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The effects of dexpanthenol in streptozotocin-induced diabetic rats: Histological, histochemical and immunological evidences

Gulle K. | Ceri N.G. | Akpolat M. | Arasli M. | Demirci B.

Article | 2014 | Histology and Histopathology29 ( 10 ) , pp.1305 - 1313

Summary. This study was designed to investigate the effects of Dexpanthenol (Dxp) on liver and pancreas histology and cytokine levels in streptozotocine (STZ)-induced diabetic rats. Twenty-four Wistar albino male rats were divided into four groups: control, Dxp, STZ-induced diabetic (STZ) and diabetic treatment with Dexpanthenol (STZ-Dxp) groups. Experimental diabetes was induced by single dose STZ (50 mg/kg) intraperitoneally (i.p.). After administration of STZ, the STZ-Dxp group began to receive a 300 mg/kg/day i.p. dose of Dxp for 6 weeks. Liver and pancreas tissues of the control group were in normal morphology. Liver tissue of . . .STZ group showed vacuolisation of hepatocytes in the liver parenchyma with enlargement of sinusoidal spaces and increasing amounts of connective tissue in the portal area. Pancreatic section of STZ group displayed ß-cells with of cytoplasmic mass, reduction of islet size, and atrophy. The STZ-Dxp group that received Dxp treatment exhibit partially normal hepatic parenchyma. Histochemical examinations revealed that the diabetes-induced glycogen depletion markedly improved with the Dxp treatment ( Daha fazlası Daha az

Correlation of renal B-mode ultrasonographic findings with diabetic nephropathy stage [Renal B-mod ultrasonografi· bulgularinin di·abetik nefropati· evresi· i·le i·li·şki·si·]

Türksoy Ö. | Tokgöz H. | Elverici E. | Dilman Ş. | Yüksel E.

Article | 2008 | Marmara Medical Journal21 ( 2 ) , pp.112 - 117

Aim: We aimed to investigate the renal morphological features detected by B-mode ultrasonography (US) in various clinical stages of diabetic nephropathy by means of a control group. Methods: As control group, 20 healthy person were selected. As study group, 69 patients with type-2 diabetes were included. All cases in both groups were evaluated with B-mode US in terms of renal length, parenchymal thickness and echogenicity. Diabetic patients were divided into 3 groups according to 24-hour urinary albumin excretion ratios (AER) (Group-1: AER300 mg/ day); and mean renal parenchymal thickness and length were measured. By SPSS programme, . . . mean values were compared between groups. Results: When mean renal length was compared between the control and study groups, a significant difference was noticed; but when mean renal parenchymal thickness was compared, no significant difference was demonstrated between the two groups. When study groups were compared, no statistically significant difference was seen. Cortical hyperechogenicity ratios; mean serum BUN and creatinine clearance rates, were correlated with nephropathy stage. Conclusion: With the progression of nephropathy in diabetic patients,renal parenchymal thickness does not significantly differ; but hyperechogenicity and a decrease in renal dimensions (control versus the study group) are observed Daha fazlası Daha az

Can ursolic acid be beneficial against diabetes in rats?

Bacanli M. | Aydin S. | Bucurgat U.U. | Başaran N. | Anlar H.G. | Çal T. | Ari N.

Article | 2018 | Turkish Journal of Biochemistry43 ( 5 ) , pp.520 - 529

Objective: Diabetes mellitus, a heteregenous metabolic and chronic disease, is a growing health problem especially in developing countries. It is claimed that diabetes associated with increased formation of free radicals and decrease in antioxidant potential and also alterations in lipid profile and enzyme levels. Ursolic acid is commonly used in traditional Chinese medicine due to its beneficial effects. The aim of this study was to investigate the effects of ursolic acid on streptozotocin-induced diabetes in Wistar albino rats. Methods: DNA damage was evaluated in the blood and liver cells of rats by alkaline comet assay. The acti . . .vities of antioxidant enzymes, oxidative stress parameters, biochemical parameters, hepatic enzyme levels and lipid profile parameters were also evaluated. Results: The results of this study demonstrate that diabetes caused genotoxic damage, changes in hepatic enzyme and lipid profile, biochemical and antioxidant enzyme activities and oxidative stress parameters in rats. Ursolic acid was found to be protective against diabetes induced effects in blood and liver samples of rats. Conclusions: According to our results, it seems that ursolic acid may be beneficial against diabetes and its adverse effects in rats. © 2018 Turkish Biochemistry Society. All rights reserved Daha fazlası Daha az

Preventive role of Pycnogenol ® against the hyperglycemia-induced oxidative stress and DNA damage in diabetic rats

Aydın S. | Bacanlı M. | Anlar H.G. | Çal T. | Arı N. | Ündeğer Bucurgat Ü. | Başaran A.A.

