Bulunan: 14 Adet 0.002 sn
Koleksiyon [10]
Tam Metin [2]
Yayın Türü [3]
Yazar [20]
Yayın Yılı [12]
Konu Başlıkları [20]
Yayın Dili [1]
Dergi Adı [12]
Protective role of alpha-tocopherol and caffeic acid phenethyl ester on ischemia-reperfusion injury via nitric oxide and myeloperoxidase in rat kidneys

Gurel, A | Armutcu, F | Sahin, S | Sogut, S | Ozyurt, H | Gulec, M | Kutlu, NO

Article | 2004 | CLINICA CHIMICA ACTA339 ( 01.Feb ) , pp.33 - 41

Background: The aim of this study was to determine the acute effects of antioxidant caffeic acid phenethyl ester (CAPE) and alpha-tocopherol (vitamin E) on nitric oxide (NO) production, neutrophil infiltration, and antioxidant enzyme activities on an in vivo model of renal ischemia-reperfusion injury. Methods: Rats were divided into five equal groups each consisting six rats: sham operation, ischemia, ischemia-reperfusion (I/R), I/R plus CAPE, and I/R plus vitamin E groups. CAPE or vitamin E was administered intraperitoneally before reperfusion. After experimental procedure, rats were sacrificed and both ipsilateral and contralatera . . .l kidneys were removed and prepared for NO concentrations, myeloperoxidase (MPO), catalase (CAT) and superoxide dismutase (SOD) activities. Results: Acute administration of vitamin E decreased NO concentrations in both ipsilateral and contralateral renal tissues compared to I/R group. SOD activity was increased in I/R and I/R + CAPE groups compared to sham operation group. The most prominent results were encountered in MPO activities, which did not change in contralateral kidneys in both ischemia and I/R groups. There was a significant decrease in ipsilateral MPO activity in ischemia group and a significant increase in I/R group compared to sham operation group. Pretreatment with intraperitoneal CAPE significantly diminished the tissue MPO activity indicating the prevention of the neutrophil sequestration into the kidney. Conclusion: There is a role for CAPE in attenuation in renal damage after I/R injury of the kidney, in part at least by inhibition of neutrophil sequestration. (C) 2003 Elsevier B.V. All rights reserved Daha fazlası Daha az

Intravesical cationic nanoparticles of chitosan and polycaprolactone for the delivery of Mitomycin C to bladder tumors

Bilensoy, Erem | Sarisozen, Can | Esendagli, Guenes | Dogan, A. Lale | Aktas, Yesim | Sen, Murat | Mungan, N. Aydin

Article | 2009 | INTERNATIONAL JOURNAL OF PHARMACEUTICS371 ( 01.Feb ) , pp.170 - 176

Cationic nanoparticles of chitosan (CS), poly-epsilon-caprolactone coated with chitosan (CS-PCL) and poly-e-caprolactone coated with poly-L-lysine (PLL-PCL) were developed to encapsulate intravesical chemotherapeutic agent Mitomycin C (MMC) for longer residence time, higher local drug concentration and prevention of drug loss during bladder discharge. Nanoparticle diameters varied between 180 and 340 nm depending on polymer used for preparation and coating. Zeta potential values demonstrated positive charge expected from cationic nanoparticles. MMC encapsulation efficiency depended on hydrophilicity of polymers since MMC is water-so . . .luble. Encapsulation was increased by 2-fold for CS-PCL and 3-fold for PLL-PCL as a consequence of hydrophilic coating. Complete drug release was obtained with only CS-PCL nanoparticles. On the other hand, CS and PLL-PCL nanoparticles did not completely liberate MMC due to strong polymer-drug interactions which were elucidated with DSC studies. As far as cellular interaction was concerned, CS-PCL was the most efficient formulation for uptake of fluorescent markers Nile Red and Rhodamine123 incorporated into nanoparticles. Especially, CS-PCL nanoparticles loaded with Rhodamine123 sharing hydrophilic properties with MMC were selectively incorporated by bladder cancer cell line, but not by normal bladder epithelial cells. CS-PCL nanoparticles seem to be promising for MMC delivery with respect to anticancer efficacy tested against MB49 bladder carcinoma cell line. (C) 2008 Elsevier B.V. All rights reserved Daha fazlası Daha az

Effect of intraabdominal administration of Allium sativum (garlic) oil on postoperative peritoneal adhesione

