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Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits

Gunay, Oyusuf | Tutuncu, Tanju | Ocalan, Tuba | Bilgihan, Ayse | Korkmaz, Gulcan | Kama, Nuri Aydin

Article | 2019 | HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI57 ( 1 ) , pp.91 - 97

Aim: The etiopathogenesis of gallstone formation is well known, but only a few studies have investigated the effects of thyrotoxicosis on gallstone formation. In this study, we investigated the contribution of thyrotoxicosis to gallstone formation in rabbits. Methods: Forty-four New Zealand rabbits were used. The rabbits were divided into six groups, with each group receiving a different diet. At the end of seven weeks, all rabbits were sacrificed, blood was collected for analysis, and cholecystectomy was performed. Results: Serum levels of both free triiodothyronine (FT3) and thyroxine (FT4) were significantly higher in rabbits rec . . .eiving thyroid hormone ( Daha fazlası Daha az

Simultaneous Occurrence of Different Follicular Neoplasms within the Same Thyroid Gland

Polat, Sefika Burcak | Arpaci, Dilek | Yazgan, Aylin | Baser, Husniye | Kilic, Mehmet | Ersoy, Reyhan | Cakir, Bekir

Article | 2016 | TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM20 ( 2 ) , pp.31 - 35

Purpose: Neoplasms of the thyroid gland are classified according to the cells they originate from and commonly develop from cells of follicular origin. The most common differentiated thyroid cancers (DTC) are papillary and follicular carcinomas. Coexistence of two different histological types of primary follicular thyroid neoplasm is a rare condition. There are previous reports of concomitant medullary and papillary thyroid cancers. However, there is scarce data about the simultaneous occurrence of the two different histological types of primary follicular thyroid tumors and this is the first study on that subject. Material and Meth . . .od: From January 2007 to September 2014, our institutional database was reviewed for patients who underwent thyroid surgery for various indications. Medical records and cytopathology reports of those patients were examined retrospectively. Simultaneous neoplasms of follicular origin were noted. Results: A total of 3.700 patients were operated. Histopathological examination revealed a benign pattern in 2.686 (73%) patients and a malignant pattern in 1.014 (27%) patients. Among the patients with the diagnosis of DTC, only 20 (1.9%) had a concomitant neoplasm within the same thyroid gland. Discussion: Such simultaneous tumors may be a part of a familial tumor syndrome or an unidentified novel gene mutation playing role in the pathogenesis of more than one type of tumor. Based on the current evidence, the synchronous occurrence of those neoplasms in a given patient is likely coincidental in the literature. Further studies on larger patient population with standardized genetic characterization are needed Daha fazlası Daha az

Effect of Prophylactic Antibiotic Use in the Development of Antibiotic Resistance in Children with Recurrent Urinary Tract Infections

Karaci, Mehmet | Karagoz, Kazim | Ornek, Zuhal | Yasar, Adem | Yuce, Necla | Okumus, Ozgur

Article | 2017 | HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI55 ( 3 ) , pp.221 - 228

Aim: Although prophylactic antibiotic treatment is still debatable, it is currently in use in recurrent urinary tract infections (UTIs). In the present study, we aimed to observe if prophylactic antibiotic use had any effect on the development of antibiotic resistance in patients with recurrent UTIs who we followed up in our clinic. Methods: The present study was performed on patients aged between one month and 16 years, who had recurrent UTIs, and were followed up by the Department of Pediatrics at Bulent Ecevit University Medical School. Patient files were retrospectively reviewed, and 50 patients who received antibiotic prophylax . . .is and 100 patients without prophylaxis were enrolled in the study. Urinary tests, subsequent urinary culture results, and antibiotic resistances were compared between the groups. Results: The mean age was 42.7 +/- 44.2 months. The most frequently cultured isolated bacterium was Escherichia coli (E. coli) (58.4%). No difference was determined in bacteria in cultures between prophylaxis receivers and non-receivers. Isolation rate of E. coli was higher in urinary cultures in females than in males ( Daha fazlası Daha az

Assessment of Relation Between Subjective Memory Complaints and Objective Cognitive Performance of Elderly Over 55 Years Old Age

