Horasanlı, Eyüp | Acar, Aydın | Muslu, Bünyamin | Çayönü, Melih | Çimencan, Murat | Kayabaşı, Serkan

Makale | 2015 | Turkish Journal of Medical Sciences45 ( 1 ) , pp.197 - 201

Background/aim: To assess mucociliary clearance in anesthetists who were exposed to waste anesthetic gases occupationally. Materials and methods: The first group consisted of 30 anesthetists who had been working at least 2 years. The control group of 30 subjects was selected from hospital staff with no history of occupational exposure to waste anesthetic gases. Mucociliary clearance time was assessed by measuring the saccharine nasal transit time (SNTT). Results: Thirty-six women and 24 men aged between 25 and 60 years were enrolled in the study. There were no differences between the anesthetist and control groups in terms of age, s . . .ex, height, or weight. The median SNTT for the anesthetists (10 min) was longer than that for the control group (8.3 min). The difference was significant (P = 0.025). In addition, there was a significant correlation between the SNTT and the working time (P = 0.02). Furthermore, anesthetists who had worked for 4 years or more had prolonged SNTT compared to those who had worked less than 4 years (P < 0.001). Conclusion: The present study demonstrated the impairment of mucociliary clearance in anesthetists. Increasing impairment with increasing working time was also detected. Background/aim: To assess mucociliary clearance in anesthetists who were exposed to waste anesthetic gases occupationally. Materials and methods: The first group consisted of 30 anesthetists who had been working at least 2 years. The control group of 30 subjects was selected from hospital staff with no history of occupational exposure to waste anesthetic gases. Mucociliary clearance time was assessed by measuring the saccharine nasal transit time (SNTT). Results: Thirty-six women and 24 men aged between 25 and 60 years were enrolled in the study. There were no differences between the anesthetist and control groups in terms of age, sex, height, or weight. The median SNTT for the anesthetists (10 min) was longer than that for the control group (8.3 min). The difference was significant (P = 0.025). In addition, there was a significant correlation between the SNTT and the working time (P = 0.02). Furthermore, anesthetists who had worked for 4 years or more had prolonged SNTT compared to those who had worked less than 4 years (P < 0.001). Conclusion: The present study demonstrated the impairment of mucociliary clearance in anesthetists. Increasing impairment with increasing working time was also detected Daha fazlası Daha az

Yamaner F. | Bayraktaroglu T. | Atmaca H. | Ziyagil M.A. | Tamer K.

Makale | 2010 | Turkish Journal of Medical Sciences40 ( 3 ) , pp.471 - 477

Aim: Leptin is an important controller of the size of fat stores by inhibiting appetite. In wrestling, fat metabolism is important not only for aerobic energy system, but also for weight control and weight loss before competition. The aim of this study was to measure and compare the serum leptin levels, glucose homeostasis, and serum lipoproteins between Turkish national wrestlers and sedentary males. Materials and methods: Forty-five Turkish national wrestlers at the end of Olympic training camp before Beijing 2008 Olympic Games and 43 sedentary students were selected as subjects. Post-exercise levels of serum leptin, HOMA (Homeost . . .asis model assessment) values, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, and VLDL-cholesterol were measured after overnight fasting. A Mann-Whitney U test was used to test the differences between 2 groups. Pearson Correlation was conducted between leptin and the other parameters. Results: No significant difference was observed among the means of leptin and total cholesterol levels of the 2 groups. Wrestlers had significantly higher fasting insulin, HDL-cholesterol, triglyceride, and HOMA levels, but a lower LDL-cholesterol level compared to the sedentary males. The positive correlation was only found between leptin and fasting insulin levels (r = 0.310, P = 0.043). Conclusion: This study indicated that wrestling training had no effect on resting leptin level after overnight fasting and wrestlers had also decreased insulin sensitivity with higher fasting insulin, HDL-cholesterol, triglyceride, and HOMA levels compared to sedentary males. © TÜBİTAK Daha fazlası Daha az

Karacaoğlan V. | Ada A.O. | Bilgen S. | Çetinkaya G.T. | Soydaş E. | Kunak C.S. | Alpar S.M.

