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Medical haemostasis in acute hepatocyte injury and experimental liver trauma

Cihan A. | Yilmaz E. | Yenidünya S. | Uçan B.H.

Article | 2005 | ANZ Journal of Surgery75 ( 4 ) , pp.239 - 243

Background: The aim of the present study was to test the effectiveness of aprotinin to reduce bleeding in liver resection of guinea pigs with acutely injured hepatocyte using intraperitoneal D(+)Galactosamine. Methods: Thirty-two guinea pigs were divided equally into four groups. Group 1 was the control group. Group 2 received intraperitoneal D(+)galactosamine. Group 3 received intraperitoneal D(+)galactosamine prior to a standard liver resection. Group 4 received 10.000 KIU/kg aprotinin infusion via jugular catheter in 10 min prior to standard liver resection in pretreated animals with D(+)galactosamine. All of the measurements and . . . surgical interventions were made 24 h after the administration of D(+)galactosamine. Bleeding amounts were recorded in groups 3 and 4 for 1 h by weighing the sponges placed into the abdomen. Liver function tests, histologic, haematologic and fibrinolytic parameters were measured. Results: Hepatocyte injury and hyperfibrinolysis were seen at the end of 24 h after application of D(+)galactosamine in groups 2, 3, and 4. Statistically significant amounts of bleeding from the resected livers were observed in group 3 and 4. In group 4, the bleeding was reduced (P < 0.05) and fibrinolytic parameters were normalized (P < 0.05) with aprotinin infusion. Conclusions: Significant bleeding diathesis and hyperfibrinolysis occurred in groups 2, 3, and 4, which had hepatocyte injury proved with histopathologic and haematologic tests. Prothrombin time (PT) and partial thromboplastin time (aPTT) in groups 3 and 4 were fivefold higher than that in the control group (P = 0.0001). The bleeding tendency according to high PT and aPTT levels were continued with application of aprotinin while reduction of bleeding was seen. Parenchymatous organ haemorrhage in acute liver failure or hyperfibrinolytic conditions could be reduced significantly with aprotinin without procoagulant effect Daha fazlası Daha az

Spontaneous rupture of a hepatic hydatid cyst into the peritoneum causing only mild abdominal pain: A case report

Karakaya K.

Article | 2007 | World Journal of Gastroenterology13 ( 5 ) , pp.806 - 808

Hydatid disease is an endemic disease in certain areas of the world. It is located mostly in the liver. Spontaneous rupture of the hydatid cyst into the peritoneum is a rare condition, which is accompanied by serious morbidity and mortality generally. We present herein a case with a spontaneous rupture of a hepatic hidatid disease into the peritoneum without any serious symptoms. A 15-year-old boy was admitted to the emergency room with a mild abdominal pain lasting for a day. Physical examination revealed only mild abdominal tenderness. There was no history of trauma or complaints related to hydatid diseases. Ultrasonography showed . . . a large amount of free fluid and a cystic lesion with irregular borders in the liver. He was operated on. Postoperative albendazol therapy was given for 2 mo. No recurrence or secondary hydatidosis was seen on CT investigation in the 3rd, 6th and 12th mo following surgery. © 2007 The WJG Press. All rights reserved Daha fazlası Daha az

Diagnostic value of diffusion weighted MRI and ADC in differential diagnosis of cavernous hemangioma of the liver.

Tokgoz, Ozlem | Unlu, Ebru | Unal, Ilker | Serifoglu, Ismail | Oz, Ilker | Aktas, Elif | Caglar, Emrah

Article | 2016 | AFRICAN HEALTH SCIENCES16 ( 1 ) , pp.227 - 233

https://dx.doi.org/10.4314/ahs.v16i1.30 https://hdl.handle.net/20.500.12628/2383

Protective effect of sildenafil on liver injury induced by intestinal ischemia/reperfusion

Inan M. | Uz Y.H. | Kizilay G. | Topcu-Tarladacalisir Y. | Sapmaz-Metin M. | Akpolat M. | Aydogdu N.

