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Onkoloji servisinde yatan hastaların psikososyal gereksinimlerini belirleme

Ertuğrul Kırık, Emel

Master Thesis | 2020 | Zonguldak Bülent Ecevit Üniversitesi, Sağlık Bilimleri Enstitüsü, Hemşirelik Anabilim Dalı Ruh Sağlığı ve Psikiyatri Hemşireliği Yüksek Lisans Programı

Araştırma onkoloji biriminde yatan hastaların psikososyal gereksinimlerini belirlemek amacıyla yapılmıştır. Tanımlayıcı-kesitsel olarak yapılan çalışmanın evrenini, Zonguldak Bülent Ecevit Üniversitesi Uygulama ve Araştırma Merkezi‟nin Onkoloji Biriminde yatan kanser hastaları, örneklemini ise 01.07.2019-31.09.2019 tarihleri arasında bu birimde yatan ve araştırmaya dahil edilme kriterlerini karşılamış olan 100 hasta oluşturmuştur. Çalışmanın verileri “Onkoloji Biriminde Yatan Hastaların Sosyodemografik, Klinik ve Psikososyal Özelliklerine İlişkin Bilgi Toplama Formu” ve “Destekleyici Bakım Gereksinimleri Ölçeği‟nin Kısa Formu” ile t . . .oplanmıştır. İstatistiksel analizler için NCSS (Number Cruncher Statistical System) 2007 programı kullanılmıştır. Verilerin analizinde tanımlayıcı istatistiksel metodlar, Shapiro-Wilk testi, Mann-Whitney U testi, Kruskal-Wallis testi, Dunn-Bonferroni testi, Pearson ki-kare testi, Fisher‟s exact test kullanılmıştır. Çalışmanın sonucunda kanser hastaları arasında psikososyal sorun yaşayanların, psikiyatrik belirtileri ve tanısı olanların, ruhsal desteğe ihtiyacı olanların, destekleyici bakım gereksinimlerinin daha fazla olduğu saptanmıştır. Sosyal destek alanların destekleyici bakım gereksinimleri, almayanlara oranla daha düşüktür. Hastada tanı süresinin uzaması ve metastaz varlığı, fiziksel ve günlük yaşamı destekleyici bakım gereksinimleri artırmaktadır. The research was conducted to determine the psychosocial needs of patients hospitalized in the oncology unit. The universe of this descriptive-cross-sectional study consisted of cancer patients hospitalized in Oncology Unit of Zonguldak Bulent Ecevit University Application and Research Center and the sample consisted of 100 patients who received treatment between 01.07.2019-31.09.2019 and fulfilled the research criteria. The data of the study were collected with “Information Collection Form Regarding Socio-demographic, Clinical and Psychosocial Features of Patients Hospitalized in Oncology Unit” and “Supportive Care Needs Scale”. NCSS 2007 program was used for statistical analysis. Descriptive statistical methods, Shapiro-Wilk test, Mann- Whitney U test, Kruskal-Wallis test, Dunn-Bonferroni test, Pearson chi-square test, Fisher's exact test were used in the analysis of the data. As a result of the study, it was found that supportive care needs were higher among cancer patients who had psychosocial problems, psychiatric symptoms and diagnoses, and those who needed psychological support. Supportive care needs of those receiving social support are lower than those who do not receive supportive care. Prolonged diagnosis and presence of metastases increase the need for physical and daily life supportive care Daha fazlası Daha az

Cancer chemotherapy and liver [Kanser kemoterapisi ve karaciger]

Şahan C. | Öztürk M.

Article | 2003 | Ondokuz Mayis Universitesi Tip Dergisi20 ( 1 ) , pp.47 - 60

The potential hepatotoxicity from cancer chemotherapy may be complex. Liver injury during cancer chemotherapy may not always reflect hepatotoxic anticancer drugs; the clinician must also consider reactions to antibiotics, analgesic, antiemetic other medications. Preexisting medical problems, tumor, immumosuppression, hepatitis viruses and other infections and nutrition deficiencies all may affect a host susceptibility to liver injury. Drugs that commonly produce hepatotoxicity are L-asparaginase, methotrexate, cytrabine, 6-thiopurines and mitramycin. The review discusses the effect of chemotherapeutic agents on the liver.

Cancer awareness among university students in Turkey

Kurtuncu M. | Akhan L.U. | Celik S. | Alkan I.

