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EEG signals classification using the K-means clustering and a multilayer perceptron neural network model

Orhan, Umut | Hekim, Mahmut | Özer, Mahmut

Article | 2011 | Expert Systems with Applications38 ( 10 ) , pp.13475 - 13481

We introduced a multilayer perceptron neural network (MLPNN) based classification model as a diagnostic decision support mechanism in the epilepsy treatment. EEG signals were decomposed into frequency sub-bands using discrete wavelet transform (DWT). The wavelet coefficients were clustered using the K-means algorithm for each frequency sub-band. The probability distributions were computed according to distribution of wavelet coefficients to the clusters, and then used as inputs to the MLPNN model. We conducted five different experiments to evaluate the performance of the proposed model in the classifications of different mixtures of . . . healthy segments, epileptic seizure free segments and epileptic seizure segments. We showed that the proposed model resulted in satisfactory classification accuracy rates. © 2010 Elsevier Ltd. All rights reserved Daha fazlası Daha az

The role of grape seed extract in the effect of swimming exercises on epilepsy

Soslu R. | Tutkun E. | Kartal A. | Ciplak M.E. | Cekin R. | Kamuk Y.U.

Article | 2013 | Life Science Journal10 ( 4 ) , pp.648 - 653

Grape seed extract (GSE) is one of the strongest known antioxidants. GSE actively prevents the formation of free radicals and assists in their elimination. Our aim was to investigate the effects on epileptiform activity of GSE administered concurrently with swimming exercises. A total of 35 male albino Wistar rats were used in this study. Epileptiform activity was induced in rats through the injection of penicillin (500 IU) into the left cerebral cortex. Thirty minutes after the application of penicillin, 200 mg/kg of GSE dissolved in normal saline was administered intraperitoneally. Based on the results of the statistical analysis, . . . a significant decrease in spike frequency was observed after 60 minutes in the 15-minute group (67%), after 40 minutes in the 30-minute group (43%), and after 40 minutes in the 60-minute group (42%), while no significant decrease was identified in the amplitude values of the groups. According to the study results, in rats performing short-, medium-, and long-term swimming exercises, GSE administration allowed epileptiform activity to decrease within a shorter period of time. Thus, patients with epilepsy can potentially perform swimming exercises more safely by regularly using antioxidant substances Daha fazlası Daha az

The effect of generalized seizure activity on ischemia-induced cardiac arrhythmias and myocardial injury with histopathological evaluation in anesthetized rats

Gonca E. | Barut F. | Şahin D.

Article | 2018 | Turkish Journal of Medical Sciences48 ( 6 ) , pp.1293 - 1301

Background/aim: Epileptic seizure leads to sudden unexpected death in epilepsy (SUDEP) among affected patients. The causes of SUDEP are still unclear. The aim of this study was to research the effect of epilepsy on myocardial injury and arrhythmias during experimentally induced acute myocardial ischemia. Materials and methods: Wistar albino rats were divided into four groups: sham, pentylentetrazole (PTZ) + sham, ischemia, and PTZ + ischemia groups. PTZ (65 mg/kg, ip) was given 2 h before ischemia. Seizure scoring was conducted by evaluating the PTZ-induced behavioral changes in the rats. The left main coronary artery was ligated in . . . anesthetized rats for 30 min. The incidence and the number of ventricular arrhythmias were determined. Histopathological scoring was performed for tissue injury by using a microscope. Results: Seizure scores were not different among the groups (P > 0.05). The incidence and number of ventricular tachycardia (VT) episodes were significantly higher in the PTZ + ischemia group than in the ischemia group (P ? 0.05). More prominent myocardial damage was observed in the PTZ + ischemia group than in the other groups (histopathological scores: PTZ + ischemia; 2.5 ± 0.5 versus ischemia; 1.2 ± 0.4, P ? 0.05). Conclusion: PTZ-induced seizure in rats increased myocardial injury and the incidence and number of VT episodes in myocardial ischemia. These results reveal that seizure in epilepsy patients may increase ventricular arrhythmia and myocardial injury during heart attack. © TÜBİTAK Daha fazlası Daha az

Prophylactic anticonvulsants in patients undergoing craniotomy: A single-center experience

Kale A.