Makale | 2017 | Turkish Journal of Medical Sciences47 ( 2 ) , pp.554 - 562

Background/aim: The association between polymorphisms of xenobiotic/drug metabolizing enzymes and TP53 and response to chemotherapy and survival of patients with nonsmall cell lung cancer (NSCLC) are limited and inconclusive. In this study, CYP2E1*5B, CYP2E1*6, CYP2E1*7B, GSTO1 (A140D), and TP53 (Arg72Pro) polymorphisms and response to platinum-based chemotherapy and survival in 137 advanced stage NSCLC patients were investigated. Materials and methods: Genetic polymorphism analyses were determined by polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP). Results: The patients with TP53 Pro/Pro . . . variant were more likely to be resistant to chemotherapy than those with Arg/Arg variants with marginal significance (P = 0.066). We also analyzed these gene variants in combination with CYP1A1 (Ile462Val), CYP1B1 (Asn453Ser), GSTM1, GSTP1 exon 5 (Ile105Val), and GSTP1 exon 6 (Ala114Val) and GSTT1 polymorphic genes that we have previously genotyped in the same patients (Ada et al., Neoplasma, 57, 512-527, 2010). The multivariate analysis revealed that adjusted hazard ratio (HR) of death of the combined variant genotypes of TP53 (Arg72Pro, Pro72Pro) and CYP1A1 (Ile462Val, Val462Val) increased significantly as compared to wild-type genotypes (HR, 6.03; 95% CI, 1.39–26.04, P = 0.016). Conclusion: These results show that combined variant genotypes of TP53 (Arg72Pro, Pro72Pro) and CYP1A1 (Ile/Val, Val/Val) are associated with worsening of survival in NSCLC patients. © TÜBİTAK Daha fazlası Daha az

Gün, Doğan Banu | Gün, Mustafa Özkan | Karamanoğlu, Ziya

Makale | 2004 | Turkish Journal of Medical Sciences34 ( 6 ) , pp.395 - 398

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Mungan, A. Görkem | Açıkgöz, Şerefden | Birol, Yüksel | Demirtaş, Selda | Tomaç, Nazan

Diğer | 2007 | Turkish Journal of Medical Sciences37 ( 6 ) , pp.373 - 376

Amaç: Montelukast, astım tedavisinde yaygın olarak kullanılan selektif ve etkili oral sistein lökotrien 1 reseptör antagonistidir. Bu çalışmamızda, malondialdehit düzeylerini ve paraoksonaz aktivitesini ölçerek, çocukluk çağı astım hastalarında oksidatif hasar ve antioksidan defans üzerine montelukast’ın etkilerini araştırdık. Hafif ve orta derecede atopik astımlı 25 çocuk hasta grubu olarak ve 25 non-atopik sağlıklı çocuk kontrol grubu olarak çalışmaya dahil edildi. Astımlı çocuklar bir ay boyunca 5 mg montelukast ile tedavi edildi. Serum paraoksonaz, malondialdehit ve HDL kolesterol seviyeleri tedavi öncesi ve sonrası ölçüldü. Mon . . .telukast tedavisi sonrası serum paraoksonaz ve paraoksonaz/HDL oranı anlamlı bir artış gösterdi. Kontrol grubu ile kıyaslandığında bu parametreler belirgin olarak yüksek bulundu. Montelukast tedavisi serum malondialdehit düzeylerinde bir artışa neden olmakla beraber, bu değişim istatistiksel olarak anlamlı değildi. Bu çalışmada montelukast’ın bronşial astımlı çocuklarda serum paraoksonaz aktivitesini etkin biçimde arttırdığı görüldü. Bu konuda yapılacak in vivo ve in vitro çalışmaların bu mekanizmayı aydınlatma konusunda faydalı olabileceğini düşünüyoruz. Montelukast, widely used in the treatment of asthma, is a selective and potent oral cysteinyl leukotriene-1 receptor antagonist. In this study, we investigated the effects of montelukast on oxidative stress and antioxidant defense in childhood asthma by measuring malondialdehyde and the paraoxonase activity. Twenty-five children with mild to moderate atopic asthma and 25 nonatopic children as controls were enrolled in the study. Asthmatic children were treated with montelukast, 5 mg tablets, for one month. Serum paraoxonase, malondialdehyde and high-density lipoprotein (HDL) cholesterol levels were measured before and after treatment. Serum paraoxonase and paraoxonase/HDL ratios were significantly increased after montelukast treatment. These parameters were significantly higher when compared with the normal subjects. Although montelukast treatment caused an enhancement in serum malondialdehyde, this increase did not reach statistical significance between the groups. The present study clearly demonstrates that montelukast increases paraoxonase activity in children with bronchial asthma. However, for better understanding of this enhancement, additional in vivo and in vitro studies are required Daha fazlası Daha az

