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MR imaging features of foot involvement in patients with psoriasis

Erdem C.Z. | Tekin N.S. | Sarikaya S. | Erdem L.O. | Gulec S.

Article | 2008 | European Journal of Radiology67 ( 3 ) , pp.521 - 525

Objective: To determine alterations of the soft tissues, tendons, cartilage, joint spaces, and bones of the foot using magnetic resonance (MR) imaging in patients with psoriasis. Materials and methods: Clinical and MR examination of the foot was performed in 26 consecutive patients (52 ft) with psoriasis. As a control group, 10 healthy volunteers (20 ft) were also studied. Joint effusion/synovitis, retrocalcaneal bursitis, retroachilles bursitis, Achilles tendonitis, soft-tissue edema, para-articular enthesophytes, bone marrow edema, sinus tarsi syndrome, enthesopathy at the Achilles attachment and at the plantar fascia attachment, . . .plantar fasciitis, tenosynovitis, subchondral cysts, and bone erosions, joint space narrowing, subchondral signal changes, osteolysis, luxation, and sub-luxation were examined. Results: Clinical signs and symptoms (pain and swelling) due to foot involvement were present in none of the patients while frequency of involvement was 92% (24/26) by MR imaging. The most common MR imaging findings were Achilles tendonitis (acute and peritendinitis) (57%), retrocalcaneal bursitis (50%), joint effusion/synovitis (46%), soft-tissue edema (46%), and para-articular enthesophytes (38%). The most commonly involved anatomical region was the hindfoot (73%). Conclusion: Our data showed that the incidence of foot involvement was very high in asymptomatic patients with psoriasis on MR imaging. Further MR studies are needed to confirm these data. We conclude that MR imaging may be of importance especially in early diagnosis and treatment of inflammatory changes in the foot. © 2007 Elsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

A comparison of corneal biomechanical properties in patients with psoriasis and healthy subjects

Celik U. | Aykut V. | Celik B. | Tas M. | Yazgan S. | Kaldirim H. | Erdur S.K.

Article | 2015 | Eye and Contact Lens41 ( 2 ) , pp.127 - 129

Objective: To evaluate the differences in corneal biomechanical properties between healthy subjects and patients with psoriasis using the ocular response analyzer (ORA). Methods: Fifty-nine eyes of 59 psoriasis patients and 66 healthy individuals were included in the study. Corneal biomechanical parameters were obtained using ORA. Ultrasound pachymetry was used to measure central corneal thickness (CCT). The main parameters assessed were corneal hysteresis (CH), corneal resistance factor (CRF), Goldmanncorrelated intraocular pressure (IOPg) measurement and cornealcompensated IOP (IOPcc) through ORA. The dry eye evaluation was perfor . . .med with tear break-up time (TBUT) and Shirmer test. Results: The mean CH values in psoriasis and healthy subject eyes were 10.7562.9 mm Hg, 11.9763.6 mm Hg, respectively (P=0.047). The mean CRF values were 10.1463.1 mm Hg and 11.6163.3 mm Hg, respectively (P=0.012). The mean CCT were 539.1636 mm and 536.3628 mm, respectively (P=0.643). Mean TBUT values were 8.262.9 sec in psoriasis group and 10.463.6 sec in healthy subjects (P,0.001). Shirmer test values were less (8.963.8 mm/5 min) in psoriasis than in healthy subjects (13.163.6 mm) (P,0.001). Conclusions: Psoriasis can influence the corneal biomechanical properties. Patients with psoriasis had lower CH and CRF, but higher IOPg and IOPcc values than healthy controls. These corneal biomechanical changes should be considered when determining IOP values. © 2014 Contact Lens Association of Opthalmologists, Inc Daha fazlası Daha az

Relationship between TLR2 and TLR4 gene polymorphisms with psoriasis [TLR2 ve TLR4 gen polimorfizmlerinin psoriasis ile ilişkisi]

Keni F.M. | Çelik S.K. | Solak N. | Genç G.Ç. | Dursun A.

Article | 2018 | Turk Dermatoloji Dergisi12 ( 1 ) , pp.28 - 32

Objective: Psoriasis is a common, chronic and recurrent disease which can affect skin and also joints. Although the etiopathogenesis of psoriasis has not precisely determined, the most supported mechanism is inflammation triggered by any factor. Toll like receptors (TLRs) family described in recent years is known to play a critical role in host immunity against a wide variety of pathogens. In our study, we aimed to reveal possible relationships of some TLR gene polymorphisms with psoriasis in this patient group. Methods: A hundred patients who diagnosed with psoriasis and 173 healthy controls were included in the study which known t . . .o be without inflammatory disease, TLR2 gene Arg677Trp, Arg753Gln, -196-174 del and TLR4 gene Asp299Gly, Thr399Ile polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism method, patient and control groups were compared in terms of gene polymorphisms mentioned. Results: In this study, it was determined psosiasis has a statistically significant relationship with GA genotype and A allele in TLR2 Arg753Gln polymorphism. Furthermore, when the patient and control groups were compared for -196-174 del gene polymorphism, it was determined that ins/del genotype had a protective effect. Conclusion: We think that variant alleles in the TLR2 gene may play an important role in the molecular etiopathogenesis of psoriasis. © Telif Hakkı 2018 Türk Dermatoloji Derneği Daha fazlası Daha az

Serum prolidase activity in psoriasis patients

Guven B. | Can M. | Genc M. | Koca R.

