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The evaluation of cystatin C, IL-Iß, and TNF-? levels in total saliva and gingival crevicular fluid from 11- to 16-year-old children

Ülker A.E. | Tulunoglu Ö. | Özmeric N. | Can M. | Demirtas S.

Article | 2008 | Journal of Periodontology79 ( 5 ) , pp.854 - 860

Background: The aim of this study was to evaluate the levels of cystatin C, interleukin-1ß (IL-1ß), and tumor necrosis factor-alpha (TNF-?) in the total saliva and gingival crevicular fluid (GCF) of periodontally healthy children (PHC) and children with gingivitis (CG) who were between 11 and 16 years old. Methods: The study was carried out with 10 PHC and 25 CG. Unstimulated total saliva and GCF samples were obtained. Clinical parameters, including probing depth (PD), clinical attachment loss (CAL), plaque index (PI), gingival index (GI), and gingival bleeding index (GBI), were assessed. GCF samples were collected from four maxilla . . .ry upper incisors. After sampling, biochemical analyses were performed using latex particle-enhanced turbidimetric immunoassay for cystatin C and enzyme-linked immunosorbent assay for IL-1ß and TNF-?. The multivariate analysis of variance test was used for statistical evaluation. Results: In total saliva, cystatin C and TNF-? levels were higher in PHC, and IL-1ß levels were higher in CG, but the differences were not statistically significant. In GCF, cystatin C levels were higher in PHC (P >0.05), whereas TNF-? and IL-1ß levels were higher in CG (P >0.05). In the CG group, there were positive correlations between the GCF cystatin C level and the PI of the sampled site (r = 0.488; Daha fazlası Daha az

Hepatorenal syndrome

Demirtaş S. | Can M. | Yarpuzlu A.

Review | 2006 | Clinical Chemistry and Laboratory Medicine44 ( 4 ) , pp.379 - 386

This article summarizes the literature on current definition, suggested pathogenetic mechanisms and the role of laboratory assessment in the differential diagnosis of hepatorenal syndrome (HRS) from other causes of renal disease that may arise during hepatic cirrhosis and some diseases affecting both liver and kidney. It should be remembered that the main theory suggested for the pathogenesis of HRS is the arterial vasodilation hypothesis of portal hypertension, ending in type 1 and type 2 HRS, but there is no consensus supporting either mechanism as a solid theory for initiation of HRS pathogenesis to date. No laboratory test can f . . .irmly establish a diagnosis of HRS, which is mainly based on the absence of any specific cause of renal failure. Laboratory and ultrasonographic tests based on non-invasive techniques are being investigated as possible diagnostic approaches. © 2006 by Walter de Gruyter Daha fazlası Daha az

Cystatin C can be affected by nonrenal factors: A preliminary study on leukemia

Demirtaş S. | Akan Ö. | Can M. | Elmali E. | Akan H.

Article | 2006 | Clinical Biochemistry39 ( 2 ) , pp.115 - 118

Objective: The aim of this study was to evaluate the influence of malignancy and the impact of nephrotoxic drugs used in bone marrow transplantation (BMT) on the circulating levels of cystatin C in leukemia. Methods: We studied nineteen patients (eleven men and eight women; mean age 30.1 ± 11.2, 27.9 ± 7.1 years) with acute lymphoblastic leukemia, acute myeloid leukemia and chronic myeloid leukemia. Cystatin C, urea, creatinine and creatinine clearance (CrCl) were measured 24 h before BMT, 1 week after BMT, 2 weeks after BMT and 3 weeks after BMT. The control group consisted of twenty healthy adults, and the mean age was 29.1 ± 8.9. . . . Results: At the pretransplantation period, values of cystatin C were significantly higher than in the control group (P < 0.05). Urea, creatinine and CrCl values were not statistically different from the controls. One week after BMT, the level of cystatin C was significantly low as compared to the levels measured 24 h before BMT, but was still significantly higher than the controls (P < 0.05), whereas the levels of urea, creatinine and CrCl were in accordance with the levels of the controls. Two and three weeks after BMT, cystatin C values maintained the significant increase (P < 0.05), whereas the values of urea, creatinine and CrCl still corresponded with those of the controls in both group. Conclusions: Our preliminary data expose that cystatin C is not a reliable GFR marker in patients during leukemia or for monitoring nephrotoxic drugs used in BMT, but we can not reach definitive conclusion due to no gold standard for comparing the diagnostic accuracy of cystatin C. Further study is needed to elucidate the precise mechanism underlying this observation. © 2005 The Canadian Society of Clinical Chemists. All rights reserved Daha fazlası Daha az

