Cekdemir, Demet | Guvenc, Serkan | Ozdemirkiran, Fusun | Eser, Ali | Topts, Tayfur | Ozkocaman, Vildan | Sahin, Handan Haydaroglu

Makale | 2019 | TURKISH JOURNAL OF HEMATOLOGY36 ( 4 ) , pp.230 - 237

Objective: The aim of the present study was to evaluate the efficacy and safety of eltrombopag, an oral thrombopoietin receptor agonist, in patients with chronic immune thrombocytopenia (ITP). Materials and Methods: A total of 285 chronic ITP patients (187 women, 65.6 %; 98 men, 34.4%) followed in 55 centers were enrolled in this retrospective cohort. Response to treatment was assessed according to platelet count (/mm(3)) and defined as complete (platelet count of >100,000/mm(3)), partial (30,000-100,000/mm(3) or doubling of platelet count after treatment), or unresponsive (

Bilensoy, Erem | Erdogar, Nazli | Mungan, Aydin N.

Gözden Geçirme | 2015 | UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY14 ( 1 ) , pp.61 - 66

Bladder cancer is the ninth most common cancer types in the world and transitional bladder cancer constitutes 90% of all bladder cancer neoplasms depending on cancer cell morphology. Clinical choice of treatment is transurethral resection (TUR), after which the recurrence rate is 50-80% and the tumor has a 14% chance of progression. To avoid recurrence and progression, adjuvant intravesical chemotherapy or immunotherapy is required. Intravesical drug delivery has many advantages. Bladder allows manipulation since it is easily accessible and a closed area, allows catheterization rendering this organ to be an advantageous site for loc . . .alized drug delivery. Drugs are administered into urinary bladder directly resulting in greater exposure of tissues to drug. On the other hand, because of periodical discharge, rapid drug dilution necessitates repeated catheterization and results in loss of drug efficacy. Another disadvantage is the very low permeability of urothelium. Urothelium limits the absorption of molecules into the systemic circulation and prevent adherence of foreign agents on the urothelial surface exerting the same effect of drugs and drug delivery systems. To overcome these problems, nanotechnological approach in the biomedical field seems promising and in this frame new drug carrier systems were focused and bioadhesive nanoparticles were developed. Nanoparticles are submicron, solid, colloidal particles in a size ranging between 10 to 1000 nm. Nanoparticles are generally prepared from biodegradable polymers with specific physicochemical properties and are loaded with active molecules to act as drug delivery systems. Bioadhesive nanoparticles allow prolonged residence time of drug in the mucosal tissues such as bladder wall and can be promising to pass the bladder permeability barrier. Due to their particle size and surface charge, they sustain the drug release at cancerous tissues and protect the drug from acidic urine pH and other degradation factors such as hydrolysis and photodegradation. In addition, nanoparticulate carriers form a drug reservoir in the action site to reduce drug loss and to improve drug efficacy. In this study, we aim to review the role and application of nanoparticles in noninvasive bladder tumors with current literature Daha fazlası Daha az

Cinar, Onder | Mungan, Necmettin Aydin

Gözden Geçirme | 2019 | UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY18 ( 1 ) , pp.30 - 33

Bladder cancer (BC) is one of the commonly diagnosed urological cancers that causes human death, ranked as the seventh most common cancer worldwide. To date, no reliable diagnostic tool has been defined to recognize non-muscle invasive bladder tumors other than cystoscopy. For this reason, scientists have focused on finding new non-invasive biomarkers that can be used to diagnose BC with higher specificity and sensitivity. The purpose of this study was to evaluate the diagnostic role and prognostic significance of microRNA-21 (miR-21) in non-muscle invasive bladder tumors. In this review, the overall diagnostic performance of miR-21 . . . was discussed on non-invasive BC based on a literature search of PubMed and Cochrane Library. Although findings are insufficient, promising results have been reported regarding circulating miR-21 as a biomarker for BC prospective studies with larger numbers of participants are needed Daha fazlası Daha az

