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Spermatogenesis and fertilization in elderly men [Yaşli erkeklerde spermatogenez ve fertilizasyon]

Ok E.

Review | 2008 | Turk Geriatri Dergisi11 ( 4 ) , pp.204 - 207

Old age leads to a series of changes both in male and female organisms and increasing male age is considered to affect spermatogenesis and fertilization as well. Recently, the upward shift in paternal age has accelerated research on the effects of advanced male age. Most studies maintain that semen parameters; in particular, sperm mobility, semen volume, and the number of sperms with normal morphology are adversely affected by the increase in male age, while sperm concentration remains unchanged. However, these age-dependent changes are at a moderate level and it is still uncertain whether this phenomenon has an impact on delayed fe . . .rtility. The relationship between advanced male age and the qualitative and quantitative changes in sperm chromosomes is a controversial subject of current interest. Consequently, further studies to be conducted on elderly men with no systemic or reproductive health-related problems in which maternal age will be eliminated could provide more tangible information Daha fazlası Daha az

The histology and the proapoptotic control in the ipsilateral and the contralateral testes following unilateral vasectomy

Hazar, Aydin Ismet | Cakiroglu, Basri | Sakalli, Ertan | Balci, Mustafa Bahadir Can | Eyyupoglu, Erkan | Tas, Tuncay | Sinanoglu, Orhun

Article | 2015 | ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA87 ( 3 ) , pp.198 - 203

Objective: The aim of this study was to enlighten both the testicular histology and the genetic aspects of the apoptotic process. Thus an experimental study was designed with a model of unilateral vasectomy. Methods: Twenty-two adult male rats were used and 4 main groups were formed. The first (A), the second (B), the third (C), and the fourth group (D) consisted of 4, 4, 4 and 10 rats respectively. Rats in group A had sham operation while rats in other groups (B, C, D) underwent left vasectomy operation including binding of ductus deferens with a 3/0 silk and cutting a minimum of 1 cm part while preserving the vascular structure un . . .der 9x magnification. Rats undergoing unilateral vasectomy were sacrificed at the 1st, 2nd and 8th weeks and their testicular structure and proapoptotic gene proteins were compared with that of the control group undergoing sham operation. Results: We found that vasectomy gradually caused destruction and both ipsilateral and contralateral testicles were affected showing initial apoptosis. Conclusion: The procedure causes destruction in the testicular structure by causing bilateral intratubular germ cell necrosis, unilateral obstruction, increase in the tubular pressure and processes that are aggravated by some probable autoimmune reactions Daha fazlası Daha az

SPERMATOGENESIS AND FERTILIZATION IN ELDERLY MEN

Ok, Elvan

Review | 2008 | TURK GERIATRI DERGISI-TURKISH JOURNAL OF GERIATRICS11 ( 4 ) , pp.204 - 207

Old age leads to a series of changes both in male and female organisms and increasing male age is considered to affect spermatogenesis and fertilization as well. Recently, the upward shift in paternal age has accelerated research on the effects of advanced male age. Most studies maintain that semen parameters; in particular, sperm mobility, semen volume, and the number of sperms with normal morphology are adversely affected by the increase in male age, while sperm concentration remains unchanged. However, these age-dependent charges are at a moderate level and it is still uncertain whether this phenomenon has an impact on delayed fe . . .rtility. The relationship between advanced male age and the qualitative and quantitative changes in sperm chromosomes is a controversial subject of current interest. Consequently, further studies to be conducted on elderly men with no systemic or reproductive health-related problems in which maternal age will be eliminated could provide more tangible information Daha fazlası Daha az

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