Is cystatin C a reliable renal marker in trauma? [5]

Can M. | Demirtaş S. | Polat O. | Yildiz A.

Letter | 2006 | Clinical Chemistry and Laboratory Medicine44 ( 4 ) , pp.510 - 511

[No abstract available]

Cystain C and neuropeptid Y levels in brain tissues after experimental subarachnoid hemorrhage

Açikgöz S. | Can M. | Güven B. | Edebali N. | Barut F. | Büyükuysal Ç. | Tekin I.Ö.

Article | 2014 | Acta Biochimica Polonica61 ( 4 ) , pp.825 - 828

The aim of this study was to investigate the changes in the levels of cystatin C, which protects neurodegeneration in the central nervous system with the inhibition of cysteine protease and by inducing autophagy in the pathogenesis of cerebral vasospasm and levels of vasoconstrictive neuropeptid Y (NPY) in the brain tissue homogenates of rat model of subarachnoid hemorrhage (SAH). Three experimental groups were used: Day 2 and Day 7 groups after SAH, and also a control group. There were seven Wistar albino rats in each group. SAH was accomplished by transclival basilar artery puncture. Rat cystatin C, rat NPY were determined with EL . . .ISA in brain tissue homogenates. Day 2 group showed significantly enhanced cystatin C values in comparision with the control group (P=0.048). NPY levels between the Day 2 and Day 7 groups and the control groups were not significantly different (P=0.315). In histopathological examination, there was less neuronal loss in the Day 2 group than in the Day 7 group. Regarding our results, it would be more valuable to measure NPY levels in specific brain areas. The increased cystatin C levels on the second day after SAH is probably a pathophysiologic mechanism to organize protease activity Daha fazlası Daha az

Determinants of plasma homocysteine in coal miners

Görkem Mungan A. | Can M. | Kiran S. | Açikgöz S. | Güven B.

Article | 2013 | Acta Biochimica Polonica60 ( 3 ) , pp.443 - 449

Aim: Several studies suggest that coal miners are under risk of severe health problems such as cardiovascular, pulmonary, neurological, renal, hematological and musculoskeletal disorders. However, there are limited data on biochemical changes in underground workers. In our study we aimed to evaluate the association between serum homocysteine (Hcy), vitamin B12, cystatin C and folate levels in the blood of underground coal miners. Materials and Methods: Eighty one coal miners who work as underground or surface workers were recruited into our study. The study population was divided into two groups: the surface worker group (control gr . . .oup, n=33) and the underground worker group (n=48). The folate, vitamin B12, Hcy, cystatin C levels and body mass indexes (BMI) of both groups were measured and compared. Serum folate, Hcy and vitamin B12 levels were measured with a competitive chemiluminescence immunassay. Serum levels of cystatin C were determined by the latex particle-enhanced turbidimetric method using a cystatin C kit. Urea values were measured with a kinetic method on an automated analyzer. Results: There were no statistically significant differences between the underground workers and surface workers in the urea, cystatin C and vitamin B12 levels. High serum Hcy levels and low folate levels were found in underground workers compared with those in surface workers. The correlation between Hcy and folate levels was also statistically significant. Similarly, there was also a significant correlation between Hcy and vitamin B12, and between Hcy and cystatin C levels. Conclusions: Elevated Hcy levels may be associated with underground working but further research is necessary to understand the relation between elevated Hcy and increased prevalence of health problems in coal miners Daha fazlası Daha az

Serum glucagon and cystatin C levels with renal doppler sonography findings in non-azotemic liver cirrhosis cases

Ustundag Y. | Hekimoglu K. | Ilikhan S. | Zaimoglu G. | Acikgöz S. | Aydemir S.

