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Primary intestinal diffuse large B-cell lymphoma forming multiple lymphomatous polyposis

Barut, Figen | Kandemir, Onak Nilüfer | Karakaya, Kemal | Kökten, Neslihan | Özdamar, Şükrü Oğuz

Article | 2011 | Turkish Journal of Gastroenterology22 ( 3 ) , pp.324 - 328

Multifokal ve atlamalı tutulum, primer gastrointestinal lenfomalar için oldukça nadir görülen bir gelişim paternidir. Klinik ve makroskopik özellikleriyle Crohn hastalığını taklit eden kaldırım taşı görünümü ile dikkat çeken bir ince barsağın multifokal diffüz büyük B hücreli lenfoma olgusu, klinik ve patolojik özellikleri ile beraber sunulmuştur. 25 yaşındaki erkek olgunun jejunoileal rezeksiyon materyalinde, arada sağlam görünümde mukoza alanları izlenen, en büyüğü 2,5 cm çapında olan, ülsere, serozayı da infiltre eden polipoid görünümde multipl lezyonlar izlendi. Mikroskopik incelemede, belirgin nükleollü, veziküler nükleuslu, ge . . .niş eozinofilik sitoplazmalı, pleomorfik, atipik karakterde lenfoid hücrelerden oluşmuş tümöral infiltrasyon gözlendi. Bu atipik hücrelerde vimentin, LCA, CD20, CD79a ile B hücre fenotipinde immün reaksiyon izlendi. Olguya, diffüz büyük B hücreli lenfoma tanısı verildi. Crohn hastalığı belirti ve bulguları ile başvuran hastalarda nadir de olsa bu antitenin olabileceği vurgulanmıştır. Multifocal and skip involvement is quite a rare developmental pattern for primary gastrointestinal lymphomas. A 25-year-old male patient with diffuse large B-cell lymphoma of the small intestine, with macroscopic features and clinical aspects imitating Crohn’s disease and attracting attention with cobblestone-like appearance, is presented herein together with the clinical and pathological features. Multiple ulcerated lesions were also observed infiltrating the serosa with polypoid appearance, 2.5 cm in largest diameter, within the resected jejunoileal specimen, which displayed patchy, healthy-appearing mucosal areas. In microscopic examination, a tumoral infiltration was observed comprised of pleomorphic, atypical lymphoid cells with abundant eosinophilic cytoplasm, marked nucleoli and vesicular nuclei. A B-cell phenotype immunoreaction was observed by vimentin, LCA, CD20, and CD79a in those atypical cells. The diagnosis of the case was diffuse large B-cell lymphoma.The possibility of the presence of this disorder, although rare, is emphasized here for patients applying to the hospital with the signs and symptoms of Crohn’s disease Daha fazlası Daha az

Rehabilitation of a large radicular cyst of the mandible without using any bone substitutes: Case report

Misir A.F. | Birol Ugur M. | Kandemir N.O.

Article | 2014 | Cumhuriyet Dental Journal1 , pp.53 - 57

The radicular cyst variously known as periapical, apical periodontal, dentoalveolar or rootend cyst is an inflammatory jaw cyst at the apices of teeth with infected and necrotic pulps. A radicular cyst arises from the epithelial residues in the periodontal ligament as a result of inflammation, usually following death of the pulp. Radicular cysts are the most common odontogenic cystic lesions of inflammatory origin and are managed either by surgical enucleation or by marsupialization. We illustrate the possibility of complete healing of a cystic periapical lesion of huge proportion in permanent dentition of a 58 year-old male patient . . . under general anesthesia with conservation of vital structures and without using any bone substitute Daha fazlası Daha az

Filgrastim helps to heal herpes zoster faster: Two case reports

Sayin M. | Bakkal, Bekir Hakan

Article | 2011 | Tumori97 ( 1 ) , pp.123 - 125

Herpes zoster is an infectious disease caused by varicella-zoster virus that may occur sporadically at any age. We report on two patients with herpes zoster who received chemotherapy for breast cancer. Both patients were immunocompromised and received filgrastimtherapy for themanagement of neutropenia. Zoster occurred during filgrastim therapy but the symptoms were alleviated rapidly in the course of therapy. We conclude that granulocyte colony-stimulating factor therapy helped symptom alleviation and accelerated the recovery fromherpes zoster in our chemotherapy-treated patients. Free full text available at

Pulmonary and central nervous system involvement in sweet's syndrome: A very rare case report

Aydemir H. | Öztoprak N. | Celebi G. | Altinyazar C. | Barut F. | Piskin N. | Akduman D.

Article | 2008 | Internal Medicine47 ( 16 ) , pp.1481 - 1484

Sweet's syndrome is a multisystem inflammatory disorder characterized by painful, erythematous plaques and aseptic neutrophilic infiltration of various organs. The absence of vasculitis is a histological criterion for diagnostic, but recent reports suggest that vasculitis can occur in Sweet's syndrome. Involvement of the central nervous system and the pulmonary system is very rare. In this case study we describe a chronic alcoholic man with Sweet's syndrome associated with acute-onset encephalitis and severe pulmonary involvement. The patient's symptoms responded dramatically to steroid treatment, and notably, a skin biopsy of his l . . .esions showed vasculitis. © 2008 The Japanese Society of Internal Medicine Daha fazlası Daha az

Ovarian heterotopic pregnancy clinically mimicking endometrioma: histopathological and immunohistochemical features

Kandemir, N. Onak | Barut, Figen | Yurdakan, G. | Bayar, U.

