Erişime Açık

Effect of ozone oxidative preconditioning in preventing early radiation-induced lung injury in rats

Bakkal, Bekir Hakan | Gultekin F.A. | Guven B. | Turkcu U.O. | Bektas S. | Can M.

Ionizing radiation causes its biological effects mainly through oxidative damage induced by reactive oxygen species. Previous studies showed that ozone oxidative preconditioning attenuated pathophysiological events mediated by reactive oxygen species. As inhalation of ozone induces lung injury, the aim of this study was to examine whether ozone oxidative preconditioning potentiates or attenuates the effects of irradiation on the lung. Rats were subjected to total body irradiation, with or without treatment with ozone oxidative preconditioning (0.72 mg/kg). Serum proinflammatory cytokine levels ...Daha fazlası

Makale 2013 Brazilian Journal of Medical and Biological Research46 ( 9 ) , pp. 7 - 796 889 Görüntülenme

Erişime Açık

Effects of ozone oxidative preconditioning on radiation-induced organ damage in rats

Gultekin F.A. | Bakkal, Bekir Hakan | Guven B. | Tasdoven I. | Bektas S. | Can M. | Comert M.

Because radiation-induced cellular damage is attributed primarily to harmful effects of free radicals, molecules with direct free radical scavenging properties are particularly promising as radioprotectors. It has been demonstrated that controlled ozone administration may promote an adaptation to oxidative stress, preventing the damage induced by reactive oxygen species. Thus, we hypothesized that ozone would ameliorate oxidative damage caused by total body irradiation (TBI) with a single dose of 6 Gy in rat liver and ileum tissues. Rats were randomly divided into groups as follows: control gr ...Daha fazlası

Makale 2013 Journal of Radiation Research54 ( 1 ) , pp. 3 - 44 875 Görüntülenme

Evaluation of the protective effect of agmatine against cisplatin nephrotoxicity with 99mTc-DMSA renal scintigraphy and cystatin-C

Salihoglu Y.S. | Elri T. | Gulle K. | Can M. | Aras M. | Ozacmak H.S. | Cabuk M.

Background: The aim of the current study was to investigate whether agmatine (AGM) has a protective effect against cisplatin-induced nephrotoxicity. Materials and methods: Thirty-two rats were randomly divided into four groups: (1) Saline (control); (2) Cisplatin (CDDP; 7.5 mg/kg intraperitoneally); (3) Agmatine (AGM; 10 mg/kg intraperitoneally); (4) Cisplatin plus agmatine (CDDP + AGM). Agmatine was given before and two consecutive days after cisplatin injection. All the animals underwent renal scintigraphy with 99mTc-DMSA. The levels of serum creatinine, cystatin C, and blood urea nitrogen ( ...Daha fazlası

Makale 2016 Renal Failure38 ( 9 ) , pp. 1 - 1502 706 Görüntülenme

Ameliorative effects of Hesperidin on radiation induced brain injury in rats

Kale A. | Pişkin Ö. | Baş Y. | Aydın B.G. | Can M. | Elmas Ö. | Büyükuysal Ç.

Background: Extensive research has been focused on radiation induced brain injury. Animal and human studies have shown that flavonoids have remarkable toxicological profiles. This study aims to investigate the neuroprotective effects of hesperidin in an experimental radiation induced brain injury. Materials and Methods: 32 adult male Wistar-Albino rats were randomly divided into 4 groups (control, hesperidin, radiation, and radiation+hesperidin groups; 8 rats in each group). 200 mg/kg doses of hesperidin were administered to the animals in the hesperidin and radiation+ hesperidin groups, radia ...Daha fazlası

Makale 2019 International Journal of Radiation Research17 ( 2 ) , pp. 2 - 236 535 Görüntülenme

Gastroprotective effects of CoQ10 on ethanol-induced acute gastric lesions

Karakaya K. | Barut F. | Hanci V. | Can M. | Comert M. | Ucan H.B. | Cakmak G.K.

Introduction: Alcohol consumption is frequently associated with gastric mucosal lesions. The purpose of this study was to determine the effect of Coenzyme-Q10 (CoQ10) supplementation on the ethanol-induced gastric mucosal damage in a rat model. Material and method: Sixty-four female wistar albino rats were randomly divided into 8 groups (n = 8). Studies were performed in ethanol induced gastric ulcer model in Wistar albino rats. Famotidine at a dose of 5 mg/kg or 20 mg/kg and CoQ10 at a single dose of 10 mg/kg or 20 mg/kg and 30 mg/kg for 7 days were administered as pretreatment. All the rats ...Daha fazlası

Makale 2015 Bratislava Medical Journal116 ( 1 ) , pp. 5 - 56 899 Görüntülenme

Cystain C and neuropeptid Y levels in brain tissues after experimental subarachnoid hemorrhage

Açikgöz S. | Can M. | Güven B. | Edebali N. | Barut F. | Büyükuysal Ç. | Tekin I.Ö.

The aim of this study was to investigate the changes in the levels of cystatin C, which protects neurodegeneration in the central nervous system with the inhibition of cysteine protease and by inducing autophagy in the pathogenesis of cerebral vasospasm and levels of vasoconstrictive neuropeptid Y (NPY) in the brain tissue homogenates of rat model of subarachnoid hemorrhage (SAH). Three experimental groups were used: Day 2 and Day 7 groups after SAH, and also a control group. There were seven Wistar albino rats in each group. SAH was accomplished by transclival basilar artery puncture. Rat cys ...Daha fazlası

Makale 2014 Acta Biochimica Polonica61 ( 4 ) , pp. 8 - 828 711 Görüntülenme

Inflammatory markers in preeclamptic patients

Can M. | Sancar E. | Harma M. | Guven B. | Mungan G. | Acikgoz S.

