Karakas-Celik S. | Piskin I.E. | Keni M.F. | Calik M. | Iscan A. | Dursun A.

Article | 2014 | Gene547 ( 2 ) , pp.186 - 190

SSPE is a progressive neurological disorder of children. Only some of the children who are infected with measles virus develop SSPE, which supports individual variation. TLR-2 and TLR-4 play an important role in innate immunity by recognizing envelope proteins of MV. Another important cytokine that plays an important role in orchestrating innate immune function is IL-17. The purpose of our study is to elucidate whether the TLR2, TLR4, IL17F and IL17A gene polymorphisms are susceptibility genes for the development of SSPE.Using the PCR-RFLP methods, the single nucleotide polymorphisms of TLR2 (Arg753Gln, Arg677Trp, -. 194 to -. 174 d . . .el), TLR4 (Asp299Gly and Thr399Ile) IL17F (His161Arg, Glu126Gly) and IL17A were studied in 54 patients with SSPE and 81 healthy controls.For Asp299Gly polymorphism of the TLR4 gene we found that there were no control individuals who were homozygous carriers of the Gly/Gly genotype, and the risk for SSPE increased at approximately 4.7 fold for the heterozygous carriers of the Asp/Gly genotype (OR 4.727, 95%-CI 1.192-18.742; P. = 0.01), when compared to healthy controls. Also our findings demonstrate that homozygosity for the Arg161 variant of the IL17F His161Arg polymorphism is inversely associated with development of SSPE (OR 0.114 95%-CI 0.026-0.494; P. Daha fazlası Daha az

Celik S.K. | Tekin N.S. | Genc G.C. | Edgunlu T. | Turkcu U.O. | Dursun A.

Article | 2019 | Kuwait Medical Journal51 ( 3 ) , pp.283 - 289

Objective: Vitiligo is a disorder of pigmentation characterized by the presence of depigmented skin macules due to a chronic and progressive loss of melanocytes from the cutaneous epidermis. Among many different etiologic hypotheses that have been suggested so far for vitiligo, the most compelling one involves a combination of environmental and genetic factors that cause autoimmune melanocyte destruction. The purpose of this study is then to determine whether there is any relationship between vitiligo and IL17 gene Glu126Gly, His161Arg and G197A polymorphisms. Design: Controlled prospective study Setting: Department of Molecular Bio . . .logy and Genetics, Bulent Ecevit University Subjects: Genetic polymorphisms of IL17 gene were detected by using polymerase chain reaction based restriction fragment length polymorphism in 86 vitiligo patients and 90 healthy controls. Intervention: For genetic analysis, 5 ml of venous blood was drawn into tubes containing EDTA from each patient. Main outcome measures: IL17 gene Glu126Gly, His161Arg and G197A polymorphisms in vitiligo patients Results: As a result of our study, we have found a significant relation between His161Arg polymorphism of IL17F gene and vitiligo patients (p = 0.045). Conclusions: Our findings suggest that the IL17F His161Arg gene polymorphism has a protective role in susceptibility to vitiligo. This may be regarded as hypothesis-generating and should further be investigated in independent studies. © 2019, Kuwait Medical Association. All rights reserved Daha fazlası Daha az

Aydin M. | Ozeren A. | Bilge M. | Atmaca H. | Unalacak M. | Dursun A. | Elbey M.A.

Article | 2005 | Texas Heart Institute Journal32 ( 1 ) , pp.28 - 34

The purpose of this prospective study was to determine the relationship between circadian blood pressure and left ventricular diastolic function in essential hypertension. The study population included 25 patients aged 56 ± 18 years with non-dipper hypertension and 25 age- and sex-matched patients with dipper hypertension. They underwent conventional Doppler echocardiography and color tissue Doppler from apical 4-and 2-chamber views. In non-dipper patients, diastolic left ventricular function was reduced significantly. The transmitral E wave decreased (0.55 ± 0.2 vs 0.62 ± 0.2 m/s, P

Kalayci M. | Çagavi F. | Bayar U. | Gül Ş. | Dursun A. | Ermis B. | Açikgöz B.

Article | 2006 | Acta Neurochirurgica148 ( 10 ) , pp.1103 - 1106

Neurocutaneous melanosis is an uncommon congenital disorder consisting of benign or malignant melanocytic tumors of the leptomeninges with large or numerous cutaneous congenital melanocytic nevi. The Dandy-Walker malformation occurs as an enlarged posterior fossa with high insertion of the tentorium, hypoplasia or aplasia of the cerebellar vermis, and cystic dilatation of the fourth ventricle. To our knowledge, the association of these two conditions has been reported only 14 times. In this article, we present a newborn patient with neurocutaneous melanosis associated with Dandy-Walker malformation, which was diagnosed by magnetic r . . .esonance imaging. © 2006 Springer-Verlag Daha fazlası Daha az

Tascilar N. | Dursun A. | Ankarali H. | Mungan G. | Sumbuloglu V. | Ekem S. | Bozdogan S.

