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Colorectal carcinomas: Clinicopathologic investigation, correlation with expression of estrogen and progesterone receptors

Ekem T.E. | Bahadir B. | Gün B.D. | Bektaş S. | Kertj¸ G. | Yurdakan G. | Özdamar Ş.O.

Article | 2008 | Turkish Journal of Cancer38 ( 3 ) , pp.118 - 122

Correlation in mortality data between breast cancer and colonic cancer, and increased incidence of colonic cancer in women with breast cancer suggest common factors in their etiology. Similarly protective effect of increasing parity from colonic cancer, and relatively better prognosis in women may imply a common role for sex steroid hormones. In this study clinicopathologic parameters as well as estrogen and progesterone receptor expressions of 60 cases of colorec-tal adenocarcinoma were investigated. Most carcinomas were moderately differentiated; stage B2 tumors were predominately located in the rectosigmoid area. Immu-nohistochem . . .ically, no nuclear staining was demonstrated for estrogen or progesterone receptors; only six displayed cytoplasmic staining with estrogen receptor. Although potential importance of estrogen and progesterone receptors has been emphasized by certain reports, its importance is still controversial in terms of both prognosis and management. Moreover, it is unclear whether to exclude cy-toplasmic staining. The significance of these receptors in colorectal carcinoma needs to be further studied Daha fazlası Daha az

Noncommunicating thoracolumbar intradural extramedullary arachnoid cyst in an 8-year-old boy: Intact removal by spontaneous delivery

Gul S. | Bahadir B. | Kalayci M. | Acikgoz B.

Article | 2010 | Pediatric Neurosurgery45 ( 6 ) , pp.410 - 413

Noncommunicating spinal intradural extramedullary arachnoid cysts are an extremely rare cause of spinal cord compression. An 8-year-old boy presented with progressive paraparesis. Magnetic resonance imaging revealed a posterior intradural extramedullary arachnoid cyst extending from T11 to L 3 vertebral bodies. The multilevel noncommunicating cyst was totally removed by simple delivery without rupture through a single-level laminoplasty. To our knowledge, no such case has been reported in the literature. Copyright © 2009 S. Karger AG, Basel.

Malignant granular cell tumor with unusual histological features

Behzatoglu K. | Bahadir B.

Article | 2007 | Pathology International57 ( 2 ) , pp.115 - 119

Malignant granular cell tumor, although uncommon, should be differentiated from a number of granular cell-containing tumors. Reported herein is a distinctive variant of malignant granular cell tumor, clinically presenting as a rapidly enlarging scrotal mass, in which some areas morphologically displayed features indistinguishable from Kaposi sarcoma. Cells in areas simulating Kaposi sarcoma were immunohistochemically the same as typical granular cells in other portions of the tumor. The recognition of this pattern is important because it may predominate and overshadow the original nature of tumor. © 2007 The Authors.

Inverted (hobnail) high-grade prostatic intraepithelial neoplasia and invasive inverted pattern

Öznur M. | Koca S.B. | Yildiz P. | Bahadir B. | Behzatoğlu K.

Article | 2015 | Oncology Letters10 ( 4 ) , pp.2395 - 2399

High-grade prostatic intraepithelial neoplasia (HGPIN) is considered to be an important precursor for prostatic adenocarcinoma. The present study aimed to investigate the histological features of the uncommon inverted (hobnail) pattern of HGPIN in transrectal ultrasonographic (TRUS) prostatic needle biopsies from 13 cases. These 13 diagnosed cases of inverted HGPIN were identified out of a total of 2,034 TRUS biopsies (0.63%), obtained from patients suspected to have prostate cancer. The hobnail pattern is comprised of secretory cell nuclei, which are histologically localized at the luminal surface of the prostate gland, rather than . . . the periphery, and exhibit reverse polarity. Histological examinations were performed and the results demonstrated that 5 of the 13 cases exhibited pure inverted histology, while HGPIN was observed to be histologically associated with other patterns in the remaining 8 patients. In addition, an association with adenocarcinoma was identified in 7 of the 13 cases. All 7 carcinomas accompanied by inverted HGPIN were conventional acinar adenocarcinoma cases; of note, for these 7 cases, the Gleason score was 7 for each. One acinar adenocarcinoma case accompanying inverted HGPIN demonstrated hobnail characteristics in large areas of the invasive component. It was observed that nuclei were proliferated in the invasive cribriform glands, which was comparable to that of inverted HGPIN, and were located on the cytoplasmic luminal surface; a similar morphology was also observed in individual glands. In conclusion, the results of the present study suggested that the hobnail HGPIN pattern may be of diagnostic importance due to its high association with adenocarcinoma and the high Gleason scores in the accompanying carcinomas. © 2015 Spandidos Publications. All rights reserved Daha fazlası Daha az

