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N-acetylcycsteine attenuates the deleterious effects of radiation therapy on incisional wound healing in rats

Tascilar O. | Çakmak G.K. | Emre A.U. | Bakkal, Bekir Hakan | Kandemir N. | Turkcu U.O. | Demir E.O.

Article | 2014 | Hippokratia18 ( 1 ) , pp.17 - 23

Background: During preoperative radiotherapy, effective doses of ionizing radiation occasionally cause wound complications after subsequent surgery. This study was designed to determine the effects of intraperitoneally or orally administered N-acetylcysteine (NAC) on anastomotic healing of irradiated rats. Material & Methods: Forty Wistar albino rats were randomized into four groups containing 10 rats each. A 3 cm long surgical full-thickness midline laparotomy was performed to all groups (Groups 1-4). Group 1 was designed as a control group without radiation therapy and NAC treatment. Groups 2, 3 and 4 received a single abdominal d . . .ose of 10 Gy irradiation before laparotomy and groups 3 and 4 received oral and intraperitoneal NAC, respectively. Results: Group comparisons demonstrated that breaking strength was significantly higher in NAC treated rats. A statistically significant difference was determined in terms of superoxide dismutase (SOD), malondealdehyde (MDA) and glutation (GSH) values between groups ( Daha fazlası Daha az

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