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Assessment of tumor markers in patients with chronic renal failure

Engin H. | Borazan A. | Aydemir S. | Yilmaz A.

Article | 2007 | Turkish Journal of Cancer37 ( 4 ) , pp.143 - 147

In this study; serum levels of different tumor markers such as alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), cancer antigen 125 (CA 125), cancer antigen 19-9 (CA 19-9), cancer antigen 15-3 (CA 15-3), and prostatespecific antigen (PSA) in 36 predialysis, 42 hemodialysis (HD), 42 continuous ambulatory peritoneal dialysis (CAPD) patients and 32 healthy volunteers as control group who did not present any clinical symptoms or signs of neoplasia with negative hepatitis markers were studied. The mean serum levels of CEA and CA 19-9 were found to be higher than the control group in predialysis, HD and CAPD patients. Serum levels . . .of CA 125 in CAPD group was found to be higher as compared to the other groups. Serum AFP, CA 15-3 and PSA levels were similar in all groups. In conclusion, serum tumor markers do not have any diagnostic utility and may be unreliable for monitoring malignancies in uremic patients Daha fazlası Daha az

Helicobacter pylori infection in hemodialysis patients: Susceptibility to amoxicillin and clarithromycin

Aydemir S. | Boyacioglu S. | Gur G. | Demirbilek M. | Can F.K. | Korkmaz M. | Yilmaz U.

Article | 2005 | World Journal of Gastroenterology11 ( 6 ) , pp.842 - 845

Aim: To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls. Methods: The subjects with dyspeptic complaints were 33 ESRD patients and 46 age- and sex-matched non-uremic controls who exhibited H pylori on antral biopsy specimens. The two groups were age and sex matched. The H pylori strains' pattern of susceptibility to amoxicillin and clarithromycin was investigated with the agar dilution technique. Results: None of the H pylori strains from either group showed resistance to amoxicillin with the agar dilution method. Twelve (36.4%) of th . . .e ESRD group strains and 7 (15.2%) of the control group strains showed resistance to clarithromycin, and this difference was statistically significant ( Daha fazlası Daha az

The effects of continuous ambulatory peritoneal dialysis and hemodialysis on serum pepsinogen concentrations in patients with chronic renal failure

Aydemir S. | Borazan A. | Acikgoz S. | Ustundag Y. | Yilmaz A.

Article | 2005 | Tohoku Journal of Experimental Medicine205 ( 3 ) , pp.263 - 268

Pepsinogen, the precursors of pepsin, is classified into two subtypes: pepsinogen I (PG I) and pepsinogen II (PG II). Patients with impaired renal function are associated with elevated concentrations of serum pepsinogen. Contradictory results have been reported about the effect of dialysis on the serum pepsinogen levels, as the previous studies were conducted only in a particular period of dialysis. We therefore investigated the effect of continuous ambulatory peritoneal dialysis (CAPD) or hemodialysis on serum pepsinogen levels in patients with chronic renal failure (CRF) before and after dialysis treatment. Thirty-four patients wi . . .th CRF were enrolled in this study and were treated by CAPD (n = 22) or hemodialysis (n = 12). As a control group, subjects with normal renal function were included (n = 20). Serum PG I and PG II levels were measured in control subjects and CRF patients before dialysis treatment and after three-month dialysis treatment. Before dialysis treatment, serum PG I levels were significantly higher in CRF patients than control subjects. In patients treated by CAPD, the serum PG I levels were significantly decreased but its levels were still higher than the values of the control subjects, whereas PG I levels remained unchanged in patients treated by hemodialysis. There were no differences in serum PG II levels between control subjects and CRF patients before or after dialysis treatment. Thus, CAPD is more effective than hemodialysis in the clearance of PG I. © 2005 Tohoku University Medical Press Daha fazlası Daha az

Trimethylaminuria (fish malodour syndrome) in chronic renal failure

Hur E. | Güngör, Özkan | Bozkurt D. | Bozgul S.M.K. | Dusunur F. | Caliskan H. | Berdeli A.

