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Nuclear morphometric analysis in gastrointestinal stromal tumors:A preliminary study

Özdamar, Şükrü Oğuz | Bektaş, Sibel | Özdamar, Sevim Erdem | Gedikoğlu, Gökhan | Gün, Banu Doğan | Bahadır, Burak

Other | 2007 | Turkish Journal of Gastroenterology18 ( 2 ) , pp.71 - 76

Amaç: Gastrointestinal stromal tümörler, mezenkimal neoplazmlar içinde yer alan özel bir tümör grubudur. Bu çalışmada, gastrointestinal stromal tümörlerin histomorfolojik ve immünhistokimyasal özellikleri, nükleer morfometrik analiz sonuçları ile karşılaştırılmıştır. Yöntem: Dokuzu benign ve 13’ü malign davranış gösteren 22 gastrointestinal stromal tümörün hematoksilen- eosin boyalı kesitlerinde, bilgisayar destekli görüntü analiz programı kullanılarak, ortalama nükleer alan, ortalama nükleer yuvarlaklık faktörü, ortalama nükleer elipslik indeksi, ortalama nükleer uzunluk ve ortalama nükleer perimetre ölçülmüştür. Morfometrik analiz . . . sonuçları, tümörlerin davranış, boyut, mitoz sayısı, nekroz varlığı, immünhistokimyasal olarak p53 ve proliferating cell nükleer antijen ekspresyonları ile karşılaştırılmıştır. Bulgular: Tümör nekrozu ile ortalama nükleer yuvarlaklık faktörü, ortalama nükleer elipslik indeksi, ortalama nükleer uzunluk ve ortalama nükleer perimetre arasında arasında anlamlı ilişki saptanmıştır ( Daha fazlası Daha az

Effects of Ankaferd Blood Stopper® on Bone Regeneration in Rat Calvarial Defects

Gül, Şanser | Bahadır, Burak | Kalaycı, Murat | Ankaralı, Handan | Erdem, Oktay | Karakaya, Kemal | Açıkgöz, Bektaş

Article | 2011 | TURKIYE KLINIKLERI TIP BILIMLERI DERGISI31 ( 2 ) , pp.390 - 396

Objective: The influence of Ankaferd Blood Stopper (R) (ABS) was experimentally investigated on calvarial defects in rats. Material and Methods: Fourteen Wistar-albino rats equally divided into two groups, control group (G1) and drug group (G2), were included in the study. In G1, only right frontal craniectomy was performed. In G2, 0.5ml ABS was topically applied with a syringe after craniectomy. Surface areas of the defects were measured after four weeks, and comparative reconstruction images with were obtained, computed tomography (CT) as well. Blood samples were also collected to evaluate prothrombin time (PT), international norm . . .alized ratio (INR) and activated partial thromboplastin time (aPTT), and tissue samples were harvested for histologic examination. Results: Mean defect area in G1 (7.20 +/- 2.62 mm(2)) was significantly larger than that in G2 (1.83 +/- 1.65 mm(2)) (p0.05). Three dimensional (3D) CT analysis and histological examination revealed prominent osteogenesis in G2. Conclusion: We observed that surface area of the calvarial defects decreased significantly after ABS administration, and this observation was confirmed by 3D CT analysis and histology. Thus, ABS seems to have a potential of bone promoting effect; however, precise mechanisms underlying this osteogenetic activity still remain unexplained Daha fazlası Daha az

Pankreasın seröz kistadenomu (Mikrokistik adenom): Olgu sunumu

Doğan, Gün Banu | Bahadır, Burak | Kökten, Neslihan | Uçan, Bülent Hamdi | Özdamar, Şükrü Oğuz

Article | 2006 | Akademik Gastroenteroloji Dergisi5 ( 2 ) , pp.130 - 133

http://www.trdizin.gov.tr/publication/paper/detail/TmpZMU56ZzQ= https://hdl.handle.net/20.500.12628/226

Safra kesesinde metaplazi, displazi ve karsinom dizgesi

Bahadır, Burak | Gün, Doğan Banu | Çolak, Sacide | Kertiş, Gürkan | Cömert, Mustafa | Özdamar, Şükrü Oğuz