Conference Object | 2008 | HISTOPATHOLOGY53 , pp.198 - 198

27th International Congress of the International-Academy-of-Pathology -- OCT 12-17, 2008 -- Athens, GREECE WOS: 000259524800452

Papuloerythroderma of Ofuji: A report of two cases [Ofuji'nin papuloeritroderması: Iki olgu sunumu]

Sarici G. | Koca R. | Işik S. | Sezer T. | Çinar S. | Kandemir N.O.

Article | 2011 | Turk Dermatoloji Dergisi5 ( 1 ) , pp.13 - 17

Papuloerythroderma of Ofuji is characterized by a pruritic eruption of widespread, red, flat papules that leads to spare skin folds. The disease occurs primarily in elderly men and is often associated with lymphadenopathy, peripheral blood eosinophilia, lymphopenia and elevated immunoglobulin E levels. Association with T and B cell lymphomas, visceral carcinomas, AIDS, atopic dermatitis, psoriasis and hypersensitivity to drugs have been reported. Topical and systemic corticosteroids, psoralen-UVA, etretinate-PUVA, acitretin-PUVA, UVB, cyclosporin, interferon ? and azathioprine have been used in the treatment of this rare disease. In . . . this manuscript, we described two patients with papuloerythroderma of Ofuji Daha fazlası Daha az

Intranodal palisaded myofibroblastoma (intranodal hemorrhagic spindle cell tumor with amianthoid fibers): A case report and literature review

Kandemir N.O. | Barut F. | Ekinci T. | Karagülle Ç. | Özdamar Ş.O.

Article | 2010 | Diagnostic Pathology5 ( 1 ) , pp.13 - 17

Oxidized low-density lipoproteins accumulate in rat lung after experimental lung edema induced by alpha- naphthylthiourea (ANTU)

Sipahi E.Y. | Ozel Tekin I. | Comert M. | Barut F. | Ustun H. | Sipahi T.H.

Article | 2004 | Pharmacological Research50 ( 6 ) , pp.585 - 591

Oxidation of the low-density lipoprotein (LDL) results in the production of modified LDLs. Oxidation of LDL cholesterol plays a role on the pathogenesis of endothelial dysfunction. This study was designed to investigate the possible participation of the oxidative modification of low density lipoprotein in the lung edema induced by alpha-naphthylthiourea (ANTU), which is a well-known noxious chemical agent on the lung endothelium. When ANTU injected intraperitoneally into rats (15 mg kg-1), it produced lung edema as indicated by an increase in lung weight/body weight (LW/BW) ratio and pleural effusion (PE) reaching a maximum within 4 . . . h. A significant lung edema was observed 4 h after intraperitoneally injection of alpha-naphthylthiourea when compared with olive oil-injected control rats. On microscopic examination of alpha-naphthylthiourea-treated rats were shown to have severe lung injury, while no change was observed in olive oil-treated control rats. While there were no staining in control lungs, positive oxidized low-density lipoproteins immune-fluorescent staining were observed in lung edema group. Our study showed that oxidized low-density lipoprotein (oxLDL) accumulated in ANTU-induced lung damage. This is the first study in which accumulation of oxLDL molecules in the intact lung tissue were shown by fluorescent immune-staining method in experimental lung edema. The potential role of oxLDL in this pathology are still under investigation. © 2004 Elsevier Ltd. All rights reserved Daha fazlası Daha az

Clinicopathological significance of fascin and CD44v6 expression in endometrioid carcinoma

Gun B.D. | Bahadir B. | Bektas S. | Barut F. | Yurdakan G. | Kandemir N.O. | Ozdamar S.O.

Article | 2012 | Diagnostic Pathology7 ( 1 ) , pp.585 - 591

Background: Fascin and CD44v6 may have significant roles as biomarkers in tumour progression and metastasis. In endometrioid carcinomas, the fascin expression profile is less defined, and the significance of CD44v6 is uncertain. We aimed to investigate the expressions of both fascin and CD44v6 in endometrioid carcinomas and to evaluate their inter-relation with clinicopathological parameters.Methods: Fascin and CD44v6 expressions were evaluated, individually and in combination, in a series of 47 endometrioid carcinomas and 10 proliferative endometrium samples. The staining extent and intensity of both markers in tumour cells were sc . . .ored semiquantitatively. The relationship between immunoexpressions and clinicopathological variables was assessed.Results: The expression rates of fascin and CD44v6 in endometrioid carcinoma were 72.34% and 46.80%, respectively. Although these expression rates were higher than those in proliferative endometrial samples, fascin expression showed a statistically significant difference from the normal group (p = 0.02), but CD44v6 did not differ (p = 0.54). Fascin expression was significantly correlated with tumour grade (p = 0.003) and neural invasion (p = 0.036) in a univariate analysis. In contrast, no significant correlation was found between CD44v6 and any of the clinicopathological parameters.Conclusions: Our findings suggest that fascin might be an independent prognostic indicator in the different steps of extracellular matrix invasion. On the other hand, CD44v6 was not a predictive factor in endometrioid cancer.Virtual Slides: The virtual slide(s) for this article can be found here: © 2012 Gun et al.; licensee BioMed Central Ltd Daha fazlası Daha az

Ovarian cancer during pregnancy

Barut A. | Arikan I. | Barut F. | Harma M. | Harma M.I. | Payasli B.

