Collective temporal coherence for subthreshold signal encoding on a stochastic small-world Hodgkin-Huxley neuronal network

Özer, Mahmut | Uzuntarla, Muhammet | Kayıkcıoğlu, Temel | Graham, Lyle J.

Article | 2008 | Physics Letters, Section A: General, Atomic and Solid State Physics372 ( 43 ) , pp.6498 - 6503

We study the collective temporal coherence of a small-world network of coupled stochastic Hodgkin-Huxley neurons. Previous reports have shown that network coherence in response to a subthreshold periodic stimulus, thus subthreshold signal encoding, is maximal for a specific range of the fraction of randomly added shortcuts relative to all possible shortcuts, p, added to an initially locally connected network. We investigated this behavior further as a function of channel noise, stimulus frequency and coupling strength. We show that temporal coherence peaks when the frequency of the external stimulus matches that of the intrinsic sub . . .threshold oscillations. We also find that large values of the channel noise, corresponding to small cell sizes, increases coherence for optimal values of the stimulus frequency and the topology parameter p. For smaller values of the channel noise, thus larger cell sizes, network coherence becomes insensitive to these parameters. Finally, the degree of coupling between neurons in the network modulates the sensitivity of coherence to topology, such that for stronger coupling the peak coherence is achieved with fewer added short cuts. © 2008 Elsevier B.V. All rights reserved Daha fazlası Daha az

Stochastic resonance on Newman-Watts networks of Hodgkin-Huxley neurons with local periodic driving

Özer, Mahmut | Perc, Matjaž | Uzuntarla, Muhammet

Article | 2009 | Physics Letters, Section A: General, Atomic and Solid State Physics373 ( 10 ) , pp.964 - 968

We study the phenomenon of stochastic resonance on Newman-Watts small-world networks consisting of biophysically realistic Hodgkin-Huxley neurons with a tunable intensity of intrinsic noise via voltage-gated ion channels embedded in neuronal membranes. Importantly thereby, the subthreshold periodic driving is introduced to a single neuron of the network, thus acting as a pacemaker trying to impose its rhythm on the whole ensemble. We show that there exists an optimal intensity of intrinsic ion channel noise by which the outreach of the pacemaker extends optimally across the whole network. This stochastic resonance phenomenon can be . . .further amplified via fine-tuning of the small-world network structure, and depends significantly also on the coupling strength among neurons and the driving frequency of the pacemaker. In particular, we demonstrate that the noise-induced transmission of weak localized rhythmic activity peaks when the pacemaker frequency matches the intrinsic frequency of subthreshold oscillations. The implications of our findings for weak signal detection and information propagation across neural networks are discussed. © 2009 Elsevier B.V. All rights reserved Daha fazlası Daha az

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