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Anticonvulsant and hypnotic effects of amiodarone

Ozbakis-Dengiz G. | Bakirci A.

Article | 2009 | Journal of Zhejiang University: Science B10 ( 4 ) , pp.317 - 322

Amiodarone hydrochloride is a potent anti-arrhythmic agent, known as a multiple ion-channel blocker in the heart. Although it has been detected in the rat brain, there are no data related to its central nervous system (CNS) effects. In this study, we evaluated anticonvulsant and hypnotic effects of amiodarone. Convulsions were induced by phentylenetetrazole (PTZ) (100 mg/kg) or caffeine (300 mg/kg) in mice. In both models, amiodarone prolonged both latency period and time to death, and acted as an anticonvulsant drug. It was found to be more effective in the PTZ model than in the caffeine model; none of the animals treated with 150 . . .mg/kg dose amiodarone had died in the PTZ model. For hypnotic effect, sleeping was induced with pentobarbital (35 mg/kg) in rats. Amiodarone dose-dependently increased the sleeping time (677.7%~725.9%). In the sleeping test, all rats in 200 mg/kg amiodarone group died. In conclusion, anticonvulsant and hypnotic effects of amiodarone have shown the depressant effects on CNS. These effects may be dependent on its pharmacological properties. © Zhejiang University and Springer-Verlag GmbH 2009 Daha fazlası Daha az

The effect of caffeine on oxidative stress in liver and heart tissues of rats [Kafeinin rat karaciger ve kalp dokusunda oksidan stres üerine etkisi]

Paşaoglu H. | Ofluoglu demir F.E. | Yilmaz Demirtaş C. | Hussein A. | Paşaoglu O.T.

Article | 2011 | Turkish Journal of Medical Sciences41 ( 4 ) , pp.665 - 671

To investigate the effect of caffeine on the levels of malondialdehyde (MDA), nitric oxide (NO), and advanced oxidation protein products (AOPP) in the liver and heart tissues of rats. The current study included 30 rats, which were divided into 3 groups: a control group and 2 caffeine-treated groups. Group 1 was given caffeine at 30 mg/kg and Group 2 was given caffeine at 100 mg/kg (a high nontoxic dose) for 14 days. MDA and AOPP levels in the liver tissue of the caffeine-treated groups decreased signicantly as a result of the dose. MDA and AOPP levels in the heart tissue also decreased, but this effect was not signicantly affected b . . .y the dose. NO levels in the liver tissue of the caffeine-treated groups were higher than those in the control group; in the heart tissues, however, NO levels were not signicantly affected by caffeine. These results show at e short-term consumption of 2 different doses of caffeine may potentially protect against oxidative stress in the liver. This effect is related to the dose of caffeine in the liver tissue. Further studies will be needed to discover e mechanisms responsible for these findings. © TÜBİTAK Daha fazlası Daha az

The effects of caffeine on the renal antioxidant activity in rats

Demir, Ebru Ofluoglu | Demirtas, Canan Yilmaz | Pasaoglu, Ozge Tugce

Article | 2016 | TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI41 ( 3 ) , pp.216 - 222

Objective: In our study, the short-term effects of caffeine on the renal antioxidant activity in rats were investigated. Methods: Caffeine was given orally at two different doses: 30 mg/kg and 100 mg/kg (a high non-toxic dose). The current study included 30 rats, which were divided into 3 groups: a control group and two caffeine-treated groups. Group 1 was given caffeine at 30 mg/kg and Group 2 was given caffeine at 100 mg/kg for 14 days. We measured advanced oxidation protein products (AOPP), malondialdehyde (MDA) and nitric oxide (NO) levels in the kidney tissue following caffeine administration. In addition, we also evaluated sup . . .eroxide dismutase (SOD), and glutathione S transferase (GST) activities in the kidney tissue. Results: Our results showed that caffeine administration decreased lipid peroxidation and advanced oxidation protein products in kidney. Especially, MDA levels in the kidney tissue of the caffeine-treated groups decreased significantly as a result of the dose. NO levels in the kidney tissue of the caffeine-treated groups were higher than those in the control group. GST activities in the kidney tissue of rats in the caffeine groups also increased significantly. In our study, we did not observe significant changes in renal SOD activities upon caffeine consuption. Conclusion: These results show that short-term consumption of two different doses of caffeine may protect against oxidative stress in the kidney tissue of rats. This effect is related to the caffeine dosage. Determining the mechanisms and antioxidant effects of caffeine at suitable dose requires advanced animal and human studies Daha fazlası Daha az

Effects of caffeine on oxidant-antioxidant mechanisms in the rat liver

Demirtaş C. | Ofluoglu E. | Hussein A. | Paşaoglu H.

