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Bulunan: 46 Adet 0.001 sn
Primary thyroid lymphoma arising in the setting of Hashimoto's thyroiditis

Dogan Gün B. | Gün M.O. | Karamanoglu Z.

Article | 2004 | Turkish Journal of Medical Sciences34 ( 6 ) , pp.395 - 398

[No abstract available]

Xenobiotic/drug metabolizing enzyme and TP53 polymorphisms and clinical outcome in advanced nonsmall cell lung cancer patients

Karacaoğlan V. | Ada A.O. | Bilgen S. | Çetinkaya G.T. | Soydaş E. | Kunak C.S. | Alpar S.M.

Article | 2017 | Turkish Journal of Medical Sciences47 ( 2 ) , pp.554 - 562

Background/aim: The association between polymorphisms of xenobiotic/drug metabolizing enzymes and TP53 and response to chemotherapy and survival of patients with nonsmall cell lung cancer (NSCLC) are limited and inconclusive. In this study, CYP2E1*5B, CYP2E1*6, CYP2E1*7B, GSTO1 (A140D), and TP53 (Arg72Pro) polymorphisms and response to platinum-based chemotherapy and survival in 137 advanced stage NSCLC patients were investigated. Materials and methods: Genetic polymorphism analyses were determined by polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP). Results: The patients with TP53 Pro/Pro . . . variant were more likely to be resistant to chemotherapy than those with Arg/Arg variants with marginal significance (P = 0.066). We also analyzed these gene variants in combination with CYP1A1 (Ile462Val), CYP1B1 (Asn453Ser), GSTM1, GSTP1 exon 5 (Ile105Val), and GSTP1 exon 6 (Ala114Val) and GSTT1 polymorphic genes that we have previously genotyped in the same patients (Ada et al., Neoplasma, 57, 512-527, 2010). The multivariate analysis revealed that adjusted hazard ratio (HR) of death of the combined variant genotypes of TP53 (Arg72Pro, Pro72Pro) and CYP1A1 (Ile462Val, Val462Val) increased significantly as compared to wild-type genotypes (HR, 6.03; 95% CI, 1.39–26.04, P = 0.016). Conclusion: These results show that combined variant genotypes of TP53 (Arg72Pro, Pro72Pro) and CYP1A1 (Ile/Val, Val/Val) are associated with worsening of survival in NSCLC patients. © TÜBİTAK Daha fazlası Daha az

Comparison of thiopental and ketamine+xylazine anesthesia in ischemia/reperfusion-induced arrhythmias in rats

Gonca, Ersöz

Article | 2015 | Turkish Journal of Medical Sciences45 ( 6 ) , pp.1413 - 1420

Background/aim: To investigate the influence of thiopental (85 mg/kg, intraperitoneally (ip)), and ketamine+xylazine (ketamine 75 mg/kg and xylazine 8 mg/kg, ip) anesthesia on the incidence and duration of ischemia/reperfusion-induced arrhythmias. Materials and methods: Myocardial ischemia was induced by a 6-min ligation of the left anterior descending coronary artery, followed by a 6-min reperfusion. Measurements were taken of the incidence and duration of ventricular arrhythmias, the mean arterial blood pressure and heart rate, and the pressure rate-product (as an index of myocardial oxygen consumption). Results: The arrhythmia sc . . .ore and the incidence of ventricular fibrillation and tachycardia were significantly decreased in the ketamine+xylazine-anesthetized rats compared with the thiopental-anesthetized group (arrhythmia score: 2.0 ± 2.1 versus 3.7 ± 1.2, P < 0.05). The heart rate was significantly lower in the ketamine+xylazine group during the entire experiment, whilst the pressure-rate product was also significantly lower in the ketamine+xylazine group at different time points of the ischemia and reperfusion periods. Conclusion: Ketamine+xylazine anesthesia has a strong antiarrhythmic effect and an apparent depressive action on the heart rate and the myocardial oxygen consumption index. Therefore, ketamine+xylazine anesthesia is not appropriate for the evaluation of possible antiarrhythmic agents. Thiopental anesthesia is preferable to ketamine+xylazine anesthesia in the in vivo ischemia-reperfusion arrhythmia model. Background/aim: To investigate the influence of thiopental (85 mg/kg, intraperitoneally (ip)), and ketamine+xylazine (ketamine 75 mg/kg and xylazine 8 mg/kg, ip) anesthesia on the incidence and duration of ischemia/reperfusion-induced arrhythmias. Materials and methods: Myocardial ischemia was induced by a 6-min ligation of the left anterior descending coronary artery, followed by a 6-min reperfusion. Measurements were taken of the incidence and duration of ventricular arrhythmias, the mean arterial blood pressure and heart rate, and the pressure rate-product (as an index of myocardial oxygen consumption). Results: The arrhythmia score and the incidence of ventricular fibrillation and tachycardia were significantly decreased in the ketamine+xylazine-anesthetized rats compared with the thiopental-anesthetized group (arrhythmia score: 2.0 ± 2.1 versus 3.7 ± 1.2, P < 0.05). The heart rate was significantly lower in the ketamine+xylazine group during the entire experiment, whilst the pressure-rate product was also significantly lower in the ketamine+xylazine group at different time points of the ischemia and reperfusion periods. Conclusion: Ketamine+xylazine anesthesia has a strong antiarrhythmic effect and an apparent depressive action on the heart rate and the myocardial oxygen consumption index. Therefore, ketamine+xylazine anesthesia is not appropriate for the evaluation of possible antiarrhythmic agents. Thiopental anesthesia is preferable to ketamine+xylazine anesthesia in the in vivo ischemia-reperfusion arrhythmia model Daha fazlası Daha az