Çakir Erdoğan D. | Cömert F. | Aktaş E. | Köktürk F. | Külah C.

Makale | 2017 | Turkish Journal of Medical Sciences47 ( 1 ) , pp.172 - 179

Background/aim: The aim of this study was to determine the prevalence of fecal carriage of extended-spectrum beta-lactamase (ESBL)-producing bacteria, enzyme types, and risk factors affecting colonization. Materials and methods: A total of 576 stool samples from outpatients were examined between October 2012 and May 2013. Screening was done with selective EMB plates. ESBL were detected by double-disk synergy and confirmed agar strip gradient methods. Enzyme types were determined by PCR. Results: The prevalence of fecal carriage was found as 30% (173 of 576). Recent use of antibiotics, hospitalization and surgical operation, diabetes . . ., crowded household populations, and old age were associated with higher carriage rates. Of the ESBL-producing bacteria, 87.5% were positive for blaCTX-M genes. Of the blaCTX-M gene-positive isolates, 95.2% were positive for blaCTX-M-1 genes; among these, 82.2% were positive for blaCTX-M-3 and 67.7% were positive for blaCTX-M-15 genes while 62.5% isolates were positive for both blaCTX-M-3 and blaCTX-M-15 genes Conclusions: A high rate (30%) of fecal carriage of ESBL bacteria was found in an adult population. The predominant beta-lactamase enzyme types were CTX-M-3 and CTX-M-15. © TÜBİTA Daha fazlası Daha az

Mahmutyazıcıoğlu, Kamran | Beşir, Fahri Halit | Bardakçı, Mustafa | Tanrıverdi, Hamit Alper | Ankaralı, Handan