Acikgoz, Mustafa | Ozen Barut, Banu | Emre, Ufuk | Tascilar, Nida | Atalay, Adnan | Kokturk, Furuzan

Article | 2014 | NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY51 ( 1 ) , pp.57 - 62

Introduction: This study investigated the frequency of forgetfulness in elderly individuals over 55 years of age and examined the association of subjective memory complaints (SMCs) with objective cognitive functions,, depression and other risk factors. Methods: We recruited 405 patients over 55 years of age who were referred to Neurology, Cardiology, or Physical Therapy and Rehabilitation outpatient clinics. All subjects were questioned regarding forgetfulness and then were administered the Subjective Memory Complaint (SMC) Scale, Mini Mental Test (MMT), Verbal Fluency Test (VFT), Clock Drawing Test (CDT) and the Geriatric Depressio . . .n Scale (GDS). Subjects with SMC were compared with those without SMC in terms of cognition, depression and some laboratory parameters. Results: Of the patients, 42.5% complained of forgetfulness. None of these patients had been admitted to hospital for this complaint. Women and patients with low education had more forgetfulness as well as poorer results on the SMC Scale, MMT, VFT, and GDS. Patients with SMC had lower hemoglobin, ferritin and free T4 levels. Female gender and depression was found to be a risk factor for SMCs. Conclusion: SMCs are common in people over 55 years of age. Being a woman as well as depression was found to be a risk factor for SMC. Since depression is a treatable condition, these people should be assessed carefully in terms of depressive symptoms. Laboratory parameters, such as hemoglobin, ferritin and free T4 levels should be investigated in patients with SMC. Unlike the other cognitive tests, CDT performance is independent of subjective memory complaints. Elderly patients rarely visit hospital with complaint of SMC, therefore, clinicians should be watchful for this problem Daha fazlası Daha az

Does Platelet Mass Index Play a Role in Predicting Biochemical Recurrence in Localized Prostate Cancer?

Girgin, Reha | Cinar, Onder | Bulut, Ersan | Onal, Cemal Ferhat

Article | 2018 | JOURNAL OF UROLOGICAL SURGERY5 ( 3 ) , pp.164 - 169

Objective: The aim of this study is to investigate the association of preoperative platelet mass index (PMI) with tumor pathologic features and postoperative biochemical recurrence in patients undergoing radical prostatectomy due to localized prostate cancer. Materials and Methods: Data of 141 patients, who underwent radical prostatectomy for localized prostate cancer between April 2004 and April 2017, were retrospectively screened. Patient age, preoperative prostate-specific antigen (PSA) level, platelet count, mean platelet volume and PMI value, neutrophil-lymphocyte ratio (NLR), tumor grade, Gleason score, tumor volume, lymph nod . . .e involvement, surgical margin positivity and biochemical recurrence at 3 months were all noted. The relationship of preoperative PMI value with age, PSA, pathologic parameters, surgical margin positivity and biochemical recurrence was evaluated. Results: The mean age of the patients was 61.79 +/- 5.98 years, the mean PSA value was 9.50 +/- 6.69 ng/mL, mean PMI was 2003.91 +/- 486.69, and the mean NLR was 2.79 +/- 2.06. There was no correlation of PMI value with PSA, pathological stage, Gleason score, lymph node involvement, tumor volume, surgical margin positivity, and biochemical recurrence. There was statistically significant negative correlation between PMI and Gleason score. Conclusion: In our study, we could not demonstrate preoperative PMI as a prognostic factor for early biochemical recurrence in patients undergoing radical prostatectomy for prostate cancer. To achieve a better conclusion that we can generalize, there is a need for prospective studies with larger patient series Daha fazlası Daha az

The Diagnostic and Prognostic Significance of MicroRNA-21 in Non-muscle Invasive Bladder Tumors

Cinar, Onder | Mungan, Necmettin Aydin

Review | 2019 | UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY18 ( 1 ) , pp.30 - 33

