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N-acetylcycsteine attenuates the deleterious effects of radiation therapy on incisional wound healing in rats

Tascilar O. | Çakmak G.K. | Emre A.U. | Bakkal, Bekir Hakan | Kandemir N. | Turkcu U.O. | Demir E.O.

Article | 2014 | Hippokratia18 ( 1 ) , pp.17 - 23

Background: During preoperative radiotherapy, effective doses of ionizing radiation occasionally cause wound complications after subsequent surgery. This study was designed to determine the effects of intraperitoneally or orally administered N-acetylcysteine (NAC) on anastomotic healing of irradiated rats. Material & Methods: Forty Wistar albino rats were randomized into four groups containing 10 rats each. A 3 cm long surgical full-thickness midline laparotomy was performed to all groups (Groups 1-4). Group 1 was designed as a control group without radiation therapy and NAC treatment. Groups 2, 3 and 4 received a single abdominal d . . .ose of 10 Gy irradiation before laparotomy and groups 3 and 4 received oral and intraperitoneal NAC, respectively. Results: Group comparisons demonstrated that breaking strength was significantly higher in NAC treated rats. A statistically significant difference was determined in terms of superoxide dismutase (SOD), malondealdehyde (MDA) and glutation (GSH) values between groups ( Daha fazlası Daha az

The biochemical effectiveness of N-acetylcysteine in experimental spinal cord injury in rats

Hanci, Volkan | Kerimoglu, Alaeddin | Koca, Kenan | Baskesen, Aykut | Kilic, Kemal | Tastekin, Didem


BACKGROUND In this study, we investigated the biochemical effectiveness of methylprednisolone, N-acetylcysteine (NAG) and methylprednisolone combined with NAC treatment in experimental spinal cord injury in rats. METHODS Thirty-two Sprague-Dawley male rats weighing 250-300 g were divided into four groups. Spinal cord injury was created extradurally with an aneurysm clip at the T4-T5 level. Following the trauma, Group C (Control group, n:8) was not given any treatment. Group M (methylprednisolone group, n:8) was treated with 30 methylprednisolone followed by a maintenance dose of 5.4 per hour. Group N (NAG group, . . .n:8) was given 150 NAG. Group MN (methylprednisolone and NAC group, n:8) was given 30 followed by an hourly maintenance dose of 5.4 methylprednisolone and 150 NAC intraperitoneally. Twenty-four hours after the trauma, the rats were decapitated under anesthesia, and their spinal cord samples were taken for biochemical examination. RESULTS Mean malonyldialdehyde (MDA) values in Groups M, N and MN were significantly reduced compared to Group C. Mean superoxide dismutase (SOD) values in Groups M, N and MN were significantly higher than in Group C ( Daha fazlası Daha az

Attenuation of bleomycin-induced lung fibrosis by oral sulfhydryl containing antioxidants in rats: Erdosteine and N-acetylcysteine

Yildirim Z. | Kotuk M. | Iraz M. | Kuku I. | Ulu R. | Armutcu F. | Ozen S.

Article | 2005 | Pulmonary Pharmacology and Therapeutics18 ( 5 ) , pp.367 - 373

Antioxidant therapy may be useful in diseases with impaired oxidant antioxidant balance such as lung fibrosis. The effects of sulfhydryl-containing antioxidant agents N-acetylcysteine (NAC) and erdosteine on the bleomycin-induced lung fibrosis were compared in rats. The animals were divided into four groups: Vehicle+vehicle, vehicle+bleomycin (2.5 U/kg), bleomycin+erdosteine (10 mg/kg), and bleomycin+NAC (3 mmol/kg). Bleomycin administration resulted in prominent lung fibrosis as measured by lung hydroxyproline content and lung histology which is almost completely prevented by erdosteine and NAC. Hydroxyproline content was 18.7±3.5 . . .and 11.2±0.6 mg/g dried tissue in bleomycin and saline treated rats, respectively ( Daha fazlası Daha az

N-acetylcysteine counteracts oxidative stress and protects alveolar epithelial cells from lung contusion-induced apoptosis in rats with blunt chest trauma

Topcu-Tarladacalisir Y. | Tarladacalisir T. | Sapmaz-Metin M. | Karamustafaoglu A. | Uz Y.H. | Akpolat M. | Cerkezkayabekir A.

Article | 2014 | Journal of Molecular Histology45 ( 4 ) , pp.463 - 471

The aim of this study was to investigate the protective effects of N-acetylcysteine (NAC) on peroxidative and apoptotic changes in the contused lungs of rats following blunt chest trauma. The rats were randomly divided into three groups: control, contusion, and contusion + NAC. All the rats, apart from those in the control group, performed moderate lung contusion. A daily intramuscular NAC injection (150 mg/kg) was given immediately following the blunt chest trauma and was continued for two additional days following cessation of the trauma. Samples of lung tissue were taken in order to evaluate the tissue malondialdehyde (MDA) level . . ., histopathology, and epithelial cell apoptosis using terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay and active caspase-3 immunostaining. In addition, we immunohistochemically evaluated the expression of surfactant protein D (SP-D) in the lung tissue. The blunt chest trauma-induced lung contusion resulted in severe histopathological injury, as well as an increase in the MDA level and in the number of cells identified on TUNEL assay together with active caspase-3 positive epithelial cells, but a decrease in the number of SP-D positive alveolar type 2 (AT-2) cells. NAC treatment effectively attenuated histopathologic, peroxidative, and apoptotic changes, as well as reducing alterations in SP-D expression in the lung tissue. These findings indicate that the beneficial effects of NAC administrated following blunt chest trauma is related to the regulation of oxidative stress and apoptosis. © 2014 Springer Science+Business Media Daha fazlası Daha az

N-acetylcysteine may reduce repetitive behaviors in children with autism: a case series

Celebi, Fahri | Koyuncu, Ahmet | Coskun, Murat

Article | 2017 | PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY27 ( 2 ) , pp.190 - 193

Objective: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social communication and interaction, and restricted, stereotypic, repetitive behaviors. Behavioral problems are common in children with ASD. Herein, we report the effect of N-acetylcysteine (NAC) treatment on repetitive behaviors in 10 children with ASD. Methods: Ten children with ASD were assessed using the Childhood Autism Rating Scale and Aberrant Behavior Checklist (ABC). The clinical follow-up was performed with ABC and Clinical Global Impressions-Improvement (CGI-I). A total of 10 patients were initiated on NAC therapy in . . . addition to their treatment with a stable dose of risperidone to avoid the potential adverse effects of higher doses of risperidone. Two patients discontinued NAC treatment before the third week. Eight patients were treated with an NAC dosage of 1200-2700 mg/day for 6-10 weeks. Results: The mean age of the patients was 8.6 years. Patients received NAC treatment for a mean duration of 8.25 weeks and a mean dosage of 2100 mg/day. Improvement in stereotypic behaviors was statistically significant in addition to the improvement in mean CGI-I score (p =.025 and .006, respectively). Conclusion: NAC adjunction to risperidone treatment may be helpful to reduce repetitive behaviors in children with ASD with limited adverse effects and good tolerability Daha fazlası Daha az

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