Balci, Elcin | Durmus, Hasan | Arslantas, Ebru Ergun | Gun, Iskender

Article | 2018 | TURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGY12 ( 2 ) , pp.96 - 99

Objective: It was aimed to determine the knowledge, attitudes and behaviors of individuals on the harmful effects of the sun and protection ways. Methods: This research is descriptive and cross-sectional. The study was completed with the participation of 1634 individuals. As a data collection tool, a questionnaire including of 23 questions was used. Results: 30.4% (n=496) of the individuals had sufficient knowledge about the harmful effects of sun. Those who were educated more than eight years had knowledge about the harmful effects of sunlight twice as much than those who were educated less. In their daily lives, the time they have . . . been exposed to sun was evaluated to be less than one hour, 1-3 hours, 4 hours and over, and results were determined 20.7%, 46.3%, and 33.0% respectively. The rate of using sunscreen cream is 40.3%; when evaluated according to gender, women were found to use twice as many sunscreen creams as men and this rate were found 54.4% and 24.2% respectively. Conclusion: It can be said that the knowledge and behaviors of the community about how to protect themselves about the harmful effects of the sun are inadequate. The fact that the health authorities is drawn attention to this subject for raising awareness of community, warned about the subject by all health workers, especially physicians, will be effective in protecting future generations from skin diseases caused by the sun influences Daha fazlası Daha az

Cobanoglu, Mutlu | Ozbey, Ozgur | Savk, Oner | Ozgezmez, Ferit

Article | 2016 | MEANDROS MEDICAL AND DENTAL JOURNAL17 ( 2 ) , pp.83 - 89

Objective: Our aim was to investigate the clinical and radiological outcomes of double-plate fixation with grafting in the treatment of non-union of humeral shaft fractures. Materials and Methods: We performed a retrospective chart review of patients operated between 2006 and 2012 due to humeral shaft non-union. Patients undergoing surgery with double-plate fixation were included and those treated with external fixator, single plate, intramedullary nails and patients with pathological fractures and infected non-unions were excluded. Surgical intervention via anterolateral or posterior approach included radial nerve identification, d . . .ecortication and reestablishment of medullary canal followed by compression plating with double-plate fixation and frequent application of autogenous grafts or allografts. Main outcome measures were success rate of non-union repair, rate of re-intervention and complications, range of motion, assessment of pain Visual analogue scale (VAS) and function Disabilities of the arm, shoulder and hand (DASH) and overall outcome Stewart-Hundley classification. Results: Ten patients were treated with double-plate fixation. The study group included six females and four males aged 36 to 70 years. Union was achieved within 4.5 and 8 months in all cases. The mean preoperative VAS score of 6.1 decreased to 2, postoperatively, with an associated decrease in the mean DASH score from 74.1 to 23.4. Excellent or good results were obtained in nine cases. There was no incidence of radial nerve palsy or infection. Conclusion: Our study provides level 4 evidence of the effectiveness of treating non-union fractures of the humeral shaft with double-plate fixation and grafting in providing good-to-excellent functional results and high union rate without any significant complication Daha fazlası Daha az

Baltaci, Sumer | Bozlu, Murat | Yildirim, Asif | Gokce, Mehmet Ilker | Tinay, Ilker | Aslan, Guven | Can, Cavit

Article | 2016 | JOURNAL OF UROLOGICAL SURGERY3 ( 3 ) , pp.74 - 79

Objective To determine the effect of age on recurrence and progression rates in a population of high-risk non-muscle invasive bladder cancer (NMIBC) patients treated with a second transurethral resection (TUR) and at least 1 year of maintenance Bacillus Calmette-Guerin (BCG) therapy. Materials and Methods In this multicenter study, we reviewed the data of patients treated for high-risk NMIBC between 2005 and 2012. Patients without a muscle-invasive cancer on second TUR and received induction BCG and at least one year of maintenance BCG therapy and at least 12 months of follow-up after completion of maintenance BCG were included. Eff . . .ect of age was analyzed both dichotomously (< 70 or >= 70 years) as well as by 10-year increments. Chi-square test, Student's T-test and analysis of variance (ANOVA) were used for comparison of the groups. Univariate and multivariate logistic regression analyses were performed to identify predictors of recurrence and progression. Results Overall, 242 eligible patients were included. Baseline parameters were similar. With a mean follow-up of 29.4 +/- 22.2 months, neither 3-year recurrence-free survival nor 3-year progression-free survival differed between the age groups when examined either dichotomously or by 10-year increments. Conclusion In high-risk NMIBC patients treated with a second TUR and received maintenance BCG therapy, age was not associated with increased rates of neither recurrence nor progression. Until a randomized prospective clinical trial assess the appropriate adjuvant intravesical therapy in the elderly, elderly patients should probably be treated in the same manner as younger patients Daha fazlası Daha az

