Filtreler

Bulunan: 44 Adet 0.089 sn

Konu Başlıkları : Rat ✕

Koleksiyon [13]

İlgili Araştırmacılar [18]

Ambargo Durumu [1]

Tam Metin [2]

Yazar [90]

Yayın Türü [3]

Yayın Yılı [19]

Yayın Dili [3]

Dergi Adı [37]

Yayıncı [18]

Konu Başlıkları [90]

Tez Danışmanı [2]

Beneficial effects of melatonin on reperfusion injury in rat sciatic nerve

Sayan, Hale | Özaçmak, Veysel Haktan | Özen, Oğuz Aslan | Coşkun, Ömer | Arslan, S. Oktay | Sezen, S. Cem | Aktaş, R. Gülhan

Studies have shown that ischemia-reperfusion (I/R) produces free radicals leading to lipid peroxidation and to damage of the nervous tissue. Melatonin, a main secretory product of the pineal gland, has free radical scavenging and antioxidant properties and has been shown to diminish I/R injury in many tissues. There are a limited number of studies related to the effects of melatonin on I/R injury in the peripheral nervous system. Therefore, in the present study, the protective effect of melatonin was investigated in rats subjected to 2 hr of sciatic nerve ischemia followed by 3 hr of reperfusi ...Daha fazlası

Makale 2004 Journal of Pineal Research37 ( 3 ) , pp. 1 - 148 1274 Görüntülenme

Erişime Açık

L-Karnitin’in, x ışınlamaya bağlı gelişen uterus hasarında antioksidan ve antiinflamatuvar yollar ile koruyucu etkileri

Karaçetin, Serkan

Bu çalışmanın amacı total vücut ışınlaması sonrası, sıçanların uterusendometriyum tabakasında meydana gelen hasara karşı L-karnitin’in antioksidan, antiinflamatuar ve radyoprotektif etkilerini araştırmaktır. Çalışmamızda 30 adet Wistar albino sıçan, kontrol, radyasyon 6 saat, radyasyon 4 gün, radyasyon 6 saat+L-karnitin, radyasyon 4 gün+L-karnitin olmak üzere 5 gruba ayrıldı. Kontrol grubuna deney süresince intraperitonal yolla serum fizyolojik uygulandı. Radyasyon 6 saat ve radyasyon 4 gün gruplarına tüm vücut tek doz 8,3 Gy X ışını uygulandı. Bu gruplar ışınlama sonrasında 6. saat ve 4. günd ...Daha fazlası

Master Tezi 2020 Akpolat Ferah, Meryem Histoloji ve Embriyoloji Anabilim Dalı 854 Görüntülenme

Does intraabdominal use of Ankaferd Blood Stopper cause increased intraperitoneal adhesions? [Ankaferd Blood Stopper'in karin içi kullanim periton içi yapişklk oluşumunu arttrr m?]

Cömert M. | Karakaya K. | Barut F. | Karadeniz Çakmak G. | Uçan H.B. | Gültekin F.A. | Emre A.U.

Background The aim of this study was to investigate whether intraabdominal Ankaferd Blood Stopper (ABS) causes increased intraabdominal adhesion formation and to determine any side effects of ABS in vivo. Methods The present experimental study was designed to examine the effects of Ankaferd solution on peritoneal adhesion formation in a rat model of cecal abrasion. Intraperitoneal adhesions were assessed macroscopically and histopathologically on the 10th postoperative day. The possible adverse affects of ABS on liver and lung tissues were analyzed histopathologically, and blood chemistry was ...Daha fazlası

Makale 2010 Ulusal Travma ve Acil Cerrahi Dergisi16 ( 5 ) , pp. 3 - 389 849 Görüntülenme

Protective effect of melatonin on contractile activity and oxidative injury induced by ischemia and reperfusion of rat ileum

Özaçmak, Veysel Haktan | Sayan, Hale | Arslan, S. Oktay | Altaner, Şemsi | Aktaş, R.Gülhan

Free radicals derived from molecular oxygen have been reported to be responsible for changes in motility and mucosal damage observed in intestinal ischemia-reperfusion injury. Melatonin has been considered as an antioxidant that prevents injuries resulted from I/R in various tissues. The present study was designed to determine the effect of melatonin on the contractile responses of acetylcholine (Ach) and KCl, on malondialdehyde (MDA), a product of lipid peroxidation, and reduced glutathione (GSH) levels and to assess histopathological changes in the smooth muscle of terminal ileum subjected t ...Daha fazlası

Makale 2005 Life Sciences76 ( 14 ) , pp. 1 - 1588 865 Görüntülenme

Neuroprotective effects of Ebselen on experimental spinal cord injury in rats

Kalayci M. | Coskun O. | Cagavi F. | Kanter M. | Armutcu F. | Gul S. | Acikgoz B.

Spinal cord injury (SCI) results in rapid and significant oxidative stress. This study was aimed to investigate the possible beneficial effects of Ebselen in comparison with Methylprednisolone in experimental SCI. Thirty six Wistar albino rats (200-250 g) were divided in to six groups; A (control), B (only laminectomy), C (Trauma; laminectomy + spinal trauma), D (Placebo group; laminectomy + spinal trauma + serum physiologic), E (Methylprednisolone group; laminectomy + spinal trauma + Methylprednisolone treated), F (Ebselen group; laminectomy + spinal trauma + Ebselen treated), containing 6 ra ...Daha fazlası

Makale 2005 Neurochemical Research30 ( 3 ) , pp. 4 - 410 779 Görüntülenme

Light and electron microscopic examination of pineal gland in rats exposed to constant light and constant darkness

Kus I. | Sarsilmaz M. | Ozen O.A. | Turkoglu A.O. | Pekmez H. | Songur A. | Kelestimur H.