Article | 2011 | Hepato-Gastroenterology58 ( 107-108 ) , pp.926 - 931

Background/Aims: It is well known that the hyperdynamic circulatory state in cirrhosis is characterized by increased splanchnic blood flow and renal vasoconstriction. The role of hyperglucagonemia in the renal hemodynamic changes that occur in this patient group is poorly understood at present. This study investigated relationships between serum glucagon levels, indicators of renal function (serum creatinine [Cr] and cystatin C levels, creatinine clearance rate [CrCl]), and renal hemodynamic findings in early and later stages of liver cirrhosis. Methodology: In total, 40 patients with non-azotemic liver cirrhosis (Group 1) and 20 he . . .althy gender- and age-matched controls (Group 2) were enrolled. The patient group was subdivided into Group la (25 patients with compensated cirrhosis [Child-Pugh A score]) and Group lb (15 patients with decompensated cirrhosis [Child-Pugh B or C]). Results: Group 1 patients had significantly elevated serum glucagon levels than Group 2 (57.8±46.7 pmol/L vs. 22.1±8.1 pmol/L, respectively Daha fazlası Daha az

The evaluation of serum cystatin C, malondialdehyde, and total antioxidant status in patients with metabolic syndrome

Demircan N. | Gürel A. | Armutcu F. | Ünalacak M. | Aktunç E. | Atmaca H.

Article | 2008 | Medical Science Monitor14 ( 2 ) , pp.926 - 931

Background: This study was designed to determine if serum cystatin C (Cys C) levels are affected by metabolic syndome and whether they correlate with lipid peroxidation and total antioxidant status (TAS) in this disorder. Material/Methods: Cases with metabolic syndrome diagnosed according to the ATP III criteria (18 females, 12 males) were compared with healthy control subjects (20 females, 17 males) matched by age and gender. Plasma Cys C, malondialdehyde (MDA), and TAS levels were studied. Results: Compared with the controls, Cys C and MDA levels were significantly higher (p

Serum cystatin C levels in gastric cancer patients: Scientific letter

Demirtaş S. | Uzunoglu N. | Can M. | Karaca L.

Article | 2007 | Turkiye Klinikleri Journal of Medical Sciences27 ( 3 ) , pp.442 - 444

Elevated activities of cysteine proteinases in cancers are attributed to impaired regulation by the endogenous cysteine proteinase inhibitors (cystatins). Cystatin C is suggested to be a reliable marker of glomerular filtration rate (GFR). The purpose of this study was to evaluate whether cystatin C concentration was influenced by gastric malignancy, which is a common cancer type and the availability of this parameter safely for screening renal dysfunction in these patients. Since there is inadequate information on the clinical significance of cystatin C expression in human gastric cancers, we studied the differences in levels of se . . .rum cystatin C in this type of cancer and also evaluated them with respect to cancer stages. The levels of cystatin C in patients with gastric adenocancer were similar to those in the control group. Similarly, the values of serum creatinine and GFR in the patients were comparable to those of the controls. Serum creatinine values in controls and in patients did not show a statistically significant difference 0.8 ± 0.16 and 0.9 ± 0.35 respectively (p> 0.05). Serum cystatin C values in controls and patients were 0.74 ± 0.32 and 0.72 ± 0.6 respectively, which was also not different statistically (p> 0.05). When the patients were evaluated with respect to the stages of the cancer, the cystatin C values did not differ significantly. The mean ± SD levels of the patients in low and advanced stages were 0.79 ± 0.51 and 0.69 ± 0.64 respectively (p> 0.05). Our study clearly demonstrates that serum cystatin C has valuable potential for the detection and monitoring of GFR and may be safely used in gastric cancer patients. Copyright © 2007 by Türkiye Klinikleri Daha fazlası Daha az

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