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Tear film osmolarity in patients with diabetes mellitus

Sagdk H.M. | Tetikoglu M. | Uçar F. | Ugurbaş S.C. | Ugurbas S.H.

Article | 2013 | Ophthalmic Research50 ( 1 ) , pp.1 - 5

Purpose: To compare tear film osmolarity (TFO) between patients with diabetes mellitus (DM) and normal healthy individuals. Methods: In this prospective case-controlled study, the TFO in 46 normal subjects (control group) and 55 patients with DM (study group) was evaluated. TFO in milliosmole (mOsm) was measured by using an auto-osmometer. The serum levels of glycosylated hemoglobin (HbA1c) and blood glucose in all participants were also measured. Mean outcome measures were TFO and its relationship with HbA1c level and duration of DM. Results: Mean TFO was 320.40 ± 21.80 mOsm/l in the study group and 308.22 ± 18.16 mOsm/l in the con . . .trol group (p < 0.001). The TFO values were significantly associated with duration of DM (r = 0.476, p < 0.001), but no significant correlation was found with HbA 1c level (r = 0.225, p = 0.114). Conclusions: The study shows a significantly higher TFO in patients with DM than in the healthy controls. TFO also correlates with the duration of DM. Copyright © 2013 S. Karger AG, Basel Daha fazlası Daha az

Effects of in vivo antioxidant enzyme activities of myrtle oil in normoglycaemic and alloxan diabetic rabbits

Sepici-Dincel A. | Açikgöz S. | Çevik C. | Sengelen M. | Yeşilada E.

Article | 2007 | Journal of Ethnopharmacology110 ( 3 ) , pp.498 - 503

In this study we aimed to evaluate the in vivo effects of myrtle oil (myrtii oleum) on the antioxidant enzymes such as superoxide dismutase and catalase, the levels of malondialdehyde in liver tissues as an index of lipid peroxidation and nitrite-nitrate levels in normoglycaemic and alloxan-induced diabetic and MO-treated rabbits. In our previous study, we assumed that MO with a dose of 50 mg/kg, possesses a hypoglycemic activity and this activity was independent from the effects of insulin. Myrtle oil exerts its hypoglycemic activity by enhanced glycolysis, glycogenesis and decreased glycogenolysis. What is more glucose load data s . . .trongly suggest that MO treatment produces hypoglycemia mainly by reducing intestinal absorption of glucose, so MO could be an ?-glycosidase enzyme inhibitor which had a hypoglycaemic effect only on alloxan-induced diabetic rabbits on the fourth hour and on orally glucose loaded group. The major finding of this new study is that, MO may not offer any protection against oxidative stress during acute studies in normoglycemic and diabetic groups. Although the levels of superoxide dismutase and catalase enzyme activities did not change during acute studies in diabetes + MO group, there was a significant change at the end of 21 days. There is a very limited knowledge about MO and its effects on diabetes. Therefore, we tried to explain the mechanism that might underlie the protective effects of MO with this paper. © 2006 Elsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

Are hypertension and diabetes mellitus risk factors for pelvic organ prolapse?

Isik H. | Aynioglu O. | Sahbaz A. | Selimoglu R. | Timur H. | Harma M.

Article | 2016 | European Journal of Obstetrics and Gynecology and Reproductive Biology197 , pp.59 - 62

Objectives Pelvic organ prolapse (POP) is an important problem for women with multifactorial etiology. This study aims to determine the role of hypertension (HT) and diabetes mellitus (DM) in POP. Study design The study included 586 women admitted to Bulent Ecevit University Hospital between September 2013 and April 2015 for hysterectomy, comprising 186 patients with POP and 400 patients without. The demographic characteristics, age, body mass index (BMI), obstetrical history, type of delivery, associated medical diseases, and benign gynecological diseases were recorded. HT, DM, or both together were particularly considered as coexi . . .sting medical diseases. Results Median gravida, parity, and live birth numbers were significantly higher in POP patients (4 vs. 3, 3 vs. 2, and 3 vs. 2 respectively, p < 0.001). POP patients were more obese than POP-absent patients (p < 0.001). Vaginal history of birth increased POP frequency to 25.8% with statistical significance (p < 0.001). There was no significant difference between groups regarding coexisting endometritis, endometrial polyp, endometriosis, endometrial hyperplasia (p > 0.05). There was a significant difference between groups regarding comorbid diseases (p < 0.001). Logistic regression analysis for risk factors of POP revealed age, BMI, vaginal parturition, and co-morbidity with HT + DM together significantly increased POP risk (p < 0.05). HT + DM together significantly increased risks with OR of 1.9 (1.1-3.16). Conclusions In addition to multiple factors increasing POP risk, comorbidities as HT + DM together should be considered as risk factors. Patients with these comorbidities should be encouraged to change their lifestyles to prevent POP. © 2015 Elsevier Ireland Ltd Daha fazlası Daha az

The effects of quercetin on bone minerals, biomechanical behavior, and structure in streptozotocin-induced diabetic rats

Kanter M. | Altan M.F. | Donmez S. | Ocakci A. | Kartal M.E.

