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A multiscale model for acid-mediated tumor invasion: Therapy approaches

Meral, Gulnihal | Stinner, Christian | Surulescu, Christina


Starting from the two-scale model for pH-taxis of cancer cells introduced previously by the authors, we consider here an extension accounting for tumor heterogeneity w.r.t. treatment sensitivity and a treatment approach including chemo-and radiotherapy. The effect of peritumoral region alkalinization on such therapeutic combination is investigated with the aid of numerical simulations.

Protection by L-carnitine against radiation-induced ileal mucosal injury in the rat: Pattern of oxidative stress, apoptosis and cytokines

Akpolat M. | Gulle K. | Topcu-Tarladacalisir Y. | Safi Oz Z. | Bakkal, Bekir Hakan | Arasli M. | Ozel Turkcu U.

Article | 2013 | International Journal of Radiation Biology89 ( 9 ) , pp.732 - 740

Purpose: In this study, we tested the effects of L-carnitine (LC) on radiation-induced ileal mucosal damage. Materials and methods: Thirty Wistar albino rats were divided into five groups. The control group received physiological saline intraperitoneally (i.p.). Radiation-1 and radiation-2 groups received whole-body X-irradiation of 8.3 Gy as a single dose. These groups were sacrificed at the 6th hour and 4th day after irradiation, respectively. The Radiation-1 + LC and the radiation-2 + LC groups received the same dose irradiation plus a daily dose of 200 mg/kg LC. LC was applied one day before and for four days after irradiation. . . .Results: The levels of serum monocyte chemotactic protein-1 (MCP-1) and interferon gamma (IFN-?) were significantly higher in the radiation groups when compared with the control. Treatment with LC decreased the serum MCP-1 and IFN-? levels considerably. In the radiations groups, the Chiu score was significantly elevated compared with that of the control group. However, LC administered prior to the irradiation reduced the severity of mucosal damage. The number of apoptotic cells of the ileal crypt in the irradiated rats increased from the 6th hour after irradiation and then decreased at 4th day. Conclusions: Our data demonstrated that LC may be beneficial to radiation enteritis. © 2013 Informa UK, Ltd Daha fazlası Daha az

N-acetylcycsteine attenuates the deleterious effects of radiation therapy on incisional wound healing in rats

Tascilar O. | Çakmak G.K. | Emre A.U. | Bakkal, Bekir Hakan | Kandemir N. | Turkcu U.O. | Demir E.O.

Article | 2014 | Hippokratia18 ( 1 ) , pp.17 - 23

Background: During preoperative radiotherapy, effective doses of ionizing radiation occasionally cause wound complications after subsequent surgery. This study was designed to determine the effects of intraperitoneally or orally administered N-acetylcysteine (NAC) on anastomotic healing of irradiated rats. Material & Methods: Forty Wistar albino rats were randomized into four groups containing 10 rats each. A 3 cm long surgical full-thickness midline laparotomy was performed to all groups (Groups 1-4). Group 1 was designed as a control group without radiation therapy and NAC treatment. Groups 2, 3 and 4 received a single abdominal d . . .ose of 10 Gy irradiation before laparotomy and groups 3 and 4 received oral and intraperitoneal NAC, respectively. Results: Group comparisons demonstrated that breaking strength was significantly higher in NAC treated rats. A statistically significant difference was determined in terms of superoxide dismutase (SOD), malondealdehyde (MDA) and glutation (GSH) values between groups ( Daha fazlası Daha az

The effects of therapeutic X-ray doses on mechanical, chemical and physical properties of poly methyl methacrylate

Dogan D.O. | Ozguven Y. | Karakus G. | Sahin O. | Polat N.T. | Yucel B. | Dogan M.

Article | 2013 | Acta Odontologica Scandinavica71 ( 1 ) , pp.45 - 49

Aim. The aim of this study was to investigate the effect of radiation doses very close to the human dose for oral cancers on mechanical, chemical and physical properties for poly methyl-methacrylate (PMMA). Methods. PMMA samples were divided into four different groups: no irradiated group, 25-Gy irradiated group, 50-Gy irradiated group and 75-Gy irradiated group. Each group contained nine samples. After 24 h, a three-point loading test was applied to each PMMA groups. The transverse strength and the elastic modulus were calculated using the test results. The results were analyzed statistically by using one-way analysis of variance. . . .The structural characterizations of the PMMA samples were carried out by a Fourier Transform Infrared (FTIR) spectrophotometer to evaluate the chemical structure differences. Results. The transverse strength values of 25-Gy, 50-Gy and 75-Gy radiation groups were significantly higher than that of the no radiation group (p < 0.05). There was no significant difference among the elastic modulus values of the study groups (p > 0.05). The FTIR findings demonstrated that the irradiation process did not change the chemical structure of the PMMA polymeric materials. Conclusion. The therapeutic radiation doses increase the mechanical properties of the PMMA; however, the chemical and structural properties have no effect. When the findings of this study are taken into account, it can be said that patients can wear dentures during the radiotherapy. © 2013 Informa Healthcare Daha fazlası Daha az

Influence of radiation exposure during radiotherapy: Evidence for the increase of versican and heparin-binding EGF-like growth factor concentrations

Ozbilgin M.K. | Aktas C. | Uluer E.T. | Buyukuysal M.C. | Gareveran M.S. | Kurtman C.

Article | 2016 | Analytical and Quantitative Cytology and Histology38 ( 2 ) , pp.126 - 132

OBJECTIVE: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy. STUDY DESIGN: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. RESULTS . . .: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure. CONCLUSION: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy. © Science Printers and Publishers, Inc Daha fazlası Daha az

Prognostic importance of Ki-67 labeling index in grade II glial tumors

Kanyilmaz G. | Önder H. | Aktan M. | Koç M. | Bora H. | Karahacioğlu E. | Erkal H.Ş.

Article | 2018 | Turk Onkoloji Dergisi33 ( 2 ) , pp.48 - 53

OBJECTIVE To date, several methods have been identified for predicting the prognostic subgroups of grade II gliomas; however, these methods have some limitations in predicting survival. So, we aimed to determine the predictive role of Ki-67 labeling index (LI) on survival. METHODS Between 1995 and 2014, patients with grade II gliomas were retrospectively analyzed. All patients received radiotherapy (RT). RESULTS This study included 78 patients with median 44 (range, 6–137) months follow-up. Patients aged ?40 years had a poorer overall survival (OS) than those aged

Dental management long term follow-up of the post radio-chemotherapy-Rhabdomyosarcoma patient: Report of a case

Misir A.F. | Zerener T. | Günhan T.

Article | 2014 | Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology26 ( 2 ) , pp.154 - 157

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood and adolescence involving the head and neck. It occurs most often in the head and neck region, genitourinary tract, retroperitoneum and the extremities. The current treatment of a combination of surgery, chemotherapy and radiotherapy has dramatically improved the long term survival rates over the last 20 years. However, some of the side effects of post-radiation include delayed eruption of teeth, retarded tooth and bone development, dwarfed teeth, partial anadontia, osteoradionecrosis, xerostomia, mucositis, candidiasis, trismus, loss of taste, soft tissue ne . . .crosis, and scar tissue formation. RMS is a comparatively rare lesion for the maxillofacial surgeons. Although documented to be the most common soft tissue sarcoma in children under 15 years of age, there is, however, a paucity of reports on the pattern of the late effects of multimodal treatment results about intra-oral involvement. This case report focused on the dental treatment and facial abnormalities in a long-term survivor of pediatric head and neck RMS patient and review of the literature. © 2012 Daha fazlası Daha az

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