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Analysis of peripheral blood lymphocyte phenotypes and Th1/Th2 cytokines profile in the systemic immune responses of Helicobacter pylori infected individuals

Kayhan B. | Arasli M. | Eren H. | Aydemir S. | Kayhan B. | Aktas E. | Tekin I.

Article | 2008 | Microbiology and Immunology52 ( 11 ) , pp.531 - 538

H. pylori elicits specific humoral and cellular immuneresponses inthemucosal immune system. However, the type and extent of T lymphocyte response in the systemic immune system is not clear for H. pylori positive patients. In this study, peripheral blood T lymphocyte phenotypes and serum Th1/Th2 based cytokines of 32 H. pylori positive patients were analyzed and compared to those of healthy controls. While ?ß TCR+ lymphocytes and their phenotype analysis were not significantly different to those of healthy controls, the percentage of pan ?? TCR+ lymphocytes was up to 2.4 times greater in the H. pylori positive group then in healthy c . . .ontrols. Furthermore, significant increases in IL-10 concentrations in serum samples of H. pylori patients indicated that their immune systems had switched toward a Th2 type immune response. The correlation between phenotype and type of T cell response in the peripheral blood during H. pylori infection is discussed. © 2008 The Societies and Blackwell Publishing Asia Pty Ltd Daha fazlası Daha az

Dyspeptic complaints after 20 weeks of gestation are not related to Helicobacter pylori seropositivity

Tanriverdi H.A. | Ustundag Y. | Tekin I.O. | Barut A.

Article | 2005 | Medical Science Monitor11 ( 9 ) , pp.531 - 538

Background: This study was to test whether an association exists between Helicobacter pylori seropositivity and severity of dyspeptic symptoms after 20 weeks of gestation in pregnant women. Material/Methods: Pregnant women (n=103) with gestational ages between 20-41 weeks and healthy non-pregnant women (controls, n=79) were prospectively enrolled in the study. Anti-H. pylori IgG serum antibody was tested to establish seropositivity. The dyspeptic symptoms were evaluated by the Glasgow Dyspepsia Severity Score in the pregnant group and classified as asymptomatic (score 0), mildly symptomatic (score 1-5), and severely symptomatic (sco . . .re ?6). The severity of dyspeptic symptoms was compared in pregnant women with H. pylori seropositivity, and pregnant and non-pregnant women were compared for H. pylori seropositivity and prevalence of dyspeptic symptoms. The results were analyzed using Student's t, Mann-Whitney-U, and chi-square tests. Results: The prevalence of H. pylori seropositivity was not different among pregnant and non-pregnant women. The median dyspeptic scores were 5 and 4, respectively, for H. pylori seropositive and negative pregnant women. Dyspeptic scores of H. pylori seropositive pregnant women were not different from those of uninfected pregnant women. H. pylori seropositivity did not differ among asymptomatic and mildly and severely symptomatic pregnant women. The non-pregnant women were more often asymptomatic than pregnant women. Conclusions: Our findings do not support any association between H. pylori seropositivity and severity of dyspeptic symptoms in late pregnancy. It seems unreasonable to screen women in late pregnancy for H. pylori seropositivity, even if they suffer from severe dyspeptic symptoms. © Med Sci Monit, 2005 Daha fazlası Daha az

HELICOBACTER PYLORI INFECTION IS AN AVOIDABLE RISK FACTOR FOR PARKINSON'S DISEASE

Calik, Murat | Gorgun, Selim | Yilmaz, Ahmet | Ozgan, Esen | Akar, Handan | Cinar, Bilge

Article | 2019 | TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI22 ( 3 ) , pp.340 - 345

WOS: 000486388800013

Role of Chlamydia pneumoniae and Helicobacteria pylori in the development of tympanosclerosis

Dinç A.E. | Cömert F. | Damar M. | Şevik Eliçora S. | Erdem D. | Işık H.