Bladder cancer (BC) is one of the commonly diagnosed urological cancers that causes human death, ranked as the seventh most common cancer worldwide. To date, no reliable diagnostic tool has been defined to recognize non-muscle invasive bladder tumors other than cystoscopy. For this reason, scientists have focused on finding new non-invasive biomarkers that can be used to diagnose BC with higher specificity and sensitivity. The purpose of this study was to evaluate the diagnostic role and prognostic significance of microRNA-21 (miR-21) in non-muscle invasive bladder tumors. In this review, the overall diagnostic performance of miR-21 . . . was discussed on non-invasive BC based on a literature search of PubMed and Cochrane Library. Although findings are insufficient, promising results have been reported regarding circulating miR-21 as a biomarker for BC prospective studies with larger numbers of participants are needed Daha fazlası Daha az

Experimental Bladder Cancer Models for Animals

Kosan, Murat | Mungan, Aydin

Review | 2015 | UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY14 ( 1 ) , pp.29 - 32

Transitional cell carcinoma (TCC) is the most common malignancy of the genitourinary tract and TCC models are being developed over the past decades. Experimental models are needed so that more effective treatments can be developed in preclinical evaluation. Even if, in vitro models are useful for initial development and evaluation of therapeutic agents and modalities, adequate animal models are still essential in the preclinical development of new effective and safe therapies. A great variety of ex vivo and in vivo models has been described in the literature. Chemical carcinogens are most commonly used to induce bladder cancer. Cell . . . culture techniques are also widely used to study different oncological processes. To test potential new drugs in a preclinical setting, a clinically relevant orthotopic bladder tumor model is highly desirable. The aim of this review article was the assessment of different animal models available for the study of bladder carcinogenesis Daha fazlası Daha az

Amblyopia and Current Treatment Approaches

Celik, Tuba

Article | 2017 | GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS15 ( 3 ) , pp.78 - 86

Ambliyopia is decrease on visual acuity due to the inhibition of healthy visiual development during early childhood. The visual development may increase by recovery of the risk factors such as refractive errors, strabismus, anatomic and congenital disorders. Today, there are many studies that defend the possibility of ambliyopia treatment in adults however, the main accepted view is if ambliyopia is not treated in early period, it will cause irreversible and life-time affecting visiual loss. In this review, we have tried to discuss the causes, diagnosis and treatment approaches of ambliyopia which is an important disease for familie . . .s and clinicians Daha fazlası Daha az

Effect of the Anesthetic Method on the Outcomes of Ureteroscopy for Proximal Ureteral Stones: A Multi-center Study of the Society of Urological Surgery Aegean Study Group

Kizilay, Fuat | Irer, Bora | Sen, Volkan | Erbatu, Oguzcan | Ongun, Sakir | Yildiz, Alperen | Cinar, Onder

Article | 2018 | JOURNAL OF UROLOGICAL SURGERY5 ( 4 ) , pp.170 - 175

Objective: To analyze the effect of the anesthesia method (spinal and general) on the outcome of ureteroscopy (URS) in patients treated for proximal ureteral stones. Materials and Methods: Patients, who underwent URS for proximal ureteral stones at various urology clinics in Turkiye, were included in the study. The patients were divided into two groups according to the anesthesia method performed; the procedure was performed under spinal anesthesia (SA) in group 1 and general anesthesia (GA) in group 2. Patients' demographic, perioperative data and complication rates were compared between the two groups in a retrospective manner. Re . . .sults: There were 309 and 329 patients in groups 1 and 2, respectively. The mean stone area and Hounsfield unit in GA group were higher ( Daha fazlası Daha az

An Experimental Study of Radiation Effect on Normal Tissue: Analysis of HIF-1 alpha, VEGF, eIF2, TIA-1, and TSP-1 Expression

Aktas, Caner | Kurtman, Cengiz | Ozbilgin, M. Kemal | Tek, Ibrahim | Toprak, Selami Kocak

