Dogan S.M. | Aydin M. | Gürsürer M. | Dursun A. | Çam F. | Onuk T. | Madak H.

Article | 2005 | Anadolu Kardiyoloji Dergisi5 ( 3 ) , pp.178 - 181

Objective: In this study, we aimed to investigate effects of metoprolol treatment on transmitral, pulmonary venous flows and spontaneous echo contrast in patients with heart failure. Methods: Twenty-four patients (mean age: 55±8 years) with heart failure were enrolled to the study. All were given metoprolol succinate with titrated target dose of 50 mg/d controlled release tablets for 1 month. Transmitral flow and pulmonary venous flow, systolic, diastolic and atrial reversal flow velocities were measured, and compared with the pretreatment values. Results: Heart rate significantly decreased. No significant change was observed in eje . . .ction fraction. When the post treatment values were compared with the pretreatment values, it was detected that isovolumetric relaxation time significantly decreased ( Daha fazlası Daha az

Aydin M. | Özeren A. | Bilge M. | Demirkiran M. | Cam F. | Dursun A. | Elbey M.A.

Article | 2004 | Turk Kardiyoloji Dernegi Arsivi32 ( 4 ) , pp.239 - 245

This study was conducted to evaluate the effect of metoprolol therapy on pulmonary venous flow pattern in patients with mild to modarete mitral stenosis in sinus rhythm. We studied 23 patients with isolated mild to moderate mitral stenosis (mitral valve area 1.6±0.3 cm2). All patients received metoprolol 100 mg once daily orallyfor 1 month. Pulsed wave Doppler transesophageal echocardiograpic examination of the pulmonary venous flow was performed at the beginning of the study and after 1 month of treatment. Peak systolic pulmonary venous fiow (PVs) velocity, PVs velocity time integral (VTI), peak diastolic pulmonary venous flow (PM) . . . velocity, PVd-VT, peak pulmonary venous atrial reversal flow (PVd) velocity, PVa-VTI, and PVa duration time were measured. Peak and mean transmitral gradient, pulmonary artery pressure, systolic and diastolic blood pressure, and heart rate, reduced significantly after metoprolol treatment. The pulmonary venous peak systolic velocity, and pulmonary venous atrial reversal flow velocity duration time increased significantly from 0.55 ± 0.19 m/s to 0.66 ± 0.12 m/s, p<0.05, and from 84 ± 27 to 11 2± 31 msec, p<0.01, respectively). Regarding VTI, PVs-VTI increased from 10.8±3.2 cm to 11.9±4.3 cm (p<0.01), PVd-VTI increased from 5.1±2.4 cm to 5.4±2.5 cm (p<0.05), and PVa-VTI increased from 2.8±1.1 cm to 3.1±1.3 cm, p<0.05. Conclusion: Metoprolol treatment increased pulmonary venous flow as an indicator of improved left atrial function in patients with mitral stenosis and sinus rhythm. These results may contribute to disclosing the underlying mechanisms of the favourable effects of beta blockade in mitral stenosis Daha fazlası Daha az