Article | 2013 | Journal of Pediatric Surgery48 ( 8 ) , pp.1707 - 1715

Background This study evaluated the protective effect of sildenafil on liver injury induced by intestinal ischemia-reperfusion. Methods Forty female Sprague Dawley rats were divided into 4 groups: sham-control (SC), ischemia (I), ischemia-reperfusion (IR), and ischemia-reperfusion + sildenafil (SIL; sildenafil gavaged at 50 mg/kg before operating). A 2-h ischemia-reperfusion was performed by clamping the superior mesenteric artery. Liver function, plasma alanine (ALT) and aspartate (AST) aminotransferase, and intestinal and liver malondialdehyde (MDA) were measured at the end of the experiment. Intestinal and liver tissue damage was . . . examined by histology. Liver samples were immunologically stained for endothelial nitric oxide synthase (eNOS) and proliferating cell nuclear antigen (PCNA). Results The ALT and AST levels were highest in the IR group and were lower in the SIL group (p < 0.05). Intestinal MDA levels were statistically higher in the IR group than in the SC, I and SIL groups. Liver MDA levels were significantly higher in the IR group than in the I and SC groups (p < 0.05) and higher than in the SIL group (p > 0.05). Intestinal damage based on Chiu scoring was more severe in the IR than in the SIL group (p < 0.05). Sildenafil reduced damage and also increased eNOS and PCNA immunoreactivity in liver tissue. Conclusions Sildenafil shows a protective effect on intestinal ischemia-reperfusion-induced liver injury, possibly by decreasing vascular resistance through increased nitric oxide levels. © 2013 Elsevier Inc Daha fazlası Daha az

The effects of dexpanthenol in streptozotocin-induced diabetic rats: Histological, histochemical and immunological evidences

Gulle K. | Ceri N.G. | Akpolat M. | Arasli M. | Demirci B.

Article | 2014 | Histology and Histopathology29 ( 10 ) , pp.1305 - 1313

Summary. This study was designed to investigate the effects of Dexpanthenol (Dxp) on liver and pancreas histology and cytokine levels in streptozotocine (STZ)-induced diabetic rats. Twenty-four Wistar albino male rats were divided into four groups: control, Dxp, STZ-induced diabetic (STZ) and diabetic treatment with Dexpanthenol (STZ-Dxp) groups. Experimental diabetes was induced by single dose STZ (50 mg/kg) intraperitoneally (i.p.). After administration of STZ, the STZ-Dxp group began to receive a 300 mg/kg/day i.p. dose of Dxp for 6 weeks. Liver and pancreas tissues of the control group were in normal morphology. Liver tissue of . . .STZ group showed vacuolisation of hepatocytes in the liver parenchyma with enlargement of sinusoidal spaces and increasing amounts of connective tissue in the portal area. Pancreatic section of STZ group displayed ß-cells with of cytoplasmic mass, reduction of islet size, and atrophy. The STZ-Dxp group that received Dxp treatment exhibit partially normal hepatic parenchyma. Histochemical examinations revealed that the diabetes-induced glycogen depletion markedly improved with the Dxp treatment ( Daha fazlası Daha az

Experimental bile-duct ligation resulted in accumulation of oxidized low-density lipoproteins in BALB/c mice liver

Cömert M. | Tekin I.Ö. | Açikgöz Ş. | Üstundag Y. | Uçan B.H. | Acun Z. | Barut F.

Article | 2004 | Journal of Gastroenterology and Hepatology (Australia)19 ( 9 ) , pp.1052 - 1057

