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The relationship between epicardial fat tissue thickness and visceral adipose tissue in lean patients with polycystic ovary syndrome

Arpaci D. | Gurkan Tocoglu A. | Yilmaz S. | Ergenc H. | Tamer A. | Keser N. | Gunduz H.

Article | 2015 | Journal of Ovarian Research8 ( 1 )

Background: Polycystic ovary syndrome (PCOS) is related to metabolic syndrome, insulin resistance, and cardiovascular metabolic syndromes. This is particularly true for individuals with central and abdominal obesity because visceral abdominal adipose tissue (VAAT) and epicardial adipose tissue (EAT) produce a large number of proinflammatory and proatherogenic cytokines. The present study aimed to determine whether there are changes in VAAT and EAT levels which were considered as indirect predictors for subclinical atherosclerosis in lean patients with PCOS. Methods: The clinical and demographic characteristics of 35 patients with PC . . .OS and 38 healthy control subjects were recorded for the present study. Additionally, the serum levels of various biochemical parameters were measured and EAT levels were assessed using 2D-transthoracic echocardiography. Results: There were no significant differences in mean age (p = 0.056) or mean body mass index (BMI) (p = 0.446) between the patient and control groups. However, the body fat percentage, waist-to-hip ratio, amount of abdominal subcutaneous adipose tissue, and VAAT thickness were higher in the PCOS patient group than in the control group. The amounts of EAT in the patient and control groups were similar (p = 0.384). EAT was correlated with BMI, fat mass, waist circumference, and hip circumference but not with any biochemical metabolic parameters including the homeostasis model assessment of insulin resistance index or the levels of triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein (HDL) cholesterol. However, there was a small positive correlation between the amounts of VAAT and EAT. VAAT was directly correlated with body fat parameters such as BMI, fat mass, and abdominal subcutaneous adipose thickness and inversely correlated with the HDL cholesterol level. Conclusions: The present study found that increased abdominal adipose tissue in patients with PCOS was associated with atherosclerosis. Additionally, EAT may aid in the determination of the risk of atherosclerosis in patients with PCOS because it is easily measured. © 2015 Arpaci et al Daha fazlası Daha az

Ovarian adenomyoma following gonadotrophin treatment for infertility

Bayar Ü. | Demirtas E. | Usubütün A. | Basaran M. | Esinler I. | Yarali H.

Article | 2006 | Reproductive BioMedicine Online13 ( 5 ) , pp.676 - 679

An ovarian adenomyoma developed in a 38-year-old infertile patient following treatment with exogenous gonadotrophins. Laparoscopic excision was performed. Histological examination showed thick muscular bundles resembling myometrium lined with endometrial glands and stroma. Gonadotrophins might be involved in the pathogenesis of extrauterine adenomyoma.

Transabdominal pulse inversion harmonic imaging improves assesment of ovarian morphology in virgin patients with PCOS: Comparison with conventional B-mode sonography

Mahmutyazicioglu K. | Tanriverdi H.A. | Özdemir H. | Barut A. | Davşanci H. | Gündogdu S.