Nuclear morphometric analysis in gastrointestinal stromal tumors: A preliminary study

Özdamar Ş.O. | Bektaş S. | Erdem Özdamar S. | Gedikoglu G. | Dogan Gün B. | Bahadir B.

Article | 2007 | Turkish Journal of Gastroenterology18 ( 2 ) , pp.71 - 76

Background/aims: Gastrointestinal stromal tumors are considered a specialized group of mesenchymal neoplasms. In this study, the histomorphologic and immunohistochemical features of gastrointestinal stromal tumors are compared with nuclear morphometric results. Methods: Morphometric nuclear parameters such as mean area, mean roundness factor, mean form ellipse, mean length and mean perimeter were evaluated in hematoxylin and eosin stained slides of 22 gastrointestinal stromal tumors (9 benign and 13 malignant) by using a computer-assisted image analysis system. Morphometric results were compared with tumor behavior and tumor size, t . . .he presence of necrosis, mitotic index, and immunohistochemical expressions of p53 and proliferating cell nuclear antigen. Results: We found that tumor necrosis was correlated with mean nuclear roundness factor, mean nuclear form ellipse, mean nuclear length and mean nuclear perimeter ( Daha fazlası Daha az

Spontaneous infarction of a pleomorphic adenoma in parotid gland: Diagnostic problems and review

Behzatoglu K. | Bahadir B. | Huq G.E. | Kaplan H.H.

Review | 2005 | Diagnostic Cytopathology32 ( 6 ) , pp.367 - 369

Although infarction of parotid gland pleomorphic adenoma (PA) following fine-needle aspiration (FNA) has been well-documented, spontaneous infarction of PA has remained as an uncommon entity in the literature. To our knowledge, we report the second case of spontaneous infarction occurring in a parotid gland PA. A 44-yr-old man presented with a 2-yr history of slowly enlarging right parotid mass, which had become painful 1 mo before performing FNA biopsy. Smears revealed abundant necrotic debris, atypical squamous cells, and small cells with dark nuclei suggestive of a carcinoma. Histologic examination of the tissue fragments demonst . . .rated degenerated clusters of cells and chondromyxoid matrix. The parotidectomy specimen had features consistent with those of an infarcted PA. Although appears to be rare, spontaneous infarction of PA should be considered in the differential diagnosis, since necrosis may mimic carcinoma and cause misinterpretation of necrosis as an indication of malignancy, in an otherwise benign salivary gland neoplasm. © 2005 Wiley-Liss, Inc Daha fazlası Daha az

CD24 and galectin-1 expressions in gastric adenocarcinoma and clinicopathologic significance

Bektas S. | Bahadir B. | Ucan B.H. | Ozdamar S.O.