Article | 2007 | Akademik Gastroenteroloji Dergisi6 ( 1 ) , pp.25 - 29

Safra kesesinde çoğunlukla safra taşı varlığı ve kronik inflamasyonla ilişkili olarak görülen metaplastik değişiklikler karsinomatöz dönüşüm sürecindeki premalign lezyonların temsilcisi olabilirler. Bunun ötesinde olası bir metaplazi, displazi, karsinom zincirinin varlığı safra kesesi karsinomlarının gelişiminde önem taşıyabilir. Gereç ve yöntem: Çalışmamızda Mayıs 2001 ile Kasım 2006 tarihleri arasında Karaelmas Üniversitesi Tıp Fakültesi Hastanesi’nde kronik kolesistit tanı sı ile izlenen ve kolesistektomi uygulanan 121 erkek ve 230 kadın hastanı n toplam 351 safra kesesi materyaline ait preparatlar metaplazi, displazi, karsinoma . . .in situ ve karsinom açısından tekrar değerlendirilmiştir. Bulgular: Saf antral tip metaplazi 81 olgu ile en sık görülen metaplazi tipi iken, 18 olguda intestinal metaplazi izlenmiştir. Sekiz olguda ise aynı anda antral ve intestinal metaplazi varlığı mevcuttur. Antral metaplazi bulunan 3, intestinal metaplazi izlenen 11, hem antral hem de intestinal metaplazi görülen olguların üçünde değişen derecelerde displazi belirlenmiştir. İntestinal metaplazi ve displazi izlenen 11 olgunun dördünde insidental karsinom saptanmıştır. Sonuç: Çalışmamızda safra keselerinde %30 oranında saptanan metaplazi varlığı metaplazinin oluşumunda rol oynayan en önemli etkenin safra taşı ve inflamasyon varlığına ikincil olarak gerçekleşen kronik doku zedelenmesi olduğunu göstermektedir. İntestinal metaplazilerin antral metaplazilerden gelişebilmesi, displaziye yol açarak karsinoma dönüşebilme olasılığı yanı sıra gerek kanserli dokularda gerekse kanser alanını çevreleyen mukozada metaplazi sıklığındaki yükseklik, bu değişiklik spektrumunun safra kesesi kanseri gelişiminde rol oynayabileceği görüşünü desteklemektedir. Metaplastic changes in the gallbladder commonly associated with cholelithiasis and chronic inflammation may represent premalignant lesions in the course of malignant transformation. Moreover, existence of a probable metaplasia-dysplasia-carcinoma sequence may bear importance in developing gallbladder carcinomas. Materials and methods: In this study, 351 cholecystectomy specimens of 121 male and 230 female patients with chronic cholecystitis seen from May 2001 to November 2006 in Karaelmas University Faculty of Medicine were re-evaluated in terms of metaplasia, dysplasia, carcinoma in situ and carcinoma. Results: While pure antral-type metaplasia was the most common metaplasia (81 cases), intestinal metaplasia was detected in 18 cases. Eight cases displayed coexistence of antral and intestinal metaplasia. Varying degrees of dysplasia were revealed in 3 cases with antral metaplasia, in 11 cases with intestinal metaplasia and in 3 cases with both antral and intestinal metaplasia. Incidental carcinoma was determined in 4 of the 11 cases with intestinal metaplasia and dysplasia. Conclusions: The occurrence of metaplasia, perceived as 30% in the current study, points out that chronic tissue injury secondary to cholelithiasis and chronic inflammation is the major factor contributing to developing metaplasia. In addition to the possibility of intestinal metaplasia developing from antral metaplasia, progressing to carcinoma by causing dysplasia, the high incidence of metaplasia in both carcinomatous components and surrounding mucosa supports the idea that this spectrum of changes may play a role in the development of gallbladder cancer Daha fazlası Daha az

Ectopic pancreas associated with choledochal cyst and multiseptate gallbladder

Bahadır, Burak | Özdamar, Şükrü | Gün, Banu D. | Bektaş, Sibel | Numanoğlu, Kemal Varın | Kuzey, Gamze M.

Article | 2006 | Pediatric and Developmental Pathology9 ( 4 ) , pp.312 - 315

Congenital choledochal cyst is a rarely seen malformation of childhood, particularly when associated with multiseptate gallbladder or ectopic pancreas. The current case represents a 15-day-old boy with jaundice. Ultrasonography suggested a cystic lesion, probably of the common bile duct. The patient underwent a total excision of type I choledochal cyst and gallbladder with Roux-en-Y anastomosis, and a wedge biopsy from the liver. Gross examination revealed multiple septa dividing the gallbladder into multiple compartments. The outer and inner surfaces of the choledochal cyst were unremarkable. Microscopically, the cyst wall was comp . . .osed of dense fibrous tissue with a single layer of cubic to columnar cells constituting the overlying epithelium. Serial sections incidentally revealed ectopic pancreatic tissue lying along the cyst wall characterized by acini, islets, and ductal structures with endocrine cells reactive for chromogranin A. Septa dividing the gallbladder were composed of fibrotic stalks containing smooth muscle fibers. Areas of papillary hyperplasia and intestinal metaplasia of gallbladder epithelium were also noted. The liver biopsy specimen demonstrated the presence of intrahepatic bile ducts, subsequently confirmed by cytokeratin 7. To our knowledge, this case represents the 1st one associated with these 3 entities and only the 2nd choledochal cyst with ectopic pancreatic tissue in its wall. © 2006 Society for Pediatric Pathology Daha fazlası Daha az

