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Comparison of early postoperative enteral nutrients versus chow on colonic anastomotic healing in normal animals

Cihan A. | Oguz M. | Acun Z. | Uçan B.H. | Armutcu F. | Gürel A. | Ulukent S.C.

Article | 2004 | European Surgical Research36 ( 2 ) , pp.112 - 115

We aimed to clarify the effects of different enteral nutrients (normal chow, complete balanced nutrition, elemental nutrition enriched with glutamine, immune-enhancing diet and fiber) on colonic anastomotic healing in the stress-free metabolic state. The study was carried out with 50 male Balb-C mice in five groups of 10 animals each. After transverse colon anastomosis, animals were fed with early enteral nutrients using normal chow (group 1), Ensure® (group 2), Alitraq® (group 3), Impact® (group 4), and Benefiber Resource® orange juice drink (group 5) for 7 days. There were no significant differences among the groups in bursting pr . . .essure (p > 0.05). There was no statistical difference in terms of hydroxyproline level among groups 1-3. The hydroxyproline levels of groups 4 and 5 were statistically higher than that of the control group (p < 0.05 for both comparisons). Under normal conditions without stress, we could not demonstrate the superior effects of early enteral feeding with specialized enteral preparations over normal diets on colonic anastomoses when the bursting pressures were compared. Copyright © 2004 S. Karger AG, Basel Daha fazlası Daha az

Aqueous humor and serum concentration of hydroxyproline in pseudoexfoliation syndrome

Yagci R. | Ersöz I. | Aydin B. | Beyaz E. | Gürel A. | Durmuş M. | Duman S.

Article | 2007 | Journal of Glaucoma16 ( 2 ) , pp.225 - 229

PURPOSE: To determine the concentration of hydroxyproline (Hyp) in aqueous humor and serum samples of patients with and without pseudoexfoliation (PEX). PATIENTS AND METHODS: Aqueous humor and serum Hyp levels were measured in cataract patients. Patients were divided into PEX and control groups. Samples were obtained from 27 cataract patients with PEX and 25 cataract patients without PEX. Patients had no elevated intraocular pressure or glaucoma. Hyp concentration was determined spectrophotometrically. RESULTS: Mean Hyp concentration in the PEX aqueous (0.86±0.27 mg/L) and serum (40.8±6.14 mg/L) samples was significantly higher than . . . that measured in the control aqueous (0.56±0.2 mg/L) and serum (34.51±6.82 mg/L) samples, respectively ( Daha fazlası Daha az

Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns [Deneysel korozif özefagus yanıklarında sarımsak yağının (Allium Sativum) yararlı etkileri]

Tanrıkulu C.Ş. | Tanrikulu Y. | Kılınç F. | Bahadır B. | Can M. | Köktürk F.

Article | 2017 | Ulusal Travma ve Acil Cerrahi Dergisi23 ( 3 ) , pp.181 - 187

BACKGROUND: Corrosive esophageal burns, particularly common in developing countries, lead to different problems in different age groups. The ingestion of corrosive substances can cause such problems as stricture of the esophagus, to acute perforation, and even death. Because stricture formation is related to the severity of the initial injury, the prevention of stricture constitutes a main goal of treatment. The aim of this study was to investigate the protective and anti-inflammatory effects of garlic (Allium sativum) oil in corrosive esophageal burn. METHODS: Twenty-eight rats were randomly divided into 4 equal groups: group 1 (sh . . .am), group 2 (control), group 3 (topical treatment), and group 4 (topical and systemic treatment). In groups 2, 3, and 4, corrosive esophageal burns were generated by applying sodium hydroxide to a 1.5-cm segment of the abdominal esophagus. Normal saline was applied to group 2, topical garlic oil to group 3, and topical and systemic garlic oil were used in group 4. RESULTS: The level of hydroxyproline was lower in the topical treatment groups than in the control group (p=0.023). There was difference in tumor necrosis factor alpha level between the systemic treatment groups and the control group (p=0.044). Treatment with garlic oil decreased stenosis index (SI) and histopathological damage score (HDS) in corrosive esophageal burn rats. The SI in the topical treatment group was significantly lower than that of the control group (p=0.016). The HDS was significantly lower in group 4 when compared with the control group (p=0.019). CONCLUSION: Garlic oil is an effective agent in promoting the regression of esophageal stenosis and tissue damage caused by corrosive burns. While the protective effect of garlic oil on tissue damage is more significant when applied topically, the anti-inflammatory effect is more pronounced when applied systemically. Therefore, we believe that the application of garlic oil in patients with corrosive esophageal burns can reduce complication rates. © 2017 TJTES Daha fazlası Daha az

Erdosteine prevents bleomycin-induced pulmonary fibrosis in rats

Sogut S. | Ozyurt H. | Armutcu F. | Kart L. | Iraz M. | Akyol O. | Ozen S.

Article | 2004 | European Journal of Pharmacology494 ( 02.Mar ) , pp.213 - 220

Oxidative stress plays an important role in the pathogenesis of idiopathic pulmonary fibrosis. Therefore, erdosteine, an antioxidant, is expected to have an inhibitor potential against the disease. Rats were given one dose of bleomycin in pulmonary fibrosis groups and saline in controls. The first dose of oral erdosteine (10 mg/kg/day) was given 2 days before the bleomycin injection to achieve the plateau level in blood and continued until killing. At day 14, fibrotic changes were evaluated, using Aschoft's criteria and lung hydroxyproline content. Bleomycin produced a fivefold increase in fibrosis score that was decreased by 87% by . . . erdosteine (P>0.001) and almost twofold increases in hydroxyproline content which were completely prevented by erdosteine. Myeloperoxidase activities and MDA levels, which were significantly higher in the bleomycin group, were then significantly attenuated by erdosteine. These results revealed that oral erdosteine may prevent the development of acute pulmonary inflammation caused by bleomycin injection via the repression of neutrophil accumulation and lipid peroxidation, resulting in the inhibition of subsequent lung fibrosis. © 2004 Elsevier B.V. All rights reserved Daha fazlası Daha az

Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat

Cakmak, G. Karadeniz | Irkorucu, O. | Ucan, B. H. | Emre, A. U. | Bahadir, B. | Demirtas, C. | Tascilar, O.

Article | 2009 | JOURNAL OF GASTROINTESTINAL SURGERY13 ( 9 ) , pp.1707 - 1716

Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor commonly known as a cholesterol-lowering drug with additional pleiotropic effects. Also, it is demonstrated that it prevents postoperative peritoneal adhesions in rat. This study was designed to assess its effects on the healing process of colonic anastomosis. Thirty-two male Wistar albino rats were randomized into two groups and subjected to colonic anastomosis. The study group was treated with simvastatin and the control group received only tap water instead. The rats were killed 3 and 7 days postoperatively. Wound complications, intra-abdominal abscesses, . . .and anastomotic leaks and stenosis were recorded. Four types of assessment were performed: bursting pressure, hydroxyproline content, histopathology, and biochemical analysis. Compared to the control group, simvastatin-treated rats displayed a higher bursting pressure (p < 0.001) and anastomotic hydroxyproline content (p < 0.05). Simvastatin treatment leads to a significant decrease in malondealdehyde levels (p < 0.05) and increase in paraoxonase activity (p < 0.001) at both time points. Histopathological analysis revealed that simvastatin administration leads to a better anastomotic healing in terms of reepithelialization, decreased granuloma formation, reduced ischemic necrosis, and inflammatory infiltration to muscle layer. Clinically relevant doses of simvastatin do not have a negative impact on colonic anastomosis but improve intestinal wound healing in rats Daha fazlası Daha az

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