Article | 2011 | Journal of the Pakistan Medical Association61 ( 9 ) , pp.914 - 916

The frequency of cancer during pregnancy is approximately 1 per 1000 live births. This rate may increase as more women postpone childbirth until later in life, when cancer becomes more frequent. Pregnancy affectsmanagement of the cancer, and the cancer affects the management of pregnancy. The most common malignancies, in order of frequency, are breast cancer, leukaemia and lymphomas as a group, melanoma, gynaecologic cancers, and bone tumours. Ovarian tumours are found in about 1 in 1000 pregnancies and 3-6% of these are malignant. Thus, ovarian cancer occurs in approximately 1 in 12,500-25,000 pregnancies. Here, we report a case of . . . ovarian mucinous carcinoma that was diagnosed at 22 weeks of gestation. After conservative surgery, she was given three cycles of carboplatin chemotherapy. She delivered at 33 weeks of gestation and after undergoing surgery she was given six cycles of paclitaxel and carboplatin chemotherapy. The patient is now being followed by the oncology department with no evidence of disease Daha fazlası Daha az

Effect of ozone oxidative preconditioning in preventing early radiation-induced lung injury in rats

Bakkal, Bekir Hakan | Gultekin F.A. | Guven B. | Turkcu U.O. | Bektas S. | Can M.

Article | 2013 | Brazilian Journal of Medical and Biological Research46 ( 9 ) , pp.789 - 796

Ionizing radiation causes its biological effects mainly through oxidative damage induced by reactive oxygen species. Previous studies showed that ozone oxidative preconditioning attenuated pathophysiological events mediated by reactive oxygen species. As inhalation of ozone induces lung injury, the aim of this study was to examine whether ozone oxidative preconditioning potentiates or attenuates the effects of irradiation on the lung. Rats were subjected to total body irradiation, with or without treatment with ozone oxidative preconditioning (0.72 mg/kg). Serum proinflammatory cytokine levels, oxidative damage markers, and histopat . . .hological analysis were compared at 6 and 72 h after total body irradiation. Irradiation significantly increased lung malondialdehyde levels as an end-product of lipoperoxidation. Irradiation also significantly decreased lung superoxide dismutase activity, which is an indicator of the generation of oxidative stress and an early protective response to oxidative damage. Ozone oxidative preconditioning plus irradiation significantly decreased malondialdehyde levels and increased the activity of superoxide dismutase, which might indicate protection of the lung from radiation-induced lung injury. Serum tumor necrosis factor alpha and interleukin-1 beta levels, which increased significantly following total body irradiation, were decreased with ozone oxidative preconditioning. Moreover, ozone oxidative preconditioning was able to ameliorate radiation-induced lung injury assessed by histopathological evaluation. In conclusion, ozone oxidative preconditioning, repeated low-dose intraperitoneal administration of ozone, did not exacerbate radiation-induced lung injury, and, on the contrary, it provided protection against radiation-induced lung damage Daha fazlası Daha az

C-Kit (CD117) expression in classic Kaposi's sarcoma: Experimental dermatology

Kandemir N.O. | Gun B.D. | Bahadir B. | Yurdakan G. | Ozdemir N. | Karadayi N. | Ozdamar S.O.

Article | 2010 | Clinical and Experimental Dermatology35 ( 5 ) , pp.525 - 530

Background. Kaposi's sarcoma is a multicentric, low-grade, vascular neoplasia. Human herpesvirus 8 is associated with all epidemiological forms of KS and has been shown in vitro to induce the tyrosine receptor kinase c-Kit in infected cells. Aim. To investigate the expression of c-Kit in cases of classic KS and to clarify its association with clinicopathological parameters and HHV8 latency-associated nuclear antigen-1 expression. Methods. In total, 35 cases of classic KS at various histological stages were included in the study. Age and gender of the patients and location and histological stage of the tumours were recorded. Formalin . . .-fixed, paraffin wax-embedded tissue sections were stained by immunohistochemistry with antibodies to c-Kit and HHV8. Results. c-Kit immunoreactivity was found in 22 cases and HHV8 immunoreactivity was present in all cases. There was no correlation in c-Kit immunoreactivity between clinicopathological parameters and HHV8 immunoreactivity. Conclusions. The results of our study show that in cases of classic KS there is a high rate of c-Kit immunoreactivity, but c-Kit expression does not show any correlation with HHV8 immunoreactivity. © 2009 British Association of Dermatologists Daha fazlası Daha az

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