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Koleksiyon [9]
Tam Metin [1]
Yayın Türü [1]
Yazar [20]
Yayın Yılı [8]
Konu Başlıkları [20]
Yayıncı [12]
Yayın Dili [1]
Dergi Adı [13]
Exogenous recombinant adiponectin improves survival in experimental abdominal sepsis

Salman B. | Yılmaz T.U. | Tezcaner T. | Demir E.O. | PaŞaoğlu Ö.T.

Article | 2014 | Balkan Medical Journal31 ( 3 ) , pp.244 - 248

Background: Adiponectin, which has anti-inflammatory features, is an important substance in several metabolic mechanisms.Aims: The aim of this study is to evauate the effects of exogenous intraperitoneal administration of adiponectin on the survival, intrabdominal adhesion and inflammatory cytokine levels in an experimental sepsis model.Study Design: Animal experimentation.Methods: Ninety rats were divided into a control group, adiponectin group and sham group. A cecal puncture abdominal sepsis model was performed in the adiponectin and control groups. Every three hours, exogenous adiponectin was administrated to the adiponectin gro . . .up. At the 3rd and 24th hours, 10 rats were sacrified in each group in order to measure plasma tumor necrosis factor-? (TNF-?), interleukin (IL) 10, soluble intracellular adhesion molecule (ICAM)-1, IL-6 and macrophage inhibitory factor levels, and the activity of nuclear factor (NF)-kB. The remaining rats were followed for survival.Results: The plasma levels of TNF-?, soluable ICAM-1, IL-6, and macrophage inhibitory factor were significantly higher in the control group than in the adiponectin and sham group ( Daha fazlası Daha az

Prognostic role of ERCC1 protein expression and its correlation with 18F-FDG uptake on pet in patients with resected non-small cell lung cancer [Küçük hücreli dışı akciğer kanseri’nde ERCC1’in prognostic Rolü ve 18F-FDG tutulumu ile korelasyonu]

Sahinoglu T. | Uysal S. | Kumbasar U. | Onder S.C. | Dogan R. | Pasaoglu I. | Demircin M.

Article | 2017 | UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi27 ( 2 ) , pp.110 - 117

ERCC1 is a protein which is found to be associated with resistance to platinum-based chemotherapy. FDG uptake is considered as a prognostic marker in patients with NSCLC and provides information beyond that of TNM staging. The aim of this study is to examine both prognostic values of ERCC1 expression and 18F-FDG uptake on PET and their relationship in patients who underwent pulmonary resection for NSCLC. Although high expression of ERCC1 was found to be associated with better survival, the difference was not considered as statistically significant (p= 0.067). There is a significant survival advantage in ERCC1 (+) patients who did no . . .t receive adjuvant therapy (p= 0.047). High maximal standard uptake value (SUVmax) was found to be associated with poor survival (hazard ratio [HR]: 1.10; 95% CI, 1.02-1.18; p= 0.009). Correlation between ERCC1 expression and mean SUVmax was statistically insignificant (p= 0.915). Among patients with SUVmax ?2.5, ERCC1 positivity was 57.4% in patients who survived and 29.4% in patients who died which was statistically significant (p= 0.048). The association between high 18F-FDG uptake on PET and poor outcome was confirmed, but we failed to detect a powerful correlation between ERCC1 expression and SUVmax. © 2017, UHOD - Uluslararasi Hematoloji Onkoloji Dergisi. All rights reserved Daha fazlası Daha az

Prognostic importance of Ki-67 labeling index in grade II glial tumors

Kanyilmaz G. | Önder H. | Aktan M. | Koç M. | Bora H. | Karahacioğlu E. | Erkal H.Ş.