Background and Aim: Oxidized low-density lipoproteins (LDL), which are produced during oxidative stress by the process of lipid peroxidation, have also been proposed to have complex roles in many other immuno-inflammatory mechanisms. It has been shown that bile-duct ligation results in oxidative stress in the liver of animals. The aim of this study was to investigate if oxidized LDL are produced in the liver tissues of bile-duct-ligated mice. Methods: Obstructive jaundice was induced in BALB/c mice by the ligation and division of the common bile duct. Liver concentrations of glutathione and malondialdehyde were measured in the sham- . . .operated (n = 10) and bile-duct-ligated (n = 10) mice on the 10th day of obstructive jaundice. The presence of oxidized LDL in the liver tissue sections was evaluated using a special, novel immunofluorescent staining method. The final step was to explore the existence of oxidized LDL under fluorescent microscopy. Results: Compared with sham-operated mice, jaundiced mice showed significantly higher levels of malondialdehyde and lower concentrations of reduced glutathione in the liver. While there was no staining in the sham-operated group, bile-duct ligation resulted in positive oxidized LDL staining in the liver tissues of mice. The present study testifies that bile-duct ligation results in oxidative stress and enhanced lipid peroxidation in the hepatic tissues of BALB/c mice and moreover, that oxidized LDL accumulate in the liver of mice with experimental obstructive jaundice. Conclusion: Oxidized LDL may be an important and direct indicator of ongoing oxidative stress and enhanced lipid peroxidation in obstructive jaundice. The potential roles of this finding were also discussed, briefly. © 2004 Blackwell Publishing Asia Pty Ltd Daha fazlası Daha az

Effects of formaldehyde inhalation on zinc, copper and iron concentrations in liver and kidney of male rats

Özen O.A. | Kus I. | Bakirdere S. | Sarsilmaz M. | Yaman M.

Article | 2011 | Biological Trace Element Research140 ( 2 ) , pp.177 - 185

In the present study, adult Wistar albino male rats were exposed to formaldehyde at different periods (subacute and subchronic) and concentrations (5.0 and 10.0 ppm) in order to figure out the changes in the concentration of Zn, Cu and Fe. It was observed that the formaldehyde inhalation caused gradual decline of body weights in the experimental groups when compared with control groups. It was found that subacute (4-week) or subchronic (13-week) exposure to formaldehyde for rats may cause growth retardation. After inhalation procedure, concentration of copper, zinc and iron were determined in liver and kidney tissues of rats using a . . .tomic absorption spectrophotometer. In addition, concentrations of Cu, Zn and Fe changed by the effect of formaldehyde in subacute and subchronic groups. © 2010 Springer Science+Business Media, LLC Daha fazlası Daha az

Vitamin E protects against oxidative damage caused by formaldehyde in the liver and plasma of rats

Gulec M. | Gurel A. | Armutcu F.

Article | 2006 | Molecular and Cellular Biochemistry290 ( 01.Feb ) , pp.61 - 67

It is well known that formaldehyde (FA) and reactive oxygen species (ROS) are cytotoxic and potentially carcinogenic. Although the individual effects of these reactants on cells have been investigated, the cytotoxicity exerted by the coexistence of FA and ROS is poorly understood. The present study was carried out to evaluate oxidant/ antioxidant status and biochemical changes occurring after chronic formaldehyde toxicity in liver tissue and plasma of rats and protective effect of vitamin E (vit E) against oxidative damage. Eighteen rats were divided into three groups: (1) control rats, (2) rats treated with FA (FAt), and (3) rats t . . .reated with FA plus vit E (FAt + vit E) groups. After the treatment, the animals were sacrificed and liver tissues were removed for biochemical investigations. As a result, FA treatment significantly increased the levels of tissue malondialdehyde (MDA), protein carbonyl (PC), nitric oxide (NO) and the activity of xanthine oxidase enzyme (XO). On the other hand, FA exposure led to decrease in superoxide dismutase (SOD) and catalase (CAT) activities in liver tissues compared to control. FA caused significant decreases in total protein (TP) and albumin (ALB) whereas increases in aspartate transaminase (AST), alanine aminotransferase (AST), alkaline phosphatase (ALP) and interleukine-2 (IL-2) levels in plasma. Vit E treatment abolished these changes at a level similar to the control group. It was concluded that vit E treatment might be beneficial in preventing FA-induced liver tissue damage, and therefore have potential for clinical use. © Springer Science + business Media, Inc. 2006 Daha fazlası Daha az

A case of hepatic lipoma: Case report [Karaciger lipomu olgusu]

Voyvoda N. | Kocak E. | Beşir H. | Koçak M.G.