Article | 2007 | Cell Biochemistry and Function25 ( 6 ) , pp.747 - 752

This study was designed to investigate the effect of quercetin (QE) on bone minerals and biomechanics in insulin-dependent diabetic rats. Diabetes was induced by 50 mg kg-1 intraperitoneal streptozotocin (STZ) in a single dose. The rats were randomly allotted into four experimental groups: A (control), B (non-diabetic + QE), C (diabetic), and D (diabetic + QE) each containing 10 animals. The diabetic rats received QE (15 mg kg-1 day-1) for 4 weeks following 8 weeks of STZ injection. Blood samples were taken to determine glucose, insulin, calcium, and magnesium levels. The rats' femora were assessed biomechanically at femoral mid-dia . . .physis and neck. It was found that QE treatment increased insulin, calcium, and magnesium levels. Three-point bending of the femoral mid-diaphysis and necks showed significantly lower maximum load values (Fmax) in animals in the STZ group than the QE + STZ or control groups (p < 0.05). The results support the conclusion that QE treatment may decrease blood glucose and increase plasma insulin, calcium, and magnesium. QE treatment may also be effective in bone mineral metabolism, biomechanical strength, and bone structure in STZ-induced diabetic rats. Copyright © 2007 John Wiley & Sons, Ltd Daha fazlası Daha az

Dendritic cell activation is blunted in patients with coronary artery disease and diabetes mellitus

Yetkin G.I. | Yucel A.A. | Tekin İ.Ö. | Yılmaz M. | Atalay H. | Yetkin E.

Article | 2019 | Journal of Diabetes and its Complications33 ( 2 ) , pp.134 - 139

Background: It has been shown that functional status of dendritic cells (DCs) in diabetic patients with unstable angina pectoris (UAP) are more mature and activated than diabetic patients without coronary artery disease (CAD) and none diabetic patients with UAP. Accordingly we aimed to assess the activation of DCs in patients with CAD with/and without Diabetes Mellitus (DM) and compare to those in subjects with normal coronary arteries (NCA). Materials and methods: Twenty three patients with severe CAD who were scheduled to coronary artery by-pass grafting surgery and 6 patients with angiographycally NCAs were included in the study. . . . Activation of peripheral blood DCs have been analyzed by flow cytometric measures of CD86 activation. Results: In patients with CAD and without DM, DC activation significantly increased after stimulation of oxidesized LDL (135 ± 121 vs 248 ± 197 p = 0.024). However this activation didn't significantly increased in patients with CAD and DM (100 ± 20 vs 120 ± 97, p = 0,54). Patients with NCAs and without DM showed marked activation of CD86 after stimulation with ox-LDL. Conclusion: We have documented that DC activation, upon stimulation of ox-LDL has blunted in patients with CAD compared to patients with NCAs. Moreover this defective activation is more pronounced in those with diabetic patients with CAD. © 2018 Elsevier Inc Daha fazlası Daha az

Type 2 diabetes mellitus associated with premature aging

Bilici M. | Arpaci D.K. | Ilikhan S.U. | Corakci B.D. | Bayraktaroglu T. | Arasli M. | Tekin I.O.