Article | 2014 | Asian Pacific Journal of Cancer Prevention15 ( 10 ) , pp.4289 - 4294

Background: One of the most important reasons for the high mortality rates of cancer is the low level of awareness, which can lead to a late diagnosis and treatments starting too late. Therefore, it is necessary for individuals, especially at younger age, to gain awareness and integrate taking the necessary precautions into their lifestyle in order to prevent cancer and ensure early diagnosis. The aim of this study was to assess the levels of awareness of factors for major cancers among students studying in two different campuses of a university in the Western Black Sea Region. Materials and Methods: This descriptive/cross-sectional . . . study was performed between January-March 2014. Students studying in the 2013-2014 academic year in a university in the Western Black Sea Region in two separate campuses were the subjects. Results: The mean age was 21.01±3.63. While female students (51.2%) were the majority in the health sciences campus (74.8%), male students (48.8% ) were the majority in the social sciences campus (76.5%). Some 9.6% of the students from the health sciences campus and 12.4% of the students from the social sciences campus thought that cancer was communicable, while most of the students from both campuses knew that smoking caused cancer. It can also be seen that the rate of answering questions regarding cancer correctly was higher among students studying in the health sciences campus. Conclusions: It was determined that students who do not study at the health sciences campus have insufficient information on cancer, cancer symptoms, and the possibility of breast cancer in males and approximately half of them regarded obesity as a risk factor for cancer Daha fazlası Daha az

Chemotherapy in elderly patients with metastatic gastric cancer; a single Turkish cancer center experience

Bilir C. | Engin H. | Bakkal, Bekir Hakan | Ilikhan S.U. | Malkoç D.

Article | 2013 | Medicinski Glasnik10 ( 2 ) , pp.298 - 303

Aim To analyze the results of chemotherapy applied at the Bülent Ecevit University School of Medicine, Department of Medical Oncology, to elderly patients with metastatic gastric cancer (GC). Methods The study retrospectively investigated hospital records including pathological reports, imaging records, chemotherapy regimens, response and toxicity profile. All patients received systemic chemotherapy for pathologically proven metastatic GC at the Bülent Ecevit University School of Medicine, Department of Medical Oncology. Results From 2005 to 2012, 23 metastatic GC patients older than 70 years were treated with systemic chemotherapy . . .as a first-line therapy. As the first-line chemotherapy, 17 (74%) patients received polychemotherapy and the remaining six (26%) patients received monotherapy. Overall, 113 cycles were administered. The median progression free survival (PFS) for the first-line chemotherapy was 6 months (95% CI, 0-16) and the median overall survival (OS) was 14 months (95% CI, 3-30). Multivariate analysis revealed that decreased OS was significantly associated with poor Eastern Cooperative Oncology Group (ECOG) performance status (p=0.045), elevated carcinoembryonic antigen (CEA) levels at the diagnosis time (p = 0.040) and decreased number of chemotherapy cycles (p=0.019) with R-Sq (adj) = 41, 6%. One patient had a complete response with docetaxel, cisplatin and fluorouracil combined (DCF) regimen and had 12 months of disease free survival (DFS). Conclusion This is the first study investigating the outcomes of chemotherapy in Turkish elderly metastatic GC patients. Docetaxel, cisplatin and fluorouracil combination were the most common regimen, which is a tolerable and effective choice in elderly patients who had good performance status Daha fazlası Daha az

Determination of Spatial Distribution of Children Treated in Children Oncology Clinic with the Aid of Geographic Information Systems

Topan A. | Bayram D. | Özendi M. | Cam A. | Öztürk Ö. | Ayyıldız T.K. | Kulakçı H.

Article | 2016 | Journal of Medical Systems40 ( 10 ) , pp.298 - 303

The main objective of this research is to examine child cancer cases in Zonguldak/Turkey descriptively in epidemiological aspect with the help of GIS. Universe of the study is composed of 60 children between 1 and 19 years old who were treated in Children Oncology Clinic with a diagnosis of cancer. Whole universe was reached without selecting a sample in the study. Data were collected by using a form prepared by obtaining expert advice and they were applied to children and their parents at study dates. Results were expressed as percentages. Chi-Square test was used in intergroup comparisons, results were assessed within 95 % confide . . .nce interval and p < 0.05 was considered as statistically significant. Variables that were used in the study were assessed, recorded in prepared data collection form and distribution maps were produced. When disease diagnosis of the children participated in the study were evaluated, the most observed three types are ALL with 33.3 % (n = 20), Medullablastoma with 13.3 % (n = 8) and Hodgkin-nonHodgkin Lymphoma with 11.7 % (n = 7). Kdz. Eregli with 31.7 % (n = 19), Center with 31.7 % (n = 19), and Caycuma with 18.3 % (n = 11) are the first-three counties where the cases were mostly observed. Statistically significant difference was found (p = 0.016) comparing disease diagnosis with living place, and distribution maps of the number of cancer cases were produced. © 2016, Springer Science+Business Media New York Daha fazlası Daha az