Role of FLT3 in the proliferation and aggressiveness of hepatocellular carcinoma

Aydın, Muammer Merve | Bayın, Nermin Sumru | Acun, Tolga | Yakıcıer, Mustafa Cengiz | Akçalı, Kamil Can

Article | 2016 | Turkish Journal of Medical Sciences46 ( 2 ) , pp.572 - 571

Background/aim: Previously we showed that Fms-like tyrosine kinase (FLT3) changes its cellular localization upon partial hepatectomy, suggesting a role in liver regeneration. FLT3 was also shown to play an important function in cellular proliferation and activation of PI3K and Ras. Thus, we aimed to investigate the role of FLT3 in hepatocellular tumorigenesis utilizing in vitro and in vivo models. Materials and methods: We used Snu398 cells that express FLT3. We investigated these cells’ in vitro proliferation and invasion abilities by treatment with the FLT3 inhibitor K-252a or by knocking-down with FLT3 shRNA,. Furthermore, the ef . . .fect of blocking FLT3 activity and expression during in vivo tumorigenesis was assessed with xenograft models. Results: After K-252a treatment or stable knock-down, these cells’ proliferation and migration abilities were highly diminished in vitro. In addition, significant diminution in tumorigenicity of Snu398 cells was also obtained in vivo. When FLT3 knocked-down Snu398 cells were injected into nude mice, we did not detect &#945;SMA expression in these tumors, suggesting a role for FLT3 in in vivo invasiveness. Conclusion: Our data provided evidence that FLT3 has a crucial role both in hepatocarcinogenesis and its invasiveness. Therefore, targeting FLT3 and/or its activity may be a promising tool for combating hepatocellular carcinomas. Background/aim: Previously we showed that Fms-like tyrosine kinase (FLT3) changes its cellular localization upon partial hepatectomy, suggesting a role in liver regeneration. FLT3 was also shown to play an important function in cellular proliferation and activation of PI3K and Ras. Thus, we aimed to investigate the role of FLT3 in hepatocellular tumorigenesis utilizing in vitro and in vivo models. Materials and methods: We used Snu398 cells that express FLT3. We investigated these cells’ in vitro proliferation and invasion abilities by treatment with the FLT3 inhibitor K-252a or by knocking-down with FLT3 shRNA,. Furthermore, the effect of blocking FLT3 activity and expression during in vivo tumorigenesis was assessed with xenograft models. Results: After K-252a treatment or stable knock-down, these cells’ proliferation and migration abilities were highly diminished in vitro. In addition, significant diminution in tumorigenicity of Snu398 cells was also obtained in vivo. When FLT3 knocked-down Snu398 cells were injected into nude mice, we did not detect &#945;SMA expression in these tumors, suggesting a role for FLT3 in in vivo invasiveness. Conclusion: Our data provided evidence that FLT3 has a crucial role both in hepatocarcinogenesis and its invasiveness. Therefore, targeting FLT3 and/or its activity may be a promising tool for combating hepatocellular carcinomas Daha fazlası Daha az

Total white blood cell count, liver enzymes, and metabolic syndrome in schizophrenia

Karakaş Uğurlu G. | Ulusoy Kaymak S. | Uğurlu M. | Örsel S. | Çayköylü A.