Article | 2016 | European Archives of Oto-Rhino-Laryngology273 ( 4 ) , pp.889 - 892

The etiology of tympanosclerosis (TS) is not known, but TS commonly develops secondary to acute and chronic otitis media (COM). Since calcification process in TS resembles that of atherosclerosis (AS), pathogens that are related to pathogenesis of AS may be involved in development of TS. This prospective and controlled study, performed at a tertiary referral center, investigated a possible relationship between the presence of Chlamydia (C.) pneumoniae and Helicobacter (H.) pylori and the development of a tympanosclerotic plaque. The presence of C. pneumoniae was examined in the surgical specimens of 62 patients (29 females and 33 ma . . .les; age range 10–70 years, mean age 30.8 ± 13.3 years), including 30 patients with TS, 14 patients with cholesteatoma, and 18 patients with chronic suppurative otitis media (CSOM). The presence of H. pylori was examined in the surgical specimens of 88 patients (41 females and 47 males; age range 6–70 years, mean age 32.5 ± 14.8 years), including 35 patients with TS, 22 patients with cholesteatoma, 20 patients with CSOM, and 11 patients with otosclerosis. Tympanosclerotic plaques and control specimens from the cholesteatoma, polypoid mucosa, or mucosal portion of the perforations and stapes supra structure were examined for the presence of H. pylori and/or C. pneumoniae using real-time polymerase chain reaction analysis. The analysis demonstrated that specimens from the tympanosclerotic plaques and the other types of COM were all negative for C. pneumoniae and H. pylori. An association between C. pneumoniae or H. pylori infection and the development of TS or other types of COM could not be established. © 2015, Springer-Verlag Berlin Heidelberg Daha fazlası Daha az

Helicobacter pylori eradication does not change circulating insulin-like growth factor 1 and insulin-like growth factor binding protein 3 levels in patients with and without precancerous gastric lesions

Ustundag Y. | Sahin H. | Ilikhan S. | Dogan B.G. | Kokturk F. | Kar F.

Article | 2013 | American Journal of the Medical Sciences346 ( 5 ) , pp.381 - 384

Background: Circulating insulin-like growth factor (IGF)-1 and IGF-binding protein (IGFBP)-3 levels in the serum of Helicobacter pylori (H pylori)-infected patients were investigated. METHODS

Helicobacter pylori infection in hemodialysis patients: Susceptibility to amoxicillin and clarithromycin

Aydemir S. | Boyacioglu S. | Gur G. | Demirbilek M. | Can F.K. | Korkmaz M. | Yilmaz U.

Article | 2005 | World Journal of Gastroenterology11 ( 6 ) , pp.842 - 845

Aim: To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls. Methods: The subjects with dyspeptic complaints were 33 ESRD patients and 46 age- and sex-matched non-uremic controls who exhibited H pylori on antral biopsy specimens. The two groups were age and sex matched. The H pylori strains' pattern of susceptibility to amoxicillin and clarithromycin was investigated with the agar dilution technique. Results: None of the H pylori strains from either group showed resistance to amoxicillin with the agar dilution method. Twelve (36.4%) of th . . .e ESRD group strains and 7 (15.2%) of the control group strains showed resistance to clarithromycin, and this difference was statistically significant ( Daha fazlası Daha az

The effect of Helicobacter pylori on insulin resistance

Aydemir S. | Bayraktaroglu T. | Sert M. | Sokmen C. | Atmaca H. | Mungan G. | Gun B.D.

