Aydemir, Selim | Tekin, Solak Nilgün | Aktunç, Erol | Numanoğlu, Gamze | Üstündağ, Yücel

Article | 2004 | Turkish Journal of Gastroenterology15 ( 3 ) , pp.192 - 195

Amaç: Celiac hastalığı ince barsakların glutene intoleransı sonucu oluşan bir hastalıktır. Epidemiolojik çalışmalarda prevalansı hakkında çok farklı veriler vardı. Hastalarda genellikle çok geniş spektrumda semptom ve bulgulara neden olabildiğinden celiac hastalığı tanısının konulması zor olabilmektedir. Hastalığın erken evrede yakalanması önemlidir. Çünkü bu hastalarda barsak lenfoması gelişme riski artmıştır. Celiac hastalığı olan hastalarda rekürren aftoz stomatit prevalansındaki yükseklik nedeniyle rekürren aftoz stomatitli hastaların celiac hastalığı yönünden araştırılması asemptomatik celiac hastalığı olan hastaların tanı alma . . .sını sağlayabilir. Bu çalışma rekürren aftoz stomatit nedeniyle başvuran olgularda celiac hastalığı prevalansını saptamak için planlanmıştır. Yöntem: Çalışma gurubu olarak rekürren aftoz stomatit öyküsü olan, kontrol grubu olarak ise rekürren aftoz stomatit öyküsü olmayan olgular alındı. Tüm olgularda anti gliadin IgG, antigliadin IgA ve anti endomisium antikorları bakıldı. Ayrıca endoskopi yapılarak duodenum distal kesiminden biyopsiler alındı. Bulgular: Rekürren aftoz stomatit öyküsü olan 41 olgunun ikisinde patolojik inceleme ile doğrulanan celiac hastalığı bulundu (%4.8). Celiac hastalığı saptanan bu iki olgunun her ikisinde de anti gliadin IgA ve endomisium antikorları pozitif bulundu. Anti gliadin IgG antikoru ise olguların birinde pozitifti. Kontrol grubundaki 49 olgunun hiçbirinde celiac hastalığı saptanmadı. Sonuç: Rekürren aftoz stomatit olgularında celiac hastalığı açısında ileri incelenmeler yapılmalıdır. Endoskopinin invaziv ve daha pahalı olması nedeniyle rekürren aftoz stomatitli olgularda celiac hastalığı ı araştırmak için öncelikli olarak serolojik tetkikler yapılmalı, seroljik markır pozitif olan olgularda endoskopik olarak duodenum ikinci kesiminden biyopsiler alınmalıdır. Background/aims: Celiac disease is a condition related to the small intestine’s intolerance to gluten. In epidemiologic studies the prevalence is highly variable. The diagnosis can be difficult due to the wide spectrum of signs and symptoms. As the risk for intestinal lymphoma is higher in these patients, early diagnosis has its privileges. The higher prevalence of recurrent aphthous stomatitis in celiac disease led us to investigate the celiac disease prevalence in patients with recurrent aphthous stomatitis, which might assist in diagnosis of asymptomatic celiac disease patients. The aim of this study was to determine the prevalence of celiac disease in patients presenting with recurrent aphthous stomatitis. Methods: The study group consisted of patients having a history of recurrent aphthous stomatitis. The control group included patients not having aphthous stomatitis. Antibodies to gliadin IgG and IgA and antibodies to endomysium were determined from the serum samples of all patients. Biopsies were obtained from the distal part of the duodenum. Results: Biopsies of two patients (4.8%) out of 41 belonging to the study group were diagnosed as celiac disease. In serum samples of both, antibodies to gliadin IgA and antibodies to endomysium were found to be positive. Antibodies to gliadin IgG antibody were positive in only one of these two patients. None of the 49 patients in the control group was diagnosed as celiac disease. Conclusion: Further evaluation of recurrent aphthous stomatitis patients for celiac disease must be performed. As the endoscopic procedures are invasive and costly, evaluation of recurrent aphthous stomatitis patients for celiac disease must include serologic markers at the beginning. If any positivity is determined in markers, then endoscopic procedures including biopsies of the duodenum must be considered as the second-step intervention Daha fazlası Daha az

