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Unpredicted effects of Ankaferd (R) on cartilage tissue

Evren, Cenk | Ugur, Mehmet Birol | Yildirim, Burhan | Bektas, Sibel | Yigit, Volkan Bilge | Cinar, Fikret

Article | 2015 | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE8 ( 1 ) , pp.922 - 927

Objective: This study aims to investigate the histopathological changes secondary to the administration of Ankaferd Blood Stopper (R) (ABS) into the auricular cartilage. Materials and methods: Both of the auricular cartilages of thirty New Zealand rabbits were marked with tattoo ink. A 0.2-cc ABS (study group, n: 30) and 0.2 cc physiological saline (control group, n: 30) were subcutaneously infused into the right auricle and left auricle, respectively. All layers were removed at 14 days. Results: The ABS group had significantly higher level of fibrosis, necrosis, foreign body reaction, inflammation, and cartilage degeneration, compa . . .red to the controls. Conclusion: Our study results showed that ABS administration into a closed cavity led to a significantly increased fibrosis and necrosis in the auricular cartilage Daha fazlası Daha az

Unpredicted effects of ankaferd® on cartilage tissue

Evren C. | Uğur M.B. | Yıldırım B. | Bektaş S. | Yiğit V.B. | Çınar F.

Article | 2015 | International Journal of Clinical and Experimental Medicine8 ( 1 ) , pp.922 - 927

Objective: This study aims to investigate the histopathological changes secondary to the administration of Ankaferd Blood Stopper ® (ABS) into the auricular cartilage. Materials and methods: Both of the auricular cartilages of thirty New Zealand rabbits were marked with tattoo ink. A 0.2-cc ABS (study group, n: 30) and 0.2 cc physiological saline (control group, n: 30) were subcutaneously infused into the right auricle and left auricle, respectively. All layers were removed at 14 days. Results: The ABS group had significantly higher level of fibrosis, necrosis, foreign body reaction, inflammation, and cartilage degeneration, compare . . .d to the controls. Conclusion: Our study results showed that ABS administration into a closed cavity led to a significantly increased fibrosis and necrosis in the auricular cartilage. © 2015, E-Century Publishing Corporation. All rights reserved Daha fazlası Daha az

Comparison of the efficiencies of buffers containing ankaferd and chitosan on hemostasis in an experimental rat model with femoral artery bleeding

Abacıoğlu, Serkan | Aydın, Kemal | Büyükcam, Fatih | Kaya, Ural | Işık, Bahattin | Karakılıç, Muhammed Evvah

Article | 2016 | TURKISH JOURNAL OF HEMATOLOGY33 ( 1 ) , pp.48 - 52

Objective: In the first assessment of trauma patients with major vascular injuries, we need effective and rapid-acting homeostatic materials. In this study we compare the efficiencies of Ankaferd Blood Stopper (R) and a chitosan linear polymer (Celox (R)) in an experimental rat model with femoral artery bleeding. Materials and Methods: Thirty male Wistar albino rats weighing 200250 g were divided into 3 groups: control, Ankaferd, and chitosan. The femoral artery and vein were visualized and bleeding was started by an incision. The bleeding time was recorded and categorized as 'bleeding stopped at the second minute', 'bleeding stoppe . . .d at the fourth minute', and 'unsuccessful' if bleeding continued after the fourth minute. Results: In the control group, 60% of the bleeding did not stop. In the first 4 min in the Ankaferd group, the bleeding stopped in all rats; only in 1 of the rats in the chitosan group did the bleeding not stop. In stopping the bleeding in the first 4 min, Ankaferd was similar to chitosan but better than the control group; the chitosan group was similar to the control, but the p-value was close to significance. Conclusion: For major arterial bleeding, the main treatment is surgical bleeding control, but outside of the hospital we can use buffers containing Ankaferd and chitosan on the bleeding region. The results of this study should be supported with larger studies. Furthermore, in our study, healthy rats were used. New studies are needed to evaluate the results of hypovolemic and hypotensive cases with major artery bleeding Daha fazlası Daha az

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