The prognostic role of inflammation and hormones in patients with metastatic cancer with cachexia

Bilir C. | Engin H. | Can M. | Temi Y.B. | Demirtas D.

Article | 2015 | Medical Oncology32 ( 3 )

We wanted to investigate the possible etiologic factors of cachexia. Forty-six patients diagnosed with cancer cachexia and 34 healthy controls were included in the study. Serum total testosterone, free testosterone, interleukin 1 (IL) alpha and beta, IL6, tumor necrosis factor (TNF) alpha, orexin, galanin, neuropeptide Y, tumor necrosis factor-like weak inducer of apoptosis and tumor necrosis factor receptor-associated factor 6, and C-reactive protein (CRP) levels were investigated. There were 36 male and 10 female patients in the cachexia group, and 24 male and 10 female patients in the control group. Median overall survival (OS) o . . .f the cachexia group after the diagnosis of cachexia was 8 (1–25) months. There were statistically significant relationships between OS and BMI, serum CRP, TRAF-6, albumin, and LDH levels in the cachexia group. In addition to cachexia, serum CRP, testosterone, and TNF alpha levels were statistically significantly correlated with OS in refractory cachexia. TRAF-6 levels was significantly correlated with type of cancer (P = 0.02). Although cachexia presents with a multifactorial ethio-pathogenesis, few of them affect the OS. Our novel results were that serum CRP, albumin, LDH, and TRAF-6 levels have a higher association with OS in patients with cancer cachexia compared to the many other parameters. An ongoing cachexia also called refractory cachexia is a recent definition. This end-stage term of cancer duration may be predicted by decreasing serum testosterone and increasing serum TNF alpha levels, as well as serum CRP levels. © 2015, Springer Science+Business Media New York Daha fazlası Daha az

Is sexual dysfunction in women with obstructive sleep apnea-hypopnea syndrome associated with the severity of the disease? A pilot study

Onem K. | Erol B. | Sanli O. | Kadioglu P. | Yalin A.S. | Canik U. | Cuhadaroglu C.

Article | 2008 | Journal of Sexual Medicine5 ( 11 ) , pp.2600 - 2609

Introduction. Obstructive sleep apnea-hypopnea syndrome (OSAHS) may have a significant negative effect on sexual function. Aim. To evaluate female sexual function in women with OSAHS. Methods. Twenty-six patients with OSAHS were evaluated in two groups according to apnea-hypopnea index as mild (5-15, Group I, N=16) or moderate-severe (?15, Group II, N=10). A third group (N=10) of patients suspected of sleeping disorders other than OSAHS who also underwent polysomnographic studies served as the control group. All women were evaluated with a detailed sexual history including Female Sexual Function Index (FSFI) questionnaire and Beck D . . .epression Inventory (BDI). Meanwhile, serum levels of estradiol, prolactin, total and free testosterone and dihydroepiandrostenedione-S were determined. Main Outcome Measures. FSFI, BDI, and serum hormonal levels. Results. The mean ages and total FSFI scores of Group I, Group II and the control group were 46 ± 7.1, 45 ± 3.8, and 41 ± 5.4 (P >0.05); 24.7 ± 5.3, 24. 5± 6.3, and 30.0 ± 2.5 (P < 0.05), respectively. The mean FSFI domain scores were not statistically different between Groups I and II (P > 0.05) (desire, 3.18 ± 1.2 vs. 2.92 ± 1.6; arousal, 3.96 ± 1.1 vs. 3.67 ± 1.2; lubrication, 4.83 ± 1.0 vs. 4.12 ± 1.1; orgasm 4.0 ± 1.1 vs. 5.15 ± 2.9; satisfaction 3.96±1.1 vs. 4.05 ± 1.4 pain; 4.84±1.2 vs. 4.65 ± 1.3). However, the mean scores of desire (3.18 ± 1.2 vs. 3.96 ± 0.7), orgasm (4.0 ± 1.1 vs. 5.0 ± 1.1), and satisfaction (3.96 ± 1.1 vs. 4.76 ± 1.0) domains of Group I were significantly lower than the control group. Meanwhile, the mean scores of desire (2.92 ± 1.6 vs. 3.96 ± 0.7) and lubrication (4.12 ± 1.1 vs. 5.22 ± 0.9) domains were statistically different between Group II and the control group. The mean BDI scores of patients in Group I, Group II and the control group were 19.3 ± 6.3, 20.2 ± 6.6, and 11.0 ± 7.1, respectively (P0.05). Conclusions. OSAHS is associated with a significant decrease in female sexual function. However, severity of OSAHS is not related with the degree of female sexual dysfunction (FSD). This situation reveals that both organic and psychogenic issues are being involved in FSD related with OSAHS. Onem K, Erol B, Sanli O, Kadioglu P, Yalin AS, Canik U, Cuhadaroglu C, and Kadioglu A. Is sexual dysfunction in women with obstructive sleep apnea-hypopnea syndrome associated with the severity of the disease? A pilot study. © 2008 International Society for Sexual Medicine Daha fazlası Daha az

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