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Posterior scleritis presenting with angle closure glaucoma

Ugurbas S.H. | Alpay A. | Ugurbas S.C.

Article | 2012 | Ocular Immunology and Inflammation20 ( 3 ) , pp.218 - 220

https://dx.doi.org/10.3109/09273948.2012.666613 https://hdl.handle.net/20.500.12628/7075

Universal markers of thyroid malignancies: Galectin-3, HBME-1, and Cytokeratin-19

Barut F. | Kandemir N.O. | Bektas S. | Bahadir B. | Keser S. | Ozdamar S.O.

Article | 2010 | Endocrine Pathology21 ( 2 ) , pp.80 - 89

Difficulties in diagnosis of thyroid lesions, even with histologic analysis, are well known. This study has been carried on to evaluate the role of immunohistochemical markers including galectin-3, Hector Battifora mesothelial cell-1 (HBME-1), and cytokeratin-19 in the diagnosis and differential diagnosis of benign and malignant thyroid lesions. The expressions of galectin-3, HBME-1, and cytokeratin-19 were tested in formalin-fixed, paraffin-embedded tissues from 458 surgically resected thyroid lesions including non-neoplastic and neoplastic lesions. Immunostaining with standard avidin-biotin complex technique was performed by using . . . monoclonal antibodies. In malignant neoplastic thyroid lesions, galectin-3, HBME-1, and cytokeratin-19 were diffusely expressed in general. Diffuse expression rates of these three markers were 72.3% (47/65), 70.7% (46/65), and 76.9% (50/65), respectively. The use of galectin-3, HBME-1, and cytokeratin-19 may provide significant contributions in the differential diagnosis of malignant thyroid tumors. Although focal galectin-3, HBME-1, and cytokeratin-19 expression may be encountered in benign lesions, diffuse positive reactions for these three markers are characteristic of malignant lesions. It has concluded that cytokeratin-19 alone and its combinations with other markers were more sensitive in accurate diagnosis of papillary carcinoma than the other combinations; meanwhile, there were similar results for follicular carcinomas with HBME-1 alone and its combinations. © 2009 Springer Science+Business Media, LLC Daha fazlası Daha az

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