Kucukosman, Gamze | Aydin, Bengu Gulhan | Yalcin, Asli | Ayoglu, Hilal Peri

Makale | 2016 | HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI54 ( 2 ) , pp.115 - 117

Jarcho-Levin syndrome (JLS) is a rare disease involving costovertebral anomalies and is accompanied by hydrocephalus, neural tube defect, and cardiac, renal and gastrointestinal problems. Due to respiratory system pathologies, there is a high mortality rate at young ages. Due to its rarity and little information in the literature related to anesthetic practice for this syndrome, we present our anesthetic experience of inguinal hernia surgery in a patient with JLS.

Girgin, Reha | Cinar, Onder | Bulut, Ersan | Onal, Cemal Ferhat

Makale | 2018 | JOURNAL OF UROLOGICAL SURGERY5 ( 3 ) , pp.164 - 169

Objective: The aim of this study is to investigate the association of preoperative platelet mass index (PMI) with tumor pathologic features and postoperative biochemical recurrence in patients undergoing radical prostatectomy due to localized prostate cancer. Materials and Methods: Data of 141 patients, who underwent radical prostatectomy for localized prostate cancer between April 2004 and April 2017, were retrospectively screened. Patient age, preoperative prostate-specific antigen (PSA) level, platelet count, mean platelet volume and PMI value, neutrophil-lymphocyte ratio (NLR), tumor grade, Gleason score, tumor volume, lymph nod . . .e involvement, surgical margin positivity and biochemical recurrence at 3 months were all noted. The relationship of preoperative PMI value with age, PSA, pathologic parameters, surgical margin positivity and biochemical recurrence was evaluated. Results: The mean age of the patients was 61.79 +/- 5.98 years, the mean PSA value was 9.50 +/- 6.69 ng/mL, mean PMI was 2003.91 +/- 486.69, and the mean NLR was 2.79 +/- 2.06. There was no correlation of PMI value with PSA, pathological stage, Gleason score, lymph node involvement, tumor volume, surgical margin positivity, and biochemical recurrence. There was statistically significant negative correlation between PMI and Gleason score. Conclusion: In our study, we could not demonstrate preoperative PMI as a prognostic factor for early biochemical recurrence in patients undergoing radical prostatectomy for prostate cancer. To achieve a better conclusion that we can generalize, there is a need for prospective studies with larger patient series Daha fazlası Daha az

Kosan, Murat | Mungan, Aydin

Gözden Geçirme | 2015 | UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY14 ( 1 ) , pp.29 - 32

Transitional cell carcinoma (TCC) is the most common malignancy of the genitourinary tract and TCC models are being developed over the past decades. Experimental models are needed so that more effective treatments can be developed in preclinical evaluation. Even if, in vitro models are useful for initial development and evaluation of therapeutic agents and modalities, adequate animal models are still essential in the preclinical development of new effective and safe therapies. A great variety of ex vivo and in vivo models has been described in the literature. Chemical carcinogens are most commonly used to induce bladder cancer. Cell . . . culture techniques are also widely used to study different oncological processes. To test potential new drugs in a preclinical setting, a clinically relevant orthotopic bladder tumor model is highly desirable. The aim of this review article was the assessment of different animal models available for the study of bladder carcinogenesis Daha fazlası Daha az

Kose, Sukran | Atalay, Sabri | Ulu, Yildiz | Sonmez, Ufuk | Serin Senger, Suheyla

Makale | 2017 | MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS6 , pp.29 - 32

