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Koleksiyon [13]
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Yayıncı [1]
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Dergi Adı [6]
Paracardiac giant cystic desmoid tumour: Case report

Akpinar I. | IşLEYEN A. | Durukan M. | Güray Ü. | Acu R. | TÜFEKçIOgLU O. | GÖLBAşI Z.

Article | 2013 | Turkiye Klinikleri Cardiovascular Sciences25 ( 3 ) , pp.162 - 165

Desmoid tumours, also called aggressive fibromatosis, are an extremely rare type of tumour arising from musculoaponeurotic tissues. Their etiology is still unknown. They are usually benign, but local invasion and relapsing are frequent. Here we report the case of a 45-year-old male patient with widespread invasion of a desmoid tumour involving superior-posterior mediastinum, retroperitoneum and right lumbocostal region. The tumour was inoperable because of important vascular and cardiac invasions. Despite the intra-abdominal location of most desmoid tumours, involvement of the superior mediastinum and their differential diagnosis am . . .ong the retroperitoneal-mediastinal masses should be definitely kept in mind. Transthoracic ecocardiography should be considered as a first method for the assessment of mediastinal invasion. Copyright © 2013 by Türkiye Klinikleri Daha fazlası Daha az

The use of Alloxan and Streptozotocin in Experimental Diabetes Models [Deneysel Diyabet Modellerinde Alloksan ve Streptozotosin Kullanımı]

Kurçer Z. | Karaoglu D.

Review | 2012 | Turkish Journal of Endocrinology and Metabolism16 ( 2 ) , pp.34 - 40

Diabetes is a chronic metabolic disease which leads to several acute and chronic complications, morbidity and mortality, and decreased lifespan and quality of life. Therefore, in research studies that aim to enlighten the pathogenesis of diabetes and investigate possible treatment strategies, experimental animal models of diabetes provide many advantages to the investigator. Models of diabetes obtained by chemical induction, diet, surgical manipulations or combination thereof and also new genetically modified animal models are some of the experimental models. Alloxan and streptozotocin (STZ), which are toxic glucose analogues that p . . .referentially accumulate in pancreatic beta cells, are widely used toxic agents to induce experimental diabetes in animals. This review gives an overview on the use of alloxan and STZ to induce chemical diabetes models with reference to their mechanisms, utilizable doses, advantages and disadvantages in diabetes research Daha fazlası Daha az

Simultaneous occurrence of different follicular neoplasms within the same thyroid gland [Aynı tiroid bezinde farklı foliküler hücre kökenli neoplazilerin birlikteliği]

Polat Ş.B. | Arpacı D. | Yazgan A. | Başer H. | Kılıç M. | Ersoy R. | Çakır B.

Article | 2016 | Turkish Journal of Endocrinology and Metabolism20 ( 2 ) , pp.31 - 35

Purpose: Neoplasms of the thyroid gland are classified according to the cells they originate from and commonly develop from cells of follicular origin. The most common differentiated thyroid cancers (DTC) are papillary and follicular carcinomas. Coexistence of two different histological types of primary follicular thyroid neoplasm is a rare condition. There are previous reports of concomitant medullary and papillary thyroid cancers. However, there is scarce data about the simultaneous occurrence of the two different histological types of primary follicular thyroid tumors and this is the first study on that subject. Material and Meth . . .od: From January 2007 to September 2014, our institutional database was reviewed for patients who underwent thyroid surgery for various indications. Medical records and cytopathology reports of those patients were examined retrospectively. Simultaneous neoplasms of follicular origin were noted. Results: A total of 3.700 patients were operated. Histopathological examination revealed a benign pattern in 2.686 (73%) patients and a malignant pattern in 1.014 (27%) patients. Among the patients with the diagnosis of DTC, only 20 (1.9%) had a concomitant neoplasm within the same thyroid gland. Discussion: Such simultaneous tumors may be a part of a familial tumor syndrome or an unidentified novel gene mutation playing role in the pathogenesis of more than one type of tumor. Based on the current evidence, the synchronous occurrence of those neoplasms in a given patient is likely coincidental in the literature. Further studies on larger patient population with standardized genetic characterization are needed. © 2016, Galenos Yayincilik. All rights reserved Daha fazlası Daha az

Electronic reference use and publication ethics in scientific articles in the area of health sciences [Saglık bilimleri alanındaki bilimsel makalelerde elektronik kaynak kullanımı ve yayın etigi]

Atici E. | Ercan I. | Cangür Ş. | Büyükuysal Ç.

