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Electroconvulsive therapy combined with antipsychotic therapy in the treatment of acute schizophrenia inpatients: symptom profile of the clinical response

Ipekcioglu, Derya | Yazar, Menekse Sila | Canbek, Ozge | Yuksel, Ozge | Meterelliyoz, Kumru Senyasar | Ilnem, Mehmet Cem

Article | 2018 | PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY28 ( 4 ) , pp.363 - 370

OBJECTIVE: The aim of the study was to examine the efficacy of electroconvulsive therapy (ECT) combined with antipsychotic (AP) medication on symptom profile in patients with a diagnosis of schizophrenia who had received acute psychiatric inpatient treatment. METHODS: In this prospective study, patients were evaluated for inclusion in the study who were diagnosed with schizophrenia according to DSM-IV diagnostic criteria and were to receive ECT. The patients were evaluated using the Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Positive Symptoms (SAPS), Scale for the Assessment of Negative Symptoms (SANS), and C . . .linical Global Impression - Improvement (CGI-I) sub-scale before the first session ECT, once following every two subsequent sessions and after the final session. RESULTS: The patients showed significant improvements in BPRS scores at each evaluation compared with their scores at baseline, and a significant clinical improvement was found on the CGI-I sub-scale at the end of treatment. Across all SAPS sub-scores, significant decreases were found, and the symptoms related to hallucinations and positive formal thought disorder showed the most rapid response to treatment. Across all SANS sub-scores, significant decreases were found, and affective flattening or blunting symptoms responded most rapidly to treatment. CONCLUSION: One of the most important findings in the present study of hospitalized patients with acute schizophrenia was the good response to treatment, which provided significant improvements in both positive and negative symptoms. The most rapid response to treatment was found for hallucinations, positive formal thought disorder, and affective flattening or blunting symptoms. The most important limitation of our study may be the small number of cases. In future, well-standardized studies using a double-blinded, comparative, prospective design and including a sufficient number of patients are needed Daha fazlası Daha az

Effects of boron compounds on the bonding strength of phenol-formaldehyde and melamine-formaldehyde adhesives to impregnated wood materials

Oezcifci, Ayhan

Article | 2006 | JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY20 ( 10 ) , pp.1147 - 1153

Wood materials are increasingly being used in the construction of structural beams, sports equipment, etc. This study was carried out to determine the bonding strength of phenol-formaldehyde (PF) and melamine-formaldehyde (MF) adhesives to impregnated wood materials. For this purpose, brutia pine (Pinus brutia Ten) and elm (Ulmus compestris L.) woods were impregnated with borax (Bx), boric acid (Ba), Bx + Ba (wt:wt 50:50%), di-ammonium phosphate (D), [D + (Bx + Ba)]/ (50 + (25 + 25%), w/w) and Tanalith-C 3310 (T-C 3310) using the vacuum method according to ASTM-D 1413-76. The effects of wood species, impregnating material and type o . . .f adhesive on the bonding strength were determined. The highest shear strength (11.09 N/mm(2)) was obtained from elm wood control (i.e., without any impregnating materials) samples with MF; thus, the impregnation process negatively affected the adhesive bonding strength. Impregnating materials, especially those containing oily or similar solutions such as T-C 3310, are not advised for wood elements which are subjected to shear Daha fazlası Daha az

New national and regional bryophyte records, 31

Ellis, L. T. | Alegro, A. | Bednarek-Ochyra, H. | Ochyra, R. | Bergamini, A. | Cogoni, A. | Erzberger, P.

Article | 2012 | JOURNAL OF BRYOLOGY34 , pp.123 - 134

WOS: 000305806500005

Comparison of the efficacy of tigecycline and teicoplanin in an experimental methicillin-resistant Staphylococcus aureus osteomyelitis model

Kandemir, O. | Oztuna, V. | Colak, M. | Akdag, A. | Camdeviren, H.

Article | 2008 | JOURNAL OF CHEMOTHERAPY20 ( 1 ) , pp.53 - 57

We evaluated the efficacy of tigecycline and teicoplanin in a rat model of MRSA osteomyelitis. Osteomyelitis was induced with an intramedullary injection of 10(8) colony-forming units (cfu) of MRSA. After osteomyelitis formation was confirmed on Day 14, infected rats were randomly divided into three groups: tigecycline (n=13), teicoplanin (n=13), and no-treatment control (n=14). A 28-day antibiotic therapy with a subcutaneous injection of tigecycline (14 mg/kg twice daily) or intramuscular administration of teicoplanin (20 mg/kg daily) was administered. Rats were then sacrificed, and the tibias were harvested. The bones were weighed . . . and then cultured. Our results indicated that bacterial growth was significantly reduced in teicoplanin and tigecycline groups, compared to the control group (p=0.019 and p=0.006, respectively). However, no difference was detected between the two antibiotic groups (p=1.000). No bacterial growth was detected in 7 out of 13 and 9 out of 13 specimens of the teicoplanin and tigecycline treated groups, respectively. Although this result was numerically in favor of tigecycline, the difference was not statistically significant (p=0.427). In conclusion, tigecycline, a novel antibiotic, appears as an effective alternative to teicoplanin in the treatment of osteomyelitis caused by MRSA Daha fazlası Daha az

The association of total sialic acid and malondialdehyde levels with metabolic and anthropometric variables in obesity

Yerlikaya, F. H. | Toker, A. | Cicekler, H. | Aribas, A.