Article | 2016 | Turkish Journal of Medical Sciences46 ( 2 ) , pp.259 - 264

Background/aim: Metabolic syndrome (MetS) is an important clinical issue in patients with schizophrenia, but its associated factors are still ambiguous. The aim of the present study was to test whether there are any associations between MetS and white blood cell (WBC) levels, liver enzymes, or sociodemographic variables. Materials and methods: The study included 91 patients with a diagnosis of schizophrenia. We used the National Cholesterol Education Program’s Third Adult Treatment Protocol criteria to evaluate MetS in patients. Schizophrenia patients with MetS were compared with those without MetS on the basis of demographic and cl . . .inical characteristics and total WBC counts. We conducted Spearman’s correlation and binary logistic regression analyses to achieve the best prediction of MetS in schizophrenia. Results: Compared with schizophrenia patients without MetS, those with MetS were older, less educated, and more likely to be smokers. They were also more likely to have a longer duration of the illness, a longer untreated period, and higher alanine aminotransferase (ALT) and WBC levels. MetS was correlated with age, duration of illness, income, ALT, gamma-glutamyl transpeptidase, WBC, and hemoglobin values. Age and WBC levels were found to be the best predictors of MetS. Conclusion: Hemograms and liver tests should be conducted to test for MetS in schizophrenia. © TÜBİTAK Daha fazlası Daha az

Premenstrual syndrome and life quality in Turkish health science students

Işik H. | Ergöl Ş. | Aynioğlu Ö. | Şahbaz A. | Kuzu A. | Uzun M.

Article | 2016 | Turkish Journal of Medical Sciences46 ( 3 ) , pp.695 - 701

Background/aim: The purpose of the present study was to investigate the incidence of PMS, risk factors affecting PMS symptoms, and life quality in health science students. Materials and methods: A total of 608 volunteer female students studying at the health campus of a state university in Turkey were included in the study. The participants were asked to fill out questionnaires on sociodemographic data, PMS symptoms, and SF-36 life quality tests. Results: The overall frequency of PMS among participants was 84.5%. The average PMS and general health SF scores were 118.34 ± 37.3 and 20.03 ± 3.72, respectively. Students who had irregula . . .r breakfast, drank ?2 cups of coffee/day, and consumed alcohol or fast food had higher PMS scores. Irregular menstruation and family history increased PMS scores and decreased life quality (P < 0.05). The life quality of the students significantly decreased as the severity of PMS increased (P < 0.001). Conclusion: Low body mass index, family history, irregular menstruation, bad eating habits such as fast food consumption and irregular breakfasts, and coffee and alcohol consumption increased PMS risk significantly. In order to improve their life quality, students should be informed about the symptoms, risk factors, and management options of PMS. © TÜBİTAK Daha fazlası Daha az

Evaluation of plantar pressure distributions in patients with anterior cruciate ligament deficiency: preoperative and postoperative changes