Article | 2018 | Medical Science Monitor24 , pp.2578 - 2582

Background: There is no consensus on the efficacy of seizure prophylaxis in patients undergoing craniotomy. Some studies show that antiepileptic use decreases the risk of seizures, but other studies do not support this. The present study investigated the role of antiepileptic drugs in patient undergoing craniotomy due to various intracranial pathologies. Material/Methods: A retrospective review was performed in adult patients undergoing craniotomy between January 2013 and June 2017. Results of 282 patients who did not have a history of seizures and had craniotomies for various reasons were included. In all patients with craniotomy p . . .lanned, prophylactic AEDs were initiated pre-operatively. Results: The incidence of postoperative seizures was 17.7% when all craniotomized patients were considered. The most commonly used anticonvulsant agent was phenytoin (75.2%). No serious antiepileptic drug reaction occurred requiring cessation of treatment. Conclusions: Prophylactic antiepileptic treatment of patients undergoing craniotomy should not be continued beyond the first perioperative week if there is no serious brain injury. The intra- or extra-axial placement of the tumor affects the prophylaxis. Further randomized controlled studies are warranted in the future to investigate the efficacy of these medications. © Med Sci Monit Daha fazlası Daha az

Erdosteine ameliorates PTZ-induced oxidative stress in mice seizure model

Ilhan A. | Aladag M.A. | Kocer A. | Boluk A. | Gurel A. | Armutcu F.

Article | 2005 | Brain Research Bulletin65 ( 6 ) , pp.495 - 499

The role of oxygen-derived free radicals has been suggested in genesis of epilepsy and in the post seizure neuronal death. The aim of this study was to investigate whether erdosteine has a preventive effect against epilepsy and postepileptic oxidative stress. The mice (n = 27) were divided into three groups: (i) PTZ-induced-epilepsy group (n = 9); (ii) PTZ-induced-epilepsy + erdosteine group (n = 9); (iii) control group (n = 9). The animals were observed for a period of 30 min for latency to first seizure onset, total seizure duration, the number of seizure episodes. Then they were sacrificed and the brains were quickly removed, and . . . frozen for biochemical analysis. Malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD) and xanthine oxidase (XO) activities were carried out in the brain tissue. The latent period between PTZ induction and seizure are longer in the PTZ + erdosteine group than in PTZ-induced-epilepsy group (P < 0.05). Biochemical analyses of brain tissue, revealed a significant increase in the MDA, XO and NO levels in the PTZ group according to erdosteine group. SOD level did not change in this group. While MDA and XO levels are significantly lower, SOD level is significantly higher in the PTZ + erdosteine group compared to PTZ and control groups (P < 0.01). The present study demonstrated that erdosteine treatment both may increase latent interval between seizures and may decrease oxidative stress, thus may ameliorate neuronal death in brain during seizures. It may be used as an adjunct therapy in epilepsy. © 2005 Elsevier Inc. All rights reserved Daha fazlası Daha az

The evaluation of personality of epileptic patients by using Cloninger's Temperament and Character Inventory [Epilepsi hastalarinin kişilik özelliklerinin cloninger'in mizaç ve karakter ölçegi ile degerlendirilmesi]

Bostanci B. | Konuk N. | Kiran S. | Kökrek Z. | Yeni S.N.

Article | 2011 | Anadolu Psikiyatri Dergisi12 ( 1 ) , pp.13 - 23

Objective: There is little research evaluating the personality of epileptic patients dimensionally in the literature. In this study we aimed to evaluate the personality traits of epileptic patients and compare them healthy controls by using Cloninger's Temperament and Character Inventory (TCI). Methods: Seventy-eight consecutive epileptic outpatients and 85 healthy controls were included. Both groups were given TCI after evaluation by SCID I, SCID II and HAM-D. The data were analyzed with regard the group differences with t test (parametric condition) or Mann-Whitney U tests by using computer program. Results: The epileptic group we . . .re found significantly different ( Daha fazlası Daha az

The effect of intra-arterial papaverine on ECoG activity in the ketamine anesthetized rat

Karatas A. | Gokce F. | Demir S. | Ankarali S.

Article | 2008 | Neuroscience Letters445 ( 1 ) , pp.58 - 61

The opium alkaloid papaverine (PPV) causes vasodilatation of the cerebral arteries through direct action on smooth muscle that reduces the constriction of smooth muscle. Intra-arterial papaverine (IAP) has been used widely to increase the regional cerebral blood flow in order to reverse the cerebral vasospasm that occurs during endovascular procedures. IAP-induced seizures have been reported, although PPV has anticonvulsive effects. This study determined the effects of IAP on electrocorticography (ECoG) in the ketamine anesthetized rats. We used 24 Sprague-Dawley male rats weighing 200-250 g. The animals were divided randomly into f . . .our groups: three treatment groups (groups 1-3) and a control (group 4). Groups 1, 2, and 3 were given 1, 7, and 14 mg/kg IAP, respectively. The ECoG was compared across groups. Our results indicated that IAP did not cause seizures and that it decreased the frequency of ketamine-induced epileptiform activity in the 14 mg/kg group. Crown Copyright © 2008 Daha fazlası Daha az

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