Article | 2013 | TURKISH JOURNAL OF HEMATOLOGY30 ( 4 ) , pp.371 - 378

Objective: This study investigated whether or not the stress and hypoxia, which are the effects of radiation on normal vascular endothelium, leading to the release of HIF-1 alpha, VEGF, eIF2, TIA-1, and TSP-1 were related and the possibility of them stimulating angiogenesis. Materials and Methods: Twenty-four male Swiss Albino mice were separated into 4 groups. The first group was the control group (Group 1), and the second, third, and fourth groups were euthanized after 24 h (Group 2), 48 h (Group 3), and 7 days (Group 4), respectively. A single-fractioned 10 Gy of ionizing radiation was applied to all mice's pelvic zone with Co-60 . . .. Bladders were removed completely from the pelvic region. Immunohistochemistry and light microscopy were used to investigate whether there would be an increase or not in the angiogenesis pathway by using the HIF-1 alpha, VEGF, eIF2, TIA-1, and TSP-1 antibodies. Results: The HIP-1 alpha antibody showed strong staining in Group 3, while the staining intensity was less in other groups. VEGF showed weak staining in Groups 1 and 4, while moderate staining in Group 2 and strong staining in Group 3 was observed. eIF2 showed strong staining in Groups 1 and 4. Groups 2 and 3 were stained weakly. In the present study, staining with TSP-1 was very strong in the samples belonging to Group 1, while other groups showed very weak staining. Conclusion: When normal tissue was exposed to radiation, the positively effective factors (HIF-1, VEGF, eIF2, and TIA-1) on the angiogenesis pathway were increased while the negative factor (TSP-1) was decreased. Radiation may initiate physiological angiogenesis in the normal tissue and accelerate healing in the damaged normal tissue Daha fazlası Daha az

A Multi-Center Study on the Efficacy of Eltrombopag in Management of Refractory Chronic Immune Thrombocytopenia: A Real-Life Experience

Cekdemir, Demet | Guvenc, Serkan | Ozdemirkiran, Fusun | Eser, Ali | Topts, Tayfur | Ozkocaman, Vildan | Sahin, Handan Haydaroglu

Article | 2019 | TURKISH JOURNAL OF HEMATOLOGY36 ( 4 ) , pp.230 - 237

Objective: The aim of the present study was to evaluate the efficacy and safety of eltrombopag, an oral thrombopoietin receptor agonist, in patients with chronic immune thrombocytopenia (ITP). Materials and Methods: A total of 285 chronic ITP patients (187 women, 65.6 %; 98 men, 34.4%) followed in 55 centers were enrolled in this retrospective cohort. Response to treatment was assessed according to platelet count (/mm(3)) and defined as complete (platelet count of >100,000/mm(3)), partial (30,000-100,000/mm(3) or doubling of platelet count after treatment), or unresponsive (

The Impact of BK Virus and Cytomegalovirus Infections on Graft in Renal Transplant Patients: Experience of a Tertiary Hospital in Turkey

Kose, Sukran | Atalay, Sabri | Ulu, Yildiz | Sonmez, Ufuk | Serin Senger, Suheyla

Article | 2017 | MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS6 , pp.230 - 237

Introduction: BK virus (BKV) and cytomegalovirus (CMV) infections are common in renal transplant patients. In this retrospective study, we investigated the frequency of BKV and CMV infections and their effects on graft. Materials and Methods: The data of 118 renal transplant recipients who were transplanted and followed-up between January 2010 and January 2011 were reviewed. Demographic characteristics, biochemical data, BKV and CMV DNA levels by polymerase chain reaction (QIAGEN, Hilden, Germany) were investigated. The patients were followed- up monthly in the first six months and then every three months. Results: A total of 118 pa . . .tients were included in the study. BK viraemia was detected in 12 (10.2%) patients and the DNA level of BKV was >10(4) copies/mL in five cases. Three patients with elevated creatinine and compatible renal biopsy findings were considered to have BKV-associated nephropathy (BKVAN). With the reduction of immunosuppressive treatment, viraemia was reduced and creatinine levels decreased within normal levels. Cytomegalovirus DNA was found to be positive in 23 (19.5%) patients, and was >500 copies/mL in 4 (3.4%) patients. The viraemia in these four patients has decreased after antiviral therapy. No CMV related disease were found in any of the patients. Cytomegalovirus DNA positivity at low levels were also detected in three patients who were diagnosed with BKVAN. None of the patients developed rejection. Conclusion: BK and CMV infections in kidney transplant patients are common and can be seen together. However, graft dysfunction and rejection rates are low with close monitoring, early diagnosis and treatment. Randomized, controlled studies with larger patient groups are necessary in order to determine the viral threshold levels associated with graft dysfunction or rejection, to decide the optimal management and to explain the role of concomitant infection Daha fazlası Daha az

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