Çetin, Engin | Deveci, Mehmet Ali | Songür, Murat | Özer, Hamza | Turanlı, Sacit

Article | 2017 | Turkish Journal of Medical Sciences47 ( 2 ) , pp.587 - 591

Background/aim: Anterior cruciate ligament (ACL) deficiency results in several kinematic changes in the lower extremities. The aim of this study is to define the plantar pressure parameters in ACL-deficient patients and to show the effect of ACL reconstruction on dynamic plantar pressure. Materials and methods: Forty patients with unilateral ACL rupture and 40 healthy controls were included in this study. Dynamic plantar pressures of both groups were recorded by the EMED SF-2 system during level walking. Thirteen of the patients who had ACL reconstructions with hamstring autografts (HS group) were reevaluated at an average of 14.5 m . . .onths following the ACL reconstructions. Results: ACL-deficient patients had significantly lower hindfoot (P = 0.007) but higher midfoot pressure values (P = 0.03) on their ipsilateral foot compared to control group subjects. Ipsilateral hindfoot pressures were also found to be significantly lower than those of the contralateral foot (P = 0.001). Hindfoot pressure values of the HS group were increased in postoperative measurements (P = 0.01). Conclusion: ACL-deficient patients have altered plantar pressure distributions and ACL reconstructions restore these changes to normal. Pedobarography might be used as a practical method for dynamic functional assessment of ACL-deficient patients. Background/aim: Anterior cruciate ligament (ACL) deficiency results in several kinematic changes in the lower extremities. The aim of this study is to define the plantar pressure parameters in ACL-deficient patients and to show the effect of ACL reconstruction on dynamic plantar pressure. Materials and methods: Forty patients with unilateral ACL rupture and 40 healthy controls were included in this study. Dynamic plantar pressures of both groups were recorded by the EMED SF-2 system during level walking. Thirteen of the patients who had ACL reconstructions with hamstring autografts (HS group) were reevaluated at an average of 14.5 months following the ACL reconstructions. Results: ACL-deficient patients had significantly lower hindfoot (P = 0.007) but higher midfoot pressure values (P = 0.03) on their ipsilateral foot compared to control group subjects. Ipsilateral hindfoot pressures were also found to be significantly lower than those of the contralateral foot (P = 0.001). Hindfoot pressure values of the HS group were increased in postoperative measurements (P = 0.01). Conclusion: ACL-deficient patients have altered plantar pressure distributions and ACL reconstructions restore these changes to normal. Pedobarography might be used as a practical method for dynamic functional assessment of ACL-deficient patients Daha fazlası Daha az

Tramadol as an adjunct for levobupivacaine in axillary plexus blockade: a prospective, randomized, double-blind study

Yurtlu, Bülent Serhan | Hancı, Volkan | Ege, Ahmet | Bostankolu, Selime Evrim | Ayoğlu, Hilal | Özkoçak, Işıl Turan

Article | 2012 | Turkish Journal of Medical Sciences42 ( 1 ) , pp.55 - 62

Amaç: Bu randomize prospektif çift kör çalışmada aksiller pleksus bloğunda levobupivakaine tramadol eklenmesinin etkilerini araştırmayı amaçladık. Yöntem ve gereç: El veya önkolda cerrahisi için aksiller pleksus bloğu planlanan 60 hasta randomize olarak iki gruba ayrıldı. Grup L’de 36 mL % 0,5 levobupivakain ve 2 ml serum fi zyolojik; Grup LT’de 36 mL % 0.5 levobupivakain ve 2 mL 100 mg tramadol kullanıldı. Rutin monitörizasyonu takiben aksiller blok sinir stimülatörüyle çoklu stimülasyon tekniği kullanılarak uygulandı. Motor (parmak, el bileği, dirsek hareketleri) ve duyusal (kutanöz pinprik duyusu) blok karakteristikleri radiyal, . . .medyan, ulnar ve muskulokutanöz sinirler için her 5 dakikada değerlendirildi. Postoperatif motor ve duyusal blok süresi, analjezik tüketimi ve nümerik ağrı skoru (NRS) kaydedildi. Bulgular: Her grupta 2’şer hastada blok başarısızlığı mevcuttu. Kalan 56 hastanın verileri analiz edildi. Çalışma grupları arasında dört sinirin motor ve duyusal blok karakteristikleri, analjezik tüketimleri ve NRS skorları arasında fark yoktu. Sonuç: Aksiller blokta % 0,5 levobupivakaine 100 mg tramadol eklenmesi intraoperatif blok kalitesini artırmamış ve postoperatif analjezi süresini uzatmamıştır Aim: To evaluate the eff ect of tramadol addition to levobupivacaine in axillary plexus blockade in a prospective, randomized double-blind study. Materials and methods: A total of 60 patients scheduled to undergo hand and forearm surgery under axillary plexus blockade were randomly divided into 2 groups. Group L received 36 mL of racemic 0.5% levobupivacaine with 2 mL of saline, whereas Group LT received 2 mL (100 mg) of tramadol instead of saline. Aft er routine monitorization, axillary block was performed with a multistimulation technique using a nerve stimulator. Motor (fi nger, wrist, and elbow movements) and sensory (pinprick sensation for the cutaneous supply) block characteristics for radial, median, ulnar, and musculocutaneous nerves were determined every 5 min. Postoperative motor and sensory block duration, analgesic consumption, and numeric rating scale (NRS) scores were also recorded. Results: In each group, 2 patients had block failures. Th e data for the remaining 56 patients were analyzed. Th ere were no signifi cant diff erences between the study groups according to motor and sensory block characteristics of 4 nerves, block durations, analgesic consumption, and NRS scores. Conclusion: Th e addition of 100 mg of tramadol to 0.5% levobupivacaine for axillary brachial plexus blockade neither improved the intraoperative block quality nor prolonged the duration of postoperative analgesia Daha fazlası Daha az