Article | 2015 | BIOTECHNIC & HISTOCHEMISTRY90 ( 1 ) , pp.31 - 37

Serum sialic acid levels are abnormally high in pathological states that exhibit tissue destruction, tissue proliferation or inflammation. We measured total serum sialic acid levels in 139 women and 125 men. Subjects were divided into quartiles according to their body mass index (BMI): Q1 (18-24.9 kg/m(2)), Q2 (25 -29.9 kg/m(2)), Q3 (30 -39.9 kg/m(2)) and Q4 (> 40 kg/m(2)). The patients in Q1 constituted the control group. Serum sialic acid levels of subjects in Q2, Q3 and Q4 were signifi cantly higher than those in Q1. Higher BMI quartiles also were associated with higher levels of serum glucose, insulin, total cholesterol, LDL-cho . . .lesterol, triglycerides, high-sensitivity C-reactive protein, malondialdehyde levels, waist circumference, blood pressure and homeostasis model assessment of insulin resistance in both women and men. Lower BMI quartiles were associated with higher levels of serum HDL-cholesterol levels in both women and men. We found positive associations among serum sialic acid levels, BMI and oxidative stress. Serum sialic acid also is related to some conventional cardiovascular risk factors including elevated lipid profile, increased blood pressure, increased serum glucose and insulin levels, and insulin resistance in obese people Daha fazlası Daha az

Effect of percutaneous nephrolithotomy on renal functions in children: assessment by quantitative SPECT of Tc-99m-DMSA uptake by the kidneys

Cicekbilek, Izzet | Resorlu, Berkan | Oguz, Ural | Kara, Cengiz | Unsal, Ali

Article | 2015 | RENAL FAILURE37 ( 7 ) , pp.1118 - 1121

Objective: To determine the impact of percutaneous nephrolithotomy (PNL) on global and regional renal function in children. Methods: In total, 40 children (41 renal units) undergoing PNL were included in this prospective study. All patients were evaluated using quantitative single-photon emission computed tomography (QSPECT) with technetium-99 m-dimercaptosuccinic acid (Tc-99m-DMSA) examinations before and 3 months after surgery. Results: The mean age was 9.5 years (range, 3-16), and the mean stone size was 3.4 cm (range, 2-6.5). Of the cases, 39 (95%) were managed as being stone-free after a single session of PNL. After additional . . .treatment procedures, 40 (97.5%) of the cases were managed as being stone-free. Of the 41 renal units, new focal cortical defects on Tc-99m-DMSA scans were seen in 4 (9.7%) patients. Total relative uptake in the treated kidneys increased from 42.3% to 44.1%. The mean creatinine level before PNL was 1.18 +/- 0.45 (0.8-1.6) mg/dL compared with 1.16 (0.7-1.5) mg/dL by the end of the follow-up period (not statistically significantly different, p>0.05). Conclusions: PNL in children is a safe and feasible method for the maximal clearance of stones. QSPECT of Tc-99m-DMSA confirmed that renal function is preserved or even improved after percutaneous stone removal Daha fazlası Daha az

Injection moulding of thin walled zirconia tubes for oxygen sensors

Soykan, HS | Karakas, Y

Article | 2005 | ADVANCES IN APPLIED CERAMICS104 ( 6 ) , pp.285 - 290

An injection moulding process has been developed for the production of net shaped zirconia tubes. A specially designed injection mould was used for shaping feedstocks containing a paraffin wax-oleic acid binder system with a mixture of ceramic powders. Many thousands of thin walled tubes were injection moulded to optimise the process parameters. Using a two stage wicking-thermal debinding process, the post-moulding processing time was decreased to approximately a seventh of the total required when binder removal was accomplished using only a thermal treatment. Characterisation of starting materials and zirconia tubes was conducted u . . .sing thermogravimetric analysis, scanning electron microscopy, dilatometry and density and size measurements. Performance of the injection moulded tubes was tested using oxygen activity measurements in molten steel under industrial steelmaking conditions. Excellent results were obtained in terms of oxygen concentration, electromotive force and soluble aluminium content, with good reproducibility and high accuracy. The proposed injection moulding process is very promising and provides an important alternative for mass production of oxygen sensor tubes Daha fazlası Daha az

The effect of project-based learning on students' statistical literacy levels for data representation

Koparan, Timur | Gueven, Buelent

Article | 2015 | INTERNATIONAL JOURNAL OF MATHEMATICAL EDUCATION IN SCIENCE AND TECHNOLOGY46 ( 5 ) , pp.658 - 686

The point of this study is to define the effect of project-based learning approach on 8th Grade secondary-school students' statistical literacy levels for data representation. To achieve this goal, a test which consists of 12 open-ended questions in accordance with the views of experts was developed. Seventy 8th grade secondary-school students, 35 in the experimental group and 35 in the control group, took this test twice, one before the application and one after the application. All the raw scores were turned into linear points by using the Winsteps 3.72 modelling program that makes the Rasch analysis and t-tests, and an ANCOVA ana . . .lysis was carried out with the linear points. Depending on the findings, it was concluded that the project-based learning approach increases students' level of statistical literacy for data representation. Students' levels of statistical literacy before and after the application were shown through the obtained person-item maps Daha fazlası Daha az