Article | 2005 | Digestive Diseases and Sciences50 ( 11 ) , pp.2090 - 2093

Helicobacter pylori causes a lifelong infection in the stomach after exposure. H. pylorihas been shown to be associated with peptic ulcer and gastric cancer development. Moreover, it is held responsible for some other nongastric diseases. Among them, coronary heart disease attracts much debate. Many studies have demonstrated a close relationship between insulin resistance and atherosclerosis. Chronic inflammation and alterations in counter-regulatory hormones are deemed responsible for the etiology of insulin resistance. We aimed to examine the effect of H. pylori on insulin resistance. Sixty-three patients were enrolled in the stud . . .y. Patients were divided into two groups according to H. pylori presence. HOMA-IR (homeostasis model assessment of insulin resistance) level was used to assess insülin resistance. Thirty-six patients were H. pylori positive and 27 were H. pylori negative. There was no difference between the two groups with regard to age, gender, or body mass index. HOMA-IR level was 1.73± 1.1 in the H. pylori-negative group, whereas it was 2.56 ± 1.54 in the H. pylori-positive group (P < 0.05). This study provides the first direct evidence for an association between chronic H. pylori infection and insulin resistance. © 2005 Springer Science + Business Media, Inc Daha fazlası Daha az

Influence of Vitamin C and e supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection

Demirci H. | Ilikhan S.U. | Öztürk K. | Üstünda? Y. | Kurt Ö. | Bilici M. | Köktürk F.

Article | 2015 | Turkish Journal of Gastroenterology26 ( 6 ) , pp.456 - 460

Background/Aims: In our study, we aimed to assess the effect of vitamin E and C supplementation to triple and quadruple Helicobacter pylori eradication regimens. Materials and Methods: Four hundred patients with H. pylori infection were classified into four groups. Patients in group A (n=100) received amoxicillin, clarithromycin, and lansoprazole for 2 weeks. In group B, patients (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, and lansoprazole for 2 weeks. Patients in group C (n=100) received amoxicillin, clarithromycin, lansoprazole, and bismuth subcitrate for 2 weeks, whereas those in gro . . .up D (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, lansoprazole, and bismuth subcitrate for 2 weeks. H. pylori eradication was assessed with the C14 urea breath test 2 months after the end of the therapy. The eradication rate was assessed using per-protocol (PP) and intention-to-treat (ITT) analyses. Results: Three hundred forty-eight patients finished the study. The eradication of H. pylori was achieved in 63 of 84 patients (75%) by PP and 63 of 100 (63%) by ITT analysis in group A, 60 of 84 (71.4%) by PP and 60 of 100 (60%) by ITT analysis in group B, 72 of 89 (80.9 %) by PP and 72 of 100 (72%) by ITT analysis in group C, and 76 of 91 (83.5%) by PP and 76 of 100 (76%) by ITT analysis in group D. There was no remarkable change between groups A and B (p>0.05). Similar results were also found between groups D and C (p>0.05). Conclusion: This study revealed that supplementing vitamins C and E to either the triple or quadruple therapies did not provide an additional advantage for achieving significantly higher eradication rates for H. pylori. © Copyright 2015 by The Turkish Society of Gastroenterology Daha fazlası Daha az

Changes in Serum Levels of ADMA, SDMA and L-NMMA with Helicobacter Pylori Eradication

Baldane, Suleyman | Korkmaz, Huseyin | Ipekci, Suleyman Hilmi | Sozen, Mehmet | Abusoglu, Sedat | Akar, Tarik | Unlu, Ali

Article | 2017 | JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM7 ( 3 ) , pp.132 - 134

Objective: Increased asymmetric dimethylarginine (ADMA) levels are associated with reduced nitric oxide (NO) levels in many systems, particularly the cardiovascular system, and cause adverse effects. The objective of this study is to evaluate the effect of eradication therapy in patients infected with Helicobacter pylori (H. pylori) on the serum level of ADMA and other metabolic products of methylarginine. Methods: Patients who were found positive both in urea breath tests and stool antigen tests were considered to have H. pylori infection. These patients received eradication therapy for 14 days (twice daily pantoprazole 40 mg, twic . . .e daily amoxicillin 1000 mg, and twice daily clarithromycin 500 mg). Blood samples were taken to measure serum ADMA, symmetric dimethylarginine (SDMA), and N-monomethyl-Larginine (L-NMMA) levels before eradication therapy and 3 months after the therapy for patients for whom eradication was achieved. Results: A total of 23 of the 45 patients included in the study were female, whereas 22 were male. The mean age of the patients was 32.4 +/- 8 years. Significant reductions in the serum ADMA, SDMA, and L-NMMA levels of the patients were observed post-eradication therapy versus pre-eradication therapy. Conclusion: This study demonstrated significant reductions in serum ADMA, SDMA, and L-NMMA levels with H. pylori eradication. Further extensive long-term studies are needed to evaluate the positive effects that reduced serum ADMA, SDMA, and L-NMMA levels after H. pylori eradication can have on all systems, particularly the cardiovascular system Daha fazlası Daha az