The status of oxidants and antioxidants in the neutrophils of patients with recurrent aphthous stomatitis

Altınyazar, Hilmi Cevdet | Gürel, Ahmet | Koca, Rafet | Armutçu, Ferah | Ünalacak, Murat

Article | 2006 | Turkish Journal of Medical Sciences36 ( 2 ) , pp.87 - 91

Recurrent aphthous stomatitis (RAS) is an inflammatory condition of unknown etiology. The exact role of the leukocytes in the pathogenesis of RAS is not known. The aim of this study was to evaluate the status of the oxidative system in neutophils of RAS patients. A total of 26 patients and 22 sex and age matched healthy control subjects were analyzed by measuring intracellular oxidant/antioxidant enzymes and related parameters; myeloperoxidase (MPO), xanthine oxidase (XO), catalase (CAT), superoxide dismutase (SOD), adenosine deaminase (AD), malondialdehyde (MDA) and nitric oxide (NO). Statistically significant increases in the acti . . .vities of SOD, CAT and levels of MDA, NO were detected in the neutrophils of patients. There was no significant difference in MPO, AD and XO activities of neutrophils. Although the functions of neutrophils were normal, there may be an oxidative stress affecting neutrophils in RAS. Recurrent aphthous stomatitis (RAS) is an inflammatory condition of unknown etiology. The exact role of the leukocytes in the pathogenesis of RAS is not known. The aim of this study was to evaluate the status of the oxidative system in neutophils of RAS patients. A total of 26 patients and 22 sex and age matched healthy control subjects were analyzed by measuring intracellular oxidant/antioxidant enzymes and related parameters; myeloperoxidase (MPO), xanthine oxidase (XO), catalase (CAT), superoxide dismutase (SOD), adenosine deaminase (AD), malondialdehyde (MDA) and nitric oxide (NO). Statistically significant increases in the activities of SOD, CAT and levels of MDA, NO were detected in the neutrophils of patients. There was no significant difference in MPO, AD and XO activities of neutrophils. Although the functions of neutrophils were normal, there may be an oxidative stress affecting neutrophils in RAS Daha fazlası Daha az

An indispensable toxin known for 2500 years: Victims of mad honey

Demir Akca A.S. | Kahveci F.O.

Article | 2012 | Turkish Journal of Medical Sciences42 ( SUPPL.2 ) , pp.1499 - 1504

Aim: Mad honey (bitter honey) is a local name for a particular type of honey used in alternative medicine to treat gastric pain, bowel disorders, and hypertension, and as a sexual stimulant in the Black Sea coastal region of Turkey. Grayonotoxin behaves like cholinergic agents and has dosage dependent adverse effects on the cardiovascular system including bradycardia, atrioventricular block (AVB), and arterial hypotension. In this manuscript, we report 37 cases of mad honey intoxication from the western Black Sea region. Materials and methods: This was a retrospective case series of 37 patients who were admitted to the emergency dep . . .artment of a tertiary center with a history of mad honey intake between June 2003 and June 2010. Results: Patients consisted of 31 males (83.7%) and 6 females (16.3%). Mean age was 56.17 ± 12.56 and 69.66 ± 11.75 in males and females, respectively. Initial physical examination findings included hypotension in 18 patients, sinus bradycardia in 17, and complete AVB in 5 patients. Conclusion: Mad honey poisoning is an important, life-threatening issue in the Black Sea region of Turkey. Mad honey intoxication should be considered in the differential diagnosis in emergency cases of bradycardia and hypotension. © TÜBİTAK Daha fazlası Daha az

Total white blood cell count, liver enzymes, and metabolic syndrome in schizophrenia

Uğurlu, Görkem Karakaş | Kaymak, Semra Ulusoy | Uğurlu, Mustafa | Örsel, Sibel | Çayköylü, Ali