Article | 2019 | Food and Chemical Toxicology124 , pp.54 - 63

Diabetes mellitus, a complex progressive metabolic disorder, leads to some oxidative stress related complications. Pycnogenol ® (PYC), a plant extract obtained from Pinus pinaster, has been suggested to be effective in many diseases including diabetes, cancer, inflammatory and immune system disorders. The mechanisms underlying the effects of PYC in diabetes need to be elucidated. The aim of this study was to determine the effects of PYC treatment (50 mg/kg/day, orally, for 28 days) on the DNA damage and biochemical changes in the blood, liver, and kidney tissues of experimental diabetic rats. Changes in the activities of catalase, s . . .uperoxide dismutase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase enzymes, and the levels of 8-hydroxy-2'-deoxyguanosine, total glutathione, malondialdehyde, insulin, total bilirubin, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, high density lipoprotein, low density lipoprotein, total cholesterol, and triglyceride were evaluated. DNA damage was also determined in the whole blood cells and the liver and renal tissue cells using the alkaline comet assay. PYC treatment significantly ameliorated the oxidative stress, lipid profile, and liver function parameters as well as DNA damage in the hyperglycemic rats. The results show that PYC treatment might improve the hyperglycemia-induced biochemical and physiological changes in diabetes. © 201 Daha fazlası Daha az

Exercise training prevents and protects streptozotocin-induced oxidative stress and ß-cell damage in rat pancreas

Coskun O. | Ocakci A. | Bayraktaroglu T. | Kanter M.

Article | 2004 | Tohoku Journal of Experimental Medicine203 ( 3 ) , pp.145 - 154

The aim of the present study was the evaluation of possible protective effects of exercise against ß-cell damage in streptozotocin (STZ)-induced diabetes in rats. The animals were divided into five groups: the control group, the STZ-induced diabetes group, the STZ-induced diabetes and light-intensity exercise group, the STZ-induced diabetes and moderate-intensity exercise group, and the STZ-induced diabetes and heavy-intensity exercise group. Animals in the exercise groups were made to swim one of three exercise protocols once a day for 12 consecutive weeks. STZ was injected intraperitoneally at a single dose of 50 mg/kg for diabete . . .s induction. Exercise training was continued for 4 weeks prior to STZ administration; these applications were continued end of the study (for 12 weeks). Erythrocyte and pancreatic tissue malondialdehyde (MDA) levels and serum nitric oxide (NO) concentration were measured. Moreover glutathione peroxidase (GSHPx), superoxide dismutase (SOD) and catalase (CAT) were also measured in pancreatic homogenates. Pancreatic ß-cells were examined by immunohistochemical methods. STZ increased lipid peroxidation and decreased the antioxidant enzyme activity significantly. Exercise, especially moderate-intensity exercise has shown protective effect probably through decreasing lipid peroxidation and increasing antioxidant enzyme activity. Islet cell degeneration and weak insulin immunohistochemical staining were observed in STZ induced diabetic rats. Increased intensity of staining for insulin and preservation of ß-cell numbers were apparent in the exercise-applied diabetic rats. Interestingly, the best result was obtained from moderate-intensity exercise. These findings suggest that exercise has a therapeutic and/or protective effect in diabetes by decreasing oxidative stress and preservation of pancreatic ß-cell integrity. © 2004 Tohoku University Medical Press Daha fazlası Daha az

Preventive role of Pycnogenol (R) against the hyperglycemia-induced oxidative stress and DNA damage in diabetic rats

Aydin, Sevtap | Bacanli, Merve | Anlar, Hatice Gul | Cal, Tugbagul | Ari, Nuray | Bucurgat, Ulku Undeger | Basaran, Arif Ahmet

Article | 2019 | FOOD AND CHEMICAL TOXICOLOGY124 , pp.54 - 63

Diabetes mellitus, a complex progressive metabolic disorder, leads to some oxidative stress related complications. Pycnogenol (R) (PYC), a plant extract obtained from Pinus pinaster, has been suggested to be effective in many diseases including diabetes, cancer, inflammatory and immune system disorders. The mechanisms underlying the effects of PYC in diabetes need to be elucidated. The aim of this study was to determine the effects of PYC treatment (50 mg/kg/day, orally, for 28 days) on the DNA damage and biochemical changes in the blood, liver, and kidney tissues of experimental diabetic rats. Changes in the activities of catalase, . . . superoxide dismutase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase enzymes, and the levels of 8-hydroxy-2'-deoxyguanosine, total glutathione, malondialdehyde, insulin, total bilirubin, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, high density lipoprotein, low density lipoprotein, total cholesterol, and triglyceride were evaluated. DNA damage was also determined in the whole blood cells and the liver and renal tissue cells using the alkaline comet assay. PYC treatment significantly ameliorated the oxidative stress, lipid profile, and liver function parameters as well as DNA damage in the hyperglycemic rats. The results show that PYC treatment might improve the hyperglycemia-induced biochemical and physiological changes in diabetes Daha fazlası Daha az

Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and ß-cell damage in rat pancreas

Coskun O. | Kanter M. | Korkmaz A. | Oter S.