Eosinophil infiltration, gastric juice and serum eosinophil cationic protein levels in Helicobacter pylori-associated chronic gastritis and gastric ulcer

Aydemir, Selim | Tekin, İshak Özel | Numanoğlu, Gamze | Borazan, Ali | Üstündağ, Yücel

Article | 2004 | Mediators of Inflammation13 ( 05.Jun ) , pp.369 - 372

INTRODUCTION: Helicobacter pylori is one of the main causes of gastroduodenal diseases, such as chronic gastritis and peptic ulcer. It has been shown that eosinophils increase in the stomach in H. pylori infection. Eosinophilic cationic protein (ECP) is a cytotoxic molecule secreted by the activated eosinophils. However, there are no sufficient data about the role of ECP in H. pylori infection and its effect on ulcer development. In this study we investigated the gastric eosinophilic infiltration, gastric juice and serum ECP levels in patients with chronic gastritis and gastric ulcer associated with H. pylori. Materials and methods: . . . Forty-four H. pylori-positive and 20 H. pylori-negative patients who underwent upper gastrointestinal system endoscopy after admitting with dyspeptic complaints were enrolled in the study. Twenty-one of the H. Pylori-positive patients had gastric ulcer while 23 patients had none. During endoscopy, multiple gastric biopsies and juices were taken. In gastric biopsies, H. pylori and eosinophilic infiltration were assessed. Additionally, gastric juice and serum ECP levels were measured. Results: Eosinophil infiltration, gastric juice ECP levels, and gastric juice/serum ECP ratios in the H. pylori-positive group were greater than in the H. pylori-negative group (p < 0.01). There was no statistically significant difference regarding serum ECP levels between the two groups (p > 0.05). When H. pylori-positive patients were compared with regard to gastric ulcer presence, however, there was no significant difference in gastric eosinophil infiltration, gastric juice ECP levels, serum ECP levels, and gastric juice/serum ECP ratios (p > 0.05). Conclusion: The results of this study suggest that eosinophils and eosinophil-released ECP may contribute to inflammatory changes seen in chronic gastritis, whereas there is no proof that they play a role in ulcer development Daha fazlası Daha az

Helicobacter pyloriinfection in hemodialysis patients: Susceptibility to amoxicillin and clarithromycin

Aydemir, Selim | Boyacioglu, Sedat | Gur, Gurden | Demirbilek, Muge | Can, Fusun Kamber | Korkmaz, Murat | Yilmaz, Ugur

Article | 2005 | WORLD JOURNAL OF GASTROENTEROLOGY11 ( 6 ) , pp.842 - 845

AIM: To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls. METHODS: The subjects with dyspeptic complaints were 33 ESRD patients and 46 age-and sex-matched non-uremic controls who exhibited H pylori on antral biopsy specimens. The two groups were age and sex matched. The H pylori strains' pattern of susceptibility to amoxicillin and clarithromycin was investigated with the agar dilution technique. RESULTS: None of the H pylori strains from either group showed resistance to amoxicillin with the agar dilution method. Twelve (36.4%) of the . . . ESRD group strains and 7 (15.2%) of the control group strains showed resistance to clarithromycin, and this difference was statistically significant ( Daha fazlası Daha az

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