Yurtlu B.S. | Hanci V. | Gür A. | Turan I.O.
Mektup | 2012 | Anesthesia and Analgesia114 ( 4 ) , pp.914 - 915
[No abstract available]
Erol B. | Bozlu M. | Hanci V. | Tokgoz H. | Bektas S. | Mungan G.
Makale | 2010 | Fertility and Sterility93 ( 1 ) , pp.280 - 282
In this experimental study, we assessed the preventive effects of coenzyme Q10 (CoQ10) in a rat model of ischemia/reperfusion injury. The results of this study show that CoQ10 administration before the reperfusion period of testicular torsion provides a significant decrease in testicular lipid peroxidation products and expressions of inducible nitric oxide synthase, endothelial nitric oxide synthase, and germ cell-specific apoptosis. © 2010 American Society for Reproductive Medicine.
Abduşoglu M.N. | ÖZkoçak Turan I. | Yurtlu B.S. | Hanci V. | Okyay R.D. | AyogLu H.
Makale | 2012 | Turkiye Klinikleri Journal of Medical Sciences32 ( 2 ) , pp.399 - 406
Objective: In this study, we aimed to examine the effects of a subhypnotic dose of ketamine on the neuromuscular block characteristics of rocuronium and intubation quality. Material and Methods: Sixty patients in ASA I-II risk group were included in the study. Group S received 5 mL of 0.9% saline and Group K received 0.5 mg.kg-1 ketamine in 5 mL volume, one minute before induction. Both groups had anesthesia induction with a propofol dose of 2.5 mg.kg-1 (Propofol 1%, Fresenius Kabi). This was considered as anesthesia start time. After 1 min, a control single twitch stimulus (0.1 Hz) was applied and recorded. All patients were given . . .0.6 mg.kg-1 rocuronium (Esmeron® 50 mg.5 ml-1 N.V. Organon, Oss, Holland) in 5 sec. When the single twitch response was depressed 100%, the patient was intubated and the full depression time (onset time) was noted. Anesthesia maintenance was achieved with O2/N2O and sevoflurane. Following the intubation, the application of train-of - four (TOF) stimulation was started. When the TOF ratio reached to 20%, rocuronium was repeated at a dose of 0.2 mg.kg-1. Clinical duration (T25), recovery index (T25- 75) and spontaneous recovery time to TOF > 0.9 were recorded. Intubation conditions were assessed by using the scale of Fuchs-Buder. The additional drugs used during the operation and neuromuscular blocker amounts were recorded. The hemodynamic values of both groups were recorded throughout the study. Postoperative recovery times, visual analogue pain scores (VAS) and Ramsay sedation scores were also recorded. Results: The time for 100% depression of single twitch in Group K was shorter than that of Group S (p<0.05). The clinical duration, recovery index and spontaneous recovery duration of the first dose of rocuronium were longer in Group K compared to Group S (p<0.05). There was no difference between the total neuromuscular blocker amounts of the study groups. There was no significant difference between the groups according to intubation scores (p>0.05), recovery times (p>0.05), VAS scores, Ramsay sedation scores or mean arterial pressure values. When the mean heart rate values of the groups were compared, all values of Group K were higher than those of Group S except control and 60th min values (p<0.001). Conclusion: According to our findings, ketamine in a subhypnotic dose shortens the onset time of rocuronium block and extends the clinical duration of first dose of rocuronium without improving the intubation quality. © 2012 by Türkiye Klinikleri Daha fazlası Daha az
Hanci V. | Ali Kiraz H. | ömür D. | Ekin S. | Uyan B. | Yurtlu B.S.
Mektup | 2013 | Revista Brasileira de Anestesiologia63 ( 1 ) , pp.163 - 166
[No abstract available]
Hanci V. | Ayoglu H. | Yilmaz M. | Yurtlu S. | Okyay R.D. | Erdogan G. | Başaran M.
Makale | 2010 | European Journal of Anaesthesiology27 ( 5 ) , pp.425 - 427
Background This prospective, double-blind and randomized study is designed to determine the effect of menstrual cycle on the injection pain of propofol. Methods Seventy-two patients scheduled for elective surgery under general anaesthesia were divided into two groups according to the phase of the menstrual cycle. Patients were at follicular phase (Pd 8-12) in Group F (n=36) and luteal phase (Pd 20-24) in Group L (n=36). Injection pain was evaluated with 10-point numeric rating scale after 25% of the total propofol dose was injected over 20 s. Results There were no significant differences in terms of patient characteristics (P
Kargi E. | Işikdemir A. | Tokgöz H. | Erol B. | Işikdemir F. | Hanci V. | Payasli C.