Gunay, Oyusuf | Tutuncu, Tanju | Ocalan, Tuba | Bilgihan, Ayse | Korkmaz, Gulcan | Kama, Nuri Aydin

Article | 2019 | HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI57 ( 1 ) , pp.91 - 97

Aim: The etiopathogenesis of gallstone formation is well known, but only a few studies have investigated the effects of thyrotoxicosis on gallstone formation. In this study, we investigated the contribution of thyrotoxicosis to gallstone formation in rabbits. Methods: Forty-four New Zealand rabbits were used. The rabbits were divided into six groups, with each group receiving a different diet. At the end of seven weeks, all rabbits were sacrificed, blood was collected for analysis, and cholecystectomy was performed. Results: Serum levels of both free triiodothyronine (FT3) and thyroxine (FT4) were significantly higher in rabbits rec . . .eiving thyroid hormone ( Daha fazlası Daha az

Bilensoy, Erem | Erdogar, Nazli | Mungan, Aydin N.

Review | 2015 | UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY14 ( 1 ) , pp.61 - 66

Bladder cancer is the ninth most common cancer types in the world and transitional bladder cancer constitutes 90% of all bladder cancer neoplasms depending on cancer cell morphology. Clinical choice of treatment is transurethral resection (TUR), after which the recurrence rate is 50-80% and the tumor has a 14% chance of progression. To avoid recurrence and progression, adjuvant intravesical chemotherapy or immunotherapy is required. Intravesical drug delivery has many advantages. Bladder allows manipulation since it is easily accessible and a closed area, allows catheterization rendering this organ to be an advantageous site for loc . . .alized drug delivery. Drugs are administered into urinary bladder directly resulting in greater exposure of tissues to drug. On the other hand, because of periodical discharge, rapid drug dilution necessitates repeated catheterization and results in loss of drug efficacy. Another disadvantage is the very low permeability of urothelium. Urothelium limits the absorption of molecules into the systemic circulation and prevent adherence of foreign agents on the urothelial surface exerting the same effect of drugs and drug delivery systems. To overcome these problems, nanotechnological approach in the biomedical field seems promising and in this frame new drug carrier systems were focused and bioadhesive nanoparticles were developed. Nanoparticles are submicron, solid, colloidal particles in a size ranging between 10 to 1000 nm. Nanoparticles are generally prepared from biodegradable polymers with specific physicochemical properties and are loaded with active molecules to act as drug delivery systems. Bioadhesive nanoparticles allow prolonged residence time of drug in the mucosal tissues such as bladder wall and can be promising to pass the bladder permeability barrier. Due to their particle size and surface charge, they sustain the drug release at cancerous tissues and protect the drug from acidic urine pH and other degradation factors such as hydrolysis and photodegradation. In addition, nanoparticulate carriers form a drug reservoir in the action site to reduce drug loss and to improve drug efficacy. In this study, we aim to review the role and application of nanoparticles in noninvasive bladder tumors with current literature Daha fazlası Daha az

Piskin, Ozcan | Aydin, Bengu Gulhan | Bas, Yilmaz | Karakaya, Kemal | Can, Murat | Elmas, Ozlem | Buyukuysal, Mustafa Cagatay

Article | 2018 | HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI56 ( 1 ) , pp.14 - 21