Article | 2009 | Turkiye Klinikleri Journal of Medical Sciences29 ( 1 ) , pp.263 - 266

Hepatic lipomas are extremely rare benign tumors. Because these lesions are asymptomatic, they are usually discovered incidentally. There is no risk of malignant degeneration. The imaging appearance of lipomas is characteristic. Computed tomography, magnetic resonance imaging, and sonographic findings of these lesions can help in characterization by allowing specific diagnosis. In computed tomography and magnetic resonance imaging, simple lipomas demonstrate fat attenuation or signal intensity and do not enhance after contrast material administration. A 46-year-old woman was admitted to the hospital because of dyspeptic symptoms. Li . . .ver ultrasound was suggestive of lipomas, whereas the diagnosis was confirmed by computed tomography and magnetic resonance imaging. In this presentation, we evaluated the effectiveness of ultrasonography, computed tomography, and magnetic resonance imaging in the diagnosis of lipomas. Copyright © 2009 by Türkiye Klinikleri Daha fazlası Daha az

Noninvasive Models to Predict Liver Fibrosis in Patients with Chronic Hepatitis B: A Study from Turkey

Korkmaz, Pinar | Demirturk, Nese | Batirel, Ayse | Yardimci, Ahmet Cem | Cagir, Unal | Nemli, Salih Atakan | Korkmaz, Fatime

Article | 2017 | HEPATITIS MONTHLY17 ( 12 ) , pp.263 - 266

Background: Manynoninvasive methods, including aspartateaminotransaminase (AST)/alanineaminotransaminase (ALT) ratio (AAR), AST-to-platelet ratio index (APRI), Bonacini cirrhosis discriminant score (CDS), fibrosis-4 (FIB4) index, and age-platelet index (API), have been described to determine the stage of hepatic fibrosis. However, thesemethodsare developed for patients with chronic hepatitisC(CHC) andproduce conflicting results in the prediction of liver fibrosis in patients with chronic hepatitis B (CHB). Objectives: The aim of this study was to evaluate the relationship between 7 noninvasive models, including AAR, APRI, CDS, API, . . .FIB-4, neutrophil-to-lymphocyte ratio (NLR), and red cell distribution width (RDW)-to-platelet ratio (RPR) in patients with CHB. Methods: The study population included all patients with CHB, undergoing liver biopsy to determine HBsAg and HBV DNA positivity in more than 6 months. Results: A total of 2520 treatment-naive CHB patients from 40 different centers were included in the study. In total, 62.6% of the patients were male, and the mean age was 40.60 +/- 12.34 years (minimum, 18 years; maximum, 77 years). The Ishak fibrosis score was >= 3 in 29.8% of the patients, indicating significant fibrosis. The mean API, APRI, CDS, NLR, FIB4, and RPR scores in the noninvasive models were significantly different between the groups with significant and low fibrosis (P < 0.05). All the noninvave models (API, APRI, AAR, CDS, NLR, RPR, and FIB4) were found to be significant in the discrimination of cirrhosis (P < 0.05). In the multiple logistic regression analysis, CDS, albumin, alkaline phosphatase (ALP), total bilirubin, neutrophil count, NLR, mean platelet volume (MPV), and FIB4 were independent indices for cirrhosis. Conclusions: In the present study, the role of noninvasive tests in the prediction of liver fibrosis stage and cirrhosis was evaluated in a large cohort of CHB patients. Overall, noninvasive models are gradually becoming more promising. Accordingly, the need for liver biopsy can be reduced with a combination of noninvasive methods in the future Daha fazlası Daha az

The value of liver and spleen ADC measurements in the diagnosis and follow up of hepatic fibrosis in chronic liver disease

Tokgoz O. | Unal I. | Gedikli Turgut G. | Yildiz S.