Makale | 2014 | Turkish Journal of Medical Sciences44 ( 5 ) , pp.853 - 861

Aim: Findings from clinical studies in postmenopausal women with late initiation of hormone replacement therapy (HRT) that test whether HRT protects cognitive functions in women are inconsistent. The aim of this study was to investigate the effects of HRT on brain metabolite ratios when initiated in the early postmenopausal period (critical window). Materials and methods: Proton magnetic resonance spectrometry (1H MRS) was performed in 4 brain regions of 47 healthy postmenopausal women (21 received HRT, 26 did not). The subjects were aged between 45 and 65 years. The duration of HRT ranged from 1 to 12 years (mean: 6.3 years). The d . . .uration of menopause was 2–12 years (mean: 6.1 years) for HRT users and 1–20 years (mean: 7.8 years) for non-HRT users. Metabolite ratios [N-acetyl aspartate/choline (NAA/Cho), NAA/creatine (Cr), and Cho/Cr] were evaluated. Results: Cho/Cr ratios were significantly increased and NAA/Cho ratios significantly decreased in all 4 regions in the HRT user group compared to the other group after elimination of the effects of age and menopause duration. Regression analysis revealed an association only between NAA/Cho and duration of menopause. Conclusion: HRT-related changes in metabolite ratios are found in all brain regions. Decreased NAA/Cho and increased Cho/Cr levels do not support the neuroprotective role of HRT in the critical window. Aim: Findings from clinical studies in postmenopausal women with late initiation of hormone replacement therapy (HRT) that test whether HRT protects cognitive functions in women are inconsistent. The aim of this study was to investigate the effects of HRT on brain metabolite ratios when initiated in the early postmenopausal period (critical window). Materials and methods: Proton magnetic resonance spectrometry (1H MRS) was performed in 4 brain regions of 47 healthy postmenopausal women (21 received HRT, 26 did not). The subjects were aged between 45 and 65 years. The duration of HRT ranged from 1 to 12 years (mean: 6.3 years). The duration of menopause was 2–12 years (mean: 6.1 years) for HRT users and 1–20 years (mean: 7.8 years) for non-HRT users. Metabolite ratios [N-acetyl aspartate/choline (NAA/Cho), NAA/creatine (Cr), and Cho/Cr] were evaluated. Results: Cho/Cr ratios were significantly increased and NAA/Cho ratios significantly decreased in all 4 regions in the HRT user group compared to the other group after elimination of the effects of age and menopause duration. Regression analysis revealed an association only between NAA/Cho and duration of menopause. Conclusion: HRT-related changes in metabolite ratios are found in all brain regions. Decreased NAA/Cho and increased Cho/Cr levels do not support the neuroprotective role of HRT in the critical window Daha fazlası Daha az

Ünal, Serap Tilki | Engin, Hüseyin | Gökmen, Ayla | Bilir, Cemil | Üstündağ, Yücel

Makale | 2013 | Turkish Journal of Medical Sciences43 ( 2 ) , pp.194 - 198

Aim: Thrombomodulin (TM) and endothelial protein C receptor (EPCR) are 2 transmembrane proteins that are thought to play an important role in cancer. We aimed to discover whether these 2 proteins are prognostic indicators in colorectal cancer. Materials and methods: Plasma TM and EPCR levels were measured using the ELISA method in 50 patients in different tumor stages that had been recently diagnosed with colorectal cancer and in a healthy control group of 50 people. Results: In colorectal cancer patients, higher plasma TM (21.3 ± 22.8 ng/mL, 13.2 ± 16.2 ng/mL, P = 0.010) and plasma EPCR levels (149.9 ± 79.6, 113.3 ± 49.3, P = 0.007 . . .) were determined compared to the control group. No statistically significant relationship was present between plasma TM, EPCR levels and tumor stage, tumor localization, tumor differentiation, lymphovascular invasion state, microvascular thrombus existence, and thrombosis progression (P > 0.05). Conclusion: We think that these 2 proteins are released into plasma as an indicator of endothelial dysfunction and can play a role in pathogenesis and biology of colorectal cancer. Aim: Thrombomodulin (TM) and endothelial protein C receptor (EPCR) are 2 transmembrane proteins that are thought to play an important role in cancer. We aimed to discover whether these 2 proteins are prognostic indicators in colorectal cancer. Materials and methods: Plasma TM and EPCR levels were measured using the ELISA method in 50 patients in different tumor stages that had been recently diagnosed with colorectal cancer and in a healthy control group of 50 people. Results: In colorectal cancer patients, higher plasma TM (21.3 ± 22.8 ng/mL, 13.2 ± 16.2 ng/mL, P = 0.010) and plasma EPCR levels (149.9 ± 79.6, 113.3 ± 49.3, P = 0.007) were determined compared to the control group. No statistically significant relationship was present between plasma TM, EPCR levels and tumor stage, tumor localization, tumor differentiation, lymphovascular invasion state, microvascular thrombus existence, and thrombosis progression (P > 0.05). Conclusion: We think that these 2 proteins are released into plasma as an indicator of endothelial dysfunction and can play a role in pathogenesis and biology of colorectal cancer Daha fazlası Daha az