Aim: The aim of this study was to evaluate the protective use of quercetin in a rat model of radiation-induced enteritis and colitis. Methods: Twenty four adult rats were randomly divided into four groups. Group SHAM was given only physiological saline, group QUER was given quercetin 50 mg/kg for 15 days, group RAD was given only irradiation and group QUER+ RAD was given quercetin 50 mg/kg, and then irradiated. Twenty four hours after the exposure to radiation, all rats were euthanized for the evaluation of the ileum and colon morphology and biochemical measurements. Results: Compared with the SHAM group, the serum malondialdehyde ( . . .MDA) level was significantly higher in group RAD (p=0.004) and was significantly decreased in group QUER+ RAD (p=0.015). The MDA levels in the ileum and colon tissues were significantly higher in group RAD (p=0.004 and p=0.002, respectively), while treatment with quercetin significantly reduced lipid peroxidation in both tissues in group QUER+ RAD (p=0.015 and p=0.009, respectively). Compared with the control group, the serum total antioxidant status (TAS) level was significantly lower in Group RAD (p=0.002) and was significantly increased in group QUER+ RAD (p=0.009). TAS in the ileum and colon tissues were significantly lower in group RAD (p=0.002 and p=0.002) and were significantly higher in both tissues in group QUER+ RAD (p=0.002 and p=0.002, respectively). Conclusion: This study confirmed that, in the model of radiation-induced ileitis and colitis in rats, quercetin effectively decreased oxidative stress and inflammatory damage to both ileum and colon tissues Daha fazlası Daha az

Cinar, Onder | Mungan, Necmettin Aydin

Review | 2019 | UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY18 ( 1 ) , pp.30 - 33

Bladder cancer (BC) is one of the commonly diagnosed urological cancers that causes human death, ranked as the seventh most common cancer worldwide. To date, no reliable diagnostic tool has been defined to recognize non-muscle invasive bladder tumors other than cystoscopy. For this reason, scientists have focused on finding new non-invasive biomarkers that can be used to diagnose BC with higher specificity and sensitivity. The purpose of this study was to evaluate the diagnostic role and prognostic significance of microRNA-21 (miR-21) in non-muscle invasive bladder tumors. In this review, the overall diagnostic performance of miR-21 . . . was discussed on non-invasive BC based on a literature search of PubMed and Cochrane Library. Although findings are insufficient, promising results have been reported regarding circulating miR-21 as a biomarker for BC prospective studies with larger numbers of participants are needed Daha fazlası Daha az

Celik, Tuba

Article | 2018 | GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS16 ( 2 ) , pp.230 - 246

Pediatric uveitis is important for clinicians due to various clinical presentations, the risk of ambliyopia and the limitation of treatment modalities. Childhood uveitis is often recognized during routine eye examination and may cause severe complications because of the limitation of treatment modalities. The patients are encountered with severe complications such as glaucoma, cataract, amblyopia and band keratopathy in the period which is passing by waiting for the development of tolerance to inflammation or follow-up with suboptimal treatment. In this review, the main causes of childhood uveitis and the treatment aproaches are discussed.

Polat, Sefika Burcak | Arpaci, Dilek | Yazgan, Aylin | Baser, Husniye | Kilic, Mehmet | Ersoy, Reyhan | Cakir, Bekir

Article | 2016 | TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM20 ( 2 ) , pp.31 - 35

Purpose: Neoplasms of the thyroid gland are classified according to the cells they originate from and commonly develop from cells of follicular origin. The most common differentiated thyroid cancers (DTC) are papillary and follicular carcinomas. Coexistence of two different histological types of primary follicular thyroid neoplasm is a rare condition. There are previous reports of concomitant medullary and papillary thyroid cancers. However, there is scarce data about the simultaneous occurrence of the two different histological types of primary follicular thyroid tumors and this is the first study on that subject. Material and Meth . . .od: From January 2007 to September 2014, our institutional database was reviewed for patients who underwent thyroid surgery for various indications. Medical records and cytopathology reports of those patients were examined retrospectively. Simultaneous neoplasms of follicular origin were noted. Results: A total of 3.700 patients were operated. Histopathological examination revealed a benign pattern in 2.686 (73%) patients and a malignant pattern in 1.014 (27%) patients. Among the patients with the diagnosis of DTC, only 20 (1.9%) had a concomitant neoplasm within the same thyroid gland. Discussion: Such simultaneous tumors may be a part of a familial tumor syndrome or an unidentified novel gene mutation playing role in the pathogenesis of more than one type of tumor. Based on the current evidence, the synchronous occurrence of those neoplasms in a given patient is likely coincidental in the literature. Further studies on larger patient population with standardized genetic characterization are needed Daha fazlası Daha az

Aktas, Caner | Kurtman, Cengiz | Ozbilgin, M. Kemal | Tek, Ibrahim | Toprak, Selami Kocak

