Bozdogan, S. T. | Erol, B. | Dursun, A. | Bozdogan, G. | Donmez, I. | Mungan, N. A. | Seydaoglu, G.

Article | 2015 | WORLD JOURNAL OF UROLOGY33 ( 3 ) , pp.389 - 395

We investigated the relationship between the distribution of the IL-1RN, TNF-beta and IL-4 polymorphism and the clinical features of bladder cancer. A total of 100 patients with bladder carcinoma and 102 healthy control subjects were enrolled in the study. The IL-1RN, IL-4 and TNF-beta gene polymorphisms were identified by PCR restriction fragment length polymorphism-based analysis. Allelic frequencies were compared between patient and the controls. Tumor stage, histopathological grade, tumor size/number and smoking condition were evaluated with IL-1RN, IL-4 and TNF-beta gene polymorphisms. Allele distribution frequencies of IL-1RN . . .and IL-4 gene polymorphisms were significantly different between patients and control groups. However, allele distribution of TNF-beta gene was not statistically significant. There was no difference in allele distribution of the three genes in both groups regarding stage, tumor size, number of tumors and smoking condition. Although allele distribution of IL-4 gene showed significant difference considering histopathological grades in both smoking and total patients group, allele distribution of IL-1RN and TNF-beta was not different. The present research suggests that the IL-1RN and IL-4 gene polymorphisms are potential genetic markers of susceptibility to bladder cancer. In the future, clinical improvements on diagnosis, treatment and prognosis of bladder carcinoma are expected owing to development of more sensitive and specific tests for genetic polymorphisms of cytokines that are effective on inflammation Daha fazlası Daha az

Onak Kandemir N. | Bektaş S. | Barut F. | Bahadir B. | Yurdakan G. | Dogan Gun B. | Mungan A.

Article | 2010 | Turk Onkoloji Dergisi25 ( 2 ) , pp.49 - 56

OBJECTIVES: The contribution of cytological methods to the diagnosis and follow-up of urinary system malignancies was investigated in this study, along with histological diagnosis and clinical follow-up results of the cases. METHODS: One hundred forty-four cases who underwent cystoscopy in ZKÜTF Urology Department between 2003 and 2007 were included in this study, and urinary cytology and biopsy samples were assessed in the Pathology Department. RESULTS: When cytological and histological diagnoses were compared, results in 17 positive cases and in 109 negative cases were consistent. Three cases were false-positive and 15 cases were . . .false-negative. In our series, sensitivity of urinary cytological diagnostic methods was 53% and specificity was 97%. CONCLUSION: Our study shows that urinary cytology has a high diagnostic value in the evaluation of urinary system diseases. However, decrease in the sensitivity of this method in low-grade urothelial tumors should be taken into account. © 2010 Association of Oncology Daha fazlası Daha az

Bozdoğan S.T. | Erol B. | Dursun A. | Bozdoğan G. | Dönmez I. | Mungan N.A. | Seydaoglu G.

Article | 2015 | World Journal of Urology33 ( 3 ) , pp.389 - 395

Materials and methods: A total of 100 patients with bladder carcinoma and 102 healthy control subjects were enrolled in the study. The IL-1RN, IL-4 and TNF-ß gene polymorphisms were identified by PCR restriction fragment length polymorphism-based analysis. Allelic frequencies were compared between patient and the controls. Tumor stage, histopathological grade, tumor size/number and smoking condition were evaluated with IL-1RN, IL-4 and TNF-ß gene polymorphisms.Purpose: We investigated the relationship between the distribution of the IL-1RN, TNF-ß and IL-4 polymorphism and the clinical features of bladder cancer.Results: Allele distr . . .ibution frequencies of IL-1RN and IL-4 gene polymorphisms were significantly different between patients and control groups. However, allele distribution of TNF-ß gene was not statistically significant. There was no difference in allele distribution of the three genes in both groups regarding stage, tumor size, number of tumors and smoking condition. Although allele distribution of IL-4 gene showed significant difference considering histopathological grades in both smoking and total patients group, allele distribution of IL-1RN and TNF-ß was not different.Conclusion: The present research suggests that the IL-1RN and IL-4 gene polymorphisms are potential genetic markers of susceptibility to bladder cancer. In the future, clinical improvements on diagnosis, treatment and prognosis of bladder carcinoma are expected owing to development of more sensitive and specific tests for genetic polymorphisms of cytokines that are effective on inflammation. © 2014, Springer-Verlag Berlin Heidelberg Daha fazlası Daha az