Article | 2009 | Journal of the Neurological Sciences277 ( 01.Feb ) , pp.17 - 21

Background and purpose: Apolipoprotein E (apoE) polymorphism is suggested to be a risk factor in stroke in some populations, either by affecting lipid parameters or independently. Its effect on lipoprotein(a) [Lp(a)] is not known. The roles of apoE polymorphism and of high Lp(a) levels in atherosclerotic stroke (AS) in the Turkish population are unclear. Our aim was to investigate the relationship of apoE alleles and Lp(a) level with AS and the relationship of apoE alleles with Lp(a) and other lipid parameters. Methods: ApoE polymorphisms and lipid parameters were prospectively evaluated in 85 patients and 77 controls with normal br . . .ain imaging. Results: Only hypertension, diabetes mellitus, associated vascular diseases and decreased high-density lipoprotein cholesterol levels were found to be independent risk factors for stroke. However, in the presence of apoE/E4 allele, increased low-density lipoprotein cholesterol (LDL-chol), apolipoprotein B (apoB) and Lp(a) levels and in the presence of apo E/E3 allele, only Lp(a) levels were determined as risk factors. Conclusion: This study showed that while apoE polymorphism was not a risk factor itself, high Lp(a), LDL-chol and apoB were determined to be risk factors in E3 or E4 carriers. © 2008 Elsevier B.V. All rights reserved Daha fazlası Daha az

Aydin M. | Özeren A. | Bilge M. | Demirkiran M. | Cam F. | Dursun A. | Elbey M.A.

Article | 2004 | Turk Kardiyoloji Dernegi Arsivi32 ( 4 ) , pp.239 - 245

This study was conducted to evaluate the effect of metoprolol therapy on pulmonary venous flow pattern in patients with mild to modarete mitral stenosis in sinus rhythm. We studied 23 patients with isolated mild to moderate mitral stenosis (mitral valve area 1.6±0.3 cm2). All patients received metoprolol 100 mg once daily orallyfor 1 month. Pulsed wave Doppler transesophageal echocardiograpic examination of the pulmonary venous flow was performed at the beginning of the study and after 1 month of treatment. Peak systolic pulmonary venous fiow (PVs) velocity, PVs velocity time integral (VTI), peak diastolic pulmonary venous flow (PM) . . . velocity, PVd-VT, peak pulmonary venous atrial reversal flow (PVd) velocity, PVa-VTI, and PVa duration time were measured. Peak and mean transmitral gradient, pulmonary artery pressure, systolic and diastolic blood pressure, and heart rate, reduced significantly after metoprolol treatment. The pulmonary venous peak systolic velocity, and pulmonary venous atrial reversal flow velocity duration time increased significantly from 0.55 ± 0.19 m/s to 0.66 ± 0.12 m/s, p<0.05, and from 84 ± 27 to 11 2± 31 msec, p<0.01, respectively). Regarding VTI, PVs-VTI increased from 10.8±3.2 cm to 11.9±4.3 cm (p<0.01), PVd-VTI increased from 5.1±2.4 cm to 5.4±2.5 cm (p<0.05), and PVa-VTI increased from 2.8±1.1 cm to 3.1±1.3 cm, p<0.05. Conclusion: Metoprolol treatment increased pulmonary venous flow as an indicator of improved left atrial function in patients with mitral stenosis and sinus rhythm. These results may contribute to disclosing the underlying mechanisms of the favourable effects of beta blockade in mitral stenosis Daha fazlası Daha az

Kulah E. | Dursun A. | Aktunc E. | Acikgoz S. | Aydin M. | Can M. | Dursun A.

Article | 2007 | Blood Pressure Monitoring12 ( 4 ) , pp.207 - 213

INTRODUCTION: Regulation of angiotensin converting enzyme (ACE) and angiotensin II (ang-II) levels is under genetic control. 1,25(OH)2 vitamin D3 treatment has been shown to reduce the ang-II level, reduce myocardial hypertrophy and to decrease blood pressure. This study was designed to examine the effect of ACE gene polymorphisms on 24-h ambulatory blood pressure measurement (24 h) values, vitamin D levels and target organ damage in hypertensive patients. METHODS: This study was carried on 118 patients with essential hypertension (female/male: 70/48, mean age: 49.1±7.6 years, hypertension duration: 56±40.5 months). All patients wer . . .e assessed for target organ damage; the eye by retinal examination, the heart with echocardiography and the kidney with blood and 24-h urine analysis. 24-h ambulatory blood pressure measurement was performed in all patients. PCR amplification was employed to detect ACE genotypes. RESULTS: ACE genotypes were as follows: DD (n=49) 41.5%; ID (n=37) 31.4% and II (n=32) 27.1%. No difference was present between groups of ACE polymorphism when 24-h ambulatory blood pressure measurement values, retinal vascular changes and microalbuminuria were taken into account. Statistically significant left ventricular mass index levels were obtained in the DD group when compared with the non-DD (ID+II) group (P: 0.009). Positive correlations have been noted between left ventricular mass index and day/night and early morning systolic pressures. A negative correlation exists between serum 25 (OH) vitamin D levels and 24-h ambulatory blood pressure measurement values ( Daha fazlası Daha az

Dursun A. | Durakbasi-Dursun H.G. | Zamani A.G. | Gulbahar Z.G. | Dursun R. | Yakicier C.