Article | 2018 | Turk Onkoloji Dergisi33 ( 2 ) , pp.48 - 53

OBJECTIVE To date, several methods have been identified for predicting the prognostic subgroups of grade II gliomas; however, these methods have some limitations in predicting survival. So, we aimed to determine the predictive role of Ki-67 labeling index (LI) on survival. METHODS Between 1995 and 2014, patients with grade II gliomas were retrospectively analyzed. All patients received radiotherapy (RT). RESULTS This study included 78 patients with median 44 (range, 6–137) months follow-up. Patients aged ?40 years had a poorer overall survival (OS) than those aged

The prognostic role of inflammation and hormones in patients with metastatic cancer with cachexia

Bilir C. | Engin H. | Can M. | Temi Y.B. | Demirtas D.

Article | 2015 | Medical Oncology32 ( 3 ) , pp.48 - 53

We wanted to investigate the possible etiologic factors of cachexia. Forty-six patients diagnosed with cancer cachexia and 34 healthy controls were included in the study. Serum total testosterone, free testosterone, interleukin 1 (IL) alpha and beta, IL6, tumor necrosis factor (TNF) alpha, orexin, galanin, neuropeptide Y, tumor necrosis factor-like weak inducer of apoptosis and tumor necrosis factor receptor-associated factor 6, and C-reactive protein (CRP) levels were investigated. There were 36 male and 10 female patients in the cachexia group, and 24 male and 10 female patients in the control group. Median overall survival (OS) o . . .f the cachexia group after the diagnosis of cachexia was 8 (1–25) months. There were statistically significant relationships between OS and BMI, serum CRP, TRAF-6, albumin, and LDH levels in the cachexia group. In addition to cachexia, serum CRP, testosterone, and TNF alpha levels were statistically significantly correlated with OS in refractory cachexia. TRAF-6 levels was significantly correlated with type of cancer (P = 0.02). Although cachexia presents with a multifactorial ethio-pathogenesis, few of them affect the OS. Our novel results were that serum CRP, albumin, LDH, and TRAF-6 levels have a higher association with OS in patients with cancer cachexia compared to the many other parameters. An ongoing cachexia also called refractory cachexia is a recent definition. This end-stage term of cancer duration may be predicted by decreasing serum testosterone and increasing serum TNF alpha levels, as well as serum CRP levels. © 2015, Springer Science+Business Media New York Daha fazlası Daha az

Retrospective Evaluation of the Female Patients with Breast Cancer: Western Black Sea Region, Unicentered, Clinical Data of Oncology

Engin, Huseyin | Saylik, Faruk | Bilir, Cemil

Article | 2013 | UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI23 ( 2 ) , pp.117 - 123

Breast cancer is the most common female cancer in the world wide with 30% of all women cancer and second most common cause of cancer death in women. Oncology department of Bulent Ecevit University Faculty of Medicine is the only cancer center in western part of Black Sea region. We investigated retrospectively our data of women breast cancer between the period of 2000 and 2010 in this region. The mean age of the study population was 49.90 +/- 12 years and mean follow-up time was 4 +/- 2 years. The distribution of patients by the age, 25% or patients under 40 years old, 32% between the 40-50 years old and 43% of them over the 50 year . . .s old. 92.6% of the patients were presented with a palpable mass. The most common type of breast cancer was invasive ductal carcinoma (IDC) in 312 patients (80%). Prognosis of the study population; 309 patients (80%) are surviving without any disease. Sixty-six patients (17%) had progression, 7 of 390 patients (1,8%) had local recurrence and 15 patients (3.8%) died. While the breast cancer is one of the most commonly seen solid organ tumors in Black Sea region and, based on the literature, no significant differences were observed for prognostic factors, longer life expectancy of the patients with advanced stage disease may be attributed to higher number of patients with hormonal positivity and therapy adherence Daha fazlası Daha az

Retrospective Evaluation of the female patients with breast cancer: Western Black Sea region, unicentered, clinical data of oncology [Meme kanserli kadınların retrospektif analizi: Batı karadeniz bölgesi tek merkez onkoloji klinik verileri]

Engin H. | Saylik F. | Bilir C.

