprednisolone on recurrent laryngeal nerve function. A total of 438 nerves under risk in 237 surgeries are investigated in 2 groups. In Group 1, patients are administered a single intraoperativ . . .e dose of methylprednisolone (1 mg/kg) intravenously for 220 nerves under risk. A total of 218 nerves under risk in Group 2 were operated and followed without methylprednisolone. The demographic data of the patients, operation time, the final pathology reports, incidence of recurrent laryngeal nerve palsy, and recovery time are documented and compared. No statistically significant difference was determined in terms of age, sex distribution, number of nerves under risk, and the operation time between groups. There were 3 unilateral RLNP in each group and the mean recovery time for Group 1 and 2 palsies were 20.4 and 19.8 days, respectively, without statistical significance. The presented data indicates that a single intraoperative dose of steroid does not seem to affect the rate and recovery period of RLNP in thyroid surgery. © 2016, International College of Surgeons. All rights reserved Daha fazlası Daha az

Tiroidektomi hastalarında ameliyat sonrası erken dönemde uygulanan soğuk buharın etkisi

Zaman, Funda

Master Thesis | 2019 | Zonguldak Bülent Ecevit Üniversitesi, Sağlık Bilimleri Enstitüsü, Hemşirelik Anabilim Dalı, Cerrahi Hastalıkları Hemşireliği Yüksek Lisans Programı

Bu çalışma, tiroidektomi hastalarında ameliyat sonrası erken dönemde uygulanan soğuk buharın etkisini incelemek amacıyla deneysel olarak yapılmıştır. Araştırma, Bülent Ecevit Üniversitesi Araştırma ve Uygulama Merkezi'nde Genel Cerrahi servisinde 01.07.2017 - 01.07.2018 tarihleri arasında gerçekleştirilmiştir. Araştırmanın örneklemini, tiroidektomi olan 60 hasta oluşturmuştur. Verilerin toplanmasında; Hasta Veri Toplama Formu, Sayısal Değerlendirme Ölçeği (Ağrı Durumları) Formu, SIS (swallowing impairment score) Formu, Öksürük Şiddeti Formu ve Ses Handikap Endeksi (Voice Handicap Index10) Formu kullanılmıştır. Hastalar 2 gruba, soğu . . .k buhar alan grup ve kontrol grubu olarak ayrılmıştır. Ameliyat sonrası her iki gruba da ilk sekiz saat içersinde saat başı 15 dk soğuk buhar uygulanmış ve ameliyat sonrası ilk sekiz saat içinde 2 saat aralıklarla boğaz ağrısı, öksürük durumları değerlendirilmiştir. Ameliyat sonrası 8. saatten sonra soğuk buhar alan gruba buhar uygulaması iki ve üç saat aralıklarla 8., 10., 12., 15., 18., 21., 24. saatlerde ilk 24 saat boyunca uygulanmaya devam etmiş , kontrol grubuna ise ameliyat sonrası 8. saatten sonra soğuk buhar uygulaması sonlandırılmıştır. Her iki grubunda ameliyat sonrası 8. saatten sonra boğaz ağrısı, öksürük, yutma güçlüğü durumları iki saat ve üç saat aralıklarla 8., 10., 12., 15., 18., 21., 24. saatlerde ilk 24 saat boyunca, ses durumları ise 24. saatte değerlendirilmiştir .Araştırmanın gerçekleştirilebilmesi için Bülent Ecevit Üniversitesi Klinik Araştırmaları Etik Kurulu’ndan etik izin, kurumdan yazılı izin, hasta yakınlarından aydınlatılmış onam alınmıştır. Verilerin değerlendirilmesinde NCSS (Number Cruncher Statistical System) 2007 (Kaysville, Utah, USA) programı kullanılmıştır. Çalışma verileri değerlendirilirken tanımlayıcı istatistiksel yöntemler (ortalama, standart sapma, medyan, frekans, yüzde, minimum, maksimum) kullanılmıştır. Nicel verilerin normal dağılıma uygunlukları Shapiro-Wilk testi ve grafiksel incelemeler ile sınanmıştır. Normal dağılım gösteren nicel değişkenlerin iki grup arası karşılaştırmalarında Student t testi, normal dağılım göstermeyen nicel değişkenlerin iki grup arası karşılaştırmalarında Mann-Whitney U test kullanılmıştır. Niteliksel verilerin v karşılaştırılmasında ise Pearson Ki-Kare testi kullanılmıştır. İstatistiksel anlamlılık Daha fazlası Daha az

The effect of preoperative dexamethasone administration on nause-vomiting and pain in thyroidectomy [?iroidektomi operasyonlarinda preoperatif uygulanan deksametazonun postoperatif bulanti-kusma ve agriya etkisi]

Altunkaya H. | Özer Y. | Cihan A. | Özkoçak I. | Demirel C.B.

Article | 2003 | Anestezi Dergisi11 ( 2 ) , pp.131 - 135

In this study; it is aimed to evaluate the effect of preoperative single dose dexamethasone on postoperative nausea, vomiting (PONV) and pain patients planned for thyroidectomy. Forty patients, ASA I-II, scheduled for thyroidectomy were included in this randomized, double-blinded and placebo controlled study. The patients were randomly divided into two groups. A blind investigator administered dexamethasone 8 mg iv (Group D, n=20) or 2 ml saline (Group S, n=20) to the patients. Anaesthesia induction was performed with propofol 2mg kg-1, 2 µg kg-1 fentanyl and rocuronium 0.6 mg kg-1. Sevoflurane IMAC was used in all patients for the . . .maintenance of anaesthesia. Pain (VAS pain scale), PONV (0-3 scale), the time for first analgesic need, total analgesic need, reaction to dressing, infection of insicion and mobilization time were recorded at postoperative 0, 15, 30, and 45th min and two hours intervals in first day. The postoperative VAS scores, PONV value and total analgesic need of Group D were significantly lower than Group S (p<0.05). There was no difference between the reaction to dressing and mobilization time of the groups. In conclusion preoperative dexamethasone administration less postoperative pain and PONV in thyroidectomy Daha fazlası Daha az

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