Sahbaz, Ahmet | Isik, Hatice | Aynioglu, Oner | Gungorduk, Kemal | Gun, Banu Dogan


Objective(s): Peritoneal adhesion is a serious problem that develops after most abdominopelvic surgeries. Allium sativum (garlic) has been used for centuries as both a nutrient and a traditional medicine. The anti-inflammatory, antibacterial, fibrinolytic, and wound-healing properties of garlic are well-recognized. We evaluated the effect of garlic on formation of postoperative adhesions in rats. Study design: Thirty Wistar-Albino female rats weighing 200-250 g were randomly divided into three groups (10 rats/group). Group 1 rats received 5 ml/kg garlic oil intraperitoneally and no surgery was performed. The ceca of Group 2 rats (co . . .ntrols) were scraped, to trigger adhesion formation, and no treatment was given. In Group 3 rats, 5 ml/kg garlic oil was added to the peritoneal cavity immediately after the cecum was scraped. All animals were sacrificed 10 d after surgery and adhesions graded in terms of severity and histopathologic characteristics. Results: All animals tolerated the operations well. No adhesions were evident upon laparotomy of Group 1 animals. In Group 2 three rats had an adhesion grade 2 and seven rats had an adhesion of grade 3, whereas in Group 3 no adhesions were found in four rats, five rats had an adhesion grade of 1. Only one rat had a grade 2 adhesion. Macroscopic adhesions and mean adhesion scores of Group 3 were significantly lower than Group 2(p < 0.001). Histopathologic evaluation of the specimens also revealed a statistically significant differences in inflammation, fibrosis, and neovascularization scores between Group 2 and 3 (p = 0.001, p = 0.001, and p = 0.011, respectively). Inflammation, fibrosis and vascularization scores in Group 3 were found significantly lower than Group 2. Conclusion: The anti-inflammatory, antibacterial, fibrinolytic, antithrombotic, and wound-healing effects of garlic likely prevent formation of peritoneal adhesions in a rat model, and garlic may be effective and cheap when used to prevent such adhesions in humans. (C) 2014 Elsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

Surgical treatment of dorsal perilunate fracture-dislocations and prognostic factors

Kara, Adnan | Celik, Haluk | Seker, Ali | Kilinc, Eray | Camur, Savas | Uzun, Metin

Article | 2015 | INTERNATIONAL JOURNAL OF SURGERY24 , pp.57 - 63

Introduction: Perilunate injuries are rare entities which can be difficult to diagnose. Most common type is dorsal perilunate fracture dislocation (97%). The purpose of treatment is anatomic reduction and stable fixation. We aimed to present the radiologic and functional results of surgically treated dorsal perilunate fracture-dislocations and discuss the factors influencing the prognosis. Methods: Between 2007 and 2013, 17 patients were operated for perilunate fracture-dislocations. The mechanism of injuries, soft tissue traumas, etiologic factors and stages according to Herzberg classification were determined. The MAYO wrist score . . . was used for functional evaluation. Scapholunate distance and scapholunate angle were measured and, degenerative changes were investigated by comparing with contralateral side on plain x-ray images in terms of radiologic evaluation. Results: Mean follow-up was 37,8 (range, 16-84) months. The average age at surgery was 35.1 (range, 18-51) years. Fifteen patients were male and two were female. Functional results were excellent in four (23.5%), good in two (11.8%), satisfactory in five (29.4%) and poor in six (35.3%) patients. Degenerative changes were determined in radiocarpal and mid-carpal joints of 14 wrists (82.4%). Scapholunate dissociation more than 2 mm was detected in three wrists. In four wrists osteochondral fragments were determined on the head of the capitate. Stage 2 lesions, delayed presentations, open fractures, scapholunate dissociations more than 2 mm had worse functional results. Conclusion: Despite anatomic reduction, ligamentous and chondral injuries that occured at the time of trauma may cause persistant wrist pain in patients who suffer perilunate fracture dislocation. Mechanism of injury, presence of soft tissue defects and the time between injury and treatment can affect clinical and radiologic results. (C) 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved Daha fazlası Daha az

Assessing effect of electrode configuration on the efficiency of electrokinetic remediation by sequential extraction analysis