Article | 2010 | Pathology and Oncology Research16 ( 4 ) , pp.569 - 577

CD24 and galectin-1 expression in gastric adenocarcinoma and their clinicopathologic significance remained largely unknown. We aimed to evaluate expressions and staining intensities of CD24 and galectin-1 in gastric adenocarcinoma and to investigate the interrelation with clinicopathologic parameters including survival. 93 cases with gastric adenocarcinoma were reevaluated histopathologically and immunohistochemistry was performed with antibodies against CD24 and galectin-1. Staining intensities of both markers in tumor cells and staining intensity of galectin-1 in tumor-associated stromal cells were scored semiquantitatively. The r . . .elationship between expression and staining intensity of CD24 and galectin-1 and clinicopathologic variables were assessed. CD24 staining intensity was associated with lymphovascular invasion (p=0.007), serosal invasion (p=0.001), stage (p=0.001) and lymph node metastasis (p=0.005). Galectin-1 staining intensity in tumor-associated stromal cells was associated with tumor location (p=0.031), lymphovascular invasion (p=0.001), perineural invasion (p=0.001), serosal invasion (p=0.001), differentiation (p=0.003), stage (p=0.001) and lymph node metastasis (p=0.001). Staining intensity of CD24 (p=0.019) and gal-1 (p=0.018) were associated with patient survival. Staining intensity of CD24 in tumor cells and galectin-1 in tumor-associated stromal cells were related with certain clinicopathologic variables. Our findings suggest that these markers are independent prognostic indicators of poor survival and may serve as useful targets for novel therapies. © 2010 Arányi Lajos Foundation Daha fazlası Daha az

Tophaceous gout of the ankle presenting as a soft tissue mass: A case report of an uncommon presentation of a common disease

Gün B.D. | Özdamar Ş.O. | Çolak S. | Bahadir B. | Kuzey G.M.

Article | 2006 | Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi52 ( 4 ) , pp.185 - 187

Gout is a metabolic disorder in which there is either an increase in production or a decrease in excretion of uric acid leading to hyperuricemia. Hyperuricemia results in the deposition of monosodium urate crystals in joints and visceral organs and continued deposition eventually results in chronic tophaceous gout. We report a case of gouty tophi in a 45-year-old man who developed nodules on both lateral aspects of the malleoli with a history of arthropathy. In laboratory investigation, blood chemistry showed marked hyperuricemia (8.40 mg/dl). Macroscopically, the lesions were circumscribed whitish-gray masses. Histologically, both . . .lesions contained areas of amorphous brown crystal deposits and they were surrounded by a foreign body type granulomatous infiltrate. The crystals revealed specific birefringence, a diagnostic characteristic of the monosodium urate crystals, with a polarizing filter. Gout deposits in skin (tophi) are uncommon. The aim of this report is to emphasize the importance of considering this disease entity in the differential diagnosis of a soft tissue lesion in a patient with chronic arthritis Daha fazlası Daha az

CD10 expression in urothelial carcinoma of the bladder

Bahadir B. | Behzatoglu K. | Bektas S. | Bozkurt E.R. | Ozdamar S.O.

Article | 2009 | Diagnostic Pathology4 ( 1 ) , pp.185 - 187

Background. CD10 antigen is a 100-kDa-cell surface zinc metalloendopeptidase and it is expressed in a variety of normal and neoplastic lymphoid and nonlymphoid tissues. The aim of this study was to evaluate CD10 expression in urothelial carcinoma of the urinary bladder and to determine the correlation between immunohistochemical (IHC) CD10 expression and histopathologic parameters including grade and stage. Methods. 371 cases of urothelial bladder carcinomas, all from transurethral resections, were included in this study. Hematoxylin-eosin (HE) stained sections from each case were reevaluated histopathologically according to WHO 200 . . .4 grading system. The TNM system was used for pathologic staging. Selected slides were also studied by IHC and a semiquantitative scoring for CD10 expression based on the percentage of positive cells was performed. Results. 157 cases (42.3%) showed immunostaining while 214 cases (57.7%) were negative for CD10. 1+ staining was seen in 65 CD10 positive cases (41.4%), and 2+ in 92 cases (58.6%). Overall CD10 expression as well as 2+ immunostaining was significantly correlated with high histologic grade. Overall CD10 expression was also significantly higher in invasive pT1 and pT2-3 tumors compared to noninvasive pTa tumors. pT1 and pT2-3 tumors were also significantly correlated with 2+ immunostaining. Conclusion. To date, only a few comparative IHC studies have assessed CD10 expression in urothelial carcinoma of the urinary bladder and this study represents the largest series. Our findings indicate that CD10 expression is strongly correlated with high tumor grade and stage in urothelial carcinoma of the bladder, and that CD10 may be associated with tumor progression in bladder cancer pathogenesis. © 2009 Bahadir et al; licensee BioMed Central Ltd Daha fazlası Daha az

