The effect of radiotherapy on cardiac function

BACKGROUND: Radiation-induced heart disease is a complication that may be encountered after radiotherapy (RT) of tumors in the vicinity of the heart. In this study, we aimed to evaluate the effect of RT on the heart, by comparing conventional and tissue Doppler echocardiography parameters obtained before and after RT. METHODS: Forty patients who had undergone RT for either lung or left breast cancer were included in the study. ECG, conventional, and tissue Doppler echocardiography were performed before and 4-6 weeks after RT. RESULTS: The mean value of the radiation dose applied to all regions of the heart was calculated as 13.1±2.2 Gy (maximum 41.7 Gy). The value for the left ventricle was 10.2±2.0 Gy (maximum 43.6 Gy). A decrease in early transmitral diastolic velocity (E), E/A ratio, EF, Em, and Em/Am, and an increase in E-wave deceleration time, isovolumic relaxation time, isovolumic contraction time, ejection time, and QTc were found after RT. CONCLUSION: We found detrimental effects of RT on systolic and diastolic cardiac functions and the electrical conduction system of the heart. Maximal prevention should be provided for the patients during RT. © 2012 Lippincott Williams & Wilkins, Inc.

Eser Adı
[dc.title]
The effect of radiotherapy on cardiac function
Yazar
[dc.contributor.author]
Dogan S.M.
Yazar
[dc.contributor.author]
Bilici H.M.
Yazar
[dc.contributor.author]
Bakkal, Bekir Hakan
Yazar
[dc.contributor.author]
Aydin M.
Yazar
[dc.contributor.author]
Karabag T.
Yazar
[dc.contributor.author]
Sayin M.R.
Yazar
[dc.contributor.author]
Aktop Z.
Yayın Yılı
[dc.date.issued]
2012
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
BACKGROUND: Radiation-induced heart disease is a complication that may be encountered after radiotherapy (RT) of tumors in the vicinity of the heart. In this study, we aimed to evaluate the effect of RT on the heart, by comparing conventional and tissue Doppler echocardiography parameters obtained before and after RT. METHODS: Forty patients who had undergone RT for either lung or left breast cancer were included in the study. ECG, conventional, and tissue Doppler echocardiography were performed before and 4-6 weeks after RT. RESULTS: The mean value of the radiation dose applied to all regions of the heart was calculated as 13.1±2.2 Gy (maximum 41.7 Gy). The value for the left ventricle was 10.2±2.0 Gy (maximum 43.6 Gy). A decrease in early transmitral diastolic velocity (E), E/A ratio, EF, Em, and Em/Am, and an increase in E-wave deceleration time, isovolumic relaxation time, isovolumic contraction time, ejection time, and QTc were found after RT. CONCLUSION: We found detrimental effects of RT on systolic and diastolic cardiac functions and the electrical conduction system of the heart. Maximal prevention should be provided for the patients during RT. © 2012 Lippincott Williams & Wilkins, Inc.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
diastolic dysfunction
Konu Başlıkları
[dc.subject]
ejection fraction
Konu Başlıkları
[dc.subject]
radiotherapy
Konu Başlıkları
[dc.subject]
tissue Doppler echocardiography
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0954-6928
İlk Sayfa Sayısı
[dc.identifier.startpage]
146
Son Sayfa Sayısı
[dc.identifier.endpage]
154
Dergi Adı
[dc.relation.journal]
Coronary Artery Disease
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
23
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1097/MCA.0b013e32835115d6
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7982
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37
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tissue conventional Doppler echocardiography patients isovolumic before (maximum diastolic E-wave increase decrease transmitral velocity BACKGROUND deceleration Maximal Wilkins Williams Lippincott during provided should prevention system relaxation conduction electrical functions cardiac systolic effects detrimental CONCLUSION ejection
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