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Electroconvulsive therapy combined with antipsychotic therapy in the treatment of acute schizophrenia inpatients: symptom profile of the clinical response

Ipekcioglu, Derya | Yazar, Menekse Sila | Canbek, Ozge | Yuksel, Ozge | Meterelliyoz, Kumru Senyasar | Ilnem, Mehmet Cem

Makale | 2018 | PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY28 ( 4 ) , pp.363 - 370

OBJECTIVE: The aim of the study was to examine the efficacy of electroconvulsive therapy (ECT) combined with antipsychotic (AP) medication on symptom profile in patients with a diagnosis of schizophrenia who had received acute psychiatric inpatient treatment. METHODS: In this prospective study, patients were evaluated for inclusion in the study who were diagnosed with schizophrenia according to DSM-IV diagnostic criteria and were to receive ECT. The patients were evaluated using the Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Positive Symptoms (SAPS), Scale for the Assessment of Negative Symptoms (SANS), and C . . .linical Global Impression - Improvement (CGI-I) sub-scale before the first session ECT, once following every two subsequent sessions and after the final session. RESULTS: The patients showed significant improvements in BPRS scores at each evaluation compared with their scores at baseline, and a significant clinical improvement was found on the CGI-I sub-scale at the end of treatment. Across all SAPS sub-scores, significant decreases were found, and the symptoms related to hallucinations and positive formal thought disorder showed the most rapid response to treatment. Across all SANS sub-scores, significant decreases were found, and affective flattening or blunting symptoms responded most rapidly to treatment. CONCLUSION: One of the most important findings in the present study of hospitalized patients with acute schizophrenia was the good response to treatment, which provided significant improvements in both positive and negative symptoms. The most rapid response to treatment was found for hallucinations, positive formal thought disorder, and affective flattening or blunting symptoms. The most important limitation of our study may be the small number of cases. In future, well-standardized studies using a double-blinded, comparative, prospective design and including a sufficient number of patients are needed Daha fazlası Daha az

Seroprevalence of Toxoplasma gondii, rubella and Cytomegalovirus among pregnant females in north-western Turkey

Aynioglu, A. | Aynioglu, O. | Altunok, E. S.

Makale | 2015 | ACTA CLINICA BELGICA70 ( 5 ) , pp.321 - 324

Objective: To examine the sero-prevalence rates of Toxoplasma gondii, rubella and Cytomegalovirus (CMV) among pregnant women in different age groups in the context of a comparison with nationwide and international data previously reported. Methods: Females of reproductive age attending to our hospital between 1 January 2012 and 1 January 2014 were included in this study. Antibodies against T. gondii, rubella and CMV were assayed using chemiluminescence immunoassay methods. The test results were evaluated retrospectively. Results: Of the participants, 2.5 and 43.9% were seropositive for Toxoplasma IgM and IgG, respectively. The corre . . .sponding figures for rubella and CMV were 1.5 and 93.8%, and 2 and 91.5%, respectively. Conclusion: The high rates of immunity against rubella and CMV infections among pregnant females in our region call into question the routine screening of pregnant females for these two diseases. On the other hand, the high rate of seronegativity for T. gondii warrants such a routine practice Daha fazlası Daha az

Spectroscopic and structural studies of 6,6'-bis(N-methylhydrazine)-2,2'-bipyridine and its mononuclear copper(II) complex

Sengul, Abdurrahman | Yilmaz, Ismail | Sahin, Ertan | Karadayi, Nevzat

Makale | 2010 | JOURNAL OF COORDINATION CHEMISTRY63 ( 19 ) , pp.3453 - 3462

The tetradentate ligand, 6,6'-bis(N-methylhydrazine)-2,2'-bipyridine (L) and its mononuclear copper(II) complex [Cu(L)](ClO4)2] (1) have been synthesized and characterized. The crystal structures of L and 1 have been determined by single-crystal X-ray diffraction. Both crystallize in the centrosymmetric monoclinic space group with crystallographic inversion symmetry. The ligand adopts a planar transoid configuration in the solid state. In 1, the Cu(II) is six-coordinate octahedral, defined by N4O2 donors from ligand and two perchlorates. The molecular units are connected by intermolecular H-bonds between the hydrazino group of the o . . .ne unit and coordinated perchlorate of the neighboring two units via N-H center dot center dot center dot O to furnish a 2-D network. Coordinated perchlorates also form an intramolecular H-bond with hydrazine influencing the crystal packing Daha fazlası Daha az

The effects of impregnation chemicals oncombustion properties of laminated wood material