Surgeon performed intraoperative ultrasound accurately predicts margin status after neaoadjuvant chemotheraphy

Çakmak, Güldeniz Karadeniz | Mutlu, Sezgin | Şen, Hazal | Engin, Hüseyin | Bahadır, Burak | Bakkal, Bekir Hakan

Conference Object | 2018 | CANCER RESEARCH78 ( 4 ) , pp.312 - 315

San Antonio Breast Cancer Symposium -- DEC 05-09, 2017 -- San Antonio, TX WOS: 000425489400315

Helicobacter pylori prevalence in gastric adenocarcinoma

Bahadır, Burak | Gün, Banu Doğan | Kertiş, Gürkan | Yurdakan, Gamze | Barut, Figen | Bektaş, Sibel | Özdamar, Şükrü Oğuz

Proceedings | 2007 | VIRCHOWS ARCHIV451 ( 2 ) , pp.236 - 236

WOS: 000249454600361

Zonguldak Karaelmas Üniversitesi tıp fakültesi patoloji anabilim dalı histokimya ve immünohistokimya laboratuvar deneyimi

Özdamar, Şükrü Oğuz | Barut, Figen | Gün, Banu Doğan | Bahadır, Burak | Numanoğlu, Gamze | Çolak, Sacide | Gökçe, Havva

Article | 2006 | Ondokuz Mayis Universitesi Tip Dergisi23 ( 3 ) , pp.79 - 85

Histochemistry is based on, to become apparent for a chemical compound which is looked for the presence, as a result of consecutive chemical reactions, where as immunohistochemistry is based on, determination of antigenic epitops with specific antibodies, in tissue or cells. The aim of this study is to investigate contributions of histochemical and immunohistochemical methods for accurate diagnosis, which are very important diagnostic tools. Total 485 specimens, where 383 cases diagnosed as tumor and 102 cases as non tumor, stained with histochemical and/or immunohistochemical methods which were referred to Department of Pathology, . . .between January 2003-December 2005. were evaluated, among 1556 tumor cases which 1050 are benign and 506 malign. 317 histochemical staining for 184 cases, 1781 immunohistochemical staining for 485 cases which orientate the accurate diagnosis for these lesions, are reevaluated. By the help of these staining, the diagnosis of 485 cases reported as following: 155 epithelial (32.0%), 49 hematopoietic (10.1%), 20 vascular (4.1%), 13 neuroendocrine (2.7%). 8 melanocytic (1.7%) neoplasm, 47 soft tissue neoplasm (9.6%), 20 central nervous system (4.1%) and 20 peripheral nerve sheath tumors (4.1%), 43 metastatic (8.9%). 7 undifferentiated (1.4%) neoplasm, 1 other tumors (0.2%) and 102 non-tumoral lesions (21.1%). Histochemical staining used mostly with non-tumoral lesions with the rate of 60.7%. Immunohistochemical staining used for all of the cases with the following diagnosis: Hematopoietic, neuroendocrine and undifferentiated tumors, peripheral nerve sheath tumors and non-tumoral lesions. 39.8 percentage of 317 histochemical staining used for non-tumoral lesions, meanwhile 32.3 percentage of 1781 immunohistochemical staining for epithelial neoplasm. The contribution rate of appropriate histochemical and immunohistochemical staining for accurate diagnosis is 38.8% and 65.5% for non-tumoral lesions and 43.9% and 56.0% for epithelial neoplasm respectively, the higher rates encountered with for vascular neoplasm with 80.0 and 82.6 percentage. Histochemical staining were frequently used for non-tumoral lesions and also used mostly for epithelial tumors among the neoplastic lesions, whereas immunohistochemical methods were mostly used in differential diagnosis for the epithelial tumors. Significant positive results which contribute to the accurate diagnosis, determined mostly in the vascular tumors, with the use of both laboratory methods together Daha fazlası Daha az

Surgeon performed intraoperative ultrasound guidance with real - time specimen scanning may allow selective cavity shavings to reduce positive margin rates

Çakmak, Güldeniz Karadeniz | Emre, Ali Uğur | Bahadır, Burak | Gençoğlu, Atalya

Proceedings | 2017 | BREAST32 , pp.79 - 85

WOS: 000397930400303

Intraobserver and interobserver reproducibility of the Fuhrman nuclear grading for renal cell carcinoma

Bektaş, Sibel | Barut, Figen | Bahadır, Burak | Gün, Banu Doğan | Kandemir, Nilüfer Onak | Gül, Aylin Ege | Keser, Sevinç

Proceedings | 2007 | VIRCHOWS ARCHIV451 ( 2 ) , pp.405 - 405

WOS: 000249454600893

Surgeon performed continuous intraoperative ultrasound guidance decreases re-excisions and mastectomy rates in breast cancer