Article | 2013 | Turkiye Klinikleri Journal of Medical Sciences33 ( 2 ) , pp.448 - 454

https://dx.doi.org/10.5336/medsci.2012-30089 https://hdl.handle.net/20.500.12628/5596

Investigation of intrafamilial transmission in Hepatitis B surface Antigen (HBsAg) positive cases in Harran University Hospital [Harran Üniversitesi Araştirma Hastanesinde Hepatit B yüzey Antijeni (HBsAg) pozitif olgularda aile i·çi bulaşin i·ncelenmesi]

Yengil E. | Kurçer M.A. | Sirmatel F.

Article | 2009 | Turkiye Klinikleri Journal of Medical Sciences29 ( 6 ) , pp.1612 - 1617

Objective: Hepatitis B virus (HBV) is a public health problemowing to communicable and widespreant. In addition to It is important issue because of preventable and prevent to people from contaminated persons. Transmission of HBV may be connected to transmission carrecteristics such as horizontal, vertical, sexual and blood, priority. Aim of this study is to determine the possible route of HBV transmission throughout a family setting. Material and Methods: 173 members (29 spouses, 82 offspring, 11 mothers, 11 fathers and 40 siblings) of 40 index cases (HBsAg carriers and chronic active hepatitis cases) attending the Harran University . . . Medical Faculty Hospital between Augst 2006 and March 2007 were screened prospectively for markers of HBV by using an ELISA. The chi-squared and Logistic regression analyses were used for statistical analysis. Results: Index cases was 18.8% of all family members, while HBsAg prevalence is 15.0% among family members except index cases. Among family members, the highest prevalences of antiHBc were in the mothers (54.5%) and sisters (45.5%), brothers (33.3%), sons (32.6%)and wifes (31.3%), the least prevalences of antiHBc were husbands (7.7%), fathers (18.2%), and doughters (22.2%) of all index cases. Transmission of HBV to both the mothers and sisters were positive was high, Transmission of HBV to fathers was low in all families. There was significant difference in cases where only the mother and husbands of index cases for HBV transmission (p= 0.012). In the logistic regression model; living with chronic hepatitis B index case (OR= 1.92; CI= 1.03-3.57), to be illiterate (OR= 6.81 CI= 1.27-22.13), born at home with traditional methods (OR= 3.70; CI= 1.15-11.87) and born at home with the help of midwife (OR= 3.44; CI= 1.47-7.91) were higher risk for hepatitits B transmision. Conclusion: The family members of index cases with inactive HBV carriers, particularly in the case of chronic active hepatitis have a high risk of transmission. Copyright © 2009 by Türkiye Klinikleri Daha fazlası Daha az

Perinatal brachial plexus palsy: Review [Perinatal brakial pleksus palsisi]

Karadavut K.I. | Başaran A.

Review | 2008 | Turkiye Klinikleri Journal of Medical Sciences28 ( 5 ) , pp.697 - 703

Brachial plexus palsy is caused by a birth injury to the brachial plexus, the nerve network that controls movement and sensation of the arm. The main result of this injury is weak or paralyzed muscles in the shoulder, arm, and hand. Fortunately, most infants with this condition make complete spontaneous recovery. Some, however, are left with varying degrees of arm weakness. Among infants who do not recover spontaneously, some will require physical therapy and occupational therapy only, and others will need both therapy and surgery. Children who develop deformities in the shoulder, arm, or hand may need orthopaedic treatment. In all . . .cases, treatment must be started early to ensure the greatest improvement. Brachial plexus palsy is diagnosed in the newborn. Primary physicians need to identify and refer patients to the multidisciplinary brachial plexus team. During the first 2-6 months after birth, the specialists on the team work together to restore normal functioning of the infant's arm. Copyright © 2008 by Türkiye Klinikleri Daha fazlası Daha az

Serum cystatin C levels in gastric cancer patients: Scientific letter

Demirtaş S. | Uzunoglu N. | Can M. | Karaca L.