Introduction: BK virus (BKV) and cytomegalovirus (CMV) infections are common in renal transplant patients. In this retrospective study, we investigated the frequency of BKV and CMV infections and their effects on graft. Materials and Methods: The data of 118 renal transplant recipients who were transplanted and followed-up between January 2010 and January 2011 were reviewed. Demographic characteristics, biochemical data, BKV and CMV DNA levels by polymerase chain reaction (QIAGEN, Hilden, Germany) were investigated. The patients were followed- up monthly in the first six months and then every three months. Results: A total of 118 pa . . .tients were included in the study. BK viraemia was detected in 12 (10.2%) patients and the DNA level of BKV was >10(4) copies/mL in five cases. Three patients with elevated creatinine and compatible renal biopsy findings were considered to have BKV-associated nephropathy (BKVAN). With the reduction of immunosuppressive treatment, viraemia was reduced and creatinine levels decreased within normal levels. Cytomegalovirus DNA was found to be positive in 23 (19.5%) patients, and was >500 copies/mL in 4 (3.4%) patients. The viraemia in these four patients has decreased after antiviral therapy. No CMV related disease were found in any of the patients. Cytomegalovirus DNA positivity at low levels were also detected in three patients who were diagnosed with BKVAN. None of the patients developed rejection. Conclusion: BK and CMV infections in kidney transplant patients are common and can be seen together. However, graft dysfunction and rejection rates are low with close monitoring, early diagnosis and treatment. Randomized, controlled studies with larger patient groups are necessary in order to determine the viral threshold levels associated with graft dysfunction or rejection, to decide the optimal management and to explain the role of concomitant infection Daha fazlası Daha az

Keni, Fatih Mehmet | Celik, Sevim Karakas | Solak, Nilgun | Genc, Gunes Cakmak | Dursun, Ahmet

Makale | 2018 | TURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGY12 ( 1 ) , pp.28 - 32

Objective: Psoriasis is a common, chronic and recurrent disease which can affect skin and also joints. Although the etiopathogenesis of psoriasis has not precisely determined, the most supported mechanism is inflammation triggered by any factor. Toll like receptors (TLRs) family described in recent years is known to play a critical role in host immunity against a wide variety of pathogens. In our study, we aimed to reveal possible relationships of some TLR gene polymorphisms with psoriasis in this patient group. Methods: A hundred patients who diagnosed with psoriasis and 173 healthy controls were included in the study which known t . . .o be without inflammatory disease, TLR2 gene Arg677Trp, Arg753Gln, -196-174 del and TLR4 gene Asp299Gly, Thr399Ile polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism method, patient and control groups were compared in terms of gene polymorphisms mentioned. Results: In this study, it was determined psosiasis has a statistically significant relationship with GA genotype and A allele in TLR2 Arg753Gln polymorphism. Furthermore, when the patient and control groups were compared for -196-174 del gene polymorphism, it was determined that ins/del genotype had a protective effect. Conclusion: We think that variant alleles in the TLR2 gene may play an important role in the molecular etiopathogenesis of psoriasis Daha fazlası Daha az

Girgin, Reha

Makale | 2017 | JOURNAL OF UROLOGICAL SURGERY4 ( 4 ) , pp.171 - 176

Objective: To investigate patient-and procedure-related factors associated with hospital re-admission following urethral manipulations for the treatment of urethral strictures. Materials and Methods: Data of patients who underwent dilation or internal urethrotomy for urethral strictures between 2011 and 2016 were retrospectively analyzed. Patients who were admitted to our institute for any reason within one month after hospital discharge were evaluated. The patient-and procedure-related factors affecting the readmission rates were revealed by multiple binary logistic regression using stepwise backward elinimination. Results: The ave . . .rage age of 76 male patients was 61.7 +/- 14.4 years. The mean maximal flow rate at preoperative uroflowmetry was 6.01 +/- 4.3 and the median American Society of Anesthesiologists score was 2.38. The process was the first for 45 (59.2%) patients, the second for 16 (21.1%) patients, the third for 9 (11.8%) patients, and the fourth for 6 (7.9%) patients. Amplatz dilators, cold knife and Ho: YAG laser were used in 50%, 27.6% and 22.4% of patients, respectively. The mean length of hospital stay was 0.89 +/- 0.31 days, and the complication rate was 19.7% (15/76). The mean urethral catheter dwell time was 8.9 +/- 14.2 day. Overall, the procedure was successful in 61 (80.3%) patients and failed (Q(max) < 15 mL/sec) in 19.7% of the cases. Fifteen (19.7%) patients were re-admitted, while 2 (2.6%) patients among them were re-hospitalized for further treatment. Comorbidity and age were independent predictors of re-admission. Conclusion: We found that younger age and lower comorbidities predicted hospital re-admission following procedures for urethral strictures Daha fazlası Daha az