Article | 2012 | Hippokratia16 ( 1 ) , pp.83 - 85

Trimethylaminuria (fish malodour syndrome) is a rare genetic metabolic disorder presented with a body odour which smells like a decaying fish. This odour is highly objectionable, that can be destructive for the social, and work life of the patient. Trimethylamine is derived from the intestinal bacterial degradation of foods that are rich of choline and carnitine. Trimethylamine is normally oxidised by the liver to odourless trimethylamine N-oxide which is excreted in the urine, so, uremia may worsen the condition. Uremia itself may cause more or less unpleasant odour. Poor uremic control may worsen the odour. We reported this case b . . .ecause Trimethylaminuria is not usually considered in the differential diagnosis of malodour in chronic renal failure and it is the first case that shown the association with Trimethylaminuria and chronic renal failure in the literature Daha fazlası Daha az

The primary arteriovenous fistula failure-a comparison between diabetic and non-diabetic patients: glycemic control matters

Afsar, Baris | Elsurer, Rengin

Article | 2012 | INTERNATIONAL UROLOGY AND NEPHROLOGY44 ( 2 ) , pp.575 - 581

Objectives Presence of diabetes mellitus has been shown to be related with the occurrence of primary arteriovenous fistula (AVF) failure in some but not in all studies. In the current study, we examined whether glycemic control as evaluated by HbA1c is independently related with primary AVF failure. Methods We recorded sociodemographic, clinical, and laboratory parameters of the patients from medical records and hospital charts prior to AVF surgery. Primary AVF failure was described as a complication of the AVF before the first successful cannulation for HD treatment. Results Our study comprised of 160 non-diabetic (Group1) and 73 d . . .iabetic patients. Among diabetic patients, 37 had HbA1c values = 7% (Group 3). In total, 74 (31.8%) patients had a history of primary AVF failure. The percentages of primary AVF failure were 27.5, 29.7, and 52.8% in Group 1, Group 2, and Group 3, respectively (P: 0.013). The percentage of patients with primary AVF failure was significantly lower in Group 1 and Group 2 than in Group 3 (P: 0.003 and P: 0.045, respectively). There was no difference with respect to primary AVF failure between Group 1 and Group 2 patients. Conclusions We suggest that poor glycemic control as assessed by HbA1c may be an important factor for the development of primary AVF failure among diabetic subjects. It is possible that differences with respect to AVF failure between diabetic and nondiabetic patients may be partly attributed to glycemic control Daha fazlası Daha az

Helicobacter pyloriinfection in hemodialysis patients: Susceptibility to amoxicillin and clarithromycin

Aydemir, Selim | Boyacioglu, Sedat | Gur, Gurden | Demirbilek, Muge | Can, Fusun Kamber | Korkmaz, Murat | Yilmaz, Ugur

Article | 2005 | WORLD JOURNAL OF GASTROENTEROLOGY11 ( 6 ) , pp.842 - 845

AIM: To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls. METHODS: The subjects with dyspeptic complaints were 33 ESRD patients and 46 age-and sex-matched non-uremic controls who exhibited H pylori on antral biopsy specimens. The two groups were age and sex matched. The H pylori strains' pattern of susceptibility to amoxicillin and clarithromycin was investigated with the agar dilution technique. RESULTS: None of the H pylori strains from either group showed resistance to amoxicillin with the agar dilution method. Twelve (36.4%) of the . . . ESRD group strains and 7 (15.2%) of the control group strains showed resistance to clarithromycin, and this difference was statistically significant ( Daha fazlası Daha az

Hormone profiles and their relation with menstrual cycles in patients undergoing hemodialysis [Hemodi·yali·z hastalarinda hormon profi·lleri· ve menstruel si·klusla i·li·şki·si·]

Arikan D.C. | Bozkurt S. | Arikan I. | Turgut E.

Article | 2011 | Turk Jinekoloji ve Obstetrik Dernegi Dergisi8 ( 1 ) , pp.32 - 39

Objective: To investigate the etiology of menstrual disorders among patients undergoing hemodialysis due to chronic renal failure by assessing menstrual history, serum hormone levels and other biochemical factors. Material and methods: Thirty patients undergoing hemodialysis and 30 healthy women at reproductive age were enrolled in our study. Demographic characteristics, hormonal and biochemical data, sonographically measured endometrial thickness values of the subjects were compared. In addition, the present and the pre-hemodialysis menstrual pattern of the patients undergoing hemodialysis were recorded. The hormonal, hematological . . . and biochemical data of the patients were compared according to their menstrual patterns. Results: No statistical significance was seen between age, BMI, gravida, parity, abortion and curettage among groups (p>0.05). Hemoglobin and hematocrit levels were significantly lower in the hemodialysis group than in the control (p0.05). Mean serum LH and prolactin levels were significantly higher in the hemodialysis group compared to the control (p0.05). Serum LH and prolactin levels were higher and serum FSH, estradiol and TSH levels were lower in patients who developed amenorrhea after hemodialysis treatment when compared to non-amenorrheic subjects. However, these differences were not statistically significant (p>0.05). Discussion: The most important factor in the etiology of menstrual disorders seen in chronic renal failure patients was high serum LH and prolactin levels. Hemodialysis is a successful treatment that extends life expectancy and ameliorates the hypothalamo- pituitary-ovarian axis in chronic renal failure patients Daha fazlası Daha az

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