Article | 2012 | Gazi Medical Journal23 ( 1 ) , pp.13 - 18

Objective: Caffeine (1, 3, 7-trimethylxanthine) is a purine alkaloid which exists in a variety of foods and drinks. Today, caffeine is a regularly consumed substance, found in coffee, tea, chocolate and cola. The main aim of our study was to compare the potential antioxidant effects of oral caffeine intake in rat the liver at two different doses over a short period of time. Methods: We measured malondialdehyde (MDA) levels, which is a product of lipid peroxidation, in rat livers following caffeine administration. In addition, we evaluated superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione S transferas . . .e (GST) activities as well as glutathione (GSH) levels in the liver. Thirty male Wister rats were used. Rats were equally divided into three groups. Group 1 was the control group, Group 2 received 30 mg/kg of caffeine and Group 3 received 100 mg/kg caffeine (non-toxic high dose) orally for 14 days (a short time period). Results: Our results showed that the 30mg/kg and 100 mg/kg caffeine doses decreased lipid peroxidation in liver. Antioxidant enzyme activities in the rat liver, like SOD, catalase, GPx and GST, showed a statistically significant increase with caffeine intake. Liver glutathione levels, in comparison to the control group, showed a slight increase, but this was not statistically significant. Results from the Spearman analysis showed a strong negative correlation between MDA levels and GPx, GST and SOD activities. Tissue GST activity and tissue catalase activity showed a strong positive correlation. Conclusion: Decreased lipid peroxidation and increased antioxidant enzyme activities demonstrate improved control of oxidative stress, suggesting that these doses of caffeine may have antioxidant activity. ©Copyright 2012 by Gazi University Medical Faculty Daha fazlası Daha az

The effects of caffeine on the renal antioxidant activity in rats [Ratlarda böbrek antioksidan aktivitesi üzerine kafeinin etkileri]

Demir E.O. | Demirtaş C.Y. | Paşaoğlu Ö.T.

Article | 2016 | Turkish Journal of Biochemistry41 ( 3 ) , pp.216 - 222

Objective: In our study, the short-term effects of caffeine on the renal antioxidant activity in rats were investigated. Methods: Caffeine was given orally at two different doses: 30 mg/kg and 100 mg/kg (a high non-toxic dose). The current study included 30 rats, which were divided into 3 groups: a control group and two caffeine-treated groups. Group 1 was given caffeine at 30 mg/kg and Group 2 was given caffeine at 100 mg/kg for 14 days. We measured advanced oxidation protein products (AOPP), malondialdehyde (MDA) and nitric oxide (NO) levels in the kidney tissue following caffeine administration. In addition, we also evaluated sup . . .eroxide dismutase (SOD), and glutathione S transferase (GST) activities in the kidney tissue. Results: Our results showed that caffeine administration decreased lipid peroxidation and advanced oxidation protein products in kidney. Especially, MDA levels in the kidney tissue of the caffeine-treated groups decreased significantly as a result of the dose. NO levels in the kidney tissue of the caffeine-treated groups were higher than those in the control group. GST activities in the kidney tissue of rats in the caffeine groups also increased significantly. In our study, we did not observe significant changes in renal SOD activities upon caffeine consuption. Conclusion: These results show that short-term consumption of two different doses of caffeine may protect against oxidative stress in the kidney tissue of rats. This effect is related to the caffeine dosage. Determining the mechanisms and antioxidant effects of caffeine at suitable dose requires advanced animal and human studies. © 2016, Turkish Biochemistry Society. All rights reserved Daha fazlası Daha az

Effects of omeprazole in caffeine and phentylenetetrazole-induced generalized seizures in mice

Dengiz G.Ö. | Halici Z. | Bakirci A.

Article | 2007 | Erciyes Tip Dergisi29 ( 3 ) , pp.184 - 188

Purpose: Because omeprazole has a carbonic anhydrase inhibitor activity, it was aimed to investigate whether omeprazole has anticonvulsant effect on caffeine and phentylenetetrazole (PTZ)-induced generalize seizures in mice. Material and Methods: Omeprazole (0.25- 0.5- 1- 2 mg/kg), diazepam (0.5 mg/kg for PTZ model and 5 mg/kg for caffeine model) and distilled water were administrated, 30 min later caffeine (300 mg/kg) or PTZ (100 mg/kg) were injected to all groups, intraperitoneally. Following the caffeine or PTZ injections, the time taken for the onset of the animals' first generalize tonic-clonic convulsion was measured in second . . ., was accepted as the latency period. Tolerance potential of omeprazole were done with 0.5 mg/kg (upon repeated administrated) in caffeine-induced convulsion model. Results: Following the caffeine and PTZ injections, omeprazole prolonged the latency periods in comparison with caffeine and PTZ groups. The longest latency was observed by omeprazole 0.5 mg/kg dose in the caffeine model (307.47 %, p< 0.05), and omeprazole had showed more protective effect in caffeine seizures than in PTZ seizures. In the tolerance study, latency periods were shortened by omeprazole on following days. Conclusion: Low doses of omeprazole, in especially caffeine-induced seizures, presented an anticonvulsant activity, but tolerance across to this action developed as the other carbonic anhydrase inhibitors Daha fazlası Daha az

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