Hür E. | Acar A. | Magden K. | Yildirim I. | Yayar O. | Köse S. | Yildiz G.

Makale | 2014 | Turkish Nephrology, Dialysis and Transplantation Journal23 ( 1 ) , pp.20 - 25

Objective: Cardiorenal syndrome (CRS) describes a dysregulation of the heart and kidneys affecting each other. Recently hemodialysis treatments were used more frequently. Aim was to analyze the effects of conventional diuretic and UF treatments. Material and Methods: Thirty-four Type 4 CRS diagnosed patients were included. Baseline characteristics were recorded. Echocardiography measured at the admission and at the end of the treatment. Results: The mean age 67.4±9.3 (51-93) years and follow-up period were 15.9±11.5 months. The patients were grouped as diuretic group, n=12 and UF group, n=22. At the beginning mitral valve A wave, bl . . .ood urea nitrogen and creatinine values were higher in the UF group while creatinine values were higher in the UF group compared to diuretic group at the end of the study. Although basal ejection fraction (EF) values were not different, it was higher in the UF group at the end of the study (42.38±12.70 % and 29±3.67 %, p 0.05). Conclusion: In Type 4 CRS, mortality and hospital admissions were not reduced by UF treatment but cardiac function assessed by EF was significantly improved suggesting this therapy to be beneficial in appropriate patients Daha fazlası Daha az

Türkili, Burak | Kurçer, Zehra | Dengiz-Özbakış, Günnur | Kandemir-Onak, Nilüfer | Mungan, Görkem | Özaçmak, Veysel Haktan | Banoğlu, Zekeriya Nur

Makale | 2012 | International Journal of Urology19 ( 3 ) , pp.257 - 263

Objectives: To determine whether angiotensin and endothelin have any role in testicular ischemia reperfusion injury by investigating the effects of the angiotensin converting enzyme inhibitor enalapril, selective non-peptide angiotensin-II type I blocker losartan and dual endothelin receptor blocker bosentan. Methods: Rats were anesthetized with thiopental sodium (50mg/kg i.p.) before the operation. The left testicular artery and vein of rats were occluded for 1h; before the bilateral orchiectomy, the organ was allowed to reperfuse for 3h or 24h. Enalapril (20mg/kg i.p.), losartan (30mg/kg i.p.), bosentan (10mg/kg i.p.) or vehicle ( . . .saline) were given 30min before reperfusion. Malondialdehyde level was measured in testicular tissue after 3h of reperfusion. Histological examination was carried out after 24h of reperfusion. Results: Ischemia reperfusion caused a significant increase in malondialdehyde level of ipsilateral testis, and histopathological injury in both ipsilateral and contralateral testes. Enalapril, losartan and bosentan treatments prevented the ischemia reperfusion-induced augmentation in malondialdehyde levels. Only bosentan treatment ameloriated ischemia reperfusion-induced histopathological alterations. Conclusions: Endothelin might play a more important role in pathogenesis of testicular ischemia reperfusion injury when compared with angiotensin. © 2011 The Japanese Urological Association Daha fazlası Daha az

Dogan S.M. | Birdane A. | Korkmaz C. | Ata N. | Timuralp B.

Makale | 2007 | Texas Heart Institute Journal34 ( 3 ) , pp.360 - 362

Behçet's syndrome is a chronic multisystem disease that presents with recurrent oral and genital ulceration and recurrent uveitis. Cardiac involvement is an extremely rare manifestation of this disorder. A 33-year-old man with Behçet's syndrome was admitted to our department with a history of cough, fever, chest pain, hemoptysis, and weight loss. Transthoracic and transesophageal echocardiography revealed a right ventricular thrombus. After 1 month of treatment with warfarin, cyclophosphamide, and corticosteroid, the intracardiac thrombus resolved. © 2007 by the Texas Heart® Institute.

Yildirim, N. | Tekin, N. S. | Dogan, S. M. | Tekin, I. O. | Aydin, M. | Dursun, A. | Gursurer, M.

Konferans nesnesi | 2007 | ATHEROSCLEROSIS SUPPLEMENTS8 ( 1 ) , pp.109 - 109

76th Congress of the European-Atherosclerosis-Society -- JUN 10-13, 2007 -- Helsinki, FINLAND WOS: 000247869100437

Karabag T. | Aydin M. | Dogan S.M.