Article | 2017 | Iranian Red Crescent Medical Journal19 ( 6 ) , pp.134 - 139

Background: A decrease of naive T-cells and a concomitant increase in memory cells are the accepted consequences of aging on the adaptive immune system. Objectives: The current case-control study aimed at considering the impact of chronic hyperglycemia that leads to glycation of modified self proteins on aging via the memory cell percentages among the patients admitted to the endocrinology department of Bulent Ecevit University Hospital in Zonguldak province, Turkey, from September to October 2015. Methods: Blood samples were collected from 81 patients with diabetes mellitus (DM) and 39 healthy volunteers with no history of autoimmu . . .ne diseases or chronic inflammatory disorders, based on the purposive sampling method. The patients were divided into 2 groups based on the presence and absence of the diabetic microvascular complications. Diabetic nephropathy, neuropathy, and retinopathy were investigated according to the American Diabetes Association criteria. T-lymphocytes subpopulations were measured in peripheral blood by the flow cytometry. CD27, CD45 RO, and CD45 RA were used to discriminate naive and memory T-cells (CD4+ and CD8+). Data for each subpopulation were reported as a percentage of the total CD4+ and CD8+ cells. Results: The mean percentage of naive (CD45RA + CD27+) and memory (CD45RO + CD27+ central memory and CD45RO + CD27-effector memory cells) CD4+ T-cells in patients with type 2 DM and healthy controls were 26.73 ± 15.04, 19.21 ± 10.80, 31.35 ± 10.94, and 15.07 ± 6.97, respectively. A decrease in the naive and an increase in memory CD4+ T-cell proportion were found in patients with type 2 DM, compared to the healthy controls (P values = 0.031 and 0.018, respectively). Conclusions: Higher memory and lower naive CD4+ T-cells probably reflect thr accelerated aging of the adaptive immune system in patients with type 2 diabetes. © 2017, Iranian Red Crescent Medical Journal Daha fazlası Daha az

Combination therapy of Nigella sativa and human parathyroid hormone on bone mass, biomechanical behavior and structure in streptozotocin-induced diabetic rats

Altan M.F. | Kanter M. | Donmez S. | Kartal M.E. | Buyukbas S.

Article | 2007 | Acta Histochemica109 ( 4 ) , pp.304 - 314

Extracts of the seeds of Nigella sativa (NS), an annual herbaceous plant of the Ranunculaceae family, have been used for many years for therapeutic purposes, including their potential anti-diabetic properties. The aim of the present study was to test the hypothesis that combined treatment with NS and human parathyroid hormone (hPTH) is more effective than treatment with NS or hPTH alone in improving bone mass, connectivity, biomechanical behaviour and strength in insulin-dependent diabetic rats. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) at a single dose of 50 mg/kg. The diabetic rats received NS (2 ml . . ./kg/day, i.p.), hPTH (6 µg/kg/day, i.p.) or NS and hPTH combined for 4 weeks, starting 8 weeks after STZ injection. The ß-cells of the pancreatic islets of Langerhans were examined by immunohistochemical methods. In addition, bone sections of femora were processed for histomorphometry and biomechanical analysis. In diabetic rats, the ß-cells were essentially negative for insulin-immunoreactivity. NS treatment (alone or in combination with hPTH) significantly increased the area of insulin immunoreactive ß-cells in diabetic rats; however, hPTH treatment alone only led to a slightly increase in the insulin-immunoreactivity. These results suggest that NS might be used in a similar manner to insulin as a safe and effective therapy for diabetes and might be useful in the treatment of diabetic osteopenia. © 2007 Elsevier GmbH. All rights reserved Daha fazlası Daha az

Nephropathy and retinopathy in type 2 diabetic patients living at moderately high altitude and sea level

Sayarlioglu H. | Erkoc R. | Dogan E. | Topal C. | Algun E. | Erem C. | Atmaca H.

Article | 2005 | Renal Failure27 ( 1 ) , pp.67 - 71

Background: High-altitude-induced hypoxia results in various diseases, such as chronic mountain sickness and high altitude retinal edema, and may affect severity and incidence of some cardiovascular diseases. In order to evaluate the effects of moderately high altitude on diabetic nephropathy and retinopathy, a cross-sectional study was planned. Material Method: Long-term type II diabetic residents of sea level (n=75, 38 male, 37 female, mean age 51.9 ± 10.5 in Trabzon and Zonguldak cities) and moderately high altitude (h=1,727 m, n=73, 28 male, 45 female, mean age 48.3±12.1, Van city) were compared. Results: No difference was obser . . .ved in terms of age, gender, diabetes duration, body mass index, smoking, systolic, diastolic, and mean arterial blood pressure values, serum glucose levels, cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, hemoglobin, HbA1C, hypertension control, or blood pressure medications and retinopathy incidence. Mean 24 h protein excretion (210.0±139.9, 127.8±112.1 mg; P=0.00), proteinuria prevalence (57.5% versus 33.3%, p=0.003), and serum creatinine levels (1.04±0.22 versus 0.84±0.21, p=0.00) were significantly higher in the highlanders, glomerular filtration rate (GFR) was significantly lower in sea level (SL) patients (90.9±26.5 versus 83±21.1, p=0.05). Conclusion: Tendency to diabetic nephropathy as indicated by higher proteinuria and creatinine levels is increased among type 2 diabetic patients living at moderately high altitude. Prospective studies are needed to confirm these findings Daha fazlası Daha az

Emphysematous pyelonephritis in a diabetic patient with kidney stone

Magden K. | Soyaltin U.E. | Yildiz G. | Celik C. | Hur E.