Türer, Dilek | Genç, Ayten

Article | 2005 | JOURNAL OF HAZARDOUS MATERIALS119 ( 01.Mar ) , pp.167 - 174

The electroremediation experiments were conducted on artificially polluted soils by introducing a single metallic contaminant (Pb, Zn and Cu) and multiple metallic contaminants (Pb + Zn + Cu). Based on sequential extraction results, it was observed that the removal efficiencies of lead, zinc and copper vary depending on types of contamination. When the soil was contaminated only by lead, the removal efficiency was found to be 48%. However, the removal efficiency of lead decreased to 32% when the soil was contaminated by the combination of lead, zinc and copper. Similar results were observed for zinc and copper. The corresponding rem . . .oval efficiency values for zinc and copper were 92% and 37%, and 34% and 31%, respectively. Effects of electrode geometry on the removal efficiency of metals were investigated by constructing a multiple anode arrangement. In this arrangement, the electrokinetic unit consists of three cylinders, which lie one inside the other, and the soil was placed in the middle cylinder. The central cylinder was the cathode well and the outer cylinder was the anode well, where eight identical anode electrodes were placed in octagonal with respect to the cathode electrode. By using this electrode arrangement in removal of metals from the soil contaminated with the combination of three metals (Pb + Zn + Cu), the removal efficiencies of lead, zinc and copper were found to be 29%, 18% and 18%, respectively. As it can be seen, these numerical values are much lower than the values that were obtained when the traditional two-plate electrode arrangement used in the electroremediation experiments (32%, 37% and 31%). (c) 2004 Elsevier B.V. All rights reserved Daha fazlası Daha az

Structural insights of RmXyn10A-A prebiotic-producing GH10 xylanase with a non-conserved aglycone binding region

Aronsson, Anna | Guler, Fatma | Petoukhov, Maxim V. | Crennell, Susan J. | Svergun, Dmitri I. | Linares-Pasten, Javier A. | Karlsson, Eva Nordberg


Hydrolysis of arabinoxylan (AX) by glycoside hydrolase family 10 (GH10) xylanases produces xylo-and arabinoxylo-oligosaccharides ((A)XOS) which have shown prebiotic effects. The thermostable GH10 xylanase RmXyn10A has shown great potential to produce (A)XOS. In this study, the structure of RmXynlOA was investigated, the catalytic module by homology modelling and site-directed mutagenesis and the arrangement of its five domains by small-angle X-ray scattering (SAXS). Substrate specificity was explored in silico by manual docking and molecular dynamic simulations. It has been shown in the literature that the glycone subsites of GH10 x . . .ylanases are well conserved and our results suggest that RmXyn10A is no exception. The aglycone subsites are less investigated, and the modelled structure of RmXyn10A suggests that loop alpha(6)beta(6) in the aglycone part of the active site contains a non-conserved alpha-helix, which blocks the otherwise conserved space of subsite + 2. This structural feature has only been observed for one other GH10 xylanase. In RmXyn10A, docking revealed two alternative binding regions, one on either side of the alpha-helix. However, only one was able to accommodate arabinose-substitutions and the mutation study suggests that the same region is responsible for binding XOS. Several non-conserved structural features are most likely to be responsible for providing affinity for arabinose-substitutions in subsites +1 and + 2. The SAXS rigid model of the modular arrangement of RmXyn10A displays the catalytic module close to the cell-anchoring domain while the carbohydrate binding modules are further away, likely explaining the observed lack of contribution of the CBMs to activity Daha fazlası Daha az

Evaluation of hs-CRP and visseral adiposity index in patients with policystic ovary syndrome by clinical and laboratory findings

Un, B. | Dolapcioglu, K. S. | Okyay, A. Guler | Sahin, H. | Beyazit, A.