Article | 2007 | Turkiye Klinikleri Journal of Medical Sciences27 ( 3 ) , pp.442 - 444

Elevated activities of cysteine proteinases in cancers are attributed to impaired regulation by the endogenous cysteine proteinase inhibitors (cystatins). Cystatin C is suggested to be a reliable marker of glomerular filtration rate (GFR). The purpose of this study was to evaluate whether cystatin C concentration was influenced by gastric malignancy, which is a common cancer type and the availability of this parameter safely for screening renal dysfunction in these patients. Since there is inadequate information on the clinical significance of cystatin C expression in human gastric cancers, we studied the differences in levels of se . . .rum cystatin C in this type of cancer and also evaluated them with respect to cancer stages. The levels of cystatin C in patients with gastric adenocancer were similar to those in the control group. Similarly, the values of serum creatinine and GFR in the patients were comparable to those of the controls. Serum creatinine values in controls and in patients did not show a statistically significant difference 0.8 ± 0.16 and 0.9 ± 0.35 respectively (p> 0.05). Serum cystatin C values in controls and patients were 0.74 ± 0.32 and 0.72 ± 0.6 respectively, which was also not different statistically (p> 0.05). When the patients were evaluated with respect to the stages of the cancer, the cystatin C values did not differ significantly. The mean ± SD levels of the patients in low and advanced stages were 0.79 ± 0.51 and 0.69 ± 0.64 respectively (p> 0.05). Our study clearly demonstrates that serum cystatin C has valuable potential for the detection and monitoring of GFR and may be safely used in gastric cancer patients. Copyright © 2007 by Türkiye Klinikleri Daha fazlası Daha az

Varicella infection treated with acyclovir in an elderly patient with rheumatoid arthritis: Case report

Özdolap Ş. | Sarikaya S. | Aktunç E. | Koca R. | Çelebi G.

Article | 2006 | Turkiye Klinikleri Journal of Medical Sciences26 ( 6 ) , pp.689 - 692

Varicella is a common and extremely contagious disease in childhood. The course of infection is usually mild to moderate in children but it may cause serious complications especially in immunosupressed adults and children. We presented a case with nosocomial varicella zoster virus infection in the form of chickenpox in a 67-year-old woman with rheumatoid arthritis (RA) for 15 years who was on treatment of methotrexate and prednisolon. The patient was treated with acyclovir and not only varicella infection but also physical findings and symptoms of RA improved. Copyright © 2006 by Türkiye Klinikleri.

A case of Klatskin tumor with high levels of CA 19-9

Koçak E. | Koçak G. | Beşir F.H. | Can M.

Article | 2007 | Turkiye Klinikleri Journal of Medical Sciences27 ( 5 ) , pp.774 - 777

Carbohydrate antigen 19-9 (CA 19-9) is used as a serum tumor marker for adenocarcinoma of the upper gastrointestinal tract, particularly primary adenocarcinoma of the pancreas. In addition, this tumor marker can be highly elevated in benign diseases such as acute pancreatitis, chronic pancreatitis, chronic liver disease and biliary tract disease. A 69 year-old man was hospitalized with jaundice, colacolored urine, right-sided upper abdominal pain, weight loss and pruritus. Laboratory data revealed a high level of serum CA19-9 of more than 100 000 U/mL and a mass in the left lobe of the liver was detected on computed tomography. ERCP . . ., PTCA and CT-guided biopsy yielded the diagnosis of Klatskin tumor. Review of the literature revealed that Klatskin tumor with high levels of CA 19-9 over 100 000 U/mL was not reported. Copyright © 2007 by Türkiye Klinikleri Daha fazlası Daha az

Rheumatoid arthritis and lyme disease: A case report [Romatoid artrit ve lyme hastaligi birlikteligi]

Borazan A. | Koçak E. | Koçak G. | Arslan T. | Üstündag Y.