Article | 2005 | Pharmacological Research51 ( 2 ) , pp.117 - 123

The aim of the present study was the evaluation of possible protective effects of quercetin (QE) against ß-cell damage in experimental streptozotocin (STZ)-induced diabetes in rats. STZ was injected intraperitoneally at a single dose of 50 mg kg -1 for diabetes induction. QE (15 mg kg -1 day, intraperitoneal (i.p.) injection) was injected for 3 days prior to STZ administration; these injections were continued to the end of the study (for 4 weeks). It has been believed that oxidative stress plays a role in the pathogenesis of diabetes mellitus (DM). In order to determine the changes of cellular antioxidant defense system, antioxidant . . . enzymes such as glutathione peroxidase (GSHPx), superoxide dismutase (SOD) and catalase (CAT) activities were measured in pancreatic homogenates. Moreover we also measured serum nitric oxide (NO) and erythrocyte and pancreatic tissue malondialdehyde (MDA) levels, a marker of lipid peroxidation, if there is an imbalance between oxidant and antioxidant status. Pancreatic ß-cells were examined by immunohistochemical methods. STZ induced a significant increase lipid peroxidation, serum NO concentrations and decreased the antioxidant enzyme activity. Erythrocyte MDA, serum NO and pancreatic tissue MDA significantly increased (P < 0.05) and also the antioxidant levels significantly decreased (P < 0.05) in diabetic group. QE treatment significantly decreased the elevated MDA and NO (P < 0.05), and also increased the antioxidant enzyme activities (P < 0.05). QE treatment has shown protective effect possibly through decreasing lipid peroxidation, NO production and increasing antioxidant enzyme activity. Islet cells degeneration and weak insulin immunohistochemical staining was observed in STZ induced diabetic rats. Increased staining of insulin and preservation of islet cells were apparent in the QE-treated diabetic rats. These findings suggest that QE treatment has protective effect in diabetes by decreasing oxidative stress and preservation of pancreatic ß-cell integrity. © 2004 Elsevier Ltd. All rights reserved Daha fazlası Daha az

Melatonin treatment against remote organ injury induced by renal ischemia reperfusion injury in diabetes mellitus

Fadillioglu E. | Kurcer Z. | Parlakpinar H. | Iraz M. | Gursul C.

Article | 2008 | Archives of Pharmacal Research31 ( 6 ) , pp.705 - 712

Oxidative stress may have a role in liver damage after acute renal injury due to various reasons such as ischemia reperfusion (IR). Diabetes mellitus (DM) is an important disease for kidneys and may cause nephropathy as a long term complication. The aim of this study was to investigate protective effect of melatonin, a potent antioxidant, against distant organ injury on liver induced by renal IR in rats with or without DM. The rats were divided into six groups: control (n=7), DM (n=5), IR (n=7), DM+IR (n=7), melatonin+IR (Mel+IR) (melatonin, 4 mg/ kg during 15 days) (n=7), and Mel+DM+IR groups (n=7). Diabetes developed 3 days after . . .single i.p. dose of 45 mg/kg streptozotocin. After 15 day, the left renal artery was occluded for 30 min followed 24 h of reperfusion in IR performed groups. DM did not alter oxidative parameters alone in liver tissue. The levels of malondialdehyde, protein carbonyl and nitric oxide with activities of xanthine oxidase and myeloperoxidase were increased in liver tissues of diabetic and non-diabetic IR groups. Nitric oxide level in DM was higher than control. The activities of catalase and superoxide dismutase were increased in IR groups in comparison with control and DM. ALT and AST levels were higher in IR and DM+IR groups than control and DM. Melatonin treatment reversed all these oxidant and antioxidant parameters to control values as well as serum liver enzymes. We concluded that renal IR may affect distant organs such as liver and oxidative stress may play role on this injury, but DM has not an effect on kidney induced distant organ injury via oxidant stress. Also, it was concluded that melatonin treatment may prevent liver oxidant stress induced by distant injury of kidney IR. © 2008 The Pharmaceutical Society of Korea Daha fazlası Daha az

Performance of small-world feedforward neural networks for the diagnosis of diabetes

Erkaymaz, Okan | Özer, Mahmut | Perc, Matjaž

Article | 2017 | Applied Mathematics and Computation311 , pp.22 - 28

We investigate the performance of two different small-world feedforward neural networks for the diagnosis of diabetes. We use the Pima Indians Diabetic Dataset as input. We have previously shown than the Watts–Strogatz small-world feedforward neural network delivers a better classification performance than conventional feedforward neural networks. Here, we compare this performance further with the one delivered by the Newman–Watts small-world feedforward neural network, and we show that the latter is better still. Moreover, we show that Newman–Watts small-world feedforward neural networks yield the highest output correlation as well . . . as the best output error parameters. © 2017 Elsevier Inc Daha fazlası Daha az

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