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Effect of the ratio of inhibitory and excitatory conductance on the regularity of spontaneous cortical activity

Özer, Mahmut | Uzuntarla, Muhammet | Graham, Lyle J.

Cortical neurons in vivo can operate in a continuum between low-conductance (LC) and high-conductance (HC) states. We investigate how changing the ratio, r, of the mean inhibitory conductance to a fixed value of the mean excitatory conductance affects the regularity of spontaneous cortical firing between the two extreme states. We show that, in general, spike regularity becomes smaller for larger r, thus as the neuron approaches the HC state. Furthermore, in the HC state, spike regularity consistently increases with an increase of the synaptic input variability, whereas with small r, thus LC s ...Daha fazlası

A computer software for an efficient finger-tapping test

Özer, Mahmut | Özdemir, Taner | Gümüş, Mustafa

Quantitative description of finger-tapping movements provides more insight into the disturbances in execution of normal motor rhythm, which might be associated with brain damage. Therefore, development of finger-tapping test devices and software is of great importance. In this study, we introduce new computer software to apply a finger-tapping test through a computer keyboard. Free and preconditioned finger-tapping tests can be carried out, and test results can be analyzed within the software and saved in the software database. The test results can also be exported on any spreadsheet platform ...Daha fazlası

Propagation of firing rate in a feedforward network with stochastic Hodgkin-Huxley neurons

Uzuntarla, Muhammet | Özer, Mahmut | Köklükaya, Etem

We study firing rate propagation in a feedforward network with multiple layers. Neurons in the network are modeled by using stochastic Hodgkin-Huxley neuronal model, which considers stochastic behaviour of voltage-gated ion channels embedded in neuronal membranes. In the model, ion channel noise due to its stochastic behaviour is related to the cell size in such a way that the noise strength increases with decreasing the cell size, mimicking the actual biophysical conditions. An external additive current noise is also injected into the first layer of the network. Therefore, neurons in the firs ...Daha fazlası

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