Karadeniz Çakmak, Güldeniz | Emre, Ali U. | Taşçılar, Öğe | Bahadır, Burak | Özkan, Selçuk

Article | 2017 | Breast33 , pp.23 - 28

Background Intraoperative ultrasound guided (IUG) breast conserving surgery (BCS) is being increasingly embraced by breast surgeons worldwide. We aimed to compare the efficacy of IUG-BCS for palpable and nonpalpable breast cancer with respect to margin status, re-excision rate, tissue sacrifice and cost-time analysis. Methods Intraoperative localization protocol includes intraoperative ultrasound prior to excision to localize the lesion and guide the initial resection. The excised specimen was then examined visually and by palpation and the specimen and cavity was examined with ultrasound. Frozen sections were obtained routinely fro . . .m a portion of all six faces of the resected specimen, and shaved cavity margins were sent for permanent histology. Results Of the 208 patients, 57.2% had nonpalpable tumors. The sensitivity of ultrasound localization was 100%. Negative margins were achieved in 92.43% of nonpalpable and 91.01% of palpable lesions at initial procedure. The involved margins were correctly identified by the surgeon via specimen sonography in 95.4% of cases. Final positive margin rate was 2.4%. Calculated resection ratio and time analysis revealed nothing significant. Conclusion IUG-BCS is an invaluable and effective modality for obtaining clear surgical margins with optimum resection volumes and reducing re-operations. Furthermore, by means of this algorithm, in case of shaving cavity margins of the tumor bed for permanent analysis, frozen section evaluation might be omitted. © 201 Daha fazlası Daha az

Distribution of ovarian tumors in Zonguldak Karaelmas University Hospital. Between 2001 and 2007

Barut, Figen | Barut, Aykut | Keretiş, Gürkan | Bektaş, Sibel | Gün, Doğan Banu | Bahadır, Burak | Yurdakan, Gamze

Other | 2008 | GORM:Gynecology Obstetrics & Reproductive Medicine14 ( 1 ) , pp.36 - 40

Hem benign hem de malign olmak üzere çok sayıda ovaryan tümör tipleri mevcuttur. Çalışmanın amacı, Zonguldak ve çevre şehirlerdeki ovaryan tümörlerin epidemiyolojisini retrospektif olarak değerlendirmektir. Patoloji ^bölümünde Mayıs 2001 ve Mart 2007 arası, değişik sebeplerden operasyona gitmiş 494 olgudan elde edilen 769 ooferektomi materyali gözden geçirilmiştir. Tümörler sınıflandırılmıştır. Ovaryan tümörlerin oranı tüm olgularda %16.0' (n:123) dır. 123 ovaryan tümörün dağılımı: %73,2'si (90) benign, %7,3'ü (9) borderline ve %19,5'i (24) ise malign tümörlerdir. Olguların 68'si (%55,3) yüzey epi-telyal-stromal tümörler; 34'ü (%27, . . .7) germ hücreli tümörler; 10'u (%8,1) seks kord-stromal tümörler; biri (%0,8) vasküler tümör ve 10'u (%8,1) metastatik tümörlerdir. Bizim çalışmamızda retrospektif olarak, kistadenom ve kista-denokarsinom, en sık görülen benign ve malign tümörler olup, bunların çoğunluğuda serözdür. Literatürlerle kıyaslandığında, överin yüzey epitelyal-stromal tümörleri daha az sıklıkla, fakat metastatik tümörleri hem over tümörleri içerisinde hem de malign grupta daha sık izlenmiştir. OBJECTIVE: There are numerous types of ovarian tumors, both benign and malignant. The aim of this study was to evaluate the epidemiology of ovarian tumors in Zonguldak and surrounding cities, retrospectively. STUDY DESIGN: Between May 2001 and March 2007, 769 oophorectomy materials from 494 cases which undergo operation for variable cause were reviewed in Department of Pathology. Tumors were classified. RESULTS: Ovarian tumor’s ratio was (n: 123) 16.0% in all cases. Distribution of 123 ovarian tumors: 73.2% (90) were benign, 7.3% (9) were borderline tumors and 19.5% (24) were malignant. 68 of the cases (55.3%) were surface epithelial-stromal tumor; 34 of the cases (27.7%) were germ cell tumors; 10 of the cases (8.1%) were sex cord-stromal tumors; one of the cases (0.8%) was vascular tumor and 10 of the cases (8.1%) were metastatic tumors. CONCLUSION: In our study cystadenoma and cystadenocarcinoma were the most frequent benign and malignant tumors respectively and most of them were serous. When compared with the literature, surface epithelial-stromal tumor of the ovary were less frequent, but metastatic tumors to ovary were more frequent in both whole and malignant groups Daha fazlası Daha az

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