Article | 2012 | BANTAO Journal10 ( 1 ) , pp.41 - 42

Emphysematous pyelonephritis (EPN) is an acute necrotizing infection of the renal parenchyma, resulting in presence of gas within either the collecting system or perinephric tissue. Females and diabetics are more prone to the disease. We present a case with EPN caused by Escherichia coli sepsis. A 54-year-old woman was admitted to emergency service in a status of septic shock. Radiodiagnostic computed tomography revealed gas bubbles bilaterally in the renal parenchyma and also left ureter. Treatment consisted of antibiotics and intravenous fluids. She died at the second day of hospitalization because of urosepsis.

Effects of low-dose doxycycline and bisphosphonate clodronate on alveolar bone loss and gingival levels of matrix metalloproteinase-9 and interleukin-1 ß in rats with diabetes: A histomorphometric and immunohistochemical study

Özdemir S.P. | Kurtis B. | Tuter G. | Bozkurt S. | Gültekin S.E. | Sengüven B. | Watanabe K.

Article | 2012 | Journal of Periodontology83 ( 9 ) , pp.1172 - 1182

Background: Bisphosphonates (BPs) and low-dose doxycycline (LDD) have been shown to inhibit bone resorption and to improve the levels of proinflammatory mediators and destructive enzymes in gingival tissues, respectively. The purpose of this study is to evaluate the effect of mono and combined BP clodronate and LDD therapies in reducing gingival levels of matrix metalloproteinase-9 (MMP-9), interleukin-1ß (IL-1ß), and alveolar bone loss in rats with diabetes. Methods: Fifty adult Wistar rats were divided into five study groups as follows: 1) group 1 = diabetes control; 2) group 2 = diabetes + periodontitis; 3) group 3 = diabetes + p . . .eriodontitis + LDD; 4) group 4 = diabetes + periodontitis + clodronate; and 5) group 5 = diabetes + periodontitis + LDD + clodronate. LDD and clodronate were given as a single agent or as combination therapy during the 7 days of the post-experimental periodontitis period. On day 7, the rats were sacrificed, the mobility of the tooth was recorded, and block biopsies were removed. The gingival tissues were analyzed histologically and immunohistochemically for expression of MMP-9 and IL-1ß. Alveolar bone loss was evaluated morphometrically under a light microscope. Data analysis was performed statistically by Kruskal-Wallis and post hoc Tukey and Spearman correlation tests. Results: Alveolar bone loss was significantly greater in groups 2 through 5 than group 1 (P 0.05). Animals with periodontitis (group 2) expressed significantly higher levels of MMP-9 and IL-1ß compared with those without periodontitis (group 1) (P Daha fazlası Daha az

The primary arteriovenous fistula failure-a comparison between diabetic and non-diabetic patients: glycemic control matters

Afsar, Baris | Elsurer, Rengin

Article | 2012 | INTERNATIONAL UROLOGY AND NEPHROLOGY44 ( 2 ) , pp.575 - 581

Objectives Presence of diabetes mellitus has been shown to be related with the occurrence of primary arteriovenous fistula (AVF) failure in some but not in all studies. In the current study, we examined whether glycemic control as evaluated by HbA1c is independently related with primary AVF failure. Methods We recorded sociodemographic, clinical, and laboratory parameters of the patients from medical records and hospital charts prior to AVF surgery. Primary AVF failure was described as a complication of the AVF before the first successful cannulation for HD treatment. Results Our study comprised of 160 non-diabetic (Group1) and 73 d . . .iabetic patients. Among diabetic patients, 37 had HbA1c values = 7% (Group 3). In total, 74 (31.8%) patients had a history of primary AVF failure. The percentages of primary AVF failure were 27.5, 29.7, and 52.8% in Group 1, Group 2, and Group 3, respectively (P: 0.013). The percentage of patients with primary AVF failure was significantly lower in Group 1 and Group 2 than in Group 3 (P: 0.003 and P: 0.045, respectively). There was no difference with respect to primary AVF failure between Group 1 and Group 2 patients. Conclusions We suggest that poor glycemic control as assessed by HbA1c may be an important factor for the development of primary AVF failure among diabetic subjects. It is possible that differences with respect to AVF failure between diabetic and nondiabetic patients may be partly attributed to glycemic control Daha fazlası Daha az

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