Aim: In this study, we aimed to evaluate two cardiovascular risk markers, hs-CRP and visseral adiposity index, in patients with policystic ovary syndrome in association with clinical and laboratory findings. Material and method: Study group included 75 patients who were diagnosed as PCOS according to the criteria of AE-PCOS 2006 and control group included 75 non-PCOS patients who were subsequently admitted to outpatient clinic for smear control, with urinary or vaginal symptoms. Physical and sonographic examinations were made to all subjects. Mean arterial pressure, waist/hip ratio and body mass index were calculated. Fasting blood . . .glucose and insulin, HbA1c, lipids, high sensitivity C-reactive protein (hs-CRP), estradiol, follicle stimulating hormon, luteinising hormone, timid stimulating hormone, prolaktin, total testosteron and sex hormone binding globulin were tested in venous blood samples collected from cases following overnight fast in follicular phase of spontaneous or induced menstruation. Visceral adiposity index was also calculated. Findings: No statistically significant difference was found between PCOS group and control group concerning hs-CRP and VAI (p > 0.05). When patients in PCOS group were further grouped as obese and non-obese, hs-CRP and VAI values in obese group were significantly higher than those in non-obese. group (p < 0.001). However, when control group were further grouped as obese and non-obese, there was no significant difference in terms of hs-CRP between groups (p > 0.05), VAI values were significantly higher in obese control group (p < 0.05). Conclusion: According to the results of our study, hs-CRP stands for a better and more specific marker than VAI to determine metabolic components and predictive risks for cardiovascular diseases in patients with PCOS. Further studies with larger populations are needed in order to determine cardiovascular risks particularly in young PCOS patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

Regional bone density changes in anterior cruciate ligament deficient knees: A DEXA study

Bayar, Ahmet | Sarikaya, Selda | Keser, Selcuk | Oezdolap, Senay | Tuncay, Ibrahim | Ege, Ahmet

Article | 2008 | KNEE15 ( 5 ) , pp.373 - 377

Bone mineral density (BMD) loss is one of the secondary problems occurring in knee joint after injury of anterior cruciate ligament (ACL). The effect of this injury on BMDs of specific regions is not clear. The aim Of this Study was to investigate BMD changes in unreconstructed ACL-deficient knees with subregion analysis of dual energy X-ray absorptiometry (DEXA). Precision and reliability studies of DEXA revealed that two region of interests (ROI) in medial condyle, two ROIs in lateral femoral condyle (LFC) and one ROI in medial tibial plateau (MTP) in anteroposterior(AP) DXA view and one ROI for each of distal femur, proximal tibi . . .a and patella in lateral view had high reproducibility and reliability. Thirty-two patients with complete ACL ruptures were collected for the study and uninjured sides served as the control. All the patients were male with a mean age of 30 years. Mean duration of ACL rupture was 24 months. There were significant BMD losses in both ROIs of LFC and ROI of MTP In AP view and all three ROIs of lateral view. Greatest BMD losses in AP and lateral views were at MTP and patella respectively. There was a significant association between patellar BMD loss and duration after trauma. Bone bruises in lateral condyle might be the cause of selective involvement of LFC. Periarticular bone mineral loss in ACL-deficient knees has a predilection for the specified region of interest rather than uniform periarticular loss. Tills may be important for graft fixation or a factor in tunnel enlargement. (C) 2008 Elsevier B.V. All rights reserved Daha fazlası Daha az

Transtibial vs anatomical single bundle technique for anterior cruciate ligament reconstruction: A Retrospective Cohort Study

Kilinc, Bekir Eray | Kara, Adnan | Oc, Yunus | Celik, Haluk | Camur, Savas | Bilgin, Emre | Erten, Yunus Turgay