Article | 2013 | UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi23 ( 2 ) , pp.117 - 123

Breast cancer is the most common female cancer in the world wide with 30% of all women cancer and second most common cause of cancer death in women. Oncology department of Bulent Ecevit University Faculty of Medicine is the only cancer center in western part of Black Sea region. We investigated retrospectively our data of women breast cancer between the period of 2000 and 2010 in this region. The mean age of the study population was 49.90 ± 12 years and mean follow-up time was 4 ± 2 years. The distribution of patients by the age, 25% or patients under 40 years old, 32% between the 40-50 years old and 43% of them over the 50 years ol . . .d. 92.6% of the patients were presented with a palpable mass. The most common type of breast cancer was invasive ductal carcinoma (IDC) in 312 patients (80%). Prognosis of the study population; 309 patients (80%) are surviving without any disease. Sixty-six patients (17%) had progression, 7 of 390 patients (1,8%) had local recurrence and 15 patients (3.8%) died. While the breast cancer is one of the most commonly seen solid organ tumors in Black Sea region and, based on the literature, no significant differences were observed for prognostic factors, longer life expectancy of the patients with advanced stage disease may be attributed to higher number of patients with hormonal positivity and therapy adherence Daha fazlası Daha az

Xenobiotic/drug metabolizing enzyme and TP53 polymorphisms and clinical outcome in advanced nonsmall cell lung cancer patients

Karacaoğlan V. | Ada A.O. | Bilgen S. | Çetinkaya G.T. | Soydaş E. | Kunak C.S. | Alpar S.M.

Article | 2017 | Turkish Journal of Medical Sciences47 ( 2 ) , pp.554 - 562

Background/aim: The association between polymorphisms of xenobiotic/drug metabolizing enzymes and TP53 and response to chemotherapy and survival of patients with nonsmall cell lung cancer (NSCLC) are limited and inconclusive. In this study, CYP2E1*5B, CYP2E1*6, CYP2E1*7B, GSTO1 (A140D), and TP53 (Arg72Pro) polymorphisms and response to platinum-based chemotherapy and survival in 137 advanced stage NSCLC patients were investigated. Materials and methods: Genetic polymorphism analyses were determined by polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP). Results: The patients with TP53 Pro/Pro . . . variant were more likely to be resistant to chemotherapy than those with Arg/Arg variants with marginal significance (P = 0.066). We also analyzed these gene variants in combination with CYP1A1 (Ile462Val), CYP1B1 (Asn453Ser), GSTM1, GSTP1 exon 5 (Ile105Val), and GSTP1 exon 6 (Ala114Val) and GSTT1 polymorphic genes that we have previously genotyped in the same patients (Ada et al., Neoplasma, 57, 512-527, 2010). The multivariate analysis revealed that adjusted hazard ratio (HR) of death of the combined variant genotypes of TP53 (Arg72Pro, Pro72Pro) and CYP1A1 (Ile462Val, Val462Val) increased significantly as compared to wild-type genotypes (HR, 6.03; 95% CI, 1.39–26.04, P = 0.016). Conclusion: These results show that combined variant genotypes of TP53 (Arg72Pro, Pro72Pro) and CYP1A1 (Ile/Val, Val/Val) are associated with worsening of survival in NSCLC patients. © TÜBİTAK Daha fazlası Daha az

Laboratory assays of the effects of oxfendazole on biological parameters of Galleria mellonella (Lepidoptera: Pyralidae)

Sugeçti, Serkan | Büyükgüzel, Ender | Büyükgüzel, Kemal

Article | 2016 | Journal of Entomological Science51 ( 2 ) , pp.129 - 137

Galleria mellonella L. larvae were reared on a standard diet amended with varying concentrations (0, 0.0015, 0.015, 0.15, and 1.5%) of the benzimidazole-derivative antihelmintic drug oxfendazole. Survivorship, developmental times, longevity, fecundity, and fertility were monitored over the treatments. Relative to the untreated control, exposure to diet containing 1.5% oxfendazole significantly decreased survivorship in larval, pupal, and adult stages, prolonged the time to reach the adult stage, and reduced adult longevity. Oxfendazole at all concentrations significantly lowered egg production per female and decreased egg hatch. The . . .se results demonstrate that this antihelmintic may be explored as a candidate for insect pest control Daha fazlası Daha az

Comparison of clinical outcomes with three different intramedullary nailing devices in the treatment of unstable trochanteric fractures [İnstabil trokanterik kırık tedavisinde kullanılan üç farklı intramedüller çivinin klinik sonuçlarının karşılaştırılması]

Zehir S. | Şahin E. | Zehir R.