Uysal, B | Ozcifci, A

Makale | 2004 | COMBUSTION SCIENCE AND TECHNOLOGY176 ( 1 ) , pp.117 - 133

In this study, the effects of impregnation materials, sodium perborate, sodium tetraborate, Imersol-WR 2000, and Tanalith-CBC, on combustion properties of three-ply laminated wood material produced from Uludag fir ( Abies bornmulleriana Mattf ) were investigated. The wood samples were impregnated with chemicals via a dipping method. Prepared materials have been bonded with Desmodur-VTKA adhesive and tested according to the procedure of ASTM-E 69 standards. As a result, the highest mass reduction in massive wood samples impregnated with Tanalith-CBC were determined. CO and CO2 ratios were obtained in massive control samples, which we . . .re unprocessed. Temperature variation in laminated samples impregnated with Tanalith-CBC, O-2 ratio in massive wood samples impregnated with sodium tetraborate, and ash ratio in laminated samples impregnated with sodium perborate were obtained Daha fazlası Daha az

Isolated HAGL lesion after arthroscopic Bankart repair in a professional soccer player

Celik, Haluk | Seckin, Mustafa Faik | Kara, Adnan | Akman, Senol

Makale | 2017 | PHYSICIAN AND SPORTSMEDICINE45 ( 2 ) , pp.199 - 202

Post-traumatic anterior shoulder instability commonly occurs following an avulsion of capsulolabral complex from glenoid (Bankart lesion) or rarely after humeral avulsion of the glenohumeral ligaments (HAGL lesion). Arthroscopic Bankart repair offers high success rates of healing. However, trauma following the treatment may cause implant failure or re-avulsion of the treated tissue. We aim to present the diagnosis and treatment of an isolated HAGL lesion in a professional soccer player who had previously undergone arthroscopic Bankart repair.

MEFV gene is a probable susceptibility gene for Behcet's disease

Imirzalioglu, N | Dursun, A | Tastan, B | Soysal, Y | Yakicier, MC

Makale | 2005 | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY34 ( 1 ) , pp.56 - 58

Objective: Behcet's disease ( BD) is a rare, chronic, multisystem inflammatory disorder. The prevalence of BD is higher in the Middle Eastern and Mediterranean populations. Another chronic inflammatory disease, familial Mediterranean fever (FMF), is also known to be highly prevalent in these populations. The prevalence of BD is higher in the FMF patient population than in populations known to be rich in BD. Both BD and FMF have some pathophysiological features in common and they result from inappropriate activation of neutrophils. Clinical manifestations of both diseases can mimic each other and the coexistence of both diseases in t . . .he same patient has been reported. Given that BD and FMF have similar pathophysiological, epidemiological, and clinical features, we hypothesized that the gene responsible for FMF, MEFV, may also play a role in the pathogenesis of BD. Methods: Forty-two BD patients who had no symptoms and family history for FMF and 66 healthy controls were screened for common MEFV gene mutations (E148Q, M680I, M694V, and V726A). Results: Fifteen patients (36%) displayed MEFV mutations ( nine M694V, five E148Q, and one M680I) and mutation rates were significantly elevated compared to 66 (11%) healthy controls (p=0.0034). Conclusion: The occurrence of frequent MEFV mutations in BD patients suggests that the MEFV gene is involved in the pathogenesis of Behcet's disease Daha fazlası Daha az

N-acetylcysteine may reduce repetitive behaviors in children with autism: a case series

Celebi, Fahri | Koyuncu, Ahmet | Coskun, Murat

Makale | 2017 | PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY27 ( 2 ) , pp.190 - 193

Objective: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social communication and interaction, and restricted, stereotypic, repetitive behaviors. Behavioral problems are common in children with ASD. Herein, we report the effect of N-acetylcysteine (NAC) treatment on repetitive behaviors in 10 children with ASD. Methods: Ten children with ASD were assessed using the Childhood Autism Rating Scale and Aberrant Behavior Checklist (ABC). The clinical follow-up was performed with ABC and Clinical Global Impressions-Improvement (CGI-I). A total of 10 patients were initiated on NAC therapy in . . . addition to their treatment with a stable dose of risperidone to avoid the potential adverse effects of higher doses of risperidone. Two patients discontinued NAC treatment before the third week. Eight patients were treated with an NAC dosage of 1200-2700 mg/day for 6-10 weeks. Results: The mean age of the patients was 8.6 years. Patients received NAC treatment for a mean duration of 8.25 weeks and a mean dosage of 2100 mg/day. Improvement in stereotypic behaviors was statistically significant in addition to the improvement in mean CGI-I score (p =.025 and .006, respectively). Conclusion: NAC adjunction to risperidone treatment may be helpful to reduce repetitive behaviors in children with ASD with limited adverse effects and good tolerability Daha fazlası Daha az