Clinicopathological significance of fascin and CD44v6 expression in endometrioid carcinoma

Gun B.D. | Bahadir B. | Bektas S. | Barut F. | Yurdakan G. | Kandemir N.O. | Ozdamar S.O.

Article | 2012 | Diagnostic Pathology7 ( 1 ) , pp.185 - 187

Background: Fascin and CD44v6 may have significant roles as biomarkers in tumour progression and metastasis. In endometrioid carcinomas, the fascin expression profile is less defined, and the significance of CD44v6 is uncertain. We aimed to investigate the expressions of both fascin and CD44v6 in endometrioid carcinomas and to evaluate their inter-relation with clinicopathological parameters.Methods: Fascin and CD44v6 expressions were evaluated, individually and in combination, in a series of 47 endometrioid carcinomas and 10 proliferative endometrium samples. The staining extent and intensity of both markers in tumour cells were sc . . .ored semiquantitatively. The relationship between immunoexpressions and clinicopathological variables was assessed.Results: The expression rates of fascin and CD44v6 in endometrioid carcinoma were 72.34% and 46.80%, respectively. Although these expression rates were higher than those in proliferative endometrial samples, fascin expression showed a statistically significant difference from the normal group (p = 0.02), but CD44v6 did not differ (p = 0.54). Fascin expression was significantly correlated with tumour grade (p = 0.003) and neural invasion (p = 0.036) in a univariate analysis. In contrast, no significant correlation was found between CD44v6 and any of the clinicopathological parameters.Conclusions: Our findings suggest that fascin might be an independent prognostic indicator in the different steps of extracellular matrix invasion. On the other hand, CD44v6 was not a predictive factor in endometrioid cancer.Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8511594927206899. © 2012 Gun et al.; licensee BioMed Central Ltd Daha fazlası Daha az

Congenital medulloblastoma

Ermis B. | Aydemir C. | Taspinar O. | Cagavi F. | Bahadir B. | Ozdemir H.

Article | 2006 | Archives of Disease in Childhood: Fetal and Neonatal Edition91 ( 5 ) , pp.185 - 187

[No abstract available]

C-Kit (CD117) expression in classic Kaposi's sarcoma: Experimental dermatology

Kandemir N.O. | Gun B.D. | Bahadir B. | Yurdakan G. | Ozdemir N. | Karadayi N. | Ozdamar S.O.

Article | 2010 | Clinical and Experimental Dermatology35 ( 5 ) , pp.525 - 530

Background. Kaposi's sarcoma is a multicentric, low-grade, vascular neoplasia. Human herpesvirus 8 is associated with all epidemiological forms of KS and has been shown in vitro to induce the tyrosine receptor kinase c-Kit in infected cells. Aim. To investigate the expression of c-Kit in cases of classic KS and to clarify its association with clinicopathological parameters and HHV8 latency-associated nuclear antigen-1 expression. Methods. In total, 35 cases of classic KS at various histological stages were included in the study. Age and gender of the patients and location and histological stage of the tumours were recorded. Formalin . . .-fixed, paraffin wax-embedded tissue sections were stained by immunohistochemistry with antibodies to c-Kit and HHV8. Results. c-Kit immunoreactivity was found in 22 cases and HHV8 immunoreactivity was present in all cases. There was no correlation in c-Kit immunoreactivity between clinicopathological parameters and HHV8 immunoreactivity. Conclusions. The results of our study show that in cases of classic KS there is a high rate of c-Kit immunoreactivity, but c-Kit expression does not show any correlation with HHV8 immunoreactivity. © 2009 British Association of Dermatologists Daha fazlası Daha az

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