Yurtlu, Bülent Serhan | Hancı, Volkan | Ege, Ahmet | Bostankolu, Selime Evrim | Ayoğlu, Hilal | Özkoçak, Işıl Turan

Makale | 2012 | Turkish Journal of Medical Sciences42 ( 1 ) , pp.55 - 62

Amaç: Bu randomize prospektif çift kör çalışmada aksiller pleksus bloğunda levobupivakaine tramadol eklenmesinin etkilerini araştırmayı amaçladık. Yöntem ve gereç: El veya önkolda cerrahisi için aksiller pleksus bloğu planlanan 60 hasta randomize olarak iki gruba ayrıldı. Grup L’de 36 mL % 0,5 levobupivakain ve 2 ml serum fi zyolojik; Grup LT’de 36 mL % 0.5 levobupivakain ve 2 mL 100 mg tramadol kullanıldı. Rutin monitörizasyonu takiben aksiller blok sinir stimülatörüyle çoklu stimülasyon tekniği kullanılarak uygulandı. Motor (parmak, el bileği, dirsek hareketleri) ve duyusal (kutanöz pinprik duyusu) blok karakteristikleri radiyal, . . .medyan, ulnar ve muskulokutanöz sinirler için her 5 dakikada değerlendirildi. Postoperatif motor ve duyusal blok süresi, analjezik tüketimi ve nümerik ağrı skoru (NRS) kaydedildi. Bulgular: Her grupta 2’şer hastada blok başarısızlığı mevcuttu. Kalan 56 hastanın verileri analiz edildi. Çalışma grupları arasında dört sinirin motor ve duyusal blok karakteristikleri, analjezik tüketimleri ve NRS skorları arasında fark yoktu. Sonuç: Aksiller blokta % 0,5 levobupivakaine 100 mg tramadol eklenmesi intraoperatif blok kalitesini artırmamış ve postoperatif analjezi süresini uzatmamıştır Aim: To evaluate the eff ect of tramadol addition to levobupivacaine in axillary plexus blockade in a prospective, randomized double-blind study. Materials and methods: A total of 60 patients scheduled to undergo hand and forearm surgery under axillary plexus blockade were randomly divided into 2 groups. Group L received 36 mL of racemic 0.5% levobupivacaine with 2 mL of saline, whereas Group LT received 2 mL (100 mg) of tramadol instead of saline. Aft er routine monitorization, axillary block was performed with a multistimulation technique using a nerve stimulator. Motor (fi nger, wrist, and elbow movements) and sensory (pinprick sensation for the cutaneous supply) block characteristics for radial, median, ulnar, and musculocutaneous nerves were determined every 5 min. Postoperative motor and sensory block duration, analgesic consumption, and numeric rating scale (NRS) scores were also recorded. Results: In each group, 2 patients had block failures. Th e data for the remaining 56 patients were analyzed. Th ere were no signifi cant diff erences between the study groups according to motor and sensory block characteristics of 4 nerves, block durations, analgesic consumption, and NRS scores. Conclusion: Th e addition of 100 mg of tramadol to 0.5% levobupivacaine for axillary brachial plexus blockade neither improved the intraoperative block quality nor prolonged the duration of postoperative analgesia Daha fazlası Daha az