Article | 2016 | INTERNATIONAL JOURNAL OF SURGERY29 , pp.62 - 69

Introduction: Most of the ACL reconstruction is done with isometric single-bundle technique. Traditionally, surgeons were trained to use the transtibial technique (TT) for drilling the femoral tunnel. Our study compared the early postoperative period functional and clinical outcomes of patients who had ACL reconstruction with TT and patients who had ACL reconstruction with anatomical single-bundle technique (AT). Material method: Fifty-five patients who had ACL reconstruction and adequate follow-up between January 2010-December 2013 were included the study. Patients were grouped by their surgery technique. 28 patients included into . . .anatomical single-bundle ACL reconstruction surgery group (group 1) and 27 patients were included into transtibial AC reconstruction group (group 2). Average age of patients in group 1 and group 2 was 28.3 +/- 6, and 27.9 +/- 6.4, respectively. Lachman and Pivot-shift tests were performed to patients. Laxity was measured by KT-1000 arthrometer test with 15, 20 and 30 pound power. All patients' muscle strength between both extremities were evaluated with Cybex II (Humac) at 60 degrees/sec, 240 degrees/sec frequencies with flexion and extension peak torque. The maximum force values of non-operated knee and the operated knee were compared to each other. Groups were evaluated by using International Knee Documentation Committee (IKDC) knee ligament healing Standard form, IKDC activity scale, modified Lysholm and Cincinnati evaluation forms. Return to work and exercise time of patients were compared. Functional and clinical outcomes of two groups were compared. NCSS 2007 and PASS 2008 Statistical Software programs were used for statistical analysis. Result: There was no statistically significant difference between Lachman and Pivot-shift results (p > 0.01). Positive value of Pivot-shift test and incidence of anterior translation in Lachman test were higher in the patients who had TT. Lysholm activity level of patients who had TT, 33.3% (n = 9) were excellent, 51.9% (n = 14) were good and 14.8% (n = 4) were moderate; patients who had AT, 57.1% (n = 16) were excellent, 39.3% (n = 11) were good and 3.6% (n = 1) was good level. There was no statistically significant difference between Lysholm Activity level of the patients (p < 0.01). Lysholm Activity level of patients who had AT significantly higher than TT. There was no statistically significant difference between Modified Cincinnati activity level of the patients (p < 0.05). Modified Cincinnati activity level of patients who had AT were significantly higher than those had TT. There was no statistically significant difference between two groups with post treatment IKDC activity level (p < 0.01). Intense activity after treatment rate of patient who had AT was significantly higher than those had TT. There was statistically significant difference between Cybex extension-flexion 60 measurement and extension 240 measurement of the patients (p < 0.01). KT-1000 arthrometer test results with AT was better than the TT in antero-posterior translation of the knee kinematics at 20 and 30 pound of forces. Return to exercise time of patients who had TT was significantly higher than those had AT (p < 0.01). There was no statistically significant difference between return to work time of patients (p > 0.05). Conclusion: Single-bundle anatomic ACL reconstruction was better than the TT in term of clinical, functional, and laboratory results. We believe that AT ACL reconstruction will increase in use and traditional method which is TT ACL reconstruction surgery will decrease in the long term. Theoretically, anatomic relocation of the ACL can provide better knee kinematics. (C) 2016 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved Daha fazlası Daha az

Preparation and characterization of cationic nanoparticles loaded with mitomycin c by double emulsion and ionotropic gelation techniques

Erdogar, Nazli | Mungan, Aydin | Bilensoy, Erem

Conference Object | 2010 | JOURNAL OF CONTROLLED RELEASE148 ( 1 ) , pp.62 - 69

WOS: 000296426400051 PubMed: 21529641

A rare cause of acute abdomen in the ED: Chemotherapy-induced pneumatosis intestinalis

Ozturk, Mesut | Camlidag, Ilkay | Nural, Mehmet Selim | Ozbalci, Gokhan Selcuk | Bekci, Tumay

Article | 2017 | TURKISH JOURNAL OF EMERGENCY MEDICINE17 ( 4 ) , pp.151 - 153

Pneumatosis intestinalis (PI) and portomesenteric venous gas (PVG) refers to the presence of air within the intestinal wall and portomesenteric vessels. Most of the time, it is associated with mesenteric ischemia that requires immediate surgical intervention as it has high mortality rate. It may also be seen secondary to various conditions, including infections, surgeries, and some chemotherapeutic drugs. A 61-year old-male was admitted to our emergency department complaining of abdominal pain after chemotherapy. Radiological evaluation of the patient demonstrated massive PVG and PI. Patient underwent urgent surgery due to the possi . . .bility of intestinal ischemia and infarction, but no necrosis was identified Chemotherapeutic drug-induced PI and PVG was the final diagnosis. Although PI and PVG are signs of mesenteric ischemia and intestinal necrosis most the of time, chemotherapeutic drugs may also cause PI and PVG rarely. Recent history of chemotheraphy and absence of any mesenteric vascular occlusion may be the diagnostic clue. Copyright (C) 2017 The Emergency Medicine Association of Turkey. Production and hosting by Elsevier B.V. on behalf of the Owner. This is an open access article under the CC BY-NC-ND license Daha fazlası Daha az

What is the role of personal characteristics of psychiatric trainees in Turkey on their mobility and migration?

Kilic, Ozge | Sonmez, Ekin | Erzin, Gamze | Guloksuz, Sinan | da Costa, Mariana Pinto

Letter | 2019 | ASIAN JOURNAL OF PSYCHIATRY42 , pp.30 - 31

WOS: 000468136700009 PubMed: 30951929

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