Article | 2014 | Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine69 ( 6 ) , pp.426 - 432

Aims: To evaluate the value of spleen and liver apparent diffusion coefficients (ADC) in chronic liver disease patients, with and without hepatocellular carcinoma (HCC), and to investigate the use of diffusionweighted imaging (DWI) in the diagnosis and follow-up of hepatic fibrosis. Materials and methods: This study population comprised 68 chronic liver disease patients (Group 1) and 70 healthy volunteers as controls (Group 2). In Group 1, 40 patients had chronic hepatitis-B, 20 had chronic hepatitis-C, 5 had non-alcoholic steatohepatitis and 3 had alcoholic steatohepatitis. Diagnosis of chronic liver disease was made by percutaneou . . .s liver biopsy and the degree of fibrosis (stage) was determined using the METAVIR scoring system. HCC diagnosis was made with a lesion biopsy. The patient group was subdivided based on the degree of fibrosis (F1, F2, F3 and F4) and presence of HCC. After patient and control groups underwent b-value 600 s/mm2 DWI examination, liver and spleen ADC values were mapped and measured. The ADC values of the patient groups (F1, F2, F3, F4; with HCC, without HCC) were compared with each other and with the control group. Results: Liver ADC values were lower in Group 1 compared to Group 2 (P,0.001). There was a statistically significant difference between the patient and control groups liver right lobe, left lobe and caudate lobe ADC values (P,0.001). Comparing the F1, F2, F3 and F4 groups, there was no statistically significant difference found in terms of ADC values (P.0.05). However, as degree of fibrosis increased there was a reduction in ADC values, though not statistically significant. Comparing the groups with HCC and without HCC, there was no statistically significant difference in ADC values (P.0.05). There was no statistical difference in average spleen ADC values between patient and control groups (P.0.05). Conclusions: In chronic liver disease, ADC values were lower. As the degree of liver fibrosis increased, ADC levels decreased, though the relationship between ADC values and fibrosis degree was not statistically significant. Quantitative DWI may help in the diagnosis of fibrosis in chronic liver disease patients, however as it does not show the degree of fibrosis, its use in treatment planning and follow-up is controversial. Spleen DWI measurement is not a sufficient method to diagnose and determine the degree of fibrosis in chronic liver disease patients. © Acta Clinica Belgica 2014 Daha fazlası Daha az

Effects of L-arginine and N?-nitro-L-arginine methyl ester on lipid peroxidation and antioxidant enzymes to liver of rats with ductus choledochus ligation [Koledok kanali tikanikligi yapilan ratlarda L-arjinin ve N ?-nitro-L-arjinin metil ester tedavisinin karaciger dokusu lipit peroksidasyonu ve antioksidan enzimler üzerine etkisi]

Gürel A. | Armutcu F. | Sögüt S. | Cihan A.

Article | 2003 | Ondokuz Mayis Universitesi Tip Dergisi20 ( 4 ) , pp.186 - 192

One of the most important reasons of liver destruction in obstructive jaundice is reactive oxygen derived compounds which are formed as a result of demolished liver circulation. In this experimental study, we investigated the effects of L-arginine and L-NAME on liver antioxidant system and lipid peroxidation in rats after ductus choledochus ligation (BDL). For this purpose, fifteen rats were divided randomly into three equal groups. BDL group (n=5): bile duct ligation was performed in rats. L-Arginine group (n=5): Anaesthetized rats were given L-arginine (1 mg/kg) for 7 days after BDL. L-NAME group (n=5): Anaesthetized rats were giv . . .en L-NAME (2 mg/kg) for 7 days after BDL. Liver tissue was removed in all rats under anesthesia seven days after surgical procedure. Tissue was homogenized and malondialdehyde (MDA) and nitric oxide levels, xanthine oxidase, superoxide dismutase (SOD) and catalase (CAT) levels were studied in the homogenate. Liver tissue MDA level of L-arginine group was significantly lower than control and L-NAME groups. Activity of SOD in L-arginine group was significantly lower than L-NAME and BDL groups. Activitiy of CAT and level of NO in L-arginine group were significantly lower than those of L-NAME group. Liver tissue MDA level of L-NAME group was significantly higher than BDL group. These findings show that L-arginine treatment is effective in prevention of oxidative liver destruction as a result of bile duct obstruction Daha fazlası Daha az

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