OBJECTIVE: This study was aimed to examine the pineal gland of rats exposed to constant light and darkness at light and electron microscopic level. DESIGN: For this purpose 18 male Wistar rats were used. Animals were divided into three groups. Rats in group I (Control) were kept under 12 hrs light: 12 hrs dark conditions. Rats in group II were exposed to constant darkness, while rats in group III were exposed to constant light for 6 weeks. At the end of the experiment, all animals were killed by decapitation. The pineal glands of rats were removed, then processed for light and electron microsc ...Daha fazlası

Makale 2004 Neuroendocrinology Letters25 ( 01.Feb ) , pp. 1 - 108 591 Görüntülenme

Effect of black cumin (Nigella sativa) on cadmium-induced oxidative stress in the blood of rats

Kanter M. | Coskun O. | Gurel A.

The protective effect of black cumin (Nigella sativa = NS) on cadmium-induced oxidative stress was studied in rats. The rats were randomly divided into three experimental groups: A (conrol), B (Cd treated), and C (Cd + NS treated), each containing 10 animals. The Cd-treated and Cd + NS-treated groups were injected subcutaneously daily with CdCl2 dissolved in isotonic NaCl in the amount of 2 mL/kg for 30 d, resulting in a dosage of 0.49 mg Cd/kg/d. The control group was injected with only isotonic NaCl (2 mL/kg/d) throughout the experiment (for 30 d). Three days prior to induction of CdCl 2, th ...Daha fazlası

Makale 2005 Biological Trace Element Research107 ( 3 ) , pp. 2 - 287 659 Görüntülenme

Effects of estradiol benzoate on the ultrastructure of the pinealocyte in the ovariectomized rat

Kus I. | Oner H. | Ozogul C. | Ayar A. | Ozen O.A. | Sarsilmaz M. | Kelestimur H.

Objective: The aim of this study was to examine the effects of ovariectomy and ovariectomy followed by estradiol benzoate administration on the ultrastructure of pinealocytes in female rat. Design: For this purpose 15 female Wistar rats were used. Animals were divided into three groups. Group I and II were designated as sham-ovariectomized (control) and ovariectomized, respectively. Group III was ovariectomized and daily injected with estradiol benzoate for one month. At the end of the experiment, all animals were anesthetized with ketamine for fixation by vascular perfusion. Pineal glands of ...Daha fazlası

Makale 2002 Neuroendocrinology Letters23 ( 05.Jun ) , pp. 4 - 410 575 Görüntülenme

Beneficial effects of Ebselen on corrosive esophageal burns of rats

Ocakci A. | Coskun O. | Tumkaya L. | Kanter M. | Gurel A. | Hosnuter M. | Uzun L.

Aim: This study was evaluated to investigate the efficacy of Ebselen, which is an organoselenium compound and glutathione peroxidase mimic, on the prevention of stricture development after esophageal caustic injuries in the rat. Methods: Thirty healthy male Wistar albino rats were utilized in this study. The rats were randomly allotted into one of three experimental groups: group A (sham) animals were uninjured. Caustic esophageal burn was created by applying 1 ml of 37.5% NaOH to the distal esophagus. Group B rats were injured but untreated. Group C rats were injured and received Ebselen (10 ...Daha fazlası

Makale 2006 International Journal of Pediatric Otorhinolaryngology70 ( 1 ) , pp. 4 - 52 806 Görüntülenme

Combination therapy of Nigella sativa and human parathyroid hormone on bone mass, biomechanical behavior and structure in streptozotocin-induced diabetic rats

Altan M.F. | Kanter M. | Donmez S. | Kartal M.E. | Buyukbas S.

Extracts of the seeds of Nigella sativa (NS), an annual herbaceous plant of the Ranunculaceae family, have been used for many years for therapeutic purposes, including their potential anti-diabetic properties. The aim of the present study was to test the hypothesis that combined treatment with NS and human parathyroid hormone (hPTH) is more effective than treatment with NS or hPTH alone in improving bone mass, connectivity, biomechanical behaviour and strength in insulin-dependent diabetic rats. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) at a single dose of 50 mg ...Daha fazlası

Makale 2007 Acta Histochemica109 ( 4 ) , pp. 3 - 314 509 Görüntülenme

Detailed spectral profile analysis of penicillin-induced epileptiform activity in anesthetized rats

Canan S. | Ankarali S. | Marangoz C.

Penicillin model is a widely used experimental model for epilepsy research. In the present study we aimed to portray a detailed spectral analysis of penicillin-induced epileptiform activity in comparison with basal brain activity in anesthetized Wistar rats. Male Wistar rats were anesthetized with i.p. urethane and connected to an electrocorticogram setup. After a short period of basal activity recording, epileptic focus was induced by injecting 400 IU/2 µl penicillin-G potassium into the left lateral ventricle while the cortical activity was continuously recorded. Basal activity, latent perio ...Daha fazlası

Makale 2008 Epilepsy Research82 ( 1 ) , pp. 7 - 14 372 Görüntülenme

The effect of locally administered organic silicon on calvarial bone defects

Turer, Akif | Onger, Mehmet Emin

Aim: The purpose of this study was to investigate the potential of the local administration of organic silicon on autogenous grafted critical-sized cortical bone defects. Material and Method: Twenty-four rats were divided into three groups: group C (passive control), group Au, and group Si. A 5-mm diameter critical-size defect was created in the calvarium of each rat. In group C, only a sterile saline-treated absorbable collagen sponge was applied to the defect area. In group Au, autogenous graft was performed and sterile saline-treated absorbable collagen sponge was applied on the autografted ...Daha fazlası

Makale 2017 JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE8 , pp. 3 - 358 296 Görüntülenme