Article | 2016 | Turkish Journal of Medical Sciences46 ( 2 ) , pp.259 - 264

Background/aim: Metabolic syndrome (MetS) is an important clinical issue in patients with schizophrenia, but its associated factors are still ambiguous. The aim of the present study was to test whether there are any associations between MetS and white blood cell (WBC) levels, liver enzymes, or sociodemographic variables. Materials and methods: The study included 91 patients with a diagnosis of schizophrenia. We used the National Cholesterol Education Program’s Third Adult Treatment Protocol criteria to evaluate MetS in patients. Schizophrenia patients with MetS were compared with those without MetS on the basis of demographic and cl . . .inical characteristics and total WBC counts. We conducted Spearman’s correlation and binary logistic regression analyses to achieve the best prediction of MetS in schizophrenia. Results: Compared with schizophrenia patients without MetS, those with MetS were older, less educated, and more likely to be smokers. They were also more likely to have a longer duration of the illness, a longer untreated period, and higher alanine aminotransferase (ALT) and WBC levels. MetS was correlated with age, duration of illness, income, ALT, gamma-glutamyl transpeptidase, WBC, and hemoglobin values. Age and WBC levels were found to be the best predictors of MetS. Conclusion: Hemograms and liver tests should be conducted to test for MetS in schizophrenia. Background/aim: Metabolic syndrome (MetS) is an important clinical issue in patients with schizophrenia, but its associated factors are still ambiguous. The aim of the present study was to test whether there are any associations between MetS and white blood cell (WBC) levels, liver enzymes, or sociodemographic variables. Materials and methods: The study included 91 patients with a diagnosis of schizophrenia. We used the National Cholesterol Education Program’s Third Adult Treatment Protocol criteria to evaluate MetS in patients. Schizophrenia patients with MetS were compared with those without MetS on the basis of demographic and clinical characteristics and total WBC counts. We conducted Spearman’s correlation and binary logistic regression analyses to achieve the best prediction of MetS in schizophrenia. Results: Compared with schizophrenia patients without MetS, those with MetS were older, less educated, and more likely to be smokers. They were also more likely to have a longer duration of the illness, a longer untreated period, and higher alanine aminotransferase (ALT) and WBC levels. MetS was correlated with age, duration of illness, income, ALT, gamma-glutamyl transpeptidase, WBC, and hemoglobin values. Age and WBC levels were found to be the best predictors of MetS. Conclusion: Hemograms and liver tests should be conducted to test for MetS in schizophrenia Daha fazlası Daha az

Serum leptin, lipoprotein levels, and glucose homeostasis between national wrestlers and sedentary males [Türk milli güreşçilerin ve sedanterlerin serum leptin ve serum lipoprotein seviyeleri ve glukoz homeostazinin karşilaştirilmasi]

Yamaner F. | Bayraktaroglu T. | Atmaca H. | Ziyagil M.A. | Tamer K.

Article | 2010 | Turkish Journal of Medical Sciences40 ( 3 ) , pp.471 - 477

Aim: Leptin is an important controller of the size of fat stores by inhibiting appetite. In wrestling, fat metabolism is important not only for aerobic energy system, but also for weight control and weight loss before competition. The aim of this study was to measure and compare the serum leptin levels, glucose homeostasis, and serum lipoproteins between Turkish national wrestlers and sedentary males. Materials and methods: Forty-five Turkish national wrestlers at the end of Olympic training camp before Beijing 2008 Olympic Games and 43 sedentary students were selected as subjects. Post-exercise levels of serum leptin, HOMA (Homeost . . .asis model assessment) values, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, and VLDL-cholesterol were measured after overnight fasting. A Mann-Whitney U test was used to test the differences between 2 groups. Pearson Correlation was conducted between leptin and the other parameters. Results: No significant difference was observed among the means of leptin and total cholesterol levels of the 2 groups. Wrestlers had significantly higher fasting insulin, HDL-cholesterol, triglyceride, and HOMA levels, but a lower LDL-cholesterol level compared to the sedentary males. The positive correlation was only found between leptin and fasting insulin levels (r = 0.310, P = 0.043). Conclusion: This study indicated that wrestling training had no effect on resting leptin level after overnight fasting and wrestlers had also decreased insulin sensitivity with higher fasting insulin, HDL-cholesterol, triglyceride, and HOMA levels compared to sedentary males. © TÜBİTAK Daha fazlası Daha az

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