Makale | 2010 | Urology75 ( 3 ) , pp.672 - 675
Objectives: To compare the local anesthetic effects of tramadol hydrochloride with prilocaine for circumcision procedure. Methods: This study included 40 patients with American Surgical Association-I scores. Patients were randomly allocated to receive either 5% tramadol (2 mg/kg) plus adrenaline (0.0125/mL) (group 1, n = 20) or 2% prilocaine plus adrenaline (0.0125/mL) (group 2, n = 20). The degree of burning sensation and pain at the injection site were documented. Sensory block was assessed 1 minute after injection and the patients were asked to grade touch and pinprick sensation. Five minutes after drug administration, incision w . . .as performed and intensity of pain, felt by the patient was evaluated on a 4-point scale (0-3). Pain at the injection site and local skin reactions were also recorded. Results: Mean ages were 9.7 and 10.3 years for groups 1 and 2, respectively. Mean duration of surgery was 19.6 minutes. In control visit, 2 of 20 (10%) in group 1 and 10 of 20 (50%) children in group 2 reported extra need for oral ibuprofen (P .05). Total postoperative ibuprofen consumptions were 10 and 50 mg for groups 1 and 2, respectively (P Daha fazlası Daha az
Ozyilmaz K. | Ayoglu H. | Okyay R.D. | Yurtlu S. | Koksal B. | Hanci V. | Erdogan G.
Makale | 2012 | Journal of Neurosurgical Anesthesiology24 ( 4 ) , pp.331 - 335
Tokgoz H. | Yurtlu S. | Hanci V. | Turksoy O. | Erol B. | Akduman B. | Mungan A.
Makale | 2010 | Journal of Endourology24 ( 6 ) , pp.1031 - 1035
Background and Purpose: This prospective, randomized, and double-blind clinical study aimed to assess the analgesic efficacy of single-dose intramuscular (IM) injection of dexketoprofen (group DE) compared with single-dose IM injection of diclofenac (group DI) in patients who were undergoing shockwave lithotripsy (SWL). Patients and Methods: A total of 70 men with single renal or ureteral stones were randomly separated into two groups. The 40 men in group DI received 75mg IM diclofenac sodium and 30 men in Group DE received 50mg IM dexketoprofen trometamol 30 minutes before SWL. A 10-point visual analog scale was used to evaluate pa . . .in. Results: The age, body mass index, and mean stone burden were comparable between the two groups (P>0.05). The mean visual analog scale score for group DE was statistically lower compared with the score for group DI (P=0.02). In 34 (85%) of the 40 men in group DI, the SWL procedure was performed with no, minor, or tolerable pain. In group DE, however, 28 (93.3%) of 30 patients evaluated the pain severity as no, minor, or tolerable (p=0.01). No major/minor adverse effects were observed in group DI, whereas in one patient in group DE, dyspepsia after injection was noticed (P=0.423). Conclusions: The severity of SWL-related pain was significantly better tolerated with dexketoprofen trometamol. During an SWL procedure, the analgesic efficacy of dexketoprofen was greater than that of diclofenac sodium. Although statistically insignificant, a little increased risk for gastric irritation was noticed with dexketoprofen. © Mary Ann Liebert, Inc. 2010 Daha fazlası Daha az
Erol B. | Tokgoz H. | Hanci V. | Bektas S. | Akduman B. | Yencilek F. | Mungan G.
Makale | 2009 | Kaohsiung Journal of Medical Sciences25 ( 7 ) , pp.374 - 380
We investigated the effect of intraperitoneal vardenafil (1 mg/kg) administration during an ischemic period in a rat model of testicular torsion/detorsion (T/D). Twenty-one adult Wistar rats were equally randomized into a control group, a T/D group and a vardenafil group. The control group was designed to collect basal values for biochemical and histopathological parameters. The T/D group underwent testicular torsion for 1 hour. The vardenafil group received vardenafil (1mg/kg) intraperitoneally at 30 minutes after torsion. All rats were sacrificed 4 hours after reperfusion to evaluate the tissue levels of malondialdehyde and total . . .antioxidant status. Germ cell apoptosis was evaluated using the apoptosis protease activating factor 1 antibody in all groups. The expressions of endothelial nitric oxide synthase (NOS) and inducible NOS were also assessed in both testes of all rats. The malondialdehyde levels in the T/D group were significantly higher than in the control and vardenafil groups. There were also significant decreases in total antioxidant status in the T/D group compared with the control and vardenafil groups. Vardenafil treatment significantly reduced apoptosis protease activating factor 1, endothelial NOS and inducible NOS levels in the vardenafil group compared with the T/D group. Administration of 1 mg/kg vardenafil during testicular torsion decreased ischemia/reperfusion cellular damage. Our results indicate that the reduction in oxidative stress by vardenafil may play a major role in its cytoprotective effects. © 2009 Elsevier Daha fazlası Daha az
Hanci V. | Yurtlu S. | Ayoglu H. | Okyay R.D. | Erdogan G. | Abduşoglu M. | Sayin E.