Article | 2013 | Archives of Dermatological Research305 ( 6 ) , pp.473 - 476

This study aimed to evaluate serum prolidase activity and the effects of gender, body mass index (BMI), disease severity and duration, and therapy type on prolidase activity in patients with psoriatic as well as the relationship between serum NO·and prolidase levels in these patients. The study included 29 clinically documented plaque patients with psoriasis and 24 healthy volunteers. Data such as age, sex, BMI, duration and severity of disease, and type of therapy were assessed. NO·levels were determined by the Griess reaction. Serum prolidase assay is based on a colorimetric determination of proline by Chinard's reagent. We did no . . .t determine any difference in serum NO·levels of psoriatic patients when compared to controls. Serum prolidase levels in psoriasis patients were significantly higher than those in controls. There was no significant difference in prolidase activity between male and female. No statistically significant correlations were found between serum prolidase levels and BMI, PASI and disease duration. When compared between topical treatment group and systemic treatment group, there was no significant difference in serum prolidase activity. In conclusion, patients with psoriasis exhibit higher serum prolidase activity independent of gender, BMI, disease severity or duration, type of treatments or NO·level. However, further studies are needed to verify these findings as well as altered collagen synthesis in patients with psoriasis. © 2013 Springer-Verlag Berlin Heidelberg Daha fazlası Daha az

Evaluation of serum uric acid levels in psoriasis vulgaris

Yilmaz E. | Tamer E. | Artüz F. | Külcü Çakmak S. | Köktürk F.

Article | 2017 | Turkish Journal of Medical Sciences47 ( 2 ) , pp.531 - 534

Background/aim: Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with the components of metabolic syndrome. In this study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by taking the presence of metabolic syndrome criteria into account, since it is one of the most important factors that affect serum uric acid levels. Materials and methods: In this cross-sectional study, we evaluated 70 psoriasis patients and 70 he . . .althy individuals who were matched with the patients according to the presence of metabolic syndrome. We evaluated the demographic features, levels of serum uric acid, Psoriasis Area Severity Index (PASI) scores, presence of psoriatic arthritis, nail involvement, and metabolic syndrome criteria of the patients. Results: Serum uric acid levels of psoriasis patients were significantly higher than those of controls. There was a positive correlation between PASI scores and serum uric acid levels of the patients. Conclusion: As hyperuricemia had a close relationship with psoriasis and PASI scores, we suggest monitoring patients with psoriasis for serum uric acid levels during treatment and follow-up. © TÜBİTAK Daha fazlası Daha az

Mast Cells and p53 Expression in Psoriasis Vulgaris

Barut, Figen | Bektaş, Sibel | Gün, Banu Doğan | Bahadır, Burak | Özdamar, Şükrü Oğuz

Article | 2011 | TURKIYE KLINIKLERI TIP BILIMLERI DERGISI31 ( 2 ) , pp.321 - 327

Evaluation of Serum Fetuin-A and Osteoprotegerin Levels in Patients with Psoriasis

Genc M. | Can M. | Guven B. | Cinar S. | Buyukuysal C. | Acikgoz B. | Mungan A.G.

Article | 2017 | Indian Journal of Clinical Biochemistry32 ( 1 ) , pp.90 - 94

Psoriasis patients are determined to have a high ratio of coronary artery calcification. Fetuin-A and osteoprotegerin are systemic calcification inhibitors and related to vascular calcification and cardiovascular mortality. In this study we investigated the relationship between fetuin-A and osteoprotegerin levels in psoriasis patients. The study included 40 healthy volunteers and 40 psoriasis patients. Venous blood were collected from healthy volunteers and psoriasis patients in order to search the fetuin-A and osteoprotegerin levels. Disease severity were grouped as mild, moderate and severe according to psoriasis area and severity . . . index (PASI). The relationship between fetuin-A and osteoprotegerin levels and clinical features as sex, PASI and presence of psoriatic arthritis were analyzed. Fetuin-A levels in psoriasis patients were statistically lower than the control group (p  0.05). Serum fetuin-A and osteoprotegerin level differences were not statistically significant between patients with psoriatic arthritis history and those without. When we grouped patients in respect of their sexes fetuin-A and osteoprotegerin levels of males and females were not significantly different (p > 0.05). No correlation was detected between the ages and PASI scores and the fetuin-A and osteoprotegerin levels of patients. As a result fetuin-A levels in psoriasis patients are found to be low but not related to disease severity. In the light of our results we concluded that fetuin-A may have a role in psoriasis pathogenesis and may contribute to the calcification process developed in psoriasis. © 2016, Association of Clinical Biochemists of India Daha fazlası Daha az

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