Morning headache in sleep apnoea: Clinical and polysomnographic evaluation and response to nasal continuous positive airway pressure

Goksan B. | Gunduz A. | Karadeniz D. | Agan K. | Tascilar F.N. | Tan F. | Purisa S.

Article | 2009 | Cephalalgia29 ( 6 ) , pp.635 - 641

Morning headache is accepted as part of clinical findings of obstructive sleep apnoea syndrome (OSAS). The prevalence of morning headache is at variable levels from 18% to 74% in patients with OSAS. However, there is controversy over the association of morning headache and OSAS. We studied morning headache prevalance and characteristics in 101 controls with apnoea-hypnoea index (AHI) < 5 and 462 OSAS patients with AHI ? 5. Morning headache was reported by only nine (8.9%) subjects in a control group compared with 156 (33.6%) of OSAS patients (P < 0.01). Morning headache prevalance was significantly higher in severe and moderate OSAS . . . groups. AHI was significantly higher in OSAS patients with morning headache compared with patients without morning headaches. Oxygen saturation nadir during rapid eye movement and non-rapid eye movement sleep as well as mean oxygen saturation value during total sleep time were also found to be significantly lower in morning headache group. However, none of the sleep parameters was found to be determinants of morning headache. Morning headache was more frequently reported by patients of female gender and with primary headache history. Morning headache was totally resolved in 90% of patients treated with nasal continuous positive airway pressure. The history of OSAS should be considered in the differential diagnosis of morning headache. © Blackwell Publishing Ltd Daha fazlası Daha az

Craniofacial differences according to AHI scores of children with obstructive sleep apnoea syndrome: Cephalometric study in 39 patients

Özdemir H. | Altin R. | Sögüt A. | Çinar F. | Mahmutyazicioglu K. | Kart L. | Uzun L.

Article | 2004 | Pediatric Radiology34 ( 5 ) , pp.393 - 399

Background: Cephalometry is useful as a screening test for anatomical abnormalities in patients with obstructive sleep apnoea syndrome (OSAS). Objective: To evaluate comprehensively the cephalo metric features of children with OSAS, with or without adenotonsillar hypertrophy, and to elucidate the relationship between cephalometric variables and apnoea-hypopnoea index (AHI) severity. Materials and methods: The study population consisted of 39 children, aged 4-12 years, with OSAS. Cephalometry was analysed using 11 measurements of the bony structures, their relationships and the size of the airways. Additionally, adenoid and tonsillar . . . hypertrophy were graded. Results: Cranial base angles (BaSN and BaSPNS) were found to correlate with increasing levels of AHI scores (P < 0.001). Protrusion of the maxilla (SNA) and mandible (SNB) did not correlate with AHI scores (P > 0.05). The length of the mandibular plane (GnGo) and the minimal posterior airway space (MPAS) were inversely correlated with AHI scores (P < 0.001). There was positive correlation between MPAS and GnGo (r = 0.740, P < 0.001), and negative correlation between MPAS and gonial angle (ArGoGn) (r = -0.541, P < 0.001). There was significant correlation between cephalometric data and adenotonsillar hypertrophy concerning BaSN, BaSPNS, ArGoGn, GnGoH, BaN-GnGo, MPAS, GnGO and MPH (P < 0.001). Conclusions: There is significant correlation between cephalometric data and AHI score severity in children with OSAS. Adenotonsillar hypertrophy affects the cephalometric measurements adversely. The study clearly mandates the institution of early and effective therapy of adenotonsillar hypertrophy in children with OSAS. © Springer-Verlag 2004 Daha fazlası Daha az

Association between continuous positive airway pressure and circulating omentin levels in patients with obstructive sleep apnoea

Uygur F. | Tanrıverdi H. | Can M. | Erboy F. | Altınsoy B. | Atalay F. | Ornek T.

Article | 2016 | Sleep and Breathing20 ( 3 ) , pp.939 - 945

Purpose: Inflammation and oxidative stress play important roles in the pathogenesis of obstructive sleep apnoea syndrome (OSAS). Omentin is expressed in visceral adipose tissue and is associated with the inflammatory response. The aim of this study was to assess the relationship between OSAS and omentin based on a comparison of its serum levels at baseline and after 3 months of continuous positive airway pressure (CPAP) therapy. Methods: Ninety-six newly diagnosed OSAS patients and 31 non-apnoeic controls were enrolled in this study. Blood samples were obtained in the morning after polysomnography. Within the OSAS group, 30 patients . . . were started on CPAP therapy and then reassessed clinically, including a blood test for serum omentin and other biochemical analysis, at 3 months. Results: Serum omentin levels were significantly lower in the OSAS group than in the control group (27.7 ± 7.6 and 42.5 ± 5.2 ng/mL, P < 0.001). In the subgroup analysis, omentin concentrations were significantly lower in patients with severe OSAS than in those with mild/moderate OSAS (P < 0.001). Circulating omentin levels were significantly correlated with the apnoea–hypopnoea index (AHI), mean SaO2, oxygen desaturation index, and serum C-reactive protein levels. Treatment with CPAP resulted in a significant increase in circulating omentin levels after 3 months, from 22.7 ± 1.4 to 41.2 ± 3.3 ng/mL (P < 0.001). Conclusions: OSAS is associated with low serum omentin levels, and these levels can be reversed by effective CPAP treatment. © 2016, Springer-Verlag Berlin Heidelberg Daha fazlası Daha az

The neutrophil-to-lymphocyte ratio in patients with obstructive sleep apnoea syndrome and its relationship with cardiovascular disease

Uygur F. | Tanriverdi H. | Aktop Z. | Erboy F. | Altinsoy B. | Damar M. | Atalay F.

Article | 2016 | Heart and Lung: Journal of Acute and Critical Care45 ( 2 ) , pp.121 - 125

Objective: To investigate the association between the neutrophil-to-lymphocyte ratio (NLR) and obstructive sleep apnoea syndrome (OSAS) severity and whether the NLR predicts cardiovascular disease (CVD) in patients with OSAS. Background: OSAS is known as a risk factor for CVD. An increased NLR was strongly correlated with cardiovascular outcomes in several studies. Methods: We retrospectively examined the laboratory data for 289 patients with suspected OSAS evaluated using polysomnography. Results: The study included 171 OSAS patients and 118 controls. The NLR was higher in OSAS group than control group. The NLR was significantly hi . . .gher in patients with CVD than in those without (3.31 ± 1.1 vs. 1.93 ± 0.8, p = 0.002). There were also significant correlations between the NLR and apnoea-hypopnoea index, mean SaO2, and oxygen desaturation index. Conclusions: There was a significant correlation between the NLR and OSAS severity and the NLR was independently associated with CVD in patients with OSAS. © 2016 Elsevier Inc Daha fazlası Daha az

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