Makale | 2013 | Turkiye Klinikleri Cardiovascular Sciences25 ( 1 ) , pp.26 - 28

Oxcarbazepine, 10 keto analogue of carbamezepine, is an antiepileptic drug used pri manly for the treatment of focal and generalized tonic clonic seizures in adults and children. Ox carbazepine has been observed to have a positive effect also on psychiatric diseases and trigeminal neuralgia. Oxcarbazepine like most of antiepileptic drugs, inhibits voltage dependent fast sodium channels. During oxcarbazepine treatment, side effects such as hyponatremia, headache, vertigo, somnolence, nausea, double vision, vomiting and ataxia can be seen. However, to date, no specific and!or severe cardiac complications of oxcarbazepine have been rep . . .orted. In this paper, we present a case of complete atrioventricular block that was considered to be caused by oxcarbazepine and that improved after cessation of the drug in a 67 year old female patient with no underlying cardiac etiology. Copyright © 2013 by Türkiye Klinik leri Daha fazlası Daha az

Çelebi G. | Büyükateş M. | Dogan S.M. | Pişkin N. | Aydemir H. | Öztoprak N. | Aktaş E.

Makale | 2009 | Mikrobiyoloji Bulteni43 ( 2 ) , pp.319 - 323

Staphylococcus lugdunensis is an infrequent cause of infective endocarditis (IE) and usually involves native valves of the heart. It causes life-threatening events such as rupture of cardiac valve or cerebral or pulmonary embolism due to necrosis on the endocardial tissue involved by the bacteria. Antibiotic therapy without cardiac surgery or delayed cardiac surgery usually follows a fatal course in S.lugdunensis endocarditis. In this report the first case of S.lugdunensis endocarditis from Turkey was presented. A 37 years-old man was admitted to the emergency department with a 2-weeks history of fever chills and accompanying interm . . .ittent pain on the left side of the thorax. Other than recurrent folliculitis continuing for 20 years, his history was unremarkable. Echocardiography revealed vegetation on the mitral valve of the patient and vancomycin plus gentamicin were initiated with the diagnosis of IE. All blood cultures (5 sets) taken on admission and within the initial 48 hours of the antibiotic therapy yielded S.lugdunensis. According to the susceptibility test results, the antibiotic therapy was switched to ampicillin-sulbac-tam plus rifampin. Blood cultures became negative after the third day of therapy, however, cardiac failure was emerged due to rupture of mitral valve and chorda tendiniea on the 12 th day of the therapy. Cardiac surgery revealed that mitral valve and surrounding tissue of the valve were evidently necrotic and fragile, anterior leaflet of the mitral valve was covered with vegetation, posterior leaflet and chorda tendiniea were ruptured. Vegetation was removed and the destructed mitral valve was replaced with a mechanical valve. Vegetation culture remained sterile, however, antibiotics were switched to vancomycin plus rifampin due to persistent fever on the 21 st day of the therapy (9 th day of operation). Fever resolved four days after the antibiotic switch. Antibiotics were stopped on the 9 th weeks of admission and the patient was discharged. He had no problem in follow-up controls for one year. In conclusion, proper antibiotic therapy combined with early cardiac surgery seems to be the optimal therapeutic approach in IE caused by S.lugdunensis Daha fazlası Daha az

Aydin M. | Tekin I.O. | Dogan S.M. | Yildirim N. | Arasli M. | Sayin M.R. | Aktop Z.

Makale | 2009 | Mediators of Inflammation2009 , pp.319 - 323

Background/Aim. Coronary artery ectasia (CAE) is considered as a variant of atherosclerosis. Tumor necrosis factor-alpha (TNF- ) and interleukin-6 (IL-6) are among the sensitive markers of systemic inflammation. The aim of this study was to evaluate the plasma levels of the cytokines; TNF- and IL-6 in CAE patients. Methods. Plasma concentrations of TNF- and IL-6 were measured in 36 patients with CAE (28 males, mean age: 58.2±12 years), and results were compared with age and sex-matched controls (n = 32) without coronary artery ectasia. TNF- and IL-6 concentrations in blood were assesed by enzyme-linked immunosorbent assay (ELISA). R . . .esults. Baseline characteristics of the two groups were similar. TNF- and IL-6 levels were significantly higher in CAE group than controls (15.6±11.2 pg/mL versus 7.8±3.7 pg/mL, Daha fazlası Daha az

Sayin, M. R. | Aydin, M. | Dogan, S. M. | Karabag, T. | Cetiner, M. A. | Aktop, Z.

Konferans nesnesi | 2011 | INTERNATIONAL JOURNAL OF CARDIOLOGY147 , pp.319 - 323

WOS: 000289284500049

Bayraktaroğlu, Taner | Kargı, Eksal | Yeşilli, Çetin | Numanoğlu, Gamze | Borazan, Ali | Üstündağ, Yücel

