Ayla-Şahinler, Ayla | Bahar, Hakan | Yavuz, Şenol | Hazer, Baki | İbiş, Cemil

Article | 2016 | Phosphorus, Sulfur and Silicon and the Related Elements191 ( 3 ) , pp.438 - 443

A series of novel N-and N,N'-bis(quinonyl)amines were synthesized from the reactions of 2,3-dichloro-1,4-naphthoquinone (1) and polyoxypropylenediamines. The novel quinone-amine polymers were treated with some thiols in next step and N,S-substituted compounds were obtained. The structures of the novel products were characterized by micro-analysis, 1H NMR, UV-VIS, 13C NMR, and MS. The electrochemical properties of some of the novel amine-quinone polymers derivatives were also investigated by cyclic voltammetry. The number of molecular weight (Mn) of polymer compounds was also determined by Gel Permeation Chromatography (GPC). © 2016 . . .Taylor & Francis Group, LLC Daha fazlası Daha az

İlhan, Elif | Karahaliloğlu, Zeynep | Kılıçay, Ebru | Hazer, Baki | Denkbaş, Emir Baki

Article | 2019 | Materials Technology , pp.438 - 443

Postoperative infection in orthopaedic and trauma surgery is one of the most feared complications. Recently, the high prevalence of multidrug-resistant bacteria has made the antibiotic treatment ineffective; thus novel non-antibiotic alternative approaches to this problem are urgently needed. Based on these expectations, in this work, in order to enhance the cytocompatibility and antibacterial performances of poly (methyl methacrylate (PMMA) and beta-tricalcium phosphate (ß-TCP) bone cements were impregnated with polystyrene (PS)-g-soybean oil graft copolymer containing AgNPs (PS-Agsbox), and we assessed the antimicrobial activity o . . .f the fabricated bone cements against Staphylococcus aureus and Escherichia coli. Nanoparticles at concentration of 1.25% (5 ß-TCP) w/w in ß-TCP bone cements were able to inhibit pathogens growth, while a concentration of 3.75% (15PMMA) was needed for PMMA bone cement. Therefore, the impregnated bone cements with PS-AgsboxNPs may be further explored as an alternative antimicrobial therapy for the treatment of infected bone defects. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Kılıçay, Ebru | Erdal, Ebru | Hazer, Baki | Türk, Mustafa | Denkbaş, Emir Baki

Article | 2016 | Artificial Cells, Nanomedicine and Biotechnology44 ( 8 ) , pp.1938 - 1948

Amphiphilic poly(3-hydroxylalkanoate) (PHA) copolymers find interesting applications in drug delivery. The aim of this study was to prepare nucleic acid adsorbed on (PHB-b-PEG-NH2) nanoparticle platform for gene delivery. For this purpose, PHB-b-PEG-NH2 block copolymers were synthesized via transesterification reactions. The copolymers obtained were characterized by Proton Nuclear Magnetic Resonance (1H-NMR), Fourier Transform Infrared Spectrometer (FTIR), Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC) techniques. The cytotoxic, apoptotic and necrotic effects of these nanoparticles in the MDA 231 human . . .breast cancer cell, the A549 human lung cancer cell and the L929 fibroblast cell lines were also investigated. © 2015 Taylor & Francis Daha fazlası Daha az