Article | 2005 | European Journal of Radiology53 ( 2 ) , pp.280 - 286

Objective: In virgin policystic ovary syndrome (PCOS) patients transabdominal sonography is the preferential method of the pelvic examination. The purpose of this study was to determine ovarian morphology by the transabdominal route by pulse inversion harmonic imaging (PIHI) in virgin PCOS patients and to compare the diagnostic image quality with conventional B-mode ultrasonography (CBU). Methods: Fifty-two ovaries in 26 virgin patients were evaluated by the transabdominal approach. Each ovary was examined using both PIHI and CBU. The sharpness of the follicular cysts walls, degree of internal echo definitions of the follicle cysts . . .and overall ovarian conspicuity was assessed subjectively, using 4 point scoring (0, being worst; 3, being best score). The number of countable follicles, the size of largest and smallest ovarian follicle and ovarian volumes were assessed quantitively by both techniques. The effect of body mass index (BMI) on qualitative and quantitative scoring was evaluated. Results: The sharpness of the cyst wall and internal echo structure was significantly better with PIHI than with CBU (P < 0.001 P < 0.001 and P < 0.001, respectively). PIHI improved overall ovarian conspicuity in 41 (78.8%) of 52 examination. The number of countable follicles was significantly lower with CBU (P < 0.001). The maximum diameter of the largest follicle was larger with PIHI sonography to compared CBU (P < 0.001). Mean ovarian volume was significantly larger with CBU (P < 0.001). When data were analyzed separately according to BMI, number of non-diagnostic overall ovarian conspicuity scores with CBU was markedly high in obese patients (88% with CBU versus 3.8% with PIHI). On the other hand, mean number of countable follicles with CBU became much more lower in the obese group (P < 0.001). Conclusion: In virgin PCOS patients, when compared to transabdominal CBU, PIHI significantly improved the detection of ovarian follicles, especially in high BMI obese subjects, through increased contrast sensitivity for cystic structures and decreased intrafollicular artifactual echoes. Transabdominal ultrasonographic examination by PIHI mode can contribute to the evaluation of ovaries. © 2004 Elsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

Polycystic ovary syndrome: Dynamic contrast-enhanced ovary MR imaging

Erdem C.Z. | Bayar U. | Erdem L.O. | Barut A. | Gundogdu S. | Kaya E.

Article | 2004 | European Journal of Radiology51 ( 1 ) , pp.48 - 53

Objective: to determine the enhancement behaviour of the ovaries in women with polycystic ovary syndrome (PCOS) by dynamic contrast-enhanced magnetic resonance (DCE-MR) imaging and to compare these data with those of normal ovulating controls. Method: 24 women with PCOS and 12 controls underwent DCE-MR imaging. Dynamic images were acquired before and after injection of a contrast bolus at 30 s and the min of 1, 2, 3, 4 and 5. On postprocessing examination: (i) the ovarian volumes; (ii) the signal intensity value of each ovary per dynamic study; (iii) early-phase enhancement rate; (iv) time to peak enhancement (Tp); and (v) percentag . . .e of washout of 5th min were determined. Data of the ovaries of the women with PCOS and controls were compared with Mann-Whitney U-test. Results: the mean values of Tp were found to be significantly lower in women with PCOS than in controls (p<0.05). On the other hand, the mean values of ovarian volume, the early-phase enhancement rate, and percentage of washout of 5th min of ovaries were significantly higher in PCOS patients (p<0.05). Examination of the mean signal intensity-time curve revealed the ovaries in women with PCOS showed a faster and greater enhancement and wash-out. Conclusion: the enhancement behaviour of ovaries of women with PCOS may be significantly different from those of control subjects on DCE-MR imaging examination. In our experience, it is a valuable modality to highlight the vascularization changes in ovarian stroma with PCOS. We believe that improved DCE-MR imaging techniques may also provide us additional parameters in the diagnosis and treatment strategies of PCOS. © 2003 Elsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

Vitamin E modulates apoptosis and c-jun N-terminal kinase activation in ovarian torsion-detorsion injury

Sapmaz-Metin M. | Topcu-Tarladacalisir Y. | Uz Y.H. | Inan M. | Omurlu I.K. | Cerkezkayabekir A. | Kizilay G.

Article | 2013 | Experimental and Molecular Pathology95 ( 2 ) , pp.213 - 219

The aim of this study was to evaluate the role of vitamin E in follicular degeneration and to assess histopathological and biochemical changes following ischemia-reperfusion (IR) injury in rat ovaries. Twenty-eight Wistar albino rats were randomly divided into four groups: sham, 4. h torsion, 24. h detorsion, and a vitamin E group. Thirty minutes before detorsion, a single dose of 200. mg/kg vitamin E was administered intraperitoneally. The ovarian histology score was determined, serum levels of malondialdehyde (MDA) and myeloperoxidase (MPO) were measured. The apoptosis of granulosa cells and the phospho-c-jun N-terminal kinase (p- . . .JNK) and phospho-p38 (p-p38) immunoreactivities of these cells were determined. MDA and MPO levels were significantly increased in the torsion and detorsion groups. Hemorrhage, edema, and congestion were also apparent in these groups. In addition, the apoptotic index and the immunoreactivity of p-JNK were highest in the detorsion group, which also showed marked follicular degeneration. However, p-p38 activity was not affected by torsion-detorsion (TD) induction. Vitamin E ameliorated TD-induced histological alterations. It also decreased serum levels of MDA and MPO, reduced the activity of p-JNK in the ovaries, and reduced numbers of apoptotic follicular cells. In conclusion, these data indicate that vitamin E attenuated ovarian follicular degeneration by inhibiting the immunoreactivity of p-JNK and reducing the apoptosis of granulosa cells. © 2013 Elsevier Inc Daha fazlası Daha az