Makale | 2010 | Kaohsiung Journal of Medical Sciences26 ( 8 ) , pp.415 - 421
The aim of this study was to evaluate the effect of education on the knowledge, attitude and behavior of anesthesiology staff and residents towards low-flow anesthesia. The staff and residents in the Department of Anesthesia and Reanimation, Zonguldak Karaelmas University were given theoretical and practical training in delivering low-flow anesthesia. To evaluate their attitudes and behaviors toward low-flow anesthesia, we collected data during the 6 months before training, during the first 3 months after training, and at 4-6 months after training. Anesthesia follow-up records, operation time, volatile anesthetic agent used, and the . . . amount (in liters) of fresh gas low mid-anesthesia were recorded in all three stages. A total of 3,158 patients received general anesthesia and inhalation anesthesia was used in 3,115 of these patients. Our study group consisted of 2,752 patients who had no absolute or relative contraindications to low-flow anesthesia. While the mean fresh gas flow was 4.00 ± 0.00 L/min before training, this level dropped to 2.98 L/min in the first 3 months after training, and to 3.26 L/min in the following 3 months. The mean fresh gas flow was significantly lower at the two post-training assessments than before training (p < 0.05). In conclusion, low-flow anesthesia may be used more frequently if educational seminars are provided to anesthetists. The use of low-flow anesthesia may increase further by allocating more time to this technique in anesthesia training programs provided at regular intervals. © 2010 Elsevier. All rights reserved Daha fazlası Daha az
Gul S. | Hanci V. | Bahadir B. | Acikgoz S. | Bektas S. | Ankarali H. | Kalayci M.
Makale | 2010 | Journal of Clinical Neuroscience17 ( 4 ) , pp.490 - 494
The present study aimed to investigate the neuroprotective efficacy of dexmedetomidine in a rat experimental spinal cord injury model. The rats (n = 40) were equally divided into four groups: G1, G2, G3, and G4. Rats in the G1 group underwent a laminectomy only. For the rats in the G2, G3, and G4 groups, spinal cord injury was induced by placing an aneurysm clip extradurally for 60 s at T10. The rats in G2 did not receive any post-injury treatment. Immediately after trauma was induced, rats in G3 were given methylprednisolone (30 mg/kg) and in G4, dexmedetomidine (10 µg/kg), both intraperitoneally. The rats were sacrificed under ane . . .sthesia 24 hours later and 1.5 cm lengths of injured spinal cord were obtained. Malonyldialdehyde values were significantly increased in G2 compared to G1, G3 and G4 (p < 0.05). The neuronal cell count in G1 was significantly higher than in G2 and G3 (p = 0.0001; p = 0.007). G4 had higher cell counts compared to G2 and G3 (p = 0.0001; p = 0.05). These findings indicated that dexmedetomidine might have neuroprotective effects in spinal cord injury. © 2009 Elsevier Ltd. All rights reserved Daha fazlası Daha az
Erdogan G. | Okyay D.Z. | Yurtlu S. | Hanci V. | Ayoglu H. | Koksal B. | Turan I.O.
Makale | 2010 | International Journal of Obstetric Anesthesia19 ( 4 ) , pp.438 - 440
We present the successful use of perioperative non-invasive mechanical ventilation in a morbidly obese pregnant woman with bronchial asthma, severe preeclampsia and pulmonary edema undergoing an emergency cesarean delivery with spinal anesthesia. The combination of non-invasive mechanical ventilation with neuraxial anesthesia may be of value in selected parturients with acute or chronic respiratory insufficiency requiring surgery. © 2010 Elsevier Ltd. All rights reserved.