Influence of radiation exposure during radiotherapy: Evidence for the increase of versican and heparin-binding EGF-like growth factor concentrations

Ozbilgin M.K. | Aktas C. | Uluer E.T. | Buyukuysal M.C. | Gareveran M.S. | Kurtman C.

Article | 2016 | Analytical and Quantitative Cytology and Histology38 ( 2 ) , pp.126 - 132

OBJECTIVE: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy. STUDY DESIGN: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. RESULTS . . .: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure. CONCLUSION: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy. © Science Printers and Publishers, Inc Daha fazlası Daha az

Drug targeting systems for cancer therapy: Nanotechnological approach

Aydın R.S.T.

Article | 2014 | Mini-Reviews in Medicinal Chemistry14 ( 13 ) , pp.1048 - 1054

Progress in cancer treatment remains challenging because of the great nature of tumor cells to be drug resistant. However, advances in the field of nanotechnology have enabled the delivery of drugs for cancer treatment by passively and actively targeting to tumor cells with nanoparticles. Dramatic improvements in nanotherapeutics, as applied to cancer, have rapidly accelerated clinical investigations. In this review, drug-targeting systems using nanotechnology and approved and clinically investigated nanoparticles for cancer therapy are discussed. In addition, the rationale for a nanotechnological approach to cancer therapy is empha . . .sized because of its promising advances in the treatment of cancer patients. © 2014 Bentham Science Publishers Daha fazlası Daha az

Severe dysplasia in a breast hamartoma: A premalign lesion? [Meme hamartomu dokusunda agir displazi: Premalign bir lezyon?]

Çakmak G.K. | Taşcilar Ö. | Gün B.D. | Erdem L.O. | Cesur A. | Balbaloglu H. | Cömert M.

Article | 2005 | Journal of the Turkish German Gynecology Association6 ( 1 ) , pp.54 - 56

Breast hamartomas are clinically and histopathologically rare cases that are known to be nonpremalignant lesions. In this report under the light of a breast hamartoma case, we aimed to discuss if breast hamartomas are as innocent lesions as they are considered to be. Although cancer development was not reported in our case, severe and disseminated dysplasia was determined in the hamartoma. As it is generally known, severe epithelial dysplasia is the final step just before the cancer development. This is consistent with the latest point of view reporting that cancer development may be seen in at least some types of hamartomas. In thi . . .s manuscript, under the light of the reported case in which severe dysplasia was determined histopathologically, the malignant potential of breast hamartomas was discussed and the literature reviewed Daha fazlası Daha az

Magnetic resonance imaging of prostate cancer

Guneyli S. | Erdem C.Z. | Erdem L.O.

Review | 2016 | Clinical Imaging40 ( 4 ) , pp.601 - 609

Prostate cancer is one of the causes of cancer-related deaths. Multiparametric magnetic resonance imaging (MRI) provides the best soft tissue resolution and plays an important role in the management of prostate cancer patients. It is the recommended imaging modality for patients with prostate cancer, and it is clinically indicated for diagnosis, staging, tumor localization, detection of tumor aggressiveness, follow-up, and MRI-guided interventions. Multiparametric MRI includes T1- and high-resolution T2-weighted imaging, diffusion-weighted imaging, and dynamic contrast-enhanced MRI. We evaluated MR images of patients with prostate c . . .ancer who underwent multiparametric endorectal MRI on a 3.0-T scanner and presented demonstrative images. © 2016 Elsevier Inc Daha fazlası Daha az

Cystatin C can be affected by nonrenal factors: A preliminary study on leukemia

Demirtaş S. | Akan Ö. | Can M. | Elmali E. | Akan H.