Gonca, Ersöz

Makale | 2015 | Turkish Journal of Medical Sciences45 ( 6 ) , pp.1413 - 1420

Background/aim: To investigate the influence of thiopental (85 mg/kg, intraperitoneally (ip)), and ketamine+xylazine (ketamine 75 mg/kg and xylazine 8 mg/kg, ip) anesthesia on the incidence and duration of ischemia/reperfusion-induced arrhythmias. Materials and methods: Myocardial ischemia was induced by a 6-min ligation of the left anterior descending coronary artery, followed by a 6-min reperfusion. Measurements were taken of the incidence and duration of ventricular arrhythmias, the mean arterial blood pressure and heart rate, and the pressure rate-product (as an index of myocardial oxygen consumption). Results: The arrhythmia sc . . .ore and the incidence of ventricular fibrillation and tachycardia were significantly decreased in the ketamine+xylazine-anesthetized rats compared with the thiopental-anesthetized group (arrhythmia score: 2.0 ± 2.1 versus 3.7 ± 1.2, P < 0.05). The heart rate was significantly lower in the ketamine+xylazine group during the entire experiment, whilst the pressure-rate product was also significantly lower in the ketamine+xylazine group at different time points of the ischemia and reperfusion periods. Conclusion: Ketamine+xylazine anesthesia has a strong antiarrhythmic effect and an apparent depressive action on the heart rate and the myocardial oxygen consumption index. Therefore, ketamine+xylazine anesthesia is not appropriate for the evaluation of possible antiarrhythmic agents. Thiopental anesthesia is preferable to ketamine+xylazine anesthesia in the in vivo ischemia-reperfusion arrhythmia model. Background/aim: To investigate the influence of thiopental (85 mg/kg, intraperitoneally (ip)), and ketamine+xylazine (ketamine 75 mg/kg and xylazine 8 mg/kg, ip) anesthesia on the incidence and duration of ischemia/reperfusion-induced arrhythmias. Materials and methods: Myocardial ischemia was induced by a 6-min ligation of the left anterior descending coronary artery, followed by a 6-min reperfusion. Measurements were taken of the incidence and duration of ventricular arrhythmias, the mean arterial blood pressure and heart rate, and the pressure rate-product (as an index of myocardial oxygen consumption). Results: The arrhythmia score and the incidence of ventricular fibrillation and tachycardia were significantly decreased in the ketamine+xylazine-anesthetized rats compared with the thiopental-anesthetized group (arrhythmia score: 2.0 ± 2.1 versus 3.7 ± 1.2, P < 0.05). The heart rate was significantly lower in the ketamine+xylazine group during the entire experiment, whilst the pressure-rate product was also significantly lower in the ketamine+xylazine group at different time points of the ischemia and reperfusion periods. Conclusion: Ketamine+xylazine anesthesia has a strong antiarrhythmic effect and an apparent depressive action on the heart rate and the myocardial oxygen consumption index. Therefore, ketamine+xylazine anesthesia is not appropriate for the evaluation of possible antiarrhythmic agents. Thiopental anesthesia is preferable to ketamine+xylazine anesthesia in the in vivo ischemia-reperfusion arrhythmia model Daha fazlası Daha az

Gonca E.

Makale | 2015 | Turkish Journal of Medical Sciences45 ( 6 ) , pp.1413 - 1420

Background/aim: To investigate the influence of thiopental (85 mg/kg, intraperitoneally (ip)), and ketamine+xylazine (ketamine 75 mg/kg and xylazine 8 mg/kg, ip) anesthesia on the incidence and duration of ischemia/reperfusion-induced arrhythmias. Materials and methods: Myocardial ischemia was induced by a 6-min ligation of the left anterior descending coronary artery, followed by a 6-min reperfusion. Measurements were taken of the incidence and duration of ventricular arrhythmias, the mean arterial blood pressure and heart rate, and the pressure rate-product (as an index of myocardial oxygen consumption). Results: The arrhythmia sc . . .ore and the incidence of ventricular fibrillation and tachycardia were significantly decreased in the ketamine+xylazine-anesthetized rats compared with the thiopental-anesthetized group (arrhythmia score: 2.0±2.1 versus 3.7±1.2, P < 0.05). The heart rate was significantly lower in the ketamine+xylazine group during the entire experiment, whilst the pressure-rate product was also significantly lower in the ketamine+xylazine group at different time points of the ischemia and reperfusion periods. Conclusion: Ketamine+xylazine anesthesia has a strong antiarrhythmic effect and an apparent depressive action on the heart rate and the myocardial oxygen consumption index. Therefore, ketamine+xylazine anesthesia is not appropriate for the evaluation of possible antiarrhythmic agents. Thiopental anesthesia is preferable to ketamine+xylazine anesthesia in the in vivo ischemia-reperfusion arrhythmia model. © TÜBİTAK Daha fazlası Daha az