Bilateral proptosis as the initial presentation of systemic nodular lymphocyte predominant Hodgkin lymphoma

Akoz, Ayla Gokmen | Dagdas, Simten | Soysal, Hulya | Ozet, Gulsum | Ustun, Huseyin

Makale | 2007 | LEUKEMIA & LYMPHOMA48 ( 7 ) , pp.1434 - 1436

WOS: 000247779300030 PubMed: 17613778

Injection moulding of thin walled zirconia tubes for oxygen sensors

Soykan, HS | Karakas, Y

Makale | 2005 | ADVANCES IN APPLIED CERAMICS104 ( 6 ) , pp.285 - 290

An injection moulding process has been developed for the production of net shaped zirconia tubes. A specially designed injection mould was used for shaping feedstocks containing a paraffin wax-oleic acid binder system with a mixture of ceramic powders. Many thousands of thin walled tubes were injection moulded to optimise the process parameters. Using a two stage wicking-thermal debinding process, the post-moulding processing time was decreased to approximately a seventh of the total required when binder removal was accomplished using only a thermal treatment. Characterisation of starting materials and zirconia tubes was conducted u . . .sing thermogravimetric analysis, scanning electron microscopy, dilatometry and density and size measurements. Performance of the injection moulded tubes was tested using oxygen activity measurements in molten steel under industrial steelmaking conditions. Excellent results were obtained in terms of oxygen concentration, electromotive force and soluble aluminium content, with good reproducibility and high accuracy. The proposed injection moulding process is very promising and provides an important alternative for mass production of oxygen sensor tubes Daha fazlası Daha az

A simple discharge risk model for predicting 1-year mortality in hospitalised acute decompansated heart failure patients with reduced ejection fraction

Karauzum, Kurtulus | Karauzum, Irem | Ural, Dilek | Baydemir, Canan | Aktas, Mujdat | Celikyurt, Umut | Kozdag, Guliz

Makale | 2018 | ACTA CARDIOLOGICA73 ( 2 ) , pp.164 - 170

Objective: The risk stratification for prognosis in heart failure is very important for optimal disease management and decision making. The aim of this study was to establish a simple discharge 1-year mortality prediction model by integrating data obtained from demographic characteristics, clinical evaluation, laboratory biomarkers and echocardiographic evaluation of hospitalised heart failure with reduced ejection fraction (HFrEF) patients with acute decompensation. Methods and results: A risk score model was developed based on beta-coefficient number of variables in a multivariable logistic regression model which was created with . . .the use of data on clinical, laboratory, imaging and therapeutic findings of 670 patients (65.4% males, 65 +/- 11 years) who was hospitalised with acute decompensated HFrEF. The mean left ventricular ejection fraction (LVEF) was 26 +/- 9%. Independent predictors of mortality were: age >= 75 years, sodium Daha fazlası Daha az

Comparison of the efficacy of tigecycline and teicoplanin in an experimental methicillin-resistant Staphylococcus aureus osteomyelitis model

Kandemir, O. | Oztuna, V. | Colak, M. | Akdag, A. | Camdeviren, H.

Makale | 2008 | JOURNAL OF CHEMOTHERAPY20 ( 1 ) , pp.53 - 57

We evaluated the efficacy of tigecycline and teicoplanin in a rat model of MRSA osteomyelitis. Osteomyelitis was induced with an intramedullary injection of 10(8) colony-forming units (cfu) of MRSA. After osteomyelitis formation was confirmed on Day 14, infected rats were randomly divided into three groups: tigecycline (n=13), teicoplanin (n=13), and no-treatment control (n=14). A 28-day antibiotic therapy with a subcutaneous injection of tigecycline (14 mg/kg twice daily) or intramuscular administration of teicoplanin (20 mg/kg daily) was administered. Rats were then sacrificed, and the tibias were harvested. The bones were weighed . . . and then cultured. Our results indicated that bacterial growth was significantly reduced in teicoplanin and tigecycline groups, compared to the control group (p=0.019 and p=0.006, respectively). However, no difference was detected between the two antibiotic groups (p=1.000). No bacterial growth was detected in 7 out of 13 and 9 out of 13 specimens of the teicoplanin and tigecycline treated groups, respectively. Although this result was numerically in favor of tigecycline, the difference was not statistically significant (p=0.427). In conclusion, tigecycline, a novel antibiotic, appears as an effective alternative to teicoplanin in the treatment of osteomyelitis caused by MRSA Daha fazlası Daha az

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