Migration of an Intrauterine Contraceptive Device to the Ovary

Özdemir H. | Mahmutyazicioglu K. | Tanriverdi H.A. | Gündogdu S. | Savranlar A. | Özer T.

Article | 2004 | Journal of Clinical Ultrasound32 ( 2 ) , pp.91 - 94

We present the case of a 37-year-old woman with a history of 2 consecutive insertions of intrauterine contraceptive devices (IUDs) 3 years before she was referred to us for sonographic evaluation of lower abdominal pain. The first of the IUDs was presumed to have been expulsed spontaneously, and 3 months after insertion of the second device, the patient had begun experiencing lower abdominal pain. Medical treatment with antibiotics and spasmolytics had been unsuccessful. We performed transvaginal sonography, which revealed the presence of an IUD in the uterus and a 2-cm linear metallic echogenic area in the left ovary, believed to r . . .epresent another IUD. Anteroposterior radiography confirmed that there were 2 IUDs in the pelvis, and CT demonstrated 1 IUD in the uterus and another in the left ovary. The patient underwent laparoscopic removal of the ovarian IUD and was discharged in good condition. To our knowledge, this is the first report of migration of an IUD to the ovary detected on transvaginal sonography. We recommend consideration of this possibility during evaluation of women with unexplained chronic pelvic pain. © 2004 Wiley Periodicals, Inc Daha fazlası Daha az

Giant ovarian lipoleiomyoma: A rare neoplasm [Dev ovaryan lipoleiomiyoma: Nadir görülen bir neoplazm]

Bektaş S. | Bahadir B. | Barut F. | Bayar Ü. | Özdamar Ş.O.

Article | 2010 | Turkiye Klinikleri Jinekoloji Obstetrik20 ( 6 ) , pp.403 - 406

Ovarian lipoleiomyoma composed of an admixture of smooth muscle and adipose tissue is a rare mesenchymal neoplasm. A 54-year-old female patient presented with pelvic pain. Ultrasonography revealed a giant mass with cystic-solid appearance filling of the Douglas pouch. With suspicion of ovarian carcinoma, operation was performed. Gross examination of the left ovary showed a mass measuring 20 x 19 x 11 cm. Histopathologically, the tumor consisted primarily of interlacing spindle cells with scattered of mature adipose tissue. Immunohistochemically, spindle cells exhibited vimentin, smooth muscle actin and desmin positivity. Adipose cel . . .ls revealed positive reaction for S100 protein. A diagnosis of lipoleiomyoma was made. Ovarian lipoleiomyoma may mimic malignancy, both clinically and radiographically, due the the fact that it may reach a giant size and because of its heterogeneous internal structure. Copyright © 2010 by Türkiye Klinikleri Daha fazlası Daha az

Ovarian heterotopic pregnancy clinically mimicking endometrioma

Onak Kandemir N. | Barut F. | Yurdakan G. | Bayar Ü. | Özdamar Ş.O.

Article | 2010 | Turk Patoloji Dergisi/Turkish Journal of Pathology26 ( 1 ) , pp.85 - 88

Heterotopic pregnancy is a very uncommon entity with a difficult preoperative diagnosis. In the present study, we presented an ovarian heterotopic pregnancy case, clinically mimicking endometrioma developed in a 33-year-old female following an in vitro fertilization procedure. The importance of clinical, histopathological, and immunohistochemical examinations in the diagnosis of heterotopic pregnancy are emphasized.

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