Üstündağ, Yücel | Sarıtaş, Ülkü | Ponchon, Thierry

Article | 2011 | Turkish Journal of Gastroenterology22 ( 3 ) , pp.237 - 242

Küçük çaplı endoskoplar gastrointestinal endoskopinin müthiş teknolojik gelişiminin en iyi örneklerinden biridir. ilk olarak pediatrik yaş grubu için 1970’li yıllarda tasarlanmışken, günümüzdeki küçük çaplı videoendoskoplar, sedasyonsuz transnazal gastrointestinal endoskopi için 1994’den sonra kullanılmışlardır. Günümüzde, sedasyonsuz endoskopi bu cihazları kullanarak transoral veya transnazal olarak, olguların %90’ında başarıyla uygulanabilmektedir. Büyük serili çalışmalar, küçük çaplı endoskopinin uygulanması mümkün, güvenli ve iyi tolere edilen bir işlem olduğunu göstermiştir. Küçük çaplı endoskoplar, daha az öğürme refleksi veya . . . boğulma hissi uyandırdıkları için, sedasyon ihtiyacını ortadan kaldırarak, gastrointestinal endoskopinin potansiyel risklerini azaltmaktadırlar. Ayrıca, küçük çaplı endoskopi ile gastrointestinal endoskopi, özellikle yaşlı, yatağa bağımlı bireylerde, standart konvansiyonel endoskoplara göre daha az sempatetik sistem aktivasyonu ve daha az oksijen desatürasyonuna neden olmaktadır. Bununla beraber, küçük çaplı endoskopinin maliyet etkinlik analizinde bir görüş birliği olamamıştır. Standart endoskopi ile aynı endikasyonları olmasına rağmen, küçük çaplı endoskopi gastrointestinal darlığı olan olgularda tercih edilmektedirler. Daha az sıklıkla olan endikasyonlar, transnazal endoskopik retrograd kolanjiografi ve postpilorik beslenme tüpü yerleştirilmesidir. Küçük çaplı endoskopi ile özofagogastroduodenoskopi işlem uygulaması kolaydır ve genel olarak bu işlem için daha fazla eğitime gerek olmamaktadır. Bununla beraber, cihazların ek maliyeti, bazı medikolegal ve teknik durumlar, bu işlemin Japonya ve Fransa hariç olmak üzere bir çok ülkede popüler olamamasına neden olmuştur. Ancak, bu teknik hakkında bilgi paylaşımı ve bu cihazların potansiyel faydalarının vurgulanması, Türkiye dahil olmak üzere bir çok ülkede daha yaygı n kullanımına yardımcı olabilecektir. inanıyoruz ki, gastrointestinal endoskopi için küçük çaplı endoskopların günlük gastrointestinal endoskopi pratiğinde rutin kullanılması, bir çok ülke için çok uzak gözükmemektedir. Small caliber endoscopes are one of the best examples of fantastic technological advancements in gastrointestinal endoscopy. First designed for pediatric patients in the 1970s, current small caliber videoendoscopes were used for unsedated transnasal gastrointestinal endoscopy after 1994. Nowadays, unsedated endoscopy can be successfully done using small caliber endoscopes via transoral or transnasal route in nearly 90% of cases. Several large studies have shown that small caliber endoscopy is feasible, safe and well-tolerated. These devices can decrease the potential risks of upper gastrointestinal endoscopy by eliminating the need for sedation since these ultrathin endoscopes induce much less gag reflex or choking sensation in patients. Moreover, gastrointestinal endoscopy with small caliber endoscopes results in less sympathetic system activation as well as less oxygen desaturation compared to standard endoscopy, especially in aged, severely ill, bedridden patients. Nevertheless, there is no overall consensus on its cost effectiveness. Though indications are similar with standard endoscopy, small caliber endoscopy can be preferred in patients with gastrointestinal stenosis. Less common indications include transnasal endoscopic retrograde cholangiography and postpyloric feeding tube insertion. The esophagogastroduodenoscopy procedure with small caliber endoscopes is easy to perform, and there is generally no need for further training for this technique. However, the additional cost of equipment and some medicolegal and technical issues have resulted in the unpopularity of small caliber endoscopy in most countries other than France and Japan. However, sharing information about this technique and stressing its potential advantages can help in its widespread use in various countries including Turkey. We believe that routine use of small caliber endoscopes during daily gastrointestinal endoscopy practice is not far away in many countries Daha fazlası Daha az