Article | 2005 | Turkiye Klinikleri Journal of Medical Sciences25 ( 5 ) , pp.736 - 739

Rheumatoid arthritis (RA) and Lyme disease are two systemic illnesses with distinctly different clinical manifestations. Although Lyme arthritis is clearly distinct from RA, it can also cause joint erosion due to chronic proliferative synovitis. In the literature we found no case report in which RA and Lyme disease coexisted. In this article we present a 27 year-old woman who had undergone treatment for RA for the previous 6 years. Two months after this period, on the basis of symptoms and laboratory findings, the patient experienced what was initially diagnosed as RA activation. However, after tests were performed, Lyme disease was . . . diagnosed. The patient was treated accordingly and successfully. Copyright © 2005 by Türkiye Klinikleri Daha fazlası Daha az

Determination of difference between groups in multivariate analysis of variance: An application [Çok degişkenli varyans analizinde gruplar arasindaki farkin tespiti: Bir uygulama]

Keskin S. | Ankarali H. | Noyan T. | Kamaci M.

Article | 2007 | Turkiye Klinikleri Journal of Medical Sciences27 ( 6 ) , pp.838 - 845

Objective: Although there is a healthy trend toward employment of multivariate analysis of variance (MANOVA) in the analysis of data from experiments which involve multiple dependent variables, there remains a need to demonstrate the wide variety of data analytic techniques available for post hoc analysis of statistically significant multivariate results. As a post-hoc test, using Stepdown Analysis after MANOVA was explained with application in this study, Material and Methods: In this study, the data set were used that contain 19 healthy (control group) pregnant, 21 pre-eclamptic pregnant and 11 eclamptic pregnant, who submitted to . . . Obstetric and Gynecologist Department of Research Hospital of Y. Y. University Medical School between 2004-2005 years. Urinary protein, systolic blood pressure, lactate dehydrogenase, alanine amino transferase, aspartat transaminase, malonyl dialdehyde and platelets measurements were measured from pregnants. Results: It showed that urinary protein, systolic blood pressure and LDH were affected on groups' differences according to results of Stepdown analysis. Conclusion: Stepdown analysis, a test for the incremental discriminatory power of a dependent variable after the effects of other dependent variables has been taken into account. This analysis is similar to stepwise regression or discriminant analysis in that it relies on a specific order of entry to determine how much an additional dependent variable adds to the explanation of the differences between the groups in the MANOVA analysis. Because of this properties, Stepdown analysis is a suitable post-hoc tes for MANOVA. Copyright © 2007 by Türkiye Klinikleri Daha fazlası Daha az

Evaluation of bone mineral density and bone turnover markers in patients with non-cirrhotic chronic hepatitis B [Sirotik olmayan kronik hepatit b'li hastalarda kemik mineral yogunlugu ve döngüsü göstergelerinin degerlendirilmesi]

Çelebi G. | Sarikaya S. | Özdolap Ş. | Mungan G. | Ankarali H. | Çelik Y. | Akduman D.

Article | 2012 | Turkiye Klinikleri Journal of Medical Sciences32 ( 2 ) , pp.324 - 330

Objective: To evaluate the bone mineral density (BMD) and the biochemical markers of bone turnover in non-cirrhotic chronic hepatitis B patients. Material and Methods: We compared 18-65 years old non-cirrhotic chronic hepatitis B patients and healthy controls for BMD and biochemical markers of bone turnover. BMD was measured at the lumbar spine and the left hip using DXA. Results: There were 31 hepatitis B patients (19 males, 12 females) and 72 healthy controls (56 males, 16 females) in the study. Their mean age was 37.4 ± 10.0 years in the study group and 38.5 ± 7.1 years in the controls. There were no differences between the two g . . .roups for the mean BMD levels and T scores. However, left hip BMD and T scores were significantly lower in male patients with chronic hepatitis B infection when compared to males in the control group. Serum calcium, phosphate, osteocalcine, intact parathyroid hormone, deoxypyridinoline and 25-hydroxycholecalciferol levels did not differ between the groups. Conclusion: In our study, left hip BMD and T scores were found to be significantly lower in the male patients with chronic hepatitis B infection when compared to males in the control group, however a significant difference was not detected when all cases were compared with the control group. Therefore, we suppose that further studies on a larger population are needed in this issue. © 2012 by Türkiye Klinikleri Daha fazlası Daha az

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