Article | 2013 | TURKISH JOURNAL OF HEMATOLOGY30 ( 4 ) , pp.371 - 378

Objective: This study investigated whether or not the stress and hypoxia, which are the effects of radiation on normal vascular endothelium, leading to the release of HIF-1 alpha, VEGF, eIF2, TIA-1, and TSP-1 were related and the possibility of them stimulating angiogenesis. Materials and Methods: Twenty-four male Swiss Albino mice were separated into 4 groups. The first group was the control group (Group 1), and the second, third, and fourth groups were euthanized after 24 h (Group 2), 48 h (Group 3), and 7 days (Group 4), respectively. A single-fractioned 10 Gy of ionizing radiation was applied to all mice's pelvic zone with Co-60 . . .. Bladders were removed completely from the pelvic region. Immunohistochemistry and light microscopy were used to investigate whether there would be an increase or not in the angiogenesis pathway by using the HIF-1 alpha, VEGF, eIF2, TIA-1, and TSP-1 antibodies. Results: The HIP-1 alpha antibody showed strong staining in Group 3, while the staining intensity was less in other groups. VEGF showed weak staining in Groups 1 and 4, while moderate staining in Group 2 and strong staining in Group 3 was observed. eIF2 showed strong staining in Groups 1 and 4. Groups 2 and 3 were stained weakly. In the present study, staining with TSP-1 was very strong in the samples belonging to Group 1, while other groups showed very weak staining. Conclusion: When normal tissue was exposed to radiation, the positively effective factors (HIF-1, VEGF, eIF2, and TIA-1) on the angiogenesis pathway were increased while the negative factor (TSP-1) was decreased. Radiation may initiate physiological angiogenesis in the normal tissue and accelerate healing in the damaged normal tissue Daha fazlası Daha az

Irer, Bora | Sen, Volkan | Erbatu, Oguzcan | Yildiz, Alperen | Ongun, Sakir | Cinar, Onder | Cihan, Ahmet

Article | 2018 | JOURNAL OF UROLOGICAL SURGERY5 ( 3 ) , pp.158 - 163

Objective:The aim of this study is to compare the efficacy and complications of holmium laser and pneumatic lithotripsy used in the ureterorenoscopic treatment of proximal ureteral stones. Materials and Methods: Data of 638 patients, who underwent ureterorenoscopy (URS) due to proximal ureteral stones in different centers, were obtained from patient files. The patients were divided into two groups according to the type of lithotripter used: group 1; laser lithotripter (n=324; 50.8%) and group 2; pneumatic lithotripter (n=314; 49.2%). URS was considered successful upon determination stone-free status with the imaging methods after tr . . .eatment. The effectiveness and the complications of holmium:yttrium-aluminum-garnet laser and pneumatic lithotripsy were compared. Results: The total success rate of URS was 82.6% and the complication rate was 8.1%. The mean age of patients was similar between the groups; however, the body mass index values, stone surface area and stone Hounsfield unit were significantly higher in group 1. Although the mean operative time, complication rate and the mean length of hospital stay were similar between the groups; the URS success and postoperative ureteral J stent use rates were significantly higher in group 1 and the push-back rate was significantly higher in group 2. Conclusion: If laser lithotripsy is available in a clinic, we believe that it is better to use it as the first option in the treatment of proximal ureter stones. However, considering that it is not easy to access laser lithotripters due to their high cost in Turkey, pneumatic lithotripters may be an effective and inexpensive alternative that can also be safely used in these cases Daha fazlası Daha az

Gencoglu, Nliay Nur | Kucukosman, Gamze | Aydin, Bengu Golhan | Okyay, Dilek Rahsan | Piskin, Ozcan | Sezer, Ustun | Harma, Mehmet Ibrahim

Article | 2019 | HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI57 ( 2 ) , pp.114 - 121

Aim: The aim was to investigate the effects of preoperative anxiety and general anesthetic administrations on intraoperative awareness among patients undergoing cesarean section. Methods: This prospective randomized study included 90 pregnant subjects. Preoperative anxiety was assessed using the Beck Anxiety Inventory. The patients were divided into three groups: group P received propofol 2.5 mg/kg, group T thiopental 5 mg/kg and group K received ketamine 1 mg/kg. Data on intraoperative hemodynamics, isolated forearm (IFA) responses and time to first pain and to first analgesic requirement evaluated using postoperative numerical rat . . .ing scale were recorded. The Modified Brice Scale (MBS) was used to assess awareness. Results: The preoperative anxiety levels in the groups were low and demographic data were similar (p>0.05). There was no statistically significant difference in IFA response between the groups (p>0.05). Group T had higher MAP at all times and NRS values at hour 0 compared to the other groups ( Daha fazlası Daha az