Makale | 2004 | Bağımlılık Dergisi5 ( 1 ) , pp.35 - 39

Bu çalışmada kısa süreli marihuana (esrar) kullanımı sonrası oligoastenospermi ve jinekomasti belirlenen bir olgunun sunulması amaçlanmıştır. Olgu: Otuzbir yaşında erkek, yaklaşık 20 günlük sol göğüs meme başı altında kitle yakınması ile başvurdu. Kitlenin ortaya çıkmaya başlamasından önceki yaklaşık 15 gün boyunca günlük esrar kullanımı tanımlamaktaydı. Fiziki muayenede sol meme areola altında hassas olmayan, çevre dokuya fikse olmamış 50 mm'lik kitle palpe edildi. Hastanın serum östradiol düzeyi yüksek bulundu. Ayrıca; sperm sayısının azalmış ve motilitesinin kaybolmuş olduğu saptandı. Meme ultrasonografisinde; sol memede 45 x 35 . . .x 25 mm'lik kitle vardı. Belirlenen kitlenin total eksizyonu ile yapılan patolojik inceleme ile hipertrofik meme dokusuna ait fibroadipoz doku içinde duktal yapılarında kistik genişlemeler dikkati çekti. A tipi veya displazi bulgusu mevcut değildi. Hastaya bu bulgularla jinekomasti tanısı konuldu ve ek tedavi planı yapılmadı. Hasta rutin poliklinik kontrollerine çağrıldı. Bu bir yıllık dönemde esrar hiç kullanmayan hastada jinekomasti bulgusu tekrarlamadı. Medikal tedavisiz bir yıllık takipte olgunun jinekomasti açısından herhangi bir yakınması yoktu ve serum estradiol seviyesi normal bulundu. Ayrıca; kontrol sperm analizinde düzelmeye başladığı saptandı. Bu olgu, bize kısa dönem esrar kullanımı ile bile jinekomasti ve oligoastenospermi gelişebileceğini düşündürmektedir. We aimed to present a case with oligoasthenospermia and gynecomastia after short term use of marihuana (cannabis). Case: Thirty one years old male admitted with complaint of sensation of mass in his left breast for the last 20 days. He was using cannabis for 15 days before noticing the mass. At physical examination; he had a subareolar nontender mass in his left breast which was approximately 50 millimeters in diameter and without signs of fixation into surrounding tissue. The patient had elevated serum estradiole levels. Sperm analysis revealed decreased sperm count and loss of sperm motility. Breast sonography revealed a hypoechoic mass 45x35x25 millimeters in diameters in his left breast. Abdomi-nal and scrotal sonographic examinations were normal. To-tal excision of the defined mass revealed hypertrophic mam-mary glands with cystic dilatations of several ductal structure in a fibroadipose tissue. There was no sign of atypia and or dysplasia. Gynecomastia was diagnosed and no further treatment was planned. He was called for routine follow up. During the next one year, he did not use cannabis and gynecomastia did not reappear. His control serum estradiol levels were decreased to normal ranges. Moreover; control sperm analyses were also evaluated as nearly normal. This case suggests that even short term use of cannabis can lead to gynecomastia and oligoasthenospermia Daha fazlası Daha az

Akpinar, I. | Sayin, M. R. | Karabag, T. | Dogan, S. M. | Sen, S. T. | Gudul, N. E. | Aydin, M.

Makale | 2013 | HERZ38 ( 3 ) , pp.317 - 320

Superior vena cava anomalies are rare malformations that are typically seen with other congenital cardiac defects. Although a persistent left superior vena cava is the most common anomaly of the systemic venous return in the thorax, its combination with an upper sinus venosus defect and absence of the innominate vein is extremely rare. Here, we report a patient diagnosed with these anomalies based on a bubble study and confirmed with magnetic resonance imaging.

Dogan, S. M. | Aktop, Z. | Aydin, M. | Karabag, T. | Sayin, M. R. | Bilici, H. M. | Atmaca, H.

Makale | 2012 | EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES120 ( 7 ) , pp.424 - 427

Background: The pathophysiology of atherosclerosis development in patients with diabetes mellitus (DM) is similar to that in nondiabetics. However, atherosclerosis develops earlier and runs a rapid course in patients with diabetes. Aortic stiffness, strain and distensibility are the parameters used to assess an increase in arterial stiffness and can be measured by invasive and non-invasive methods. Method: Aortic elastic properties were compared among patients with normal oral glucose tolerance test but impaired fasting glucose and healthy individuals. The study group consisted of 50 subjects with impaired fasting glucose who had no . . . known risk factors for atherosclerosis. The control group was composed of the same number of volunteers. Results: It was found that aortic strain and distensibility were reduced (8.78 +/- 4.3 vs. 10.65 +/- 2.6 Daha fazlası Daha az

Yildirim, N. | Tekin, N. S. | Dogan, S. M. | Tekin, I. O. | Aydin, M. | Dursun, A. | Gursurer, M.

Konferans nesnesi | 2007 | ATHEROSCLEROSIS SUPPLEMENTS8 ( 1 ) , pp.109 - 110

76th Congress of the European-Atherosclerosis-Society -- JUN 10-13, 2007 -- Helsinki, FINLAND WOS: 000247869100438