Article | 2015 | Ulusal Travma ve Acil Cerrahi Dergisi21 ( 6 ) , pp.469 - 476

BACKGROUND: The aim of this study was toreport our experience regarding the use of three different methods for intramedullary nailing in the treatment of intertrochanteric fractures. METHODS: Patients with A2 and A3 type fractures operated on for unstable trochanteric fractures were included into this retrospective cohort study. Patients were divided into three groups based on the technique used; Talon distal fix nail/lag screw (n=78; mean age, 78.5±6.6), PFNA nail (n=96; mean age, 77.2±6.8) or InterTan nails (n=102; mean age, 76.8±6.7). Harris hip scores were recorded at the last outpatient visit and survival information was obtain . . .ed by phone interview and civil registry database. RESULTS: Baseline characteristics were similar among groups. Operation time, fluoroscopy time and blood loss were significantly higher in InterTan group. Screw cut-out occurred in eight patients in PFNA group. In-hospital mortality occurred in nine (3.2%) patients. Length of hospital stay and postoperative tip-apex distance was not different among groups. At follow-up, healing time and Harris hip scores were also similar among groups. One-year survival rate was 83.1±4.5% in Talon distal fix nail/lag screw, 84.0±3.8% in PFNA group and 84.4±3.7% in InterTan group (p=0.33). CONCLUSION: New Talon distal fix nail/lag screw was associated with lower cut-out rates than PFNA and shorter operative times than InterTan. Further study is warranted to clearly establish the potential advantages of Talon distal fix over any other technique described herein. © 2015 TJTES Daha fazlası Daha az

Clinical and epidemiological characteristics of children with germ cell tumors: A single center experience in a developing country

İncesoy-Özdemir S. | Ertem U. | Şahin G. | Bozkurt C. | Yüksek N. | Ören A.C. | Balkaya E.

Article | 2017 | Turkish Journal of Pediatrics59 ( 4 ) , pp.410 - 417

Germ cell tumor (GCT) is a rare malignancy accounting for 2-3% of all pediatric tumors. The overall survival rate of children and adolescents with GCT is more than 80% after adopting combined therapy. The aim of this study is to review clinical presentation, management, and outcome in a single-center series with extracranial GCT. Clinical characteristics, pathologic presentations, and survival outcomes of 101 children with GCT, treated at our hospital from 1988 to 2011, were analyzed. Sixty-two of patients were female and 39 of them were male. Fifty-eight (57%) patients had gonadal tumor (24 testicular, 34 ovarian), 43 (43%) extrago . . .nadal. Histologically, teratomas were found most frequently (26 mature, 10 immature), followed by yolk sac tumors (n: 33), mixed malignant tumors (n: 13), embryonal carcinoma (n: 10), disgerminoma (n: 8) and seminoma (n: 1). Twenty-six patients were diagnosed as mature teratoma and we excluded them in the evaluation of staging and survival. Five-year overall and relaps-free survival were 80.3% (mean follow-up time: 215.8 months) and 73.4% (mean follow-up time: 176.2 months), respectively. Five-year survival rates were 93.2% and 90.2% in malign GCTs diagnosed after 1999. © 2017, Turkish Journal of Pediatrics. All rights reserved Daha fazlası Daha az

Biological and immune response of Galleria mellonella (Lepidoptera: Pyralidae) to sodium tetraborate