Article | 2006 | Mediators of Inflammation2006 , pp.207 - 213

Objectives. Behçet's disease (BD) is a systemic vasculitis with recurrent oral and genital ulcers and uveitis. MEFV gene, which is the main factor in familial Mediterranean fever (FMF), is also reported to be a susceptibility gene for BD. The pyrin domain of MEFV gene is a member of death-domain superfamily and has been proposed to regulate inflammatory signaling in myeloid cells. This study was designed to determine if mutations in pyrin domain of MEFV gene are involved in BD. Methods. We analyzed the pyrin domain of MEFV gene in 54 Turkish patients with BD by PCR-analysis and direct sequencing. Results. Neither deletion or inserti . . .on mutations nor point mutations in pyrin domain were found in any patient. Conclusion. Although pyrin gene mutations have been reported in patients with BD, pyrin domain is not mutated. However, alterations in other regions of MEFV gene and interaction between pyrin domains are needed to be further investigated. Copyright © 2006 Ahmet Dursun et al Daha fazlası Daha az

Ozeren A. | Aydin M. | Bilge M. | Dursun A. | Onuk T.

Letter | 2005 | International Journal of Cardiology102 ( 2 ) , pp.341 - 343

[No abstract available]

Cakmak Genc G. | Dursun A. | Nagy N. | Celikmakas A. | Acuner B.

Article | 2019 | The American Journal of dermatopathology41 ( 10 ) , pp.778 - 780

[No abstract available]

Kulah E. | Dursun A. | Acikgoz S. | Can M. | Kargi S. | Ilikhan S. | Bozdogan S.

Article | 2007 | Kidney and Blood Pressure Research29 ( 6 ) , pp.344 - 350

Background: The contribution of genetic factors in hypertension cannot be denied. Methods: In this study we evaluated the relationship between vitamin D receptor (VDR) gene polymorphisms (Bsm-I, Apa-I and Fok-I), and target organ damage in 74 patients (female/male 49/25, mean age 49.2 ± 8 years) with essential hypertension. The VDR genotypes were evaluated by polymerase chain reaction and digestion of the amplified products by related enzymes. Patients with diabetes mellitus or impaired glucose tolerance and severe obesity were excluded. All patients underwent a complete physical examination, full biochemistry and urinalysis; in add . . .ition, all of them were assessed for target organ damage. Twenty-four-hour ambulatory blood pressure monitoring was performed in all patients. Results: No significant difference was detected in biochemistry results and physical examination between groups for Bsm-I and Apa-I VDR gene polymorphisms. Patients were distributed as FF (n = 39) and non-FF (Ff/ff, n = 35) for Fok-I polymorphism. A negative correlation was present between vitamin D levels and day-time interval and early morning average by the measurement of 24-hour ambulatory blood pressure in the non-FF group. Serum cystatin-C was higher in the non-FF group (p = 0.012). In addition on retinal examination, the degree and presence of retinopathy were significantly higher in the non-FF group when compared to the FF group (p = 0.025, p = 0.018, respectively). Conclusion: Knowing the VDR gene polymorphisms status may be helpful in preventing target organ damage in hypertensive patients. Copyright © 2006 S. Karger AG Daha fazlası Daha az

Bozdoğan S.T. | Erol B. | Dursun A. | Bozdoğan G. | Dönmez I. | Mungan N.A. | Seydaoglu G.

Article | 2015 | World Journal of Urology33 ( 3 ) , pp.389 - 395

Materials and methods: A total of 100 patients with bladder carcinoma and 102 healthy control subjects were enrolled in the study. The IL-1RN, IL-4 and TNF-ß gene polymorphisms were identified by PCR restriction fragment length polymorphism-based analysis. Allelic frequencies were compared between patient and the controls. Tumor stage, histopathological grade, tumor size/number and smoking condition were evaluated with IL-1RN, IL-4 and TNF-ß gene polymorphisms.Purpose: We investigated the relationship between the distribution of the IL-1RN, TNF-ß and IL-4 polymorphism and the clinical features of bladder cancer.Results: Allele distr . . .ibution frequencies of IL-1RN and IL-4 gene polymorphisms were significantly different between patients and control groups. However, allele distribution of TNF-ß gene was not statistically significant. There was no difference in allele distribution of the three genes in both groups regarding stage, tumor size, number of tumors and smoking condition. Although allele distribution of IL-4 gene showed significant difference considering histopathological grades in both smoking and total patients group, allele distribution of IL-1RN and TNF-ß was not different.Conclusion: The present research suggests that the IL-1RN and IL-4 gene polymorphisms are potential genetic markers of susceptibility to bladder cancer. In the future, clinical improvements on diagnosis, treatment and prognosis of bladder carcinoma are expected owing to development of more sensitive and specific tests for genetic polymorphisms of cytokines that are effective on inflammation. © 2014, Springer-Verlag Berlin Heidelberg Daha fazlası Daha az