Bozdoğan, Ömer | Gonca, Ersöz | Ekerbiçer, Nuran

Diğer | 2010 | Turkish Journal of Medical Sciences40 ( 2 ) , pp.249 - 256

Amaç: Adenozin supraventriküler taşikardili hastaların tedavisinde kullanılan etkili bir ilaçtır. Ancak, adenozinin iskemi ve reperfüzyon aritmileri üzerine adsenozin etkisi ile ilgili sadece bir kaç çalışma vardır ve bunlarında sonuçları tartışmalıdır. Bu çalışmada adenozinin iskemi-reperfüzyon aritmileri üzerine etkisinin araştırılması amaçlanmıştır. Yöntem ve gereç: Sol koroner arter bağlanarak 6 dakika iskemi ve bağ gevşetilerek 15 dakika reperfüzyon yapılmıştır. Bir A1 adenozin reseptor agonisti olan CCPA (2 Chloro - N6 – Cyclopentyl-adenosine) ve anatgonisti, DPCPX (8- Cyclopentyl-1,3-dipropylxanthine), 5 ?g/kg dozunda tek ve . . .birlikte iskemiden önce, iskeminin ikinci dakikasında ve reperfüzyonu hemen takiben intravenöz olarak verilmiştir. Bulgular: Sadece ligasyonun ikinci dakikasında verilen CCPA, 15 dakikalık reperfüzyon boyunca oluşan aritmi süresini azaltmıştır. Bu dönemde verilen adenozin antagonisti, DPCPX, adenozinin bu antiaritmik etkisini ortadan kaldırmıştır. Reperfüzyon sırasında ve ligasyondan önce verilen adenozinin reperfüzyonu takiben oluşan aritmiler üzerine bir etkisi olmamıştır. Sonuç: İskemi ve reperfüzyon sırasında veriliş zamanı, adenozinin etkisinde önemlidir. Bu çalışma adenozin ile oluşturulan antiaritminin, A1 adenozin reseptorlarının aktivasyonu ile ilgili olduğunu göstermiştir. Aim: Adenosine has been commonly used to treat supraventricular tachycardia in clinics. However, there are only a few studies on the effects of adenosine on ischemia or reperfusion induced arrhythmia and they conflict with the results of the present study. During this study, we aimed to clarify the effect of adenosine on ischemia-reperfusion induced arrhythmia. Materials and methods: Left coronary artery was ligated for 6 min and it was released for 15 min to produce reperfusion. A1 adenosine agonist CCPA (2 Chloro - N6 &#8211; Cyclopentyl-adenosine), and A1 selective antagonist DPCPX (8 &#8211; Cyclopentyl - 1,3 -dipropylxanthine) in 5 &#956;g/kg dose alone and in combination were given intravenously before ligation, at the second minute of the ligation and just following the reperfusion. Results: Adenosine given only at the second minute of the ligation is found to decrease the total duration of arrhythmia observed in the reperfusion stage. DPCPX given in this period is found to block the antiarrhythmic effect of adenosine. Adenosine given after reperfusion and before ligation was not effective in decreasing reperfusion induced arrhythmia. Conclusion: The time dependent effect of the administration during ischemia and reperfusion was important for the effect of adenosine. The present study showed that antiarrhythmia produced by adenosine is related to the activation of A1 adenosine receptor Daha fazlası Daha az