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Apheresis-inducible cytokine pattern change in children with homozygous familial hypercholesterolemia

Küçükçongar A. | Yenicesu I. | Tümer L. | Kasapkara C.S. | Ezgü F.S. | Paşaoglu O. | Demirtaş C.

Article | 2013 | Transfusion and Apheresis Science48 ( 3 ) , pp.391 - 396

Familial hypercholesterolemia is a genetic disorder that leads to severe atherosclerosis related cardiovascular complications in young adults. Extracorporeal elimination is a method of LDL-lowering procedures effective in patients with homozygous or severe heterozygous FH utilized in cases. The recruitment of leucocytes into the arterial intima is dependent on a cascade of events mediated through a diverse family of adhesion molecules. Several pro-inflammatory adhesion molecules are cleared by various lipid apheresis methods. This study showed that, LDL-apheresis led to several changes in circulating inflammatory factors which induc . . .ed antiinflammatory and antiatherogenic changes in the plasma profile in homozygous familial hypercholesterolemic patients. © 2013 Elsevier Ltd Daha fazlası Daha az

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