Article | 2006 | Clinical Biochemistry39 ( 2 ) , pp.115 - 118

Objective: The aim of this study was to evaluate the influence of malignancy and the impact of nephrotoxic drugs used in bone marrow transplantation (BMT) on the circulating levels of cystatin C in leukemia. Methods: We studied nineteen patients (eleven men and eight women; mean age 30.1 ± 11.2, 27.9 ± 7.1 years) with acute lymphoblastic leukemia, acute myeloid leukemia and chronic myeloid leukemia. Cystatin C, urea, creatinine and creatinine clearance (CrCl) were measured 24 h before BMT, 1 week after BMT, 2 weeks after BMT and 3 weeks after BMT. The control group consisted of twenty healthy adults, and the mean age was 29.1 ± 8.9. . . . Results: At the pretransplantation period, values of cystatin C were significantly higher than in the control group (P < 0.05). Urea, creatinine and CrCl values were not statistically different from the controls. One week after BMT, the level of cystatin C was significantly low as compared to the levels measured 24 h before BMT, but was still significantly higher than the controls (P < 0.05), whereas the levels of urea, creatinine and CrCl were in accordance with the levels of the controls. Two and three weeks after BMT, cystatin C values maintained the significant increase (P < 0.05), whereas the values of urea, creatinine and CrCl still corresponded with those of the controls in both group. Conclusions: Our preliminary data expose that cystatin C is not a reliable GFR marker in patients during leukemia or for monitoring nephrotoxic drugs used in BMT, but we can not reach definitive conclusion due to no gold standard for comparing the diagnostic accuracy of cystatin C. Further study is needed to elucidate the precise mechanism underlying this observation. © 2005 The Canadian Society of Clinical Chemists. All rights reserved Daha fazlası Daha az

Ovarian cancer during pregnancy

Barut A. | Arikan I. | Barut F. | Harma M. | Harma M.I. | Payasli B.

Article | 2011 | Journal of the Pakistan Medical Association61 ( 9 ) , pp.914 - 916

The frequency of cancer during pregnancy is approximately 1 per 1000 live births. This rate may increase as more women postpone childbirth until later in life, when cancer becomes more frequent. Pregnancy affectsmanagement of the cancer, and the cancer affects the management of pregnancy. The most common malignancies, in order of frequency, are breast cancer, leukaemia and lymphomas as a group, melanoma, gynaecologic cancers, and bone tumours. Ovarian tumours are found in about 1 in 1000 pregnancies and 3-6% of these are malignant. Thus, ovarian cancer occurs in approximately 1 in 12,500-25,000 pregnancies. Here, we report a case of . . . ovarian mucinous carcinoma that was diagnosed at 22 weeks of gestation. After conservative surgery, she was given three cycles of carboplatin chemotherapy. She delivered at 33 weeks of gestation and after undergoing surgery she was given six cycles of paclitaxel and carboplatin chemotherapy. The patient is now being followed by the oncology department with no evidence of disease Daha fazlası Daha az

SPATIAL DISTRUBITON OF CHILDREN TREATED BY CANCER IN ZONGULDAK, TURKEY

Topan, Aysel | Bayram, Dilek | Ozendi, Mustafa | Cam, Ali | Ozturk, Ozlem | Ayyildiz, Tulay Kuzlu | Kulakci, Hulya

Conference Object | 2016 | XXIII ISPRS CONGRESS, COMMISSION VIII41 ( B8 ) , pp.231 - 236

This research is focused on the examination of child cancer cases in Zonguldak ( Turkey) descriptively in epidemiological aspect thanks to GIS. Universe of the study is composed of 60 children between 0-19 years old, treated in Children Oncology Clinic of Health Application and Research Center in BEU. Whole universe was reached without selecting a sample in the study. Data were collected by using a form prepared by obtaining expert advice and they were applied to children and their parents at study dates. Results were expressed as percentages. Chi-Square test was used in intergroup comparisons, results were assessed within 95% confi . . .dence interval and p < 0.05 was considered as statistically significant. Variables that were used in the study were assessed, recorded in prepared data collection form and distribution maps were produced. When disease diagnosis of the children participated in the study were evaluated, it was observed that 33.3% (n=20) were being treated for ALL, 13.3% (n=8) for Medullablastoma and 11.7% (n=7) for Hodgkin-nonHodgkin Lymphoma. It was detected that 31.7% (n=19) were in Eregli, 31.7% (n=19) were in Central district and 18.3% (n=11) were in Caycuma, when the places where children were living were evaluated. Statistically significant difference was found (p=0.016) comparing disease diagnosis with living place, and overall distribution map of the number of cancer cases was produced in this context. This is the first research subjecting the distribution of cancer cases for Zonguldak province Daha fazlası Daha az

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