Durmuş, Yonca | Büyükgüzel, Kemal

Article | 2008 | Journal of Economic Entomology101 ( 3 ) , pp.777 - 783

Inorganic insecticides are commonly used in urban pest management because of their low mammalian toxicity. We tested the effects of sodium tetraborate (ST) on life parameters of greater wax moth, Galleria mellonella (L.) (Lepidoptera: Pyralidae), to determine its sublethal toxicity on the insect. Survival, development, adult longevity, and fecundity of the wax moth were investigated by rearing larvae on artificial diets containing ST at concentrations of 0.005,0.1,0.2, or 0.3%. Larvae reared on medium at the highest concentration of ST (0.3%) had significantly decreased survival to the seventh instar and prolonged time required to r . . .each the seventh instar. This concentration reduced pupa and adult yields to 12.5%, and it also prolonged development by 5 d. ST did not significantly influence adult longevity. Dietary ST led to significant decreases in fecundity and egg viability. Oviposition of survivors at the highest ST concentration (0.3%) was completely inhibited. Lysozyme content was decreased in larval hemolymph and fat body at high dietary ST concentrations. Fat body lysozyme content was significantly increased two-fold for larvae reared on diet at the lowest concentration of ST (0.005%). However, the highest concentration (0.3%) dramatically decreased fat body lysozyme content from 0.12 ± 0.013 to 0.006 ± 0.003 mg/ml in seventh instars. We infer that sublethal levels of dietary ST substantially influence life history parameters and immunocompetence in G. mellonella. © 2008 Entomological Society of America Daha fazlası Daha az

Assessment of tumor characteristics and factors affecting survival in patients with primary metastatic breast carcinoma: A Multicenter Study of the Anatolian Society of Medical Oncology

Uyeturk U. | Oksuzoglu B. | Akman T. | Turker I. | Sener N. | Tastekin D. | Bal O.

Article | 2014 | Medical Oncology31 ( 4 ) , pp.777 - 783

Primary metastatic breast cancer (PMBC) comprises 3-10 % of all BCs. PMBC is a heterogeneous disease. To date, little is known about the tumor characteristics, treatment results, and overall survival (OS) of patients with PMBC. Patients were considered to have PMBC if distant metastasis was evident within 3 months of the initial diagnosis of BC. Between September 2007 and April 2013, 466 PMBC patients were included in this study and analyzed retrospectively. The median age of the patients was 50 (18-90) years. Bone/soft tissue metastases were more frequent in the hormone receptor (HR)(+) human epidermal growth factor receptor (HER)2 . . .(-) group compared with the HR(-)HER2(-) and HR(-)HER2(+) groups (p < 0.001), whereas visceral organ metastasis was more frequent in the HR(-)HER2(-) and HR(-)HER2(+) groups (p < 0.001). The OS was affected by Eastern Cooperative Oncology Group performance status, tumor histology, receptor status, and the site of metastasis (p < 0.001, p < 0.001, p < 0.001, and p = 0.011, respectively). According to the first-line systemic treatment choices of the patients, the longest median OS was observed in the HR(+)HER2(+) group who received hormonotherapy combined with trastuzumab after chemotherapy (86 months, 95 % CI 23.8-148.1) and the shortest median OS was observed in the HR(-)HER2(-) group who received chemotherapy only (24 months, 95 % CI 17.9-30.0) (p < 0.001). Bisphosphonate therapy or radiotherapy had no significant effect on OS (p = 0.733, 0.603). In multivariate analysis, hormonotherapy, chemotherapy + trastuzumab, trastuzumab + hormonotherapy following chemotherapy, and surgery were the most important prognostic factors for OS, respectively (p < 0.001, p = 0.025, p = 0.027, p = 0.029). The general characteristics of the primary tumor are important for the prognosis and survival of patients with PMBC. Interestingly, patients who underwent primary breast tumor surgery, even those at the metastatic stage upon admission, had the longest survival. © 2014 Springer Science+Business Media New York Daha fazlası Daha az

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