Senormanci, Omer | Konkan, Ramazan | Guclu, Oya | Senormanci, Guliz

Makale | 2014 | NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY51 ( 3 ) , pp.280 - 282

WOS: 000346118900016 PubMed: 28360639

Baltaci, Sumer | Bozlu, Murat | Yildirim, Asif | Gokce, Mehmet Ilker | Tinay, Ilker | Aslan, Guven | Can, Cavit

Makale | 2016 | JOURNAL OF UROLOGICAL SURGERY3 ( 3 ) , pp.74 - 79

Objective To determine the effect of age on recurrence and progression rates in a population of high-risk non-muscle invasive bladder cancer (NMIBC) patients treated with a second transurethral resection (TUR) and at least 1 year of maintenance Bacillus Calmette-Guerin (BCG) therapy. Materials and Methods In this multicenter study, we reviewed the data of patients treated for high-risk NMIBC between 2005 and 2012. Patients without a muscle-invasive cancer on second TUR and received induction BCG and at least one year of maintenance BCG therapy and at least 12 months of follow-up after completion of maintenance BCG were included. Eff . . .ect of age was analyzed both dichotomously (< 70 or >= 70 years) as well as by 10-year increments. Chi-square test, Student's T-test and analysis of variance (ANOVA) were used for comparison of the groups. Univariate and multivariate logistic regression analyses were performed to identify predictors of recurrence and progression. Results Overall, 242 eligible patients were included. Baseline parameters were similar. With a mean follow-up of 29.4 +/- 22.2 months, neither 3-year recurrence-free survival nor 3-year progression-free survival differed between the age groups when examined either dichotomously or by 10-year increments. Conclusion In high-risk NMIBC patients treated with a second TUR and received maintenance BCG therapy, age was not associated with increased rates of neither recurrence nor progression. Until a randomized prospective clinical trial assess the appropriate adjuvant intravesical therapy in the elderly, elderly patients should probably be treated in the same manner as younger patients Daha fazlası Daha az

Polat, Sefika Burcak | Arpaci, Dilek | Yazgan, Aylin | Baser, Husniye | Kilic, Mehmet | Ersoy, Reyhan | Cakir, Bekir

Makale | 2016 | TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM20 ( 2 ) , pp.31 - 35

Purpose: Neoplasms of the thyroid gland are classified according to the cells they originate from and commonly develop from cells of follicular origin. The most common differentiated thyroid cancers (DTC) are papillary and follicular carcinomas. Coexistence of two different histological types of primary follicular thyroid neoplasm is a rare condition. There are previous reports of concomitant medullary and papillary thyroid cancers. However, there is scarce data about the simultaneous occurrence of the two different histological types of primary follicular thyroid tumors and this is the first study on that subject. Material and Meth . . .od: From January 2007 to September 2014, our institutional database was reviewed for patients who underwent thyroid surgery for various indications. Medical records and cytopathology reports of those patients were examined retrospectively. Simultaneous neoplasms of follicular origin were noted. Results: A total of 3.700 patients were operated. Histopathological examination revealed a benign pattern in 2.686 (73%) patients and a malignant pattern in 1.014 (27%) patients. Among the patients with the diagnosis of DTC, only 20 (1.9%) had a concomitant neoplasm within the same thyroid gland. Discussion: Such simultaneous tumors may be a part of a familial tumor syndrome or an unidentified novel gene mutation playing role in the pathogenesis of more than one type of tumor. Based on the current evidence, the synchronous occurrence of those neoplasms in a given patient is likely coincidental in the literature. Further studies on larger patient population with standardized genetic characterization are needed Daha fazlası Daha az