Demirci, Hakan | Uygun, Ahmet | Uygun, Sevil İlikhan | Öztürk, Kadir | Üstündağ, Yücel | Kurt, Ömer | Bilici, Muammer

Letter | 2016 | Turkish Journal of Gastroenterology27 ( 3 ) , pp.290 - 291

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Sarıtaş, Ülkü | Üstündağ, Yücel | Baron, Todd H.

Article | 2011 | Turkish Journal of Gastroenterology22 ( 5 ) , pp.449 - 463

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Dökmeci, Abdulkadir | Üstündağ, Yücel | Hulagu, Saadettin | Tuncer, İlyas | Akdoğan, Meral | Demirsoy, Hüseyin | Köklü, Seyfettin

Article | 2014 | Turkish Journal of Gastroenterology25 ( 5 ) , pp.546 - 552

Background/Aims: To evaluate the association between insulin resistance and hepatic fibrosis in patients with chronic hepatitis C.Materials and Methods: A total of 104 chronic hepatitis C patients were included in this non-interventional, openlabel, observational, multicenter, cross-sectional study conducted at 20 gastroenterology clinics in Turkey. The primary end point was the correlation between stage of hepatic fibrosis and insulin resistance evaluated via the homeostasis model of assessment-insulin resistance index. Confounders of hepatic fibrosis and insulin resistance were the secondary end points. Results: The mean age of pa . . .tients was 52.8 years; 65.4% were female. Type 2 diabetes was present in 6.8% and insulin resistance noted in 38.0% of patients. Further, 45.7% of the patients had mild (A0/A1) and the remaining had moderate/severe (A2/A3) hepatic necroinflammatory activity. Patient distribution according to Metavir fibrosis stage was as follows: F0/F1 (57.0%); F2 (6.5%); F3 (23.7%); and F4 (12.9%). A univariate analysis revealed significant positive correlations between Metavir fibrosis stage and insulin resistance (r=0.297; p=0.007). Logistic regression analysis showed that significant predictors of insulin resistance were high alanine transaminase levels (odds ratio, 0.97; 95% confidence interval, 0.944-0.997) and liver fibrosis stage (odds ratio, 0.114; 95% confidence interval, 0.0210.607).Conclusion: Our findings revealed significant associations between insulin resistance and hepatic fibrosis. Background/Aims: To evaluate the association between insulin resistance and hepatic fibrosis in patients with chronic hepatitis C.Materials and Methods: A total of 104 chronic hepatitis C patients were included in this non-interventional, openlabel, observational, multicenter, cross-sectional study conducted at 20 gastroenterology clinics in Turkey. The primary end point was the correlation between stage of hepatic fibrosis and insulin resistance evaluated via the homeostasis model of assessment-insulin resistance index. Confounders of hepatic fibrosis and insulin resistance were the secondary end points. Results: The mean age of patients was 52.8 years; 65.4% were female. Type 2 diabetes was present in 6.8% and insulin resistance noted in 38.0% of patients. Further, 45.7% of the patients had mild (A0/A1) and the remaining had moderate/severe (A2/A3) hepatic necroinflammatory activity. Patient distribution according to Metavir fibrosis stage was as follows: F0/F1 (57.0%); F2 (6.5%); F3 (23.7%); and F4 (12.9%). A univariate analysis revealed significant positive correlations between Metavir fibrosis stage and insulin resistance (r=0.297; p=0.007). Logistic regression analysis showed that significant predictors of insulin resistance were high alanine transaminase levels (odds ratio, 0.97; 95% confidence interval, 0.944-0.997) and liver fibrosis stage (odds ratio, 0.114; 95% confidence interval, 0.0210.607).Conclusion: Our findings revealed significant associations between insulin resistance and hepatic fibrosis Daha fazlası Daha az

Sarıtaş, Ülkü | Üstündağ, Yücel | Gedikoğlu, Gökhan

Letter | 2011 | Turkish Journal of Gastroenterology22 ( 2 ) , pp.224 - 226

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Üstündağ, Yücel | Sarıtaş, Ülkü

Article | 2017 | Turkish Journal of Gastroenterology28 ( 3 ) , pp.157 - 158

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Üstündağ, Yücel | Karakaya, Kemal | Aydemir, Selim

Article | 2009 | Turkish Journal of Gastroenterology20 ( 4 ) , pp.279 - 281

Papilla bölgesinde duodenal divertikül olan hastalarda safra yollarının endoskopik kanülasyonu çok zor olabilmektedir. Yetmiş yaşında bir bayan hasta akut kolanjit ve koledokolithiazis tanılarıyla hastanemize başvurdu. Hastaya sıvı resüsitasyonu ve antibiyotik tedavisi başlandı. Endoskopik retrograd kolanjiyopankreatografide duodenal divertikül nedeniyle safra yolları kanüle edilemedi. Farklı girişimlere rağmen safra yolları kanüle edilemedi. Endoskopik klip yardımıyla divertikülden kısmen everte edilen papilla fikse edildi. Papillanın sabitlenmesi safra yollarının direkt kanulasyonuna imkan sağladı. Kolanjiografide koledokta multip . . .le kalkül izlendi. Sfinkterotomi, safra yollarından taş ekstraksiyonu yapılan hasta Endoskopik retrograd kolanjiyopankreatografiyi takip eden 9. gün iyi durumda taburcu edildi. Bu yazıda, özellikle büyük periampullar divertikül nedeniyle kanülasyonu çok zor olan olgularda, pankreas ve safra yollarının kanülasyonunda etkili ve güvenli bir yöntem olan endoskopik klip yardımıyla safra yolları kanülasyonu yöntemini hatırlatmak istedik. Endoscopic cannulation of the biliary tract may be challenging in cases with juxtapapillary, duodenal diverticula. A 70-yearold woman admitted to the hospital with the diagnosis of choledocholithiasis and acute cholangitis. She was placed on antibiotic treatment and parenteral fluid resuscitation. On endoscopic retrograde cholangiopancreatography, the papilla could not be cannulated because of the duodenal diverticulum. Various attempts at biliary cannulation failed. Endoscopic clips were used for evertion and fixation of a partially everted papilla from the diverticulum and for securing it in an orientation that allowed direct cannulation of the biliary tree. Cholangiography demonstrated multiple calculi within the choledochus. She was discharged from the hospital on the 9th day following endoscopic retrograde cholangiopancreatography in good condition. With this report, we aimed to remind physicians that the clipassisted method is a safe and effective technique for pancreatic and/or biliary cannulation, and should be preferred in patients in whom cannulation is extremely difficult due to large periampullary diverticula Daha fazlası Daha az

Demirci, Hakan | İlikhan, Sevil Uygun | Öztürk, Kadir | Üstündağ, Yücel | Kurt, Ömer | Bilici, Muammer | Köktürk, Furuzan