Background: Preeclampsia is characterized by hypertension and proteinuria that begins in the second half of pregnancy. Endothelial dysfunction and trophoblastic hypoperfusion seen in preeclampsia suggested to be part of an increased maternal inflammatory response to pregnancy. In this study, we aimed to evaluate some inflammatory markers in pre-eclamptic and normotensive pregnants. Methods: The study included 36 cases with mild preeclamp-sia, 36 cases with severe preeclampsia and 33 cases of normotensive pregnant. High sensitive C-reactive protein (hsCRP) and serum amyloid A (SAA) were measure ...Daha fazlası

Makale 2011 Clinical Chemistry and Laboratory Medicine49 ( 9 ) , pp. 1 - 1472 168 Görüntülenme

Intestinal fatty acid binding protein (I-FABP) as a promising test for Crohn's disease: A preliminary study

Sarikaya M. | Ergül B. | Do?an Z. | Filik L. | Can M. | Arslan L.

Background: Crohn's disease (CD) is a chronic inflammatory bowel disease that can affect any part of the gastrointestinal tract from the mouth to the anus. The clinical course presents with remissions and activations. Also, clinical findings or endoscopic activity do not always reflect the overall appropriate disease activity. This is why specific markers are always an issue of concern for the diagnosis, prediction of relapse, and monitoring of CD activity. Fatty acid binding proteins (FABPs) are intracellular proteins that are expressed abundantly in several tissues. Intestinal FABP (I-FABP) ...Daha fazlası

Makale 2015 Clinical Laboratory61 ( 01.Feb ) , pp. 8 - 91 431 Görüntülenme

Hepatorenal syndrome

Demirtaş S. | Can M. | Yarpuzlu A.

This article summarizes the literature on current definition, suggested pathogenetic mechanisms and the role of laboratory assessment in the differential diagnosis of hepatorenal syndrome (HRS) from other causes of renal disease that may arise during hepatic cirrhosis and some diseases affecting both liver and kidney. It should be remembered that the main theory suggested for the pathogenesis of HRS is the arterial vasodilation hypothesis of portal hypertension, ending in type 1 and type 2 HRS, but there is no consensus supporting either mechanism as a solid theory for initiation of HRS pathog ...Daha fazlası

İnceleme 2006 Clinical Chemistry and Laboratory Medicine44 ( 4 ) , pp. 3 - 386 385 Görüntülenme

Folate-receptor 1 level in periodontal disease: A pilot study

Alkan D. | Guven B. | Turer C.C. | Balli U. | Can M.

Background: The purpose of this study was to investigate gingival crevicular fluid (GCF) and serum folate-receptor 1 (FOLR1) levels in subjects with different periodontal status. Methods: The study consists of three groups: Healthy group (n = 15), gingivitis group (n = 15) and chronic periodontitis group (n = 15). Clinical periodontal parameters including probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI) and bleeding on probing (BOP) were assessed. GCF and serum samples were collected from each patient and were analyzed FOLR1 levels by enzyme-linked immunosorbent ...Daha fazlası

Makale 2019 BMC Oral Health19 ( 1 ) 455 Görüntülenme

Ischemia modified albumin and plasma oxidative stress markers in Alzheimer's disease

Can M. | Varlibas F. | Guven B. | Akhan O. | Yuksel G.A.

Objectives: The objective of this study was to determine ischemia modified albumin (IMA) and oxidant status in Alzheimer's disease (AD). Therefore, we evaluated the IMA and oxidant status by measuring serum uric acid, albumin and gamma-glutamyltransferase (GGT) in AD. Methods: The plasma albumin, uric acid, GGT and IMA levels were measured by spectrophotometric methods in 32 AD patients and 32 healthy controls. The Mini Mental Status Examination and Clinical Dementia Rating Scale were used to evaluate the cognitive functions of AD patients. Results: AD patients had significantly higher IMA lev ...Daha fazlası

Makale 2013 European Neurology69 ( 6 ) , pp. 3 - 380 312 Görüntülenme

Lipid peroxidation and homocysteine levels in Behçet's disease

Mungan A.G. | Can M. | Açikgöz S. | Eştürk E. | Altinyazar C.

Background: The aim of this study was to investigate serum paraoxonase (PON1) activity in relation to homocysteine, malondialdehyde (MDA) and lipid parameters in active and inactive Behçet's disease (BD). Methods: A total of 46 consecutive BD patients and 25 healthy control subjects were included in the present study. Results: Serum PON1 activity in both active and inactive BD was significantly lower compared with healthy subjects (p

Makale 2006 Clinical Chemistry and Laboratory Medicine44 ( 9 ) , pp. 1 - 1118 435 Görüntülenme

Filtreler

Koleksiyon [7]

İlgili Araştırmacılar [39]

Ambargo Durumu [1]

Tam Metin [2]

Yazar [90]

Yayın Türü [3]

Yayın Yılı [15]

Yayın Dili [3]

Dergi Adı [66]

Yayıncı [31]

Konu Başlıkları [90]