Özbakiş-Dengiz G. | Hekimoglu A. | Kandemir N. | Kurcer Z.

Article | 2012 | Turkish Journal of Gastroenterology23 ( 5 ) , pp.456 - 462

Background/aims: Statins have additional pleiotropic effects beyond their lipid-lowering effects. In this study, the effects of statins were evaluated in an indomethacin-induced gastric injury model in rats. Materials and Methods: Animals were divided into eight groups. Distilled water (control group), omeprazole (30 mg/kg), atorvastatin (20 and 40 mg/kg), simvastatin (20 and 40 mg/kg), and rosuvastatin (20 and 40 mg/kg) were given orally (gavage). Thirty minutes later, indomethacin (25 mg/kg) was administered orally to all groups. Six hours later, the animals were sacrificed by decapitation. The mean ulcer indexes for each group we . . .re calculated, and the stomachs were evaluated histopathologically. Results: The ulcer indexes were as follows: control 1.72±0.16, omeprazole 0±0.00, and atorvastatin, simvastatin and rosuvastatin (at 20 and 40 mg/kg doses, respectively) 4.28±0.39, 4.99±0.96, 1.72±0.73, 1.90±0.48, 1.85±0.26, and 1.67±0.18. Atorvastatin significantly increased the indomethacin-induced ulcer index at both doses and the erosion score at 40 mg/kg dose. Although the 20 mg/kg dose of simvastatin inhibited mononuclear leukocyte infiltration, the 40 mg/kg dose induced hyperemia. Rosuvastatin did not decrease mononuclear leukocyte or neutrophil infiltrations at 20 mg/kg dose, and only neutrophil infiltration at the 40 mg/kg dose. Conclusions: In patients with gastric discomfort, statins must be used carefully. If statin therapy is needed, we recommend to avoid using atorvastatin and to use the other statins only in the minimum effective dose Daha fazlası Daha az

Özbakış, Günnur Dengiz | Hekimoğlu, Aşkın | Kandemir, Nilüfer | Kurcer, Zehra

Article | 2012 | Turkish Journal of Gastroenterology23 ( 5 ) , pp.456 - 462

Amaç: Statinlerin lipid düşürücü etkilerinin yanısıra ilave pleiotropik etkileri vardır. Bu çalışmada, statinlerin sıçanlarda indometazinle oluşturulan mide hasarı üzerine etkileri değerlendirildi. Gereç ve Yöntem: Hayvanlar sekiz gruba ayrıldı. Kontrol grubuna distile su, diğer gruplara omeprazol (30 mg/kg), atorvastatin (20-40 mg/kg), simvastatin (20-40 mg/kg) ve rosuvastatin (20-40 mg/kg) oral yolla verildi. Otuz dakika sonra, bütün gruplara yine oral yolla indometazin (25 mg/kg) uygulandı. Altı saat sonra, hayvanlar dekapitasyon ile öldürüldü. Her grup için ortalama ülser indeksleri hesaplandı. Daha sonra, mideler histopatolojik . . . olarak değerlendirildi. Bulgular: Ülser indeksleri kontrol grubunda 1.72±0.16, omeprazol grubunda 0±0.00, atorvastatin, simvastatin ve rosuvastatinin 20 ve 40 mg/kg dozlarında sırasıyla 4.28±0.39, 4.99±0.96, 1.72±0.73, 1.90±0.48, 1.85±0.26 ve 1.67±0.18 tespit edildi. Atorvastatin her iki dozda indometazinle oluşturulan ülser indeksini ve 40 mg/kg dozda erozyon skorunu anlamlı olarak artırmıştır. Simvastatinin 20 mg/kg dozu mononükleer lökosit infilrasyonunu inhibe etmesine rağmen, 40 mg/kg dozu hiperemiyi artırmıştır. Rosuvastatin 20 mg/kg dozda hem mononükleer lökosit hem de nötrofil infiltrasyonlarını, 40 mg/kg dozda ise sadece nötrofil infiltrasyonunu azaltmıştır. Sonuç: Mide rahatsızlığı olan hastalarda, statinler dikkatli kullanılmalıdır. Statin tedavisi mutlaka gerekiyorsa, atorvastatin kullanılmamasını ve diğer statinlerin de etkili en düşük dozlarda kullanılmasını tavsiye etmekteyiz. Background/aims: Statins have additional pleiotropic effects beyond their lipid-lowering effects. In this study, the effects of statins were evaluated in an indomethacin-induced gastric injury model in rats. Materials and Methods: Animals were divided into eight groups. Distilled water (control group), omeprazole (30 mg/kg), atorvastatin (20 and 40 mg/kg), simvastatin (20 and 40 mg/kg), and rosuvastatin (20 and 40 mg/kg) were given orally (gavage). Thirty minutes later, indomethacin (25 mg/kg) was administered orally to all groups. Six hours later, the animals were sacrificed by decapitation. The mean ulcer indexes for each group were calculated, and the stomachs were evaluated histopathologically. Results: The ulcer indexes were as follows: control 1.72±0.16, omeprazole 0±0.00, and atorvastatin, simvastatin and rosuvastatin (at 20 and 40 mg/kg doses, respectively) 4.28±0.39, 4.99±0.96, 1.72±0.73, 1.90±0.48, 1.85±0.26, and 1.67±0.18. Atorvastatin significantly increased the indomethacin-induced ulcer index at both doses and the erosion score at 40 mg/kg dose. Although the 20 mg/kg dose of simvastatin inhibited mononuclear leukocyte infiltration, the 40 mg/kg dose induced hyperemia. Rosuvastatin did not decrease mononuclear leukocyte or neutrophil infiltrations at 20 mg/kg dose, and only neutrophil infiltration at the 40 mg/kg dose. Conclusions: In patients with gastric discomfort, statins must be used carefully. If statin therapy is needed, we recommend to avoid using atorvastatin and to use the other statins only in the minimum effective dose. Top Summary Introduction Materials And Methods Results Discussion Reference Daha fazlası Daha az