Article | 2015 | Turkish Journal of Gastroenterology26 ( 6 ) , pp.456 - 460

Background/Aims: In our study, we aimed to assess the effect of vitamin E and C supplementation to triple and quadruple Helicobacter pylori eradication regimens. Materials and Methods: Four hundred patients with H. pylori infection were classified into four groups. Patients in group A (n=100) received amoxicillin, clarithromycin, and lansoprazole for 2 weeks. In group B, patients (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, and lansoprazole for 2 weeks. Patients in group C (n=100) received amoxicillin, clarithromycin, lansoprazole, and bismuth subcitrate for 2 weeks, whereas those in gro . . .up D (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, lansoprazole, and bismuth subcitrate for 2 weeks. H. pylori eradication was assessed with the C14 urea breath test 2 months after the end of the therapy. The eradication rate was assessed using per-protocol (PP) and intention-to-treat (ITT) analyses. Results: Three hundred forty-eight patients finished the study. The eradication of H. pylori was achieved in 63 of 84 patients (75%) by PP and 63 of 100 (63%) by ITT analysis in group A, 60 of 84 (71.4%) by PP and 60 of 100 (60%) by ITT analysis in group B, 72 of 89 (80.9 %) by PP and 72 of 100 (72%) by ITT analysis in group C, and 76 of 91 (83.5%) by PP and 76 of 100 (76%) by ITT analysis in group D. There was no remarkable change between groups A and B (p>0.05). Similar results were also found between groups D and C (p>0.05).Conclusion: This study revealed that supplementing vitamins C and E to either the triple or quadruple therapies did not provide an additional advantage for achieving significantly higher eradication rates for H. pylori Background/Aims: In our study, we aimed to assess the effect of vitamin E and C supplementation to triple and quadruple Helicobacter pylori eradication regimens. Materials and Methods: Four hundred patients with H. pylori infection were classified into four groups. Patients in group A (n=100) received amoxicillin, clarithromycin, and lansoprazole for 2 weeks. In group B, patients (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, and lansoprazole for 2 weeks. Patients in group C (n=100) received amoxicillin, clarithromycin, lansoprazole, and bismuth subcitrate for 2 weeks, whereas those in group D (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, lansoprazole, and bismuth subcitrate for 2 weeks. H. pylori eradication was assessed with the C14 urea breath test 2 months after the end of the therapy. The eradication rate was assessed using per-protocol (PP) and intention-to-treat (ITT) analyses. Results: Three hundred forty-eight patients finished the study. The eradication of H. pylori was achieved in 63 of 84 patients (75%) by PP and 63 of 100 (63%) by ITT analysis in group A, 60 of 84 (71.4%) by PP and 60 of 100 (60%) by ITT analysis in group B, 72 of 89 (80.9 %) by PP and 72 of 100 (72%) by ITT analysis in group C, and 76 of 91 (83.5%) by PP and 76 of 100 (76%) by ITT analysis in group D. There was no remarkable change between groups A and B (p>0.05). Similar results were also found between groups D and C (p>0.05).Conclusion: This study revealed that supplementing vitamins C and E to either the triple or quadruple therapies did not provide an additional advantage for achieving significantly higher eradication rates for H. pylor Daha fazlası Daha az

Engin, Hüseyin | Üstündağ, Yücel

Letter | 2009 | Turkish Journal of Gastroenterology20 ( 3 ) , pp.231 - 232

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Aydemir, Selim | Savranlar, Ahmet | Engin, Hüseyin | Özer, Tülay | Cihan, Alper | Üstündağ, Yücel | Gün, Doğan Banu

Article | 2006 | Turkish Journal of Gastroenterology17 ( 1 ) , pp.50 - 52

Mide adenokanseri nedeniyle subtotal gastrektomi ve gastrojejunostomi yapıldıktan bir sene sonra nüks eden ve midede diffuz, plak tarzında kalsifikasyon gelişen 53 yaşındaki erkek hastayı sunduk. Bu vaka literatürde mide kanseri operasyonundan bir yıl sonra midede tümör kalsifikasyonu tanımlanan ilk vakadır. Bu vaka sebebiyle mide duvar kalsifikasyonu nedenlerini tartıştık. We present the case of a 53-year-old male with subtotal gastrectomy and gastrojejunostomy due to gastric cancer who later developed cancer relapse and diffuse plaque-like calcification in the residual gastric tissue. As far as we know, this is the first case in t . . .he English literature in whom gastric tumor calcification developed one year after gastric cancer operation. We also discuss possible mechanisms of gastric wall calcification in such cases Daha fazlası Daha az