Interactions of the aminoglycoside neamine and 2-deoxystreptamine with copper(II) and zinc(II)

Baran, Y | Kau, PM | Lawrance, GA | Sutrisno | von Nagy-Felsobuki, EI

Article | 2001 | INORGANIC REACTION MECHANISMS3 ( 1 ) , pp.31 - 38

Acid dissociation constants for the aminoglycosides neomycin and neamine and of 2-deoxystreptamine are reported. Solution NMR studies indicate that complexation with copper(II) and zinc(II) involves principally the primary amine donors, and formation constants with both neamine and 2-deoxystreptamine (2-DOS) and these metal ions are reported (at 25degreesC, I = 0.5 mol dm(-3)). Complexation studies probed by electrospray mass spectrometry identify both 1:1 and 1:2 species for Cu(II) and Zn(II) with 2-DOS, but only 1:1 species with neamine, consistent with behaviour in bulk solution. Preliminary formation kinetics of Cu(II) with neam . . .ine indicate rapid complexation at high pH but slower two-step processes near pH 7, consistent with complications in the thermodynamic determinations in the intermediate pH regime. Reaction of 2-DOS and neamine with Cu(II) in methanol appears as a single process, with the former occurring similar to10(3)-fold faster Daha fazlası Daha az

Effects of a new hemostatic agent Ankaferd Blood Stopper (R) on the intraocular tissues in rat model

Alpay, Atilla | Bektas, Sibel | Alpay, Aysegul | Ugurbas, Silay Canturk | Evren, Cenk | Ugurbas, Suat Hayri

Article | 2012 | CUTANEOUS AND OCULAR TOXICOLOGY31 ( 2 ) , pp.128 - 131

Purpose: To investigate the histopathological changes due to administration of Ankaferd Blood Stopper (R) (ABS) into intraocular tissues by an anterior chamber and intravitreal injections. Methods: Twenty Wistar albino rats were divided into four equal groups. Group 1 was injected 0.01 mL ABS into anterior chamber. Group 2 was injected intravitreal 0.02 mL ABS. Groups 3 and 4, which were used as controls, were injected into the anterior chamber and intravitreal 0.01 mL and 0.02 mL balanced salt solution (BSS), respectively. At 2, 5, 10, 15 and 20 days after injection, the eyes were examined under an operating microscope and were sub . . .sequently enucleated for histopathological examination. Results: Ophthalmic examination of the rats prior to enucleation revealed ocular complications ranging from conjunctival hyperemia to corneal perforation in group 1 and increased conjunctival hyperemia and discharge in group 2. No physical and histopathological anomalies were detected in groups 3 and 4. All eyes in group 1 showed mixed type inflammatory cell reaction, foreign-body reaction, stromal congestion, disintegration of the collagen fibers and loss of the epithelium of the posterior wall in the iris and ciliary body were observed histopathologically. All eyes in group 2 showed disintegration and separation of the retina, brown pigment accumulation and mixed type inflammatory cell reaction. Conclusion: Our results indicate that the commercially available form of ABS solution exerts a toxic effect on intraocular tissues. We consider that the intraocular use of different concentrations, rather than multiple time point of ABS should be investigated Daha fazlası Daha az

MEFV gene is a probable susceptibility gene for Behcet's disease

Imirzalioglu, N | Dursun, A | Tastan, B | Soysal, Y | Yakicier, MC

Article | 2005 | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY34 ( 1 ) , pp.56 - 58

Objective: Behcet's disease ( BD) is a rare, chronic, multisystem inflammatory disorder. The prevalence of BD is higher in the Middle Eastern and Mediterranean populations. Another chronic inflammatory disease, familial Mediterranean fever (FMF), is also known to be highly prevalent in these populations. The prevalence of BD is higher in the FMF patient population than in populations known to be rich in BD. Both BD and FMF have some pathophysiological features in common and they result from inappropriate activation of neutrophils. Clinical manifestations of both diseases can mimic each other and the coexistence of both diseases in t . . .he same patient has been reported. Given that BD and FMF have similar pathophysiological, epidemiological, and clinical features, we hypothesized that the gene responsible for FMF, MEFV, may also play a role in the pathogenesis of BD. Methods: Forty-two BD patients who had no symptoms and family history for FMF and 66 healthy controls were screened for common MEFV gene mutations (E148Q, M680I, M694V, and V726A). Results: Fifteen patients (36%) displayed MEFV mutations ( nine M694V, five E148Q, and one M680I) and mutation rates were significantly elevated compared to 66 (11%) healthy controls (p=0.0034). Conclusion: The occurrence of frequent MEFV mutations in BD patients suggests that the MEFV gene